Gender, HIV-related clinical events, and mortality: preliminary observational data from the community programs for clinical research on AIDS (CPCRA).

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Gender, HIV-related clinical events, and mortality: preliminary observational data from the community programs for clinical research on AIDS (CPCRA).

Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0031). Unique Identifier : AIDSLINE ICA8/92399988
Melnick S; Sherer R; Hillman D; Rodriguez E; Lackman C; Capps L; Korvick J; Vermund S; Carlyn M; Deyton L; Division of AIDS, NIAID/NIH, Bethesda, MD.

Abstract: OBJECTIVES: Possible gender differences in HIV-associated clinical events and mortality may have care implications. Gender differences were assessed using observational data collected on 843 women (20%) and 3,359 men (80%) from 17 CPCRA centers. METHODS: Demographic and clinical data were collected at least every 6 months. The relative risk (RR) of event/death incurred by women compared to men was computed by the Cox model, with stratification by CPCRA center, CD4, AIDS, age, weight, Karnofsky, and race. Incident events were defined as those occurring for the first time during the follow-up interval, excluding participants with any HIV-related event at enrollment. RESULTS: 40% of the 4,202 participants were African-American, 18% Latino/Hispanic, 42% White. 70% were aged 30-49. 19% of women and 28% of men were drug-users. 42% had CD4 less than 200; 70% had CD4 less than 500. RR's were computed for several clinical events, including PCP, oral and esophageal candidiasis (OCa, ECa), herpes zoster (HZV), M. avium (MAI), and cytomegalovirus (CMV). The average length of follow-up was 6.6 months. TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSIONS: These preliminary findings suggest no significant gender differences in clinical events/death after adjustment for important confounders.

Keywords: Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY Adult Comparative Study Ethnic Groups Female Follow-Up Studies Human HIV Infections/COMPLICATIONS/*EPIDEMIOLOGY Male Middle Age Opportunistic Infections/COMPLICATIONS/*EPIDEMIOLOGY Proportional Hazards Models Risk United States/EPIDEMIOLOGY ABSTRACT
921230
M92C5359

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .