1992

HIV infection and legal concerns. [videorecording]: [Oakland, Calif.] : Kaiser Permanente, [1990] 1 videocassette (49 min.) : sd., col. ; 1/2 in (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9201348A
When the physician is HIV positive. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1991 1 videocassette (50 min.) : sd., col. ; 1/2 in (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9201378A; Wolfe E
Women and HIV infection. [videorecording]: [Oakland, Calif.] : Kaiser Permanente, [1991] 1 videocassette (47 min.) : sd., col. ; 1/2 in (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9201379A; Wolfe E
Bloodborne pathogens standard for environmental workers. [videorecording]: [Tucson, Ariz.] : Medfilms, c1992 1 videocassette (10 min., 30 sec.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9201346A; Reeter AK
[Comment eviter le SIDA, syndrome d'immunodeficience acquise : une information complete, des conseils utiles, des reponses a toutes vos questions.]: Kigali, Rwanda : Croix-Rouge rwandaise, [1987?] 30 p. : ill Unique Identifier : AIDSLINE CAT/9214864
AIDS bulletin : report from Institute of Actuaries, AIDS Working Party.: [London?] : The Institute, v. : ill Unique Identifier : AIDSLINE CAT/9215297
African madness. 1st ed.: New York : A.A. Knopf : Distributed by Random House, 1988 xviii, 202 p Unique Identifier : AIDSLINE CAT/9215274; Shoumatoff A
Health services research methodology : a focus on AIDS : conference proceedings.: Rockville, MD (OASH, Parklawn Building, Room 18-12, Rockville 20857) : National Center for Health Services Research and Health Care Technology Assessment, Public Health Service, U.S. Dept. of Health and Human Services, [1989] vii, 205 p. : ill (DHHS publication ; no. (PHS) 89-3439) Unique Identifier : AIDSLINE CAT/9215160; Sechrest L; Freeman HE; Mulley AG; Technology Assessment (U.S.)
New perspectives on HIV-related illnesses : progress in health services research : conference proceedings, Miami, Florida, May 17-19, 1989.: Rockville, MD (OASH, Parklawn Building, Room 18-12, Rockville 20857) : National Center for Health Services Research and Health Care Technology Assessment, Public Health Service, U.S. Dept. of Health and Human Services, [1989] vii, 215 p. : ill (DHHS publication ; no. (PHS) 89-3449) Unique Identifier : AIDSLINE CAT/9215197; LeVee WN; Technology Assessment (U.S.)
[El:SIDA : un reto a la sanidad, la sociedad, y la etica.]: Madrid : UPCM, 1989 160 p. : ill (Dilemas eticos de la medicina actual ; 3) Unique Identifier : AIDSLINE CAT/9215068; Gafo Fernandez J
[Zu einer sozialen Atiologie von AIDS : der soziologische Beitrag zur Krankheitserklarung.]: Bremen : Universitat Bremen, [1989] 132 p (Bremer soziologische Texte ; Bd. 3) Unique Identifier : AIDSLINE CAT/9215652; Koch V
Women and infants at risk for HIV infection : guidelines and protocols for prevention and care.: Project Development. Office of Maternal and Child Health [San Francisco : The Project, 1990?] v, 92 p Unique Identifier : AIDSLINE CAT/9214787
[El:SIDA : medicina y etica.]: Madrid : Palabra, c1991 173 p (Libros MC) Unique Identifier : AIDSLINE CAT/9215626; Alberola I
Women, AIDS & communities : a guide for action.: New York, NY : Women's Action Alliance ; Metuchen, N.J. : Scarecrow Press, c1991 xi, 129 p. : ill Unique Identifier : AIDSLINE CAT/9215648; Pearlberg G
Cocaine, AIDS, and intravenous drug use.: New York : Haworth Press, c1991 124 p. : ill (Journal of addictive diseases, ISSN 1055-0887 ; v. 10, no. 4) Unique Identifier : AIDSLINE CAT/9215332; Friedman SR; Lipton DS; Stimmel B
[Homosexualites et sida : actes du colloque international, 12 et 13 avril 1991.]: Lille : Cahiers Gai-Kitsch-Camp, [1991?] 267 p (Cahiers Gai-Kitsch-Camp. Universite, ISSN 0998-4372 ; 4) Unique Identifier : AIDSLINE CAT/9215422; Pollak M
AIDS crisis in America : a reference handbook.: Santa Barbara, Calif. : ABC-CLIO, c1992 xvi, 268 p (Contemporary world issues) Unique Identifier : AIDSLINE CAT/9214842; Hombs ME
Multicultural human services for AIDS treatment and prevention : policy, perspectives, and planning.: New York : Haworth Press, c1992 122 p Unique Identifier : AIDSLINE CAT/9214975; Morales J; Bok M
Abstracts of papers presented at the 1991 meeting on modern approaches to new vaccines : including prevention of AIDS, September 19 - September 23, 1991.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, [1991?] xxxi, 132 p Unique Identifier : AIDSLINE CAT/9214817; Brown F
Atlas of the neuropathology of HIV infection.: Oxford ; New York : Oxford University Press, 1993 xxiii, 290 p. : ill Unique Identifier : AIDSLINE CAT/9214640; Gray F
Women, children, and HIV/AIDS.: New York : Springer Pub. Co., c1993 xv, 312 p. : ill Unique Identifier : AIDSLINE CAT/9215891; Cohen FL; Durham JD
AIDS : problems and prospects. 1st ed.: New York : W.W. Norton, c1993 viii, 162 p. : ill (A Hospital practice book) Unique Identifier : AIDSLINE CAT/9215695; Corey L
LENTINAN AS A HOST DEFENSE POTENTIATOR (HDP): Int J Immunotherapy; 5(4):145-54 1989. Unique Identifier : AIDSLINE ICDB/92668381; Chihara G; Maeda YY; Suga T; Hamuro J; Biotechnology Res. Center, Teikyo Univ., Kawasaki 213, Japan; Lentinan, a (1----6); (1----3)-beta-D-glucan having marked antitumor activity in syngeneic and autochthonous hosts, appears to represent HDPs which can improve the physiological constitution of the host against cancer and various kinds of infections, unlike so-called biological response modifiers. HDPs can restore or
ACTIVITY OF LENTINAN AGAINST CANCER AND AIDS: Int J Immunotherapy; 5(4):203-13 1989. Unique Identifier : AIDSLINE ICDB/92668386; Kaneko Y; Chihara G; Taguchi T; Ajinomoto Co. Inc., 5-8 Kyobashi, 1-chome, Chuo-ku, Tokyo 104,; Japan; Lentinan is a purified polysaccharide composed exclusively of glucose units with a beta(1----3) linkage as the main chain and a beta(1----6) linkage as the branched chain. Based on the results of animal experiments, the antitumor activity of lentinan is assumed to be due to potentiating the activity of the host defens
PERCUTANEOUS GASTROSTOMY: INDICATIONS, TECHNIQUES, AND COMPLICATIONS: Gastrointestinal Radiology Reviews. Volume 1. Herlinger H and Megibow A, eds. New York, Marcel Dekker, p. 15-24, 1990.. Unique Identifier : AIDSLINE ICDB/92668996; Ho CS; Yee AC; Dept. of Radiology, Toronto General Hosp., Toronto, Ontario,; Canada; In 1983, several radiologists independently described a nonendoscopic method of percutaneous gastrostomy using the Seldinger technique under fluoroscopic control. The technique, indications, complications, and related aspects of this type of percutaneous gastrostomy are reviewed. The major indication for percutaneous
IMUTHIOL, A T-CELL SPECIFIC IMMUNOPOTENTIATOR: Int J Immunotherapy; 6(1):25-35 1990. Unique Identifier : AIDSLINE ICDB/92669937; Renoux G; Renoux M; Immunology Lab., Faculty of Medicine, 37032 Tours, France; Imuthiol (Institut Merieux, Lyon, France ), purified sodium diethyldithiocarbamate (Ditiocarb, DTC), evinces distinctive properties, not actually shared by other biologicals. Imuthiol recruits T cells from precursors and activates T-cell functions, including interleukin-2 production
CMV RETINITIS IN THE AIDS PATIENT: AIDS Updates; 3(3):1-12 1990. Unique Identifier : AIDSLINE ICDB/92669953; Resta S; Wolitz R; Merigan TC; Div. of Infectious Diseases, Stanford Univ., Stanford, CA; Human cytomegalovirus (HCMV) belongs to the herpes viruses and shares with the other members of this family of viruses some basic characteristics. CMV retinitis in the patient (pt) with AIDS is reviewed, including ocular manifestations in AIDS, clinical manifestation and treatment
KAPOSI'S SARCOMA IN HIV-NEGATIVE HOMOSEXUAL MEN [LETTER]: Lancet; 335(8682):168-9 1990. Unique Identifier : AIDSLINE ICDB/92688101; Friedman-Kien AE; Saltzman BR; Cao Y; Nestor MS; Mirabile M; Li JJ; Peterman TA; Dept. of Microbiology, New York Univ. Medical Center, New York,; NY 10016; Kaposi s sarcoma (KS) was rarely seen in the United States before 1980. An aggressive type of KS has become widespread during the HIV/AIDS epidemic, mainly affecting homosexual men. 349 homosexual or bisexual men with biopsy proven KS seen in a university hospital-based dermatology pra
CNS LYMPHOMAS IN AIDS PATIENTS: NEURORADIOLOGY AND NEUROPATHOLOGY (MEETING ABSTRACT): Neuroradiology; 33(Suppl):S116 1991. Unique Identifier : AIDSLINE ICDB/92686318; Berkefeld J; Hacker H; Lang C; Schlote W; No affiliation given; The CT and MRI morphology of 30 cases with CNS lymphomas in AIDS patients was reviewed and compared with histological findings. Surprisingly, CT and MRI showed a bright spectrum of appearances, ranging from solid, nodular tumors to necrotic masses and very irregular types of spreading, which can mimic glioblastoma or
GADOLINIUM ENHANCEMENT OF THE CISTERNAL PORTION OF THE OCULOMOTOR NERVE: CLINICAL AND PATHOLOGICAL SIGNIFICANCE (MEETING ABSTRACT): Neuroradiology; 33(Suppl):S151 1991. Unique Identifier : AIDSLINE ICDB/92686342; Marx AS; Blake P; Ross M; Atlas S; Brown D; Washington Hosp. Center, Washington, DC; Gadolinium enhancement of the 2nd, 5th and 7th cranial nerves on MRI has recently been described in patients (pts) with respective cranial neuropathies. We report 10 pts with enhancement of the cisternal portion of the 3rd nerve. 50 control pts referred for pituitary microadenomas were also studied with coronal pre- a
MRI AND NEUROLOGICAL COMPLICATIONS OF ADULT T-CELL LEUKEMIA (MEETING ABSTRACT): Neuroradiology; 33(Suppl):S160 1991. Unique Identifier : AIDSLINE ICDB/92686345; Dumas JL; Visy JM; Brugieres P; Lhote F; Vassel P; Amouroux J; Goldlust D; Inst. of Tropical Neurology, Dept. of Medicine, Limoges, France; Our purpose was the MRI assessment of a lumbosacral localization of adult T-cell leukemia with HTLV-1 infection and search of CNS-associated involvement. Materials and methods: A 21-yr-old woman from Ivory Coast presented a meningoradiculopathy with adult T-cell leukemia-like
THE EPIDEMIOLOGY OF KAPOSI'S SARCOMA IN NEW SOUTH WALES PRIOR TO THE AIDS EPIDEMIC (MEETING ABSTRACT): Clinical Oncology Society of Australia Inc. Annual Scientific Meeting: From Laboratory to Clinic--an Integrated Approach to Cancer Research and Therapy. December 4-6, 1991, Sydney, Australia, p. 75, 1991.. Unique Identifier : AIDSLINE ICDB/92686657; Kaldor J; Coates M; Taylor R; Natl. Centre in HIV Epidemiology and Clinical Res., Sydney, New; South Wales, Australia; The role of immunosuppression in Kaposi s sarcoma (KS) has been established through the observation of KS in transplant recipients and the occurrence of KS as a manifestation of the acquired immunodeficiency syndrome (AIDS). More recently, it has been proposed that an infectious agent other than the human immunodefici
ABDOMINAL SURGERY IN PATIENTS WITH AIDS-RELATED LYMPHOMAS (MEETING ABSTRACT): Proc Annu Meet Am Soc Clin Oncol; 11:A17 1992. Unique Identifier : AIDSLINE ICDB/92680748; Jarrin G; Kemeny M; Lee M; St. Vincent's Medical Center, New York, NY 10011; In a retrospective chart review at St. Vincent s Hospital, 231 cases of non-Hodgkin s lymphoma (NHL) were admitted between 1986 and 1991 and 90 of these pts were known to be HIV antibody-positive. These cases of NHL were predominantly extranodal with 44 pts presenting with abdomina
IMPLANTATION OF THE PAS PORT VENOUS ACCESS DEVICE IN THE ONCOLOGY CLINIC BY A MEDICAL ONCOLOGIST (MEETING ABSTRACT): Proc Annu Meet Am Soc Clin Oncol; 11:A1384 1992. Unique Identifier : AIDSLINE ICDB/92682113; Leming PD; Christ Hosp. Cancer Center, Cincinnati, OH 45219; The PAS Port (Pharmacia Deltec, Inc.) is a low-profile titanium venous access port designed to be implanted under the skin in the forearm and attached to a catheter threaded into the superior vena cava/atrium. Between August 1989 and November 1991, 78 attempts at placement using the Seldinger technique and minor surgi
QUALITY OF LIFE (QL) ASSESSMENT IS PREDICTIVE OF SURVIVAL IN PATIENTS (PTS) WITH AIDS-RELATED MALIGNANCIES (MEETING ABSTRACT): Proc Annu Meet Am Soc Clin Oncol; 11:A1424 1992. Unique Identifier : AIDSLINE ICDB/92682153; Remick S; Blanchard C; Portuese E; Wighten T; Powell D; Hilstro J; McSharry J; Haase R; Albany Medical Coll., Albany, NY 12208; A total of 43 pts (25 KS + 18 NHL), enrolled in 2 chemotherapy protocols, completed 2 QL scales: Functional Living Index Cancer (FLIC) and Brief Symptom Inventory (BSI) at time of on-study. Clinical variables recorded for each pt included age, sex, performance status (PS), tumor stage, B-symptoms (BS), prior opportuni
ROLE OF ADF/THIOREDOXIN IN SIGNAL TRANSDUCTION MECHANISMS: INVOLVEMENT IN CELLULAR PROLIFERATION (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2090 1992. Unique Identifier : AIDSLINE ICDB/92684627; Biguet C; Wakasugi N; Wakasugi H; Tursz T; Laboratoire de Biologie des Tumeurs Humaines, URA 1156 CNRS,; Institut Gustave Roussy, 94805 Villejuif, France; We have shown that ADF (adult T-cell leukemia [ATL]-derived factor) is produced and released at high levels by both HTLV-I-infected ATL cells and EBV-immortalized B lymphocytes. ADF is the human equivalent of the disulfide-reducing enzyme thioredoxin (TRX). Recombinant ADF alone or in synergy with other cytokines, suc
ISOLATION AND DIFFERENTIATION OF A BIPHENOTYPIC CELL LINE FROM A PATIENT (PT) WITH MYELODYSPLASTIC SYNDROME (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2100 1992. Unique Identifier : AIDSLINE ICDB/92684633; Banerjee R; Bekesi JG; Deak G; Strauchen J; Holland JF; Acs G; Mount Sinai Sch. of Medicine, Dept. of Biochemistry, New York, NY; 10029; We isolated a cell line from the pleural exudate of a pt with myeloplastic syndrome exhibiting chronic myelomonocytic leukemia. After 3 generations, in vitro cells were mostly immature T cells (TCR gamma/delta+) containing myeloid marker CD15 but neither CD13 nor CD33. The cells are tumorigenic in nude mice, causing s
CATABOLISM OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE (D4T) IN ISOLATED HEPATOCYTES AND IN RHESUS MONKEYS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A3253 1992. Unique Identifier : AIDSLINE ICDB/92685792; Sommadossi JP; Zhou Z; Hitchcock MJ; McClure HM; el Kouni M; Cretton E; Univ. of Alabama at Birmingham, Birmingham, AL 35294; The present study evaluated the in vitro and in vivo catabolic fate of D4T, a novel anti-HIV agent. Following a 2-hr exposure of hepatocytes to 10 uM [3H]D4T, the predominant intracellular catabolite was beta-aminoisobutyric acid (BAIBA), representing 16% of the radioactivity by 90 min. Thymine levels decreased to 0.5
TGF-BETA: MULTIFUNCTIONAL EFFECTOR AND RESPONSE PATTERNS ASSOCIATED WITH CARCINOGENESIS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A580-1 1992. Unique Identifier : AIDSLINE ICDB/92687914; Roberts AB; Kim SJ; Sporn MB; Lab. of Chemoprevention, NCI, Bethesda, MD 20892; The ability of TGF-beta to inhibit the growth of most epithelial and lymphoid cells suggests that one of the mechanisms whereby these cells undergo carcinogenic transformation and escape from normal growth control might involve an altered response to this negative regulator. Characterization of the response pattern to
CLINICAL INSIGHTS IN HIV-RELATED MALIGNANCIES (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A591 1992. Unique Identifier : AIDSLINE ICDB/92687930; Kaplan MH; Dept. of Medicine, North Shore Univ. Hosp., Manhasset, NY 11030; HIV infection not only produces severe immunodeficiency, but also has produced an epidemic of lymphoma and Kaposi s sarcoma as well as other neoplastic conditions. We have been following 1530 HIV-infected patients (pts). We have recorded the appearance of the following neoplastic conditions: Kaposi s sarcoma (KS) +/-
CHROMOSOMAL TRANSLOCATIONS REVEAL NOVEL PROTO-ONCOGENES (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A603-4 1992. Unique Identifier : AIDSLINE ICDB/92687947; Korsmeyer SJ; Dept. of Medicine, Washington Univ. Sch. of Medicine, St. Louis,; MO 63110; Bcl-2 is a 25-kD integral mitochondrial membrane protein that blocks programmed cell death without promoting cell division. The t(14;18) chromosomal breakpoint found in follicular B-cell lymphoma juxtaposes Bcl-2 with the Ig heavy chain gene, resulting in marked overproduction of Bcl-2. Transgenic mice bearing a Bcl-2
CLINICAL APPLICATIONS OF HEMATOPOIETIC GROWTH FACTORS: Immunol Ser; 49:359-78 1990. Unique Identifier : AIDSLINE ICDB/92669152; Steward WP; Scarffe JH; Dexter TM; Testa NG; Dept. of Medical Oncology, Paterson Inst. for Cancer Res.,; Christie Hosp. and Holt Radium Inst., Manchester, UK; Growth factors play a major role in the control of hemopoiesis. Recombinant DNA technology recently has allowed the production of sufficient amounts of five of these for use in clinical testing: erythropoietin, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte CSF (G-CSF), macrophage CSF, and inte
DEOXYCYTIDINE DEAMINASE-RESISTANT FORM IS THE ACTIVE FORM OF +/-2',3'-DIDEOXY-3'-THIACYTIDINE (+/- SDDC) FOR THE INHIBITION OF HEPATITIS B VIRUS (HBV) AND HUMAN IMMUNODEFICIENCY VIRUSES (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2385 1992. Unique Identifier : AIDSLINE ICDB/92685587; Chang CN; Doong SL; Zhou JH; Skalski V; Chu CK; Cheng YC; Dept. of Pharmacology, Yale Univ., New Haven, CT 06510; In culture, +/-SddC was found to have potent activity against HIV as well as human HBV. The -form (-SddC), which is resistant to deoxycytidine deaminase, was found to be the more active antiviral stereo isomer and less toxic than the +form (+SddC) in terms of anti-cell growth and antimitochondrial DNA synthesis. The -
INTERFERON THERAPY IN CANCER: Principles of Cancer Biotherapy. Second Edition. Oldham RK, ed. New York, Marcel Dekker, p. 363-93, 1991.. Unique Identifier : AIDSLINE ICDB/92686022; Goldstein D; Laszlo J; Rudnick SA; Smalley RV; Center for Immunology, Sydney, Australia; Interferon (IFN) was first characterized in 1957, but clinical trials only began in the 1970s. Data from large-scale trials did not support the notion of widespread efficacy of IFN, but rather delineated a clearer, but narrower, role. The potential mechanisms of action of IFNs as direct antineoplastic agents and as im
CUTANEOUS T-CELL, HTLV-1-ASSOCIATED NON-HODGKIN'S LYMPHOMAS (MEETING ABSTRACT): Dublin 91: Joint Annual Scientific Meeting and Exhibition of the Royal College of Radiologists and the Faculty of Radiologists, the Royal College of Surgeons in Ireland. September 25-28, 1991, Dublin, Ireland, p. 135, 1991.. Unique Identifier : AIDSLINE ICDB/92686426; Bunn PA Jr; Dept. of Medicine, Div. of Medical Oncology, Univ. of Colorado; Cancer Center, Denver, CO; The Working Formulation classification of non-Hodgkin s lymphomas does not include most of the T-cell lymphomas. The cutaneous T-cell lymphomas are low-grade lymphomas, which include mycosis fungoides and the Sezary Syndrome. The malignant cells have a mature helper T-cell phenotype (CD2+, CD3+, CD4+, CD8-) and low ex
HIV-RELATED MALIGNANCIES (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A590-1 1992. Unique Identifier : AIDSLINE ICDB/92687929; Levine AM; Div. of Hematology, Univ. of Southern California Sch. of; Medicine, Los Angeles, CA 90033; Organ transplantation, with subsequent iatrogenic immunosuppression and chronic antigenic stimulation may be seen as a model by which to begin the study of AIDS-related malignancies. Thus, patients (pts) who have undergone allogeneic transplantation are at increased risk for certain tumors, including Kaposi s sarcoma
Age accelerates the progression from HIV-seroconversion to AIDS in women. Italian Seroconversion Study (HIV-ISS).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0033). Unique Identifier : AIDSLINE ICA8/92399985; Rezz G; Pezzotti P; Dorrucci M; Angarano G; Castelli F; Sinicco A; Costigliola P; Canessa A; Pristera R; Zerboni R; et al; OBJECTIVES: To estimate the risk of developing AIDS for women compared to that of men, and to identify predictors of clinical progression in women. METHODS: We conducted a longitudinal study, enrolling individuals for whom the seroconversion period could be estimated (i.e. availability of a negative serological test a
Gender differences in the natural history of HIV infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0030). Unique Identifier : AIDSLINE ICA8/92399986; Szabo S; Miller LH; Sacks HS; Gurtman AC; Rose DN; Kee RA; Cheung TW; Cohen SE; Mount Sinai School of Medicine, New York, NY.; OBJECTIVE: To compare the natural history of HIV infection in men and women. METHODS: Retrospective chart review of 149 HIV infected women (HW) and 111 HIV infected men (HM) registered in the Infectious Disease clinic from 8/87 to 7/91 at an inner city tertiary care center. RESULTS: 149 HW age 33 +/- 7.6 yrs (mean +/-
Gender differences in the spectrum of HIV disease. ARCA Spectrum of Disease Working Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0032). Unique Identifier : AIDSLINE ICA8/92399987; Creagh T; Thompson M; Morris A; Whyte B; AIDS Research Consortium of Atlanta, Inc., Georgia.; OBJECTIVE: To determine gender differences in the spectrum of HIV disease in adults. METHODS: All HIV-infected adults (greater than 13 yrs) entering the office or clinic of a participating site between February 1, 1990 and December 1, 1990 were eligible for enrollment. Thirty-two private practitioners (Internal Medici
Gender, HIV-related clinical events, and mortality: preliminary observational data from the community programs for clinical research on AIDS (CPCRA).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0031). Unique Identifier : AIDSLINE ICA8/92399988; Melnick S; Sherer R; Hillman D; Rodriguez E; Lackman C; Capps L; Korvick J; Vermund S; Carlyn M; Deyton L; Division of AIDS, NIAID/NIH, Bethesda, MD.; OBJECTIVES: Possible gender differences in HIV-associated clinical events and mortality may have care implications. Gender differences were assessed using observational data collected on 843 women (20%) and 3,359 men (80%) from 17 CPCRA centers. METHODS: Demographic and clinical data were collected at least every 6 mo
Sexually transmitted diseases and HIV among young Thai men.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0028). Unique Identifier : AIDSLINE ICA8/92399989; Eiumtrakul S; Matanasarawoot A; Tulvatana S; Celentano D; Nelson K; Wright N; Chiang Mai University.; OBJECTIVE: Sexually transmitted diseases (STDs) have been identified as risk factors for heterosexually transmitted HIV infection in numerous epidemiologic studies. While studies of heterosexual transmission in the USA have suggested a low efficiency of HIV transmission, the rate of heterosexual transmission appears t
What proportion of HIV infections are attributable to genital ulcers in sub-Saharan Africa?: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo10 (abstract no. MoC 0029). Unique Identifier : AIDSLINE ICA8/92399990; Hayes RJ; Schulz KF; London School of Hygiene and Tropical Medicine, UK.; OBJECTIVES: The heterosexual transmission of HIV is assumed to be facilitated in the presence of other STDs, but the strength of this effect, and the proportion of HIV infections in sub-Saharan Africa attributable to the presence of STDs, are unknown. This study considers problems in the estimation of this cofactor ef
Natural history of HIV-1 infection in African women: a prospective cohort study in Kigali (Rwanda), 1988-1991.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo11 (abstract no. MoC 0035). Unique Identifier : AIDSLINE ICA8/92399991; Msellati P; Leroy V; Lepage P; Hitimana DG; Mukamabano B; Van Goethem C; Van de Perre P; Dabis F; INSERM U. 330, Bordeaux, France.; OBJECTIVES: 1) To evaluate prospectively morbidity and mortality in a cohort of HIV-1 infected women. 2) To compare these features with those of a cohort of HIV-uninfected women. METHODS: In the context of a study on perinatal transmission of HIV-1, we enrolled at delivery 215 HIV seropositive (HIV+) and 216 HIV seron
Women with HIV disease: clinical progression and survival in a cohort followed at a university medical center.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo11 (abstract no. MoC 0034). Unique Identifier : AIDSLINE ICA8/92399992; Benson C; Sha B; Urbanski P; Pottage J; Kessler H; Rush Medical College, Chicago, IL.; OBJECTIVE: To evaluate the clinical progression and overall survival following the diagnosis of HIV infection in a cohort of women followed at a university medical center. DESIGN: Single site, longitudinal, observational study. METHODS: Women evaluated in the HIV Treatment Program at Rush were included if they were se
A model of HIV transmission by syringe sharing in English prisons using surveys of injecting drug users.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0038). Unique Identifier : AIDSLINE ICA8/92399993; Dolan K; Medley G; Stimson GV; Centre for Research on Drugs and Health Behaviour, University of; London, UK.; OBJECTIVES: To construct a model of HIV transmission and the effects of prevention strategies by using survey data and HIV prevalence data for IDUs. METHOD: Assume: each IDU only has access to one syringe at a time and IDUs (n) using a syringe share it randomly. Probability of transfer of infection when an uninfected
A strategy for the control of HIV infection in African prison establishments.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0041). Unique Identifier : AIDSLINE ICA8/92399994; Simooya OO; Maboshe MN; Hira SK; Mukunyandela MN; In 1987/8, a survey was conducted in 5 Zambian Prison Institutions, to establish; (1), sexual habits and practices, (2) seroprevalence of human immunodeficiency virus-1 (HIV-1) infection and (3), incidence of venereal disease amongst Prison inmates. Specifically, it was designed to determine whether or not homosexuali
Prisoners with HIV/AIDS and TB/MDR-TB: the epidemic within the epidemic. Analysis, demographics and treatment access in New York state corrections facilities.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0036). Unique Identifier : AIDSLINE ICA8/92399995; Machon SC; Correctional Assoc. of NY/ACT U.; ISSUE/PROBLEM: The rapid escalation of HIV caseload in jails and prisons has also been accompanied by an even faster escalating number of diagnosed cases of TB. In addition is the number of mortalities linked to MDR-TB for the HIV infected, which approaches 100%. In NY State, and particularly NY City, the open door be
Program for the prevention and control of HIV/AIDS in Spanish prisons.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0037). Unique Identifier : AIDSLINE ICA8/92399996; Diez M; Martin L; Granados A; ISSUE/PROBLEM: In the last few years the number of intravenous drug users (IVDU) has increased in Spanish prisons. Since intravenous drug use is a known risk factor for HIV infection, the Spanish Prison Health Service implemented in 1989 a Program for the Prevention and Control of HIV/AIDS in Spanish prisons. DESCRIPT
The policy response to HIV in prisons worldwide.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0039). Unique Identifier : AIDSLINE ICA8/92399997; Hammett T; Harding TW; Egger S; Heilpern H; Abt Associates, Cambridge, MA.; OBJECTIVES: This paper compares actual prison policies on HIV disease with WHO s recommendations (1987). METHODS: Data are from surveys for WHO (Harding, 42 nations), US Justice Dept. (Hammett, US and Canada ), and the Australian Dept. of Community Services and Health (Egger and Hei
Women in prison: information and solidarity.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo12 (abstract no. MoD 0040). Unique Identifier : AIDSLINE ICA8/92399998; Mazzola E; Ronconi S; Terzi M; DAI, Donne AIDS Informazione, Torino, Italy.; PROBLEMS: In Italian prisons there are a great number of drug addicts (34% of prisoners), 30% of them are seropositive. The spread of HIV inside prisons is increasing rapidly, also because of the lack of prevention projects. Prisoners with HIV/AIDS are isolated and stigmatizated. Among them, women are the most isolate
A monoclonal antibody which blocks infection with feline immunodeficiency virus.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0042). Unique Identifier : AIDSLINE ICA8/92399999; Hosie MJ; Willett BJ; Dunsford TH; Neil JC; Jarrett O; OBJECTIVES: Although cells expressing the feline homologue of CD4 (fCD4) are highly susceptible to infection with feline immunodeficiency virus (FIV), it has been shown that FIV infects fCD4- cells, such as feline macrophages, astrocytes and fCD8+ T-cells. Similarly, HIV has been shown to infect various CD4- cell line
HIV-specific immune responses in rabbits immunized with HIV-like particles and recombinant vaccinia virus.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0045). Unique Identifier : AIDSLINE ICA8/92400000; Hesselton RM; Mazzara GP; Panicali D; Sullivan JL; University of Massachusetts Medical School, Worcester.; OBJECTIVES: To evaluate immune responses to a trivalent recombinant vaccinia virus vaccine which expresses three HIV-1 (IIIB) genes (env, gag, and pol). In addition we evaluated immune responses to HIV-1 pseudovirion particles produced in mammalian cells infected with the trivalent vaccine. METHODS: Rabbits were prime
Membrane fusion induced by the HIV-1 env glycoprotein.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0047). Unique Identifier : AIDSLINE ICA8/92400001; Blumenthal R; Golding H; Broder CC; Berger EA; Puri A; Willey RL; Martin MA; Dimitrov DS; NCI, NIH, Bethesda, MD 20892.; OBJECTIVES: To gain insight into initial steps of entry of HIV into cells. METHODS: Membrane fusion of HIV-1 with CD4+ cells was measured by spectrofluorometry and infection assays. HIVenv-mediated cell fusion and syncytia formation is monitored by image enhanced fluorescence video microscopy following infection of ce
Molecular characterization of a panel of HIV-1 broadly neutralizing, CD4 binding site directed human anti-gp120 monoclonal antibodies (MAbs).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0046). Unique Identifier : AIDSLINE ICA8/92400002; Marasco WA; Bagley J; Posner M; Dillon P; Rosen C; Robinson J; Haseltine WA; Sodroski J; New England Deaconess Hospital, Boston, MA.; Two classes of neutralizing antibodies (Abs) are elicited against HIV-1 in infected humans: type-restricted and broadly reactive. The best characterized of the type-restricted Abs are those directed against the V3 loop. Envelope glycoprotein variation within the V3 loop and outside the loop can allow for escape of vir
Potency and broadness of neutralization of HIV-1 by alpha-V3 MAbS is enhanced by synergy with CD4 and cell killing with alpha-CD3 MAbS.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0043). Unique Identifier : AIDSLINE ICA8/92400003; Potts B; Wu Y; Field K; Paradis T; Higgins P; White-Scharf M; Posner M; Cavacini L; Herlihy W; Repligen Corporation, Cambridge, MA.; OBJECTIVE: Identify ways to increase the potency and broaden the reactivity of HIV-1 neutralizing reagents to the V3 loop and the CD4 binding domain of the HIV-1 gp120 envelope. METHODS: Broadly neutralizing alpha-V3 MAbs and alpha-CD4 binding domain reagents have been evaluated individually, in combination to demonst
Structural basis for recognition of the HIV-1 V3 determinant by a neutralizing monoclonal antibody.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo13 (abstract no. MoA 0044). Unique Identifier : AIDSLINE ICA8/92400004; Profy A; Stura E; Stanfield R; Rini J; Fieser G; Silver S; Wilson I; Repligen Corp, Cambridge, MA.; OBJECTIVE: Determine the structural requirements for recognition of the HIV-1 V3 neutralization determinant by a V3-directed monoclonal antibody. METHODS: Sequences recognized by the V3-directed neutralizing antibody R/V3-50.1 were determined using a panel of synthetic peptides. To better understand the interaction, t
CD4 independent entry by HIV-2: properties of an alternative cell surface receptor.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo14 (abstract no. MoA 0049). Unique Identifier : AIDSLINE ICA8/92400005; Clapham P; McKnight A; Simmons G; Cordell J; Dean C; Weiss R; Chester Beatty Labs, Institute of Cancer Research, London, UK.; INTRODUCTION AND OBJECTIVES: We have recently shown that a substrain of HIV-2ROD (LAV-2/B) efficiently infected CD4-negative human RD, Daudi and Raii cell lines. Other HIV-2 strains either failed (e.g. CBL-20) to infect or infected less efficiently (e.g. SBL6669) than LAV-2/B, although most HIV-2 isolates tested induc
Gp120-induced conformational change in CD4 is important for HIV-mediated syncytium formation.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo14 (abstract no. MoA 0050). Unique Identifier : AIDSLINE ICA8/92400006; Manzoni C; Mous J; Pharma Research New Technologies, Hoffmann-La Roche Ltd, Basel,; Switzerland.; OBJECTIVE: To study the mechanism of HIV-entry and identify novel ways of interfering with post-binding steps. RESULTS: During our mutational analysis of HIV-1 gp120--CD4 interaction, we identified a peculiar CD4 mutant, called V1*, which was characterised by a different folding pattern (no binding of Leu3a or gp120)
HIV-1 virion-associated outer envelope protein gp120 is cleaved at the V3-loop by incubation with recombinant soluble (rs) CD4.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo14 (abstract no. MoA 0051). Unique Identifier : AIDSLINE ICA8/92400007; Werner A; Struble HK; Levy JA; Department of Medicine, University of California, San Francisco.; OBJECTIVES: To examine whether proteolytic cleavage of the HIV-1 V3 loop is involved in the virus infection of peripheral blood mononuclear cells (PMC). METHODS: Molecularly cloned and biologically active HIV-1 strains were grown in human PMC. Titration and blocking experiments with rsCD4 were performed in PMC. Virus
Receptor-mediated activation of the viral envelope involves the exposure of novel neutralizing envelope determinants.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo14 (abstract no. MoA 0048). Unique Identifier : AIDSLINE ICA8/92400008; Allan JS; Whitehead EM; Strout K; Shuler K; Kanda P; Southwest Foundation for Biomedical Research, San Antonio, TX.; OBJECTIVES: Interaction of simian immunodeficiency viruses from African green monkeys (SIVagm) with soluble receptor molecules (sCD4) results in profound enhancement (100-fold) of in vitro infection in contrast to sCD4 blocking of HIV-1 and HIV-2. We have previously shown that this enhancing effect is a direct consequ
Cervical intraepithelial neoplasia in HIV-infected women.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0057). Unique Identifier : AIDSLINE ICA8/92400009; Fruchter R; Maiman M; Serur E; Cuthill S; State Univ. of New York-Health Science Center, Brooklyn.; OBJECTIVES: To compare, in HIV-infected and HIV-negative women, 1) the characteristics of cervical intraepithelial neoplasia (CIN) and (2) the course of CIN after treatment. METHODS: (1) Women with Pap smears of CIN1 or worse attending a colposcopy service were counselled and tested for HIV. Lesion extension was deter
Combination zidovudine and dideoxyinosine in asymptomatic HIV(+) patients.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0055). Unique Identifier : AIDSLINE ICA8/92400010; Ragni M; Dafni R; Amato DA; Korvick J; Merigan TC; Univ. of Pittsburgh, PA.; OBJECTIVES: Longterm antiretroviral therapy may be limited by toxicity and resistance. In order to evaluate whether potentially synergistic drug combinations may reduce drug toxicity and delay resistance, we conducted a Phase I/II open label, randomized trial of combination ZDV and ddI in 116 asymptomatic HIV(+) indiv
Double blind, placebo controlled trial of high dose acyclovir for the prevention of cytomegalovirus (CMV) disease in late stage HIV disease. European-Australian Acyclovir Study Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0056). Unique Identifier : AIDSLINE ICA8/92400011; Youle M; OBJECTIVES: To evaluate the efficacy and safety of high dose acyclovir as prophylaxis against CMV disease in HIV seropositives with low CD4 positive cell (CD4) counts and to ascertain any survival benefit. METHODS: Three h
Nevirapine (NVP) alone and in combination with zidovudine (ZDV): safety and activity. The ACTG 164/168 Study Team.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0053). Unique Identifier : AIDSLINE ICA8/92400012; Cheeseman SH; U Mass, Worcester.; OBJECTIVES: To determine safety and activity of NVP in HIV-infected persons (HIVP). METHODS: Sequential cohorts of HIVP received daily doses of 12.5, 50, 200, and 400 mg NVP, alone or in combination with ZDV 200 mg p.o. q8h. Plasma levels of NVP and ZDV were assayed by HPLC. HIV p24 antigen was measured after acid hyd
Therapy of AIDS or symptomatic HIV infection with simultaneous or alternating regimens of AZT and DDI.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0054). Unique Identifier : AIDSLINE ICA8/92400013; Yarchoan R; Lietzau JA; Brawley O; Nguyen BY; Pluda JM; Wyvill KM; Broder S; National Cancer Institute, Bethesda, MD 20892.; OBJECTIVES: There are arguments to support the use of either simultaneous or alternating drug combinations in the therapy of HIV infection. The present randomized pilot study was designed to study the toxicity and activity profiles of simultaneous and alternating regimens of azidothymidine (
Zidovudine vs. alpha interferon vs. the combination in patients with early HIV infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo15 (abstract no. MoB 0052). Unique Identifier : AIDSLINE ICA8/92400014; Lane HC; Herpin B; Banks S; Walker RE; Davey RT; Kovacs J; Polis M; Falloon J; Masur H; National Institutes of Health, Bethesda, MD.; OBJECTIVES: To compare the effects of zidovudine (ZDV), alpha interferon (alpha IFN) and a combination of these 2 drugs in delaying the progression of HIV disease. METHODS: One hundred and eighty HIV infected patients with greater than or equal to 500 CD4 cells/mm3 were randomized to oral ZDV (1200 mg qd with downward
Anal cytologic abnormalities and papillomavirus infection in men with HIV infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo16 (abstract no. MoB 0058). Unique Identifier : AIDSLINE ICA8/92400015; Palefsky J; Shiboski S; Moss A; University of California, San Francisco 94143.; OBJECTIVES: Previous studies have shown a high prevalence of potentially precancerous anal cytologic abnormalities and anal human papillomavirus (HPV) infection among men with C.D.C. Group IV HIV disease. The objective of this study was to determine the prevalence of, and risk factors for anal cytologic abnormalities
Hodgkin's disease and HIV infection (HD-HIV): a report of 92 patients from the GICAT (Italian Cooperative Group on AIDS and Tumors), with emphasis on prospective study with combined chemotherapy and zidovudine (AZT) in 16 patients.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo16 (abstract no. MoB 0059). Unique Identifier : AIDSLINE ICA8/92400016; Vaccher E; Tirelli U; Milo D; Chieppa F; Alberici F; Branz F; Ambrosini G; Giudici M; Lazzarin A; Cargnel A; et al; Centro di Riferimento Oncologico Aviano, Italy.; Between November 1986 and June 1991, 92 pts (84 M, 8 F) with HD-HIV were seen by the GICAT. 83% were IVDU, 8% homosexual men, 5% IVDU+homosexual and 4% heterosexuals. At diagnosis of HD-HIV, 16% pts had AIDS, 20% ARC, 33% PGL and 31% were asymptomatic; median CD4 count was 249/mmc. LP subtype was diagnosed in 2%, NS i
Acute primary HIV-1 infection (API): risk of developing AIDS.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0063). Unique Identifier : AIDSLINE ICA8/92400017; Sinicco A; Sciandra M; Lucchini A; Fora R; Caramello P; Gioannini P; Inst. of Infect. Dis., Univ. of Turin, Italy.; OBJECTIVE: to evaluate the risk of developing AIDS after API. PATIENTS AND METHODS: from 9/85 to 9/91 we enrolled 134 newly infected subjects (NI) in a prospective study. Only NI who had a previous negative HIV test in the 12 months preceding seroconversion were admitted to the study. The 134 NI were divided in two gr
Media and Magic: the effects of Magic Johnson's HIV diagnosis on HIV antibody testing rates.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0060). Unique Identifier : AIDSLINE ICA8/92400018; Mills S; Fischer-Ponce L; San Francisco Dept of Public Health, AIDS Office, CA.; OBJECTIVE: To determine the effects of sports celebrity Magic Johnson s HIV diagnosis on HIV antibody testing rates in San Francisco. METHODOLOGY: We calculated the expected HIV testing rates following the announcement and media coverage of Magic Johnson s HIV diagnosis based on the observed three month trends prior t
Progression of HIV infection among homosexual men in HBV vaccine cohorts in Amsterdam (AM), New York City (NY) and San Francisco (SF), 1978-1991.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0065). Unique Identifier : AIDSLINE ICA8/92400019; van Griensven GJ; Hessol NA; Koblin BA; Stevens CE; Katz MH; Coutinho RA; Municipal Health Service, AM.; OBJECTIVE: To study progression of HIV infection from date of HIV seroconversion to AIDS and death in order to evaluate the impact of socio-demographic variables and the use of zidovudine ( AZT ) and Pneumocystis carinii pneumonia (PCP) prophylaxis (PCP
Racial differences in rate of CD4 decline in HIV-1 infected homosexual men.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0064). Unique Identifier : AIDSLINE ICA8/92400020; Easterbrook PJ; Margolick J; Saah AJ; Farzadegan H; Kaslow R; Vlahov D; Chmiel J; Johns Hopkins School of Public Health, Baltimore, MD.; OBJECTIVE: To determine if racial differences exist in the rate of CD4 cell decline, progression to AIDS and survival in HIV-1 infected homosexual men. METHODS: Prospective cohort study of 321 non-Hispanic white (W) and 102 black (B) HIV-1 seropositive homosexual men recruited from the Baltimore/Washington D.C. metrop
Thailand's first anonymous alternative test site: a lesson for Asian countries.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0061). Unique Identifier : AIDSLINE ICA8/92400021; Phanuphak P; Sittitrai W; Barry J; Sarang-Bin S; Hanvanich M; Program on AIDS, Thai Red Cross Society, Bangkok.; ISSUE: People at risk for HIV infection often hesitate to take an anti-HIV test for fear of social stigmatization should test results turn out to be positive. Thus, many HIV infected persons remain undetected and spread the infection unknowingly. In some cases, people resort to the less threatening strategy of donatin
Twelve year follow-up of a haemophilic cohort.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo17 (abstract no. MoC 0062). Unique Identifier : AIDSLINE ICA8/92400022; Lee C; Sabin C; Phillips A; Elford J; Griffiths P; Janossy G; Haemophilia Centre, Royal Free Hospital, London, England.; OBJECTIVE: To describe the progression of HIV disease in a haemophilic cohort. METHODS: A longitudinal clinical and laboratory study was conducted in 111 patients from time of first seroconversion in October 1979 until 1st January 1992. RESULTS: 38/111 (34%) have developed AIDS. 39/111 (35%) have died (4 of liver fail
Survival analysis by gender and risk group for HIV in Edinburgh.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo18 (abstract no. MoC 0066). Unique Identifier : AIDSLINE ICA8/92400023; Brettle RP; Richardson AM; Burns SM; Fielding K; Leen CL; City Hospital, Edinburgh, UK.; OBJECTIVE: Survival analysis for HIV infected individuals. METHOD: Between 1984-91 306/603 HIV infected patients were seen with a seroconversion date (stored sera up to 2 years apart). Survival was analysed (Kaplan-Meier method and log rank test) from seroconversion to AIDS, to CD4 200 (the date determined by the firs
Family support for AIDS patients in a rural population in south west Uganda: how much a myth?: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo19 (abstract no. MoD 0071). Unique Identifier : AIDSLINE ICA8/92400024; Seeley J; Kajura E; Okongo M; Wagner HU; Mulder DW; MRC(UK) Research Programme on AIDS, Entebbe, Uganda.; OBJECTIVE: It is commonly assumed that the extended family in Africa provides a safety net for individuals in times of need. The aim of this study is to assess family response to coping with the care of AIDS patients in a rural population in South West Uganda . METHOD: Over a six mo
Need for comprehensive care in HIV-infected families.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo19 (abstract no. MoD 0068). Unique Identifier : AIDSLINE ICA8/92400025; Kreyenbroek M; Kosten T; Boer K; Mulder-Kampinga G; Scherpbier H; Academic Medical Centre, Amsterdam, Netherlands.; ISSUE/PROBLEM: HIV-infected pregnant women are facing complex and intense problems. A multidisciplinary approach is needed to ensure comprehensive care, both inside and outside the hospital, and continuity to the family system. DESCRIPTION OF PROJECT: The following issues will be discussed: Abortion a free choice? Soc
Provision of comprehensive community based services to children/families with HIV infection in the US.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo19 (abstract no. MoD 0070). Unique Identifier : AIDSLINE ICA8/92400026; Boland M; Harvey D; Burr C; Conviser R; National Pediatric HIV Resource Center, University of Medicine &; Dentistry-New Jersey Medical School, Newark.; ISSUE/PROBLEM: The HIV epidemic is growing rapidly among children, adolescents and women in the US and increasingly affects entire families, comprised largely of low income persons of color. Taken together, children, youth, and women account for over 12% of all AIDS cases. The problems associated with poverty, drug us
Study of the behaviour of HIV positive or negative IVDUs in their family circle.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo19 (abstract no. MoD 0067). Unique Identifier : AIDSLINE ICA8/92400027; Aeberhard F; Peigne F; Ferrand I; Bonnefis S; Sourigues C; Cordonnier JP; Centre Cassini, Hopital Cochin, Paris, France.; DESCRIPTION OF PROJECT: The Centre Cassini, which is the second structure of the Assistance Publique-Hopitaux de Paris was opened on October 1st, 1990. The centre is linked to Dr Peigne s psychiatry department at the hospital Cochin, but it is located outside the hospital. It favours the welcoming, informing directing
The family of HIV infected persons: co-infected.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo19 (abstract no. MoD 0069). Unique Identifier : AIDSLINE ICA8/92400028; Rosa de Castro MJ; Adams IK; Federal University of Minas Cerais, Belo Horizonte, Brazil.; ISSUE/PROBLEM: While multidisciplinary clinics focus on biopsychosocial as well as clinical problems of the HIV infected person, the family also has its complaints which need to be diagnosed. The family of persons with HIV have difficulty helping their infected member without psychosocial support. DESCRIPTION OF PROJE
Identification of individual amino acids within the V3 region determining syncytium formation and replication rate of viruses chimeric for V3.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo20 (abstract no. MoA 0073). Unique Identifier : AIDSLINE ICA8/92400029; De Jong J; De Ronde A; Keulen W; Tersmette M; Goudsmit J; HRL, UvA, Amsterdam, The Netherlands.; OBJECTIVES: Determination of position and kind of amino acids within the V3 region associated with the syncytium forming capacity and replication rate of V3-chimeric viruses. METHODS: V3 regions differing in four amino acids derived from a non-syncytium inducing (168.1/NSI) and a syncytium inducing isolate (168.10/SI)
Novel determinants of tropism of HIV-1 in gp120 and gp41.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo20 (abstract no. MoA 0076). Unique Identifier : AIDSLINE ICA8/92400030; Peden K; Silver J; Fujita K; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD; 20892.; OBJECTIVE: To ascertain the sequence changes that account for the enhanced replicative capacity of the ELI strain of HIV-1 passaged in H9 cells. METHODS: Virus stocks prepared from HeLa cells transfected with molecular clones of HIV-1ELI were used to infect peripheral blood mononuclear cells (PBMC) and CD4-positive ce
Phenotype associated env gene variation among 8 related HIV-1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo20 (abstract no. MoA 0075). Unique Identifier : AIDSLINE ICA8/92400031; Groenink M; Andeweg AC; van der Jagt RC; Schuitemaker H; Bosch ML; Huisman JG; Tersmette M; Centr. Lab. Netherlands Red Cross Blood Transf. Serv., Amsterdam.; OBJECTIVES: To genetically compare phenotypically heterogeneous HIV-1 variants and to analyze regions of the HIV-1 env gene previously identified as determinants of biological properties. METHODS: Eight phenotypically heterogeneous HIV-1 clones, recovered directly from a single patient peripheral blood mononuclear cel
Small amino acid change in the HIV-1 V3 loop can affect viral infectivity and not cytopathicity.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo20 (abstract no. MoA 0072). Unique Identifier : AIDSLINE ICA8/92400032; Cheng-Mayer C; Cancer Research Institute, Univ. of California, San Francisco.; OBJECTIVE: To examine whether single amino acid change in env, specifically a region of gp120 that encompasses the V3 loop affects infectivity and cytopathicity of HIV-1 in vitro. METHODS: Biologic properties of site-directed mutants of HIV-1 were determined. Sequence analyses confirmed the nature of the mutations and
Structure-function relationships of HIV1 envelope V3 loop in regulation of host cell tropism.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo20 (abstract no. MoA 0074). Unique Identifier : AIDSLINE ICA8/92400033; Ebenbichler C; Gu R; Henkel T; Westervelt P; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis.; OBJECTIVE: To identify the determinants within env that regulate host cell tropism, and analyse their structural features and mechanism of action. RESULTS: Chimeric viruses were constructed with sequences from a monocyte-tropic isolate (ADA) or those from brain or spleen tissues of AIDS patients together with sequence
A double blind study of ddl vs continued AZT among HIV+ individuals with CD4 counts 200 to 500/mm3 treated with AZT for at least six months.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0081). Unique Identifier : AIDSLINE ICA8/92400034; Montaner JS; Rachlis A; Gill J; Beaulieu R; Tsoukas C; Fanning M; Cameron W; Lalonde R; Bergeron M; Schlech W; et al; OBJECTIVES: To compare efficacy and toxicity of ddl (didanosine, Videx ) and AZT (zidovudine, Retrovir) in HIV infected patients with CD4 counts 200 to 500/mm3 following at least 6 mon
ACTG protocol 116B/117; clinical outcome of a randomized double blind controlled study of DDI and ZDV. AIDS Clinical Trials Group. 116B/117 Study Team.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0079). Unique Identifier : AIDSLINE ICA8/92400035; Kahn J; Lagakos S; Richman D; Dolin R; Pettinelli C; McLaren C; Cross A; Beltangady M; Smaldone L; OBJECTIVES: We conducted a large multi-centered, randomized, controlled study to compare the clinical efficacy and safety of ZDV with didanosine (ddI) in subjects with at least 16 weeks of prior ZDV treatment and tolerant of ZDV. The primary study endpoints were the incidence of death and new opportunistic infections.
Comparative evaluation of AZT and DDI in previously untreated patients with early or advanced ARC: preliminary results of the Italian Randomized Multicenter Study ISS-902.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0080). Unique Identifier : AIDSLINE ICA8/92400036; Vella S; Floridia M; Tomino C; Dally LG; Sebastiani G; Fragola V; Chiesi A; Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVES: 1) To determine whether DDI therapy is as effective as AZT in delaying clinical progression to AIDS or advanced ARC among patients with previously untreated ARC (at least one symptom and CD4+ 500/mm3). 2) To evaluate the pattern of toxicit
Nucleoside analogues and patterns of salivary, pancreatic and total amylase in HIV positive individuals.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0078). Unique Identifier : AIDSLINE ICA8/92400037; Sweeney JN; Valentine CB; Gompells M; Pinching AJ; Sherwood R; Deenmamode J; Moncrieff KC; Aber VR; St Mary's Hospital, London, UK.; OBJECTIVES: To assay total, salivary and pancreatic amylase in a group of HIV positive patients attending St Mary s Hospital London to determine whether stage of HIV infection or administration of nucleoside analogues affects serum amylase concentrations. METHODS: Stored serum from 102 HIV positive patients attending
Relative effects of ddC or ddI versus ZDV on health status, function and disability in N3300 (ACTG 114) and ACTG 116b/117.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0077). Unique Identifier : AIDSLINE ICA8/92400038; Bozzette SA; Kanouse D; Berry S; Duan N; Downes-LeGuin T; Hays R; Petinnelli C; Richman DD; Gocke D; Kahn J; UCSD.; OBJECTIVES: To compare the effects of didoxycytidine ( ddC ) or didanosine (dideoxyinosine, ddI) to zidovudine (ZDV) on health status, functioning, and disability in patients with advanced HIV disease. METHODS: Participants were enrolled in 1 of 2 rando
Switching from AZT to DDI can be beneficial in AIDS patients who already have tolerated AZT therapy for at least six months: preliminary results of a randomized multicenter study (ISS-901).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo21 (abstract no. MoB 0082). Unique Identifier : AIDSLINE ICA8/92400039; Floridia M; Vella S; Tomino C; Dally LG; Sebastiani G; Chiesi A; Agresti MG; ISS, Rome.; OBJECTIVES: To evaluate whether switching to new dideoxynucleoside therapy (DDI) is of benefit with respect to survival, onset of new AIDS-defining pathologies, and clinical status, among AIDS patients who have already tolerated AZT therapy for 6-18 mw
Associations of HLA-DR2/DRB1*1501- and DRB1*1401-containing haplotypes with rapid progression of HIV infection. Multicenter AIDS Cohort Study (MACS).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0087). Unique Identifier : AIDSLINE ICA8/92400040; Kaslow R; Apple R; Friedman H; Detels R; Saah A; Rinaldo C; Phair J; Cetus Corp, Sunnyvale, CA.; OBJECTIVES: To detect associations between the frequency of class II HLA genes and the rate of progression of HIV infection in Caucasian homosexual/bisexual men. METHODS: We categorized MACS participants by rate of loss of CD4+ cells and selected 60 with very rapid (R) and 60 with very slow or no (S) decline. DNA extrw
Cohort of gay men in New York: ten year follow-up.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0088). Unique Identifier : AIDSLINE ICA8/92400041; Lange M; Inada Y; Buimovici-Klein E; Cooper LZ; Grieco MH; St. Luke's-Roosevelt Hospital Center/Columbia University, NY, NY; 10025.; OBJECTIVE: To report the 10 year status of a prospectively followed cohort of initially healthy gay male volunteers recruited between 11/81 & 12/82 in New York city. METHOD: Cohort members were followed twice a year from 1981 to 1987 and subsequently at annual intervals to 1992. Clinical and laboratory parameters w
CD4 is a relatively poor predictor of progression to AIDS over five years due to its nonspecificity.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0084). Unique Identifier : AIDSLINE ICA8/92400042; Jacobson D; McCutchan JA; Jin H; Abramson I; Nelson J; Durand D; Bertrand J; Stine C; Atkinson H; Grant I; HIV Neurobehavioral Research Center, University of California,; San Diego.; OBJECTIVES: To evaluate measures of 1) immune function (delayed cutaneous hypersensitivity to recall antigens), 2) immune activation (beta 2-microglobulin and total globulin), 3) marrow (hematocrit) and liver (albumin) function, and 4) CD4 lymphocyte depletion as predictors of progression to AIDS over 60 months. METHO
Factors influencing correspondence between CD4% and CD4 count in HIV infected homosexual men and intravenous drug users (IVDU).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0086). Unique Identifier : AIDSLINE ICA8/92400043; Munoz A; He D; Cohn S; Margolick J; Hoover DR; Saah A; Vlahov D; Johns Hopkins School of Public Health, Baltimore, MD.; OBJECTIVES: (i) To develop a simple model that describes correspondence between CD4% and CD4# in HIV infected individuals; (ii) to determine if risk group, gender, AIDS and prophylaxis modify the correspondence between CD4% and CD4#. METHODS: We used 3856 and 3067 observations taken semi-annually on 479 seropositive h
Fever with skin rash and absence of anti-HIV core in HIV seroconverters are predictors of rapid progression to AIDS.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0085). Unique Identifier : AIDSLINE ICA8/92400044; Keet I; Krijnen P; Koot M; Lange JM; Goudsmit J; Miedema F; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands.; OBJECTIVES: To analyse if rapid progressors to AIDS can already be identified around the period of HIV seroconversion. METHODS: In a prospective study 763 HIV negative homosexual men were seen at 3-6 monthly intervals since 1984, of whom 108 men seroconverted for HIV during follow up. In these 108 men we studied if th
Low viral load as defined by negative PCR is associated with slower progression of HIV disease. The Vancouver Lymphadenopathy-AIDS Study (VLAS) Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo22 (abstract no. MoC 0083). Unique Identifier : AIDSLINE ICA8/92400045; Woodfall B; Schechter MT; Le TN; Craib KJ; Cassol S; Montaner JS; O'Shaughnessy MV; UBC & BC Centre for Excellence in HIV and Related Diseases,; Vancouver, Canada.; OBJECTIVE: To evaluate the rate of progression to AIDS and the rate of CD4 decline in a group of seropositive men with low viral burdens as determined by a negative PCR. METHODS:This analysis involved 97 members of our cohort, 59 seroprevalent men (SP), and 38 seroincident men (SI) with a median follow-up of 100 month
AIDS from blood transfusions screened negative for HIV antibody, United States.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo23 (abstract no. MoC 0092). Unique Identifier : AIDSLINE ICA8/92400046; Holmberg S; Conley LJ; Rogers MF; Division of HIV/AIDS, Centers for Disease Control (CDC), Atlanta,; GA.; OBJECTIVES: To ascertain the number and features of AIDS cases in the United States that have resulted from receipt of blood screened negative for HIV antibody, since such screening began in most U.S. blood collection centers in March 1985. METHODS: Review of all transfusion-AIDS (TA-A
HIV prevalence in people with no fixed abode--a study of blood donorship patterns & risk determinants.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo23 (abstract no. MoC 0093). Unique Identifier : AIDSLINE ICA8/92400047; Bhimani GV; Gilada IS; Indian Health Organisation, Bombay.; OBJECTIVES: To study the blood donorship patterns and risk determinants amongst the professional blood and organ sellers, to establish their HIV prevalence and to develop guidelines for safety of blood/blood products. METHODS: Following the news reports about 75% of the blood products manufactured in
Performance of rapid anti-HIV assays for screening of donor blood under field conditions in Africa.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo23 (abstract no. MoC 0090). Unique Identifier : AIDSLINE ICA8/92400048; Heessen FW; Klokke AH; van Asten HA; Kigadye FC; Dolmans WM; Shao JF; Van den Akker R; Veierna JP; Nijmegen University, Netherlands.; OBJECTIVE: The performance of three rapid assays for the detection of HIV-antibodies in donor blood was evaluated in eight district hospital laboratories in Mwanza region and in the regional centre. METHOD: Blood samples were evaluated in four reference laboratories and a panel of 67 HIV-positive and 88-HIV negative s
Potential deferral criteria predictive for HIV-positivity in blood donors in Thailand.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo23 (abstract no. MoC 0089). Unique Identifier : AIDSLINE ICA8/92400049; Kitayaporn D; Bejrachandra S; Chongkolwatana V; Chandanayingyong D; Weniger BG; HIV/AIDS Collaboration, Bangkok.; OBJECTIVES: In order to develop donor deferral criteria to prevent HIV transmission by recently-infected donors in the seronegative window phase, we determined factors predictive for HIV seropositivity from data routinely collected on blood donors at a public university teaching hospital. METHODS: Records of all 281 H
Time period from infectiousness as blood donor to development of detectable antibody and the risk of HIV transmission from transfusion of screened blood. HIV Lookback Study Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo23 (abstract no. MoC 0091). Unique Identifier : AIDSLINE ICA8/92400050; Petersen L; Satten G; Dodd R; Centers for Disease Control, Atlanta.; OBJECTIVES: In considering the natural history of early HIV infection, the time period from infectiousness to development of detectable HIV antibody is unknown. Knowledge of this period is critical in assessing the risk of HIV transmission from HIV-antibody-screened blood transfusions. METHODS: We studied 701 HIV-sero
Analysis of the zinc-finger-like domains in the HIV-1 nucleocapsid protein by alanine scanning mutagenesis.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0001). Unique Identifier : AIDSLINE ICA8/92400051; Goettlinger H; Dorfman T; Luban J; Goff S; Haseltine W; Dana-Farber Cancer Institute, Boston, MA.; OBJECTIVES: Retroviral nucleocapsid proteins, including that of HIV-1, invariably carry one or two copies of a zinc-finger-like domain that is believed to be involved in the encapsidation of genomic viral RNA into nascent virus particles. Our objective was to identify the functionally important residues in the HIV-1 z
Assembly of HIV-1 gag protein: a new target for antiviral therapy?: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0002). Unique Identifier : AIDSLINE ICA8/92400052; Niedrig M; Gelderblom HR; Pauli G; Marz J; von Poblotzki A; Wolf H; Modrow S; Behringwerke AG, Research Department, Marburg.; OBJECTIVES: Sequential overlapping gag oligopeptides of Human Immunodeficiency Virus type 1 (HIV-1), 22-24 amino acids long, were synthesized and tested in vitro for antiviral activity. The hypothesis has to be tested that oligopeptides representing the domains which participate in the protein-protein interaction duri
Functional study of HIV-1 matrix proteins in virus assembly and infectivity.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0003). Unique Identifier : AIDSLINE ICA8/92400053; Yu X; Yuan X; Lee TH; Essex M; Harvard School of Public Health, Boston, MA 02115.; OBJECTIVES: To study the functional role of the HIV-1 matrix protein in viral replication, and the potential use of p17 mutants to block HIV-1 replication. METHODS: In-frame deletions were introduced into the HIV-1 p17 region. Viral protein synthesis, processing, and virus assembly and infectivity were analyzed for wi
Ganciclovir (GCV) and granulocyte-macrophage colony stimulating factor (GM-CSF) vs GCV alone as treatment for cytomegalovirus (CMV) retinitis (ACTG 073).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0005). Unique Identifier : AIDSLINE ICA8/92400054; Hardy D; Spector S; Polsky B; Crumpacker C; van der Horst C; Holland G; Freeman W; Helnemann MH; Sharuk G; Klystra J; et al; UCLA.; OBJECTIVE: To assess the safety, tolerance and efficacy of combined GCV/GM-CSF compared to GCV alone as initial therapy for CMV retinitis in AIDS patients. Time to first consecutive neutropenic event (ANC less than 750/mm3 on two occasions 24 hrs apart), proport
Production of chimeric virus-like particles containing the HIV-1 gag/pol and HIV-2 gag gene products.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0004). Unique Identifier : AIDSLINE ICA8/92400055; Meiko K; Shioda T; Kitamura T; Iwakura Y; Shibuta H; Japanese Foundation of AIDS Prevention.; OBJECTIVE: To examine whether the functional domains in gag and pol gene products of HIV-1 and HIV-2 are conserved for particle formation and core maturation. METHODS: StuI-ScaI fragment(no. 453-2278) and StuI-SspI(no.453-5039) with 4 base-pair deletion at NcoI site(no.1855) of HIV-2 GH123 clone were adequately insert
Recombinant granulocyte-colony stimulating factor (rG-CSF) in the treatment of neutropenic AIDS patients (pts).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo5 (abstract no. MoA 0006). Unique Identifier : AIDSLINE ICA8/92400056; Fuhrer J; Shelton M; Heller H; SUNY, Stony Brook 11794.; BACKGROUND: Patients with the acquired immunodeficiency syndrome (AIDS), often suffer cytopenias. Neutropenia in AIDS patients may be secondary to an adverse drug toxicity (e.g. zidovudine [ AZT ], ganciclovir [DHPG]), bone marrow infiltrating opportuni
Granulocyte-colony stimulating factor G-CSF in AIDS-patients with leukocytes less than or equal to 1.0 x 10(9)/L.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0007). Unique Identifier : AIDSLINE ICA8/92400057; Bratt G; Grutzmeier S; Lund B; Sandstrom E; Department of Dermatovenerology, South Hospital, Stockholm.; ISSUE: AIDS-patients, that are treated with chemotherapy for Kaposi s sarcoma and Ganciclovir/DHPG) for CMV-retinitis often get severe neutropenia, that limits the treatment and increases the incidence of bacterial infections. Can treatment with G-CSF increase white blood cell count WBC, lower the incidence of bacteri
Potential of selectively deglycosylated HIV-1 gp120 as a more effective vaccine antigen.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0010). Unique Identifier : AIDSLINE ICA8/92400058; Lee TH; Lee CN; Lee WR; Cheng YL; Lin HL; Essex M; Harvard School of Public Health, Boston, Massachusetts 02115.; OBJECTIVES: Immune decoy mediated by carbohydrate moieties of viral envelop proteins was observed previously in some retroviruses. HIV-1 gp120 is a heavily glycosylated protein with approximately half of its molecular mass contributed by N-linked sugars. One prediction of the hypothesis that certain N-linked sugars of
Recombinant human erythropoietin (r-HuEPO) treatment IND protocol for the anemia of AIDS--overall results and AZT subgroup analysis.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0008). Unique Identifier : AIDSLINE ICA8/92400059; Phair J; Abels R; Northwestern University Medical School, Chicago, IL.; OBJECTIVES: Anemia associated with HIV infection may be due to reduced erythropoiesis related to the disease itself or to concomitant medications (e.g., zidovudine [ AZT ]). Clinical studies have shown r-HuEPO to be effective in correcting the anemia of
Significance of cell antigens in SIV vaccines.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0012). Unique Identifier : AIDSLINE ICA8/92400060; Stott J; Mills KH; Chan WL; Page M; Taffs LF; Kitchin PA; National Institute for Biological Standards and Control, Potters; Bar, Herts, UK.; OBJECTIVE: To establish the role of cell antigens in protection against SIV. METHODS: Groups of 4 cynomolgus monkeys were vaccinated with inactivated SIV, virus-infected C8166 cells, uninfected C8166 or RK-13 cells. Vaccinated macaques were then challenged intravenously with 10 MID50 of SIV grown in either human cells
Specificity of antibodies produced against native or desialylated recombinant HIV-1 gp160.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0009). Unique Identifier : AIDSLINE ICA8/92400061; Benjouad A; Gluckman JC; Rochat H; Montagnier L; Bahraoui E; CNRS URA 1455, Marseille, France.; OBJECTIVE: In contrast to antibodies produced against native or fully deglycosylated HIV-1 gp160 in rabbits, antibodies raised against desialylated HIV-1 gp160 recognized also gp140 from HIV-2 at high titers. The population of antibodies responsible for this cross-reactivity was further analyzed. METHODS: Rabbits were
Vaccine-therapy with gp160: effect on human anti-gp120 antibody spectrotype.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo6 (abstract no. MoA 0011). Unique Identifier : AIDSLINE ICA8/92400062; Biselli R; Loomis LD; Del Bono V; Burke DS; Redfield RR; Birx DL; Department of Retroviral Research, Walter Reed Army Institute of; Research.; OBJECTIVES: Infection with HIV type 1 causes a progressive failure of the immune system and, among other things, a decline in the number and/or function of B-cell clones recruited in specific humoral responses. Spectrotypic analysis, as obtained by Isoelectric Focusing (IEF) and reverse blotting, is one technique for
Analysis of viral burden and expression during primary HIV infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0015). Unique Identifier : AIDSLINE ICA8/92400063; Graziosi C; Pantaleo G; Demarest J; Saag M; Shaw G; Fauci AS; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD.; OBJECTIVES: To determine the patterns of viral burden (i.e. frequency of HIV infected cells) and HIV expression following acute symptomatic HIV infection. METHODS: Standard quantitative polymerase chain reaction (PCR) employing primer pairs specific for LTR and gag gene segments of HIV-1 were used for determination of
Characterization of the natural antibody response to the hypervariable neutralization domain of HIV-1.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0016). Unique Identifier : AIDSLINE ICA8/92400064; Zwart G; Wolfs TF; van der Hoek L; Valk M; Goudsmit J; Human Retrovirus Laboratory, AMC, Amsterdam.; OBJECTIVES: The neutralization domain in the third variable region (V3) of the external envelope glycoprotein, is perhaps not the ideal, but the most promising candidate for rational vaccine design. Our objective was to obtain insight into the quality of the human antibody response to this variable domain after natura
Characterization of HIV-infected patients using a rapid flow cytometric in situ hybridization method.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0014). Unique Identifier : AIDSLINE ICA8/92400065; Lewis D; Liu F; Chubbage M; Blick M; Baylor College of Medicine, Houston, Texas.; OBJECTIVES: We recently showed, using conventional in situ hybridization and laser confocal microscopy, that the numbers of HIV RNA producing cells in HIV-infected people was much greater than previously reported (Lewis, et al, J Infect Dis 162:1373, 1990). This assay, although sensitive, is time consuming and technic
Determinants of antibody (ab) response in volunteers primed with vac-env and boosted with rgp160. The NIAID AIDS Vaccine Clinical Trials Network.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0013). Unique Identifier : AIDSLINE ICA8/92400066; Graham BS; Belshe R; Clements M; Dolin R; Corey L; Matthews T; Esterlitz J; Fast P; OBJECTIVES: To determine factors associated with the magnitude and duration of HIV-1-specific ab response induced by primary immunization with gp160 recombinant vaccinia (vac-env) (Bristol/Myers-Squibb) and booster immunization with rgp160 (MicroGeneSys). METHODS: Parameters of interval between primary vaccination and
The role of humoral immunity in primary HIV-1 infection (PI).: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0017). Unique Identifier : AIDSLINE ICA8/92400067; Daar ES; Chernyavskiy T; Moudgil T; Cedars-Sinai Medical Center, UCLA School of Medicine.; OBJECTIVES: During PI, a rapid decline in the initially high plasma (P) and cellular (C) viral titers (VT) is observed. We will demonstrate the significance of the humoral immune response during PI. METHODS: We have performed quantitative virologic and P neutralization studies on the blood of 3 patients who presented
Vaccine protection from SIV infected cell challenge is MHC class I related.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo7 (abstract no. MoA 0018). Unique Identifier : AIDSLINE ICA8/92400068; Heeney J; Bontrop R; Van Els C; De Vries P; Jonker M; Osterhaus A; Dept. of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The; Netherlands.; OBJECTIVE: To determine if vaccine protection against infected cells is related to the MHC type of donor and recipient. METHODS: Twenty four MHC typed Macaca mulatta vaccinated with either formalin inactivated whole SIV adjuvanted with MDP (n = 8) or in ISCOM (n = 8) preparations. Controls included measle virus (MV) M
A phase I study of recombinant CD4-Pseudomonas exotoxin (CD4-PE40) in HIV-infected individuals.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo8 (abstract no. MoB 0020). Unique Identifier : AIDSLINE ICA8/92400069; Davey RT Jr; Boenning CM; Herpin BR; Batts DH; Walker RE; Polis MA; Falloon J; Kovacs JA; Masur H; Metcalf JA; et al; N.I.H., Bethesda, MD 20892.; OBJECTIVES: CD4-PE40 is a soluble recombinant fusion toxin containing the gp120-binding domains of human CD4 linked to the translocation and catalytic domains of Pseudomonas exotoxin. This chimeric protein has selective toxicity in vitro against HIV-1-infected, gp120-expressing cells. In this phase 1 trial we sought t
Anti-HIV active immunization. Evidence for persistent cell mediated immunity after a 2 year follow up.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo8 (abstract no. MoB 0024). Unique Identifier : AIDSLINE ICA8/92400070; Picard O; Achour A; Lachgar A; Bernard J; Bizzini B; Zagury D; Hopital Saint-Antoine, Paris, France.; A two year phase I immunization trial has been performed in 25 HIV seronegative volunteers using gp160 antigens. GP160 immunogens were presented in different form (recombinant vaccinia, soluble gp160 and synthetic peptides) and administered according to 4 different protocols using vaccinia. Individuals have been inclu
