Cervical intraepithelial neoplasia in HIV-infected women.

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Cervical intraepithelial neoplasia in HIV-infected women.

Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0057). Unique Identifier : AIDSLINE ICA8/92400009
Fruchter R; Maiman M; Serur E; Cuthill S; State Univ. of New York-Health Science Center, Brooklyn.

Abstract: OBJECTIVES: To compare, in HIV-infected and HIV-negative women, 1) the characteristics of cervical intraepithelial neoplasia (CIN) and (2) the course of CIN after treatment. METHODS: (1) Women with Pap smears of CIN1 or worse attending a colposcopy service were counselled and tested for HIV. Lesion extension was determined by colposcopy and CIN severity by biopsy. (2) HIV-seropositive and HIV-seronegative CIN patients were treated by standard ablative therapy and followed with at least one Pap smear. Persistence/recurrence was defined as biopsy-proven CIN and rates were calculated by the product-limit method. RESULTS: (1) Compared to 132 HIV-seronegative CIN patients, 52 HIV-seropositive CIN patients were older, had more severe CIN (p less than 0.01), more extensive cervical lesions (p less than 0.05) and more associated vulvovaginal lesions (p less than 0.1). In HIV-seropositive women, CIN was more severe after adjustment for age. (2) CIN persisted or recurred within one year in 40% of 33 HIV-positive CIN patients compared to 7% of 109 HIV-negative CIN patients (p less than 0.05). Recurrence rate was not related to age or CIN severity. CONCLUSIONS: In patients with equivalent cytology, CIN is likely to be more extensive and of higher grade in the HIV-infected. Since CIN is more likely to recur, HIV-infected women must be closely monitored by colposcopy and new therapeutic strategies developed. TABULAR DATA, SEE ABSTRACT VOLUME.

Keywords: Carcinoma in Situ/*COMPLICATIONS/SURGERY Cervix Neoplasms/*COMPLICATIONS/SURGERY Colposcopy Female Human HIV Infections/*COMPLICATIONS HIV Seropositivity/COMPLICATIONS Treatment Outcome Vaginal Smears ABSTRACT
921230
M92C5338

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .