Anal cytologic abnormalities and papillomavirus infection in men with HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Anal cytologic abnormalities and papillomavirus infection in men with HIV infection.

Int Conf AIDS. 1992 Jul 19-24;8(1):Mo16 (abstract no. MoB 0058). Unique Identifier : AIDSLINE ICA8/92400015
Palefsky J; Shiboski S; Moss A; University of California, San Francisco 94143.

Abstract: OBJECTIVES: Previous studies have shown a high prevalence of potentially precancerous anal cytologic abnormalities and anal human papillomavirus (HPV) infection among men with C.D.C. Group IV HIV disease. The objective of this study was to determine the prevalence of, and risk factors for anal cytologic abnormalities and HPV infection in men with Group II HIV disease and HIV-negative homosexual men. METHODS: Thirty-four HIV-positive and 28 HIV-negative homosexual men followed as part of the San Francisco General Hospital Cohort Study were studied with two consecutive anal swabs for the presence of anal cytologic abnormalities and anal HPV infection using the ViraPap/ViraType HPV detection method. A questionnaire on sexual and other behaviors was administered, and CD4 levels measured. Univariate and multivariate analyses were conducted. RESULTS: Of HIV-positive men, 28% had abnormal and cytology and 64% had anal HPV infection. Of HIV-negative men, 7% had abnormal anal cytology and 38% had anal HPV infection. Univariate analyses revealed associations between abnormal cytology and both CD4 counts less than 200/mm3 (OR = 15.4, p = 0.002) and HIV infection (OR = 5.1, p = 0.06). Associations were also observed between anal HPV infection and both CD4 counts less than 200/mm3 (OR = 10.4, p = 0.03) and HIV infection (OR = 2.9, p = 0.07). In logistic regression models controlling for HIV status and CD4 counts less than 200/mm3, abnormal cytology was significantly associated with current smoking of at least one pack of cigarettes per day (OR = 12.8, p = 0.05) and anal HPV infection was significantly associated with history of genital herpes (OR = 12.3, p = 0.03). CONCLUSIONS: We conclude that both abnormal anal cytology and anal HPV infection are associated with HIV infection and increased immunosuppression as measured by CD4 counts less than 200/mm3. In addition to HIV-associated immunosuppression, smoking and genital herpes infection may play a role in the pathogenesis of potentially precancerous anal disease, and possibly in the development of anal cancer.
Keywords: Anus/*PATHOLOGY Cohort Studies CD4-Positive T-Lymphocytes Herpes Genitalis/COMPLICATIONS Homosexuality Human HIV Infections/*COMPLICATIONS HIV Seropositivity/COMPLICATIONS Leukocyte Count Logistic Models Male Papillomavirus/*ISOLATION & PURIF Precancerous Conditions/*COMPLICATIONS Questionnaires San Francisco/EPIDEMIOLOGY Smoking Tumor Virus Infections/*COMPLICATIONS/EPIDEMIOLOGY/MICROBIOLOGY ABSTRACTKWDanus/KWDpathologycohortstudiescd4-positivet-lymphocytesherpesgenitalis/complicationshomosexualityhumanhivinfections/KWDcomplicationshivseropositivity/complicationsleukocytecountlogisticmodelsmalepapillomavirus/KWDisolation&purifprecancerousconditions/KWDcomplicationsquestionnairessanfrancisco/epidemiologysmokingtumorvirusinfections/KWDcomplications/epidemiology/microbiologyabstract
921230
M92C5332

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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