Pentoxifylline (trental) decreases tumor necrosis factor (TNF) and HIV replication in patients with AIDS. ACTG #160 Team. AIDS Clinical Trial Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo8 (abstract no. MoB 0019). Unique Identifier : AIDSLINE ICA8/92400071; Dezube BJ; Pardee AB; Chapman B; Beckett L; Korvick J; Ahlers CM; Ecto L; Chatis P; Crumpacker CS; Beth Israel Hospital, Boston, MA.; OBJECTIVES: This AIDS Clinical Trial Group (ACTG) protocol is studying whether pentoxifylline, a drug that decreases TNF, can decrease HIV expression, increase AZT activity, and reverse cachexia. This is based on the observation that TNF induces HIV r
Pharmacokinetics, safety and tolerance of a TAT antagonist.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo8 (abstract no. MoB 0021). Unique Identifier : AIDSLINE ICA8/92400072; Petty BG; Ginsberg R; Lewis L; Kuwahara S; Noe D; Zhi J; Molle M; Nerhood L; Tam S; Hsu MC; et al; Johns Hopkins University School of Medicine, Baltimore, MD.; OBJECTIVES: To assess the single- and multiple-dose pharmacokinetics, safety, and tolerance of Ro 24-7429, an antagonist of the human immunodeficiency virus (HIV) TAT protein. METHODS: This was a dose-escalating, randomized, double-blind, vehicle-controlled study in asymptomatic or mildly symptomatic HIV-infected pati
The safety, pharmacokinetics, and antiviral activity of N-acetylcysteine in HIV-infected individuals.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo8 (abstract no. MoB 0022). Unique Identifier : AIDSLINE ICA8/92400073; Walker RE; Lane HC; Boenning CM; Polis MA; Kovacs JA; Falloon J; Davey RT; Sussman H; Gabel L; Correa-Coronas R; et al; National Institutes of Health, Bethesda, MD.; OBJECTIVES: To evaluate the safety and pharmacokinetics of repeated administration of NAC in HIV-infected individuals and to assess changes in immunologic, virologic, and biochemical markers of HIV disease over a 14 week study period. BACKGROUND: HIV infection is associated with reduced serum and intracellular thiol l
Combination prime-boost approach to HIV vaccination in seronegative individuals: enhanced immunity with additional subunit gp160 protein boosting.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo9 (abstract no. MoB 0027). Unique Identifier : AIDSLINE ICA8/92400074; McElrath J; Peterson E; Dragavon J; Berger D; Hoffman M; Klucking S; Greenberg P; Corey L; University of Washington School of Medicine, Seattle.; OBJECTIVES: The purpose of this study is to determine the potential benefit of an additional boost with soluble recombinant gp160 (VaxSyn, MicroGeneSys) to the immune response elicited in HIV seronegative individuals after priming with a vaccinia recombinant containing HIV envelope (HIVAC-1e, Oncogen/
Phase 1 dose escalation MTP-PE study of an HIV-1 gp120 vaccine in sero-negative adults.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo9 (abstract no. MoB 0025). Unique Identifier : AIDSLINE ICA8/92400075; Kahn J; Chernoff D; Sinangil F; Murcar N; Wynne D; Coleman R; Haigwood N; Steimer K; Dekker C; AIDS Division, San Francisco General Hospital, University of; California.; OBJECTIVES: We conducted a phase 1 randomized double-blind study to determine safety and immunogenicity in HIV-seronegative adults of three injections of a vaccine composed of 25 micrograms of recombinant HIV gp 120 antigen combined with MF 59 emulsion containing a muramyl tripeptide covalently linked with dipalmitoyl
Safety and immunogenicity of IIIB rgp120/HIV-1 vaccine in seronegative volunteers. The NIAID-sponsored AIDS Vaccine Clinical Trials Network.: Int Conf AIDS. 1992 Jul 19-24;8(1):Mo9 (abstract no. MoB 0026). Unique Identifier : AIDSLINE ICA8/92400076; Clements ML; Belshe R; Duliege AM; Schwartz D; Gorse G; Izu A; Ammann A; Johns Hopkins University, Baltimore, MD.; OBJECTIVES: A recombinant subunit vaccine consisting of IIIB rgp120/HIV-1 in alum elicited type-specific neutralizing antibodies in chimpanzees and fully protected them against intravenous challenge with HIV-1/IIIB. Using the same immunization schedule, a trial with IIIB rgp120/HIV-1 vaccine is being conducted in huma
Somebody else in your picture--the Black C.A.P. model.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th65 (abstract no. ThD 1502). Unique Identifier : AIDSLINE ICA8/92400077; Stewart D; Falconer DA; Black Coalition For AIDS Prevention, Toronto, Canada.; ISSUE: The Black communities in Toronto consist of predominantly immigrants from a diversity of cultural backgrounds with most originating from the Caribbean. With limited resources, the Black Coalition For AIDS Prevention (Black CAP) had the challenges of incorporating gender, class and sexual orientation and making
HIV-seropositivity, violence and the function of a self-help group in a Buenos Aires prison. HIV+ self-help group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th65 (abstract no. ThD 1500). Unique Identifier : AIDSLINE ICA8/92400078; Vazquez Acuna M; Faas L; University of Amsterdam.; ISSUE: Finding ways to diminish outbursts of violence amongst HIV-seropositive men in Buenos Aires prison Villa Devoto. PROJECT: The HIV+ inmates form a self-help group that, with help of a judge, establishes contacts with NGOs that bring updated information on HIV-disease, give classes in first aid and hygiene and pr
Participatory approach to AIDS prevention. The Kasisi Project in Zambia.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th65 (abstract no. ThD 1501). Unique Identifier : AIDSLINE ICA8/92400079; Phiri N; Kweekeh F; Nyambe J; Chirwa BU; ISSUE PROBLEM: Introducing AIDS intervention in a rural community posed a major challenge to both local and health workers. Most local people did not perceive AIDS as a major problem. HIV infected persons were thought to be suffering from traditionally perceived illnesses. e.g. ICHIFUBA CHAMANKOWESHA. DESCRIPTION OF P
Discovery of potent, orally bioavailable inhibitors of HIV protease.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th66 (abstract no. ThA 1507). Unique Identifier : AIDSLINE ICA8/92400080; Norbeck D; Kempf D; Marsh K; Paul D; Knigge M; Vasavanonda S; Clement J; Kohlbrenner W; Sham H; Wideburg N; et al; Abbott Laboratories, Abbott Park, IL.; OBJECTIVES: The production of infectious HIV requires specific processing of the gag and gag-pol polyproteins by a virally encoded aspartic protease. Inhibitors of the HIV protease therefore have attracted intense interest as potential drugs for the treatment of AIDS, but clinical evaluation of these agents has been h
HIV-1 (Rf) variants with a single amino acid substitution at the protease (Val82 to Ala) have a reduced sensitivity to C-2 symmetrical inhibitors of HIV-1 protease.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th66 (abstract no. ThA 1506). Unique Identifier : AIDSLINE ICA8/92400081; Patterson CE; Cheng YS; Buckery R; Otto MJ; Winslow DL; DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0328.; OBJECTIVES: We have isolated HIV-1 (Rf) variants that have a reduced susceptibility to several C-2 symmetrical inhibitors of the HIV protease. Molecular cloning of the viral protease gene and characterization of its sequence is our first attempt toward an understanding of the resistant properties of these viral varian
In vitro isolation and partial characterization of HIV variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV-1 protease.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th66 (abstract no. ThA 1505). Unique Identifier : AIDSLINE ICA8/92400082; Otto MJ; Garber S; Winslow D; Cheng YS; Reid CD; Aldrich P; Jadhav PK; DuPont Merck Pharmaceutical Company, Glenolden, PA.; OBJECTIVES: Recent reports have shown that the inhibition of HIV protease results in the inhibition of infectious virus production in vitro. HIV protease, therefore, appears to be an attractive target for anti-HIV therapy. Since development of resistance is a serious concern with any new antiviral, we attempted to iso
Novel, low molecular weight HIV-1 protease inhibitors.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th66 (abstract no. ThA 1503). Unique Identifier : AIDSLINE ICA8/92400083; Vaillancourt M; Vanasse B; Cohen E; Sauve G; Institut Armand-Frappier, Laval, Quebec, Canada.; OBJECTIVE: The catastrophic dimensions of the HIV-AIDS pandemic has spurred a worldwide quest for new therapeutic agents. One such therapeutic approach is the use of inhibitors of HIV-protease. Previous studies has shown that if the protease is catalytically defective and/or inhibited, viral maturation is blocked, and
Shut off of HIV replication in chronically-infected macrophages by an inhibitor of HIV protease.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th66 (abstract no. ThA 1504). Unique Identifier : AIDSLINE ICA8/92400084; Perno CF; Bergamini A; Capozzi M; Milanese M; Thaisrivongs S; Zon G; Rocchi G; Calio R; Univ. Rome Tor Vergata, Italy.; OBJECTIVES: Assess the efficacy of inhibitors of late stages of HIV replication in chronically-infected macrophages (HIV-M/M) (the major reservoir of the virus). METHODS: Mature macrophages (M/M) were infected in vitro with HIV, and exposed at various time points to the protease inhibitor U-75875 (
Anonymous questionnaire to assess consumption of prescribed and alternative medication and patterns of recreational drug use in a HIV positive population.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1508). Unique Identifier : AIDSLINE ICA8/92400085; Valentine CB; Weston R; Kitchen V; Main J; Moncrieff KC; Aber VR; St Mary's Hospital, Paddington, London.; OBJECTIVES: To establish patterns of usage of prescribed medication, alternative medication consumption, the beliefs of our patients surrounding these agents and patterns of recreational drug use. METHODS: All patients attending our HIV clinic during a representative 2 week period were asked to complete an anonymous s
Cognitive deficit & neurological impairment in pediatric HIV.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1509). Unique Identifier : AIDSLINE ICA8/92400086; Stein Z; Mellins CA; Levenson RL Jr; Zawadzki R; Kairam R; HIV Center for Clinical & Behavioral Studies, NYS Psych. Inst.,; NY.; OBJECTIVE: To explore the potential contribution to cognitive functioning of: HIV infection, neurological impairment, and pre-natal drug-exposure. METHOD: 49 children who were HIV-exposed and between the ages of 2.5 and 8.5 years received neurological (standard clinical examination) and psychological (McCarthy Scales
Comparison of neuropsychologic performance between AIDS-free i.v. drug users and homosexual men.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1513). Unique Identifier : AIDSLINE ICA8/92400087; Concha M; Selnes OA; Royal W; Updike M; Nance-Sproson T; Vlahov D; Palenicek J; McArthur JC; Johns Hopkins Medical Institutions, Baltimore, MD.; OBJECTIVE: To compare the neuropsychologic performance between AIDS-free IV drug users and homosexual/bisexual men according to HIV serostatus and CD4+ count. METHODS: Baseline neuropsychologic performance of 107 IV drug users and 230 homosexual/bisexual men was compared. Tests measured attention, memory, and psychomo
Progressive multifocal leukoencephalopathy: disease progression, stabilization and response to intrathecal Ara-C in 26 patients.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1512). Unique Identifier : AIDSLINE ICA8/92400088; Britton CB; Romagnoli M; Sisti M; Powers JM; Columbia University, New York, New York.; We evaluated twenty-six patients with progressive multifocal leukoencephalopathy (PML) and HIV infection. Thirteen patients were treated with intrathecal cytosine arabinoside (ara-C). PATIENT CHARACTERISTICS AND TREATMENT CRITERIA: Twenty-five men and one woman were referred for evaluation of possible PML over a four
Quinolinic acid and the pathogenesis of AIDS dementia.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1511). Unique Identifier : AIDSLINE ICA8/92400089; Brew BJ; Corbeil J; Pemberton L; Heyes M; Evans L; Penny R; Cooper DA; Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.; OBJECTIVES: Quinolinic acid (QUIN), an excitotoxin acting through the N Methyl D Aspartate receptor, has been found to be markedly elevated in the cerebrospinal fluid of patients with AIDS dementia complex (ADC), raising the possibility of its importance in the pathogenesis of ADC.
Utility of HIV-1 p24 antigen measurement in CSF from patients with and without cognitive impairment.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th67 (abstract no. ThB 1510). Unique Identifier : AIDSLINE ICA8/92400090; Royal W 3d; Concha M; McArthur JC; Selnes OA; Nance-Sproson TE; Johns Hopkins School of Medicine, Baltimore, MD.; OBJECTIVE: To determine the relationship between CSF measurements of HIV-1 p24 antigen (p24Ag) in samples from HIV-1 seropositive individuals and the presence of HIV-related dementia . METHODS: Blood (plasma or serum) and CSF samples were assayed for p24Ag in antigen capture EIA fol
A network-informed strategy for preventing HIV among street gang members.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1516). Unique Identifier : AIDSLINE ICA8/92400091; Potterat J; Bethea P; Muth S; Woodhouse D; Muth J; El Paso County Department of Health and Environment, Colorado; Springs, CO.; OBJECTIVE: Develop and use social network analytic tools to identify high risk people within a network of street gang members for HIV prevention activities. METHODS & RESULTS: Social network analysis identified a densely connected block of 92 gang members and their consorts in Colorado Springs, all sexually linked
Homosexual role separation and the spread of HIV.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1518). Unique Identifier : AIDSLINE ICA8/92400092; Van Druten HA; Hendriks JC; Van Griensven GJ; University of Nijmegen, The Netherlands.; OBJECTIVES: A role separation mixing model is developed to study preference in homosexual role behavior and the changes therein as a possible co-factor in the spread of HIV. The model is linked to data from the Amsterdam cohort study. METHODS: Homosexual men from the Amsterdam cohort study are classified into four sex
HIV infection in long distance truck drivers in Kenya: seroprevalence, seroincidence, and risk factors.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1514). Unique Identifier : AIDSLINE ICA8/92400093; Job B; Omari MA; Mutere AN; Plummer FA; Moses S; Ndinya-Achola JO; Kreiss JK; University of Nairobi, Kenya.; OBJECTIVE: To determine the seroprevalence, seroincidence, and correlates of HIV infection among long distance truck drivers in Kenya . METHOD: Truck drivers along the Mombasa-Nairobi highway were enrolled at a roadside research clinic near Nairobi between June 1989 and December 1991
HIV infection within networks of prostitute women and injecting drug users.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1519). Unique Identifier : AIDSLINE ICA8/92400094; Muth SQ; Woodhouse DE; Potterat JJ; Muth JB; Darrow WW; El Paso County Health Dept., Colorado Springs, CO.; OBJECTIVES: This is an ongoing longitudinal study to describe the social networks of prostitute women, injecting drug users (IDU) and their sexual and needle partners, and to determine how network structure influences the spread of HIV within those networks. METHODS: Since 1988, 125 prostitute women, 207 IDU, and 269
HIV prevalence among attenders of a clinic for STD: the potential risk of heterosexual transmission in Amsterdam.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1517). Unique Identifier : AIDSLINE ICA8/92400095; Fennema JS; van Ameijden EJ; Coutinho RA; van Doornum GJ; Henquet C; van den Hoek JA; Municipal Health Service, Amsterdam, The Netherlands.; OBJECTIVE: To estimate HIV prevalence among attenders of an STD-clinic and assess the potential risk of further heterosexual (HETS) transmission of HIV. METHODS: In 1991 we conducted a cross sectional linked anonymous HIV study among clinic attenders who came for a new consultation in a 11 week study period. Participa
The effect of partner mixing and migration on the spread of gonorrhea, chlamydia and HIV, a model study.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th68 (abstract no. ThC 1515). Unique Identifier : AIDSLINE ICA8/92400096; Stigum H; Falck W; Magnus P; Bakketeig LS; Dep. of Epidemiology, Natl Inst of Public Health, Oslo, Norway.; OBJECTIVE: To evaluate the importance of core groups with high sexual activity on the spread of gonorrhea, chlamydia and HIV in the heterosexual population. METHODS: A set of differential equations is used to model the spread of STD s in a heterosexual population which includes a core group of highly sexually active s
Detection of HIV-1 in breast milk, multiple sexual partners, and mother-to-child transmission of HIV-1: a cohort study.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th69 (abstract no. ThC 1524). Unique Identifier : AIDSLINE ICA8/92400097; Bulterys M; Chao A; Farzadegan H; Nawrocki P; Dushimimana A; Habimana P; Kurawige J; Musanganire F; Burnley A; Saah A; Johns Hopkins Univ.; OBJECTIVES: 1) To examine a possible association between detection of HIV-1 proviral DNA in milk and mother-to-child transmission (MCT). 2) To study MCT and detection of HIV-1 in milk in relation to a recent history of multiple sexual partners. METHODS: Prospective cohort study of 304 HIV-1 sero(+) and 298 sero(-) wom
Milk HIV-1 IgG, SIgA and IgM in a cohort of HIV-1 infected mothers. Kigali, Rwanda (1988-1990).: Int Conf AIDS. 1992 Jul 19-24;8(1):Th69 (abstract no. ThC 1521). Unique Identifier : AIDSLINE ICA8/92400098; Van de Perre P; Simonon A; Hitimana DG; Karita E; Msellati P; Mukambano B; Van Goethem C; Dabis F; Lepage P; AIDS Reference Laboratory, National AIDS Control Program, Kigali,; Rwanda.; OBJECTIVES: 1. To estimate the frequency of HIV-1 antibodies in milk of infected mothers at various times in the post partum period. 2. To evaluate their potential protective effect on mother-to-child transmission of HIV-1. METHODS: In a cohort of 215 HIV-1 infected mothers, milk samples were collected at day 15, mont
Prevalence of HIV in breast milk and correlation with maternal-infant transmission. The CDS/JHU AIDS Project Team.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th69 (abstract no. ThC 1523). Unique Identifier : AIDSLINE ICA8/92400099; Ruff A; Coberly J; Burnley A; Boulos R; Desormeaux J; Halsey N; Farzadegan H; Johns Hopkins Univ, Baltimore, MD.; OBJECTIVE: To determine the prevalence of HIV DNA and/or p24 antigen (p24) in breast milk and the association with maternal-infant HIV transmission. METHODS: Milk was collected at three month intervals from 40 HIV+ and 15 HIV- women. Cells were tested for HIV DNA by PCR and aqueous phase for p24 by EIA. Sequential mil
Prevention of maternal-infant HIV-transmission by weaning.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th69 (abstract no. ThC 1522). Unique Identifier : AIDSLINE ICA8/92400100; Kuznetsova II; Porkhachova TM; Pokrovsky VV; Central Research Institute of Epidemiology, Moscow, Russia.; OBJECTIVE: to determine the influence of breast-feeding on HIV-seroprevalence among newborns of HIV-infected mothers. METHODS: All the examined HIV(+) women which had delivery after May 1988 were suggested to wean their infants. RESULTS: Among 32 observed mother-child pairs 2 children died in perinatal period, 2--em
Risk factors for vertical transmission of HIV-1 infection. The European Collaborative Study.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th69 (abstract no. ThC 1520). Unique Identifier : AIDSLINE ICA8/92400101; Newell ML; Institute of Child Health, London, UK.; OBJECTIVES: to determine maternal factors influencing the rate of vertical transmission METHODS: In 19 European centres children born to women known to be HIV-infected before the time of delivery were followed prospectively from birth, using a standard protocol. Information was collected on both mothers and children.
Beliefs, social norms and other factors affecting condom use and monogamy in Zimbabwe.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1529). Unique Identifier : AIDSLINE ICA8/92400102; Kasprzyk D; Montano DE; Wilson D; Battelle Seattle Research Center, WA.; OBJECTIVES: (1) To elicit factors affecting condom use and monogamy in Zimbabwe and to compare these factors among 8 targeted risk groups (CSWs, Clients, STD patients, Truckers, Fishermen, Urban and Rural community individuals and Urban workplace individuals), by gender, and by r
Changes in behavioral intentions among adolescents following HIV disclosure by a national sports celebrity.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1526). Unique Identifier : AIDSLINE ICA8/92400103; Rugg D; Banspach S; Short L; Centers for Disease Control, Atlanta, GA.; OBJECTIVE: To assess self-reported intentions to maintain or change to safer sexual practices among 2,840 U.S. adolescents due to a national sports celebrity s (Magic Johnson) public disclosure of positive HIV antibody status. METHODS: Students (9th-11th grade, ages 14-18) in 16 Colorado schools and 9 San Diego school
Do you believe in Magic? The public health consequences of Magic Johnson's announcement for inner-city women.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1527). Unique Identifier : AIDSLINE ICA8/92400104; Rapkin B; Mantell JE; Tross S; Ortiz-Torres B; New York University.; OBJECTIVES: Few HIV-related media events have received as much attention as Magic Johnson s (the U.S. basketball star) public disclosure of his HIV+ status. We examine the impact of this event on inner-city women s behavior, testing decisions and health beliefs, using data from the Cultural Network Project. METHODS: M
HIV exposure risk-relevant behaviors in the U.S. Army.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1528). Unique Identifier : AIDSLINE ICA8/92400105; Temoshok L; Blake SM; Rundell JR; Sharp ES; Ledsky R; Henry M. Jackson Foundation, Rockville, MD.; OBJECTIVE: To estimate the prevalence of HIV exposure risk-relevant behaviors in an ethnically and geographically diverse, sexually active population; and to identify knowledge, attitudinal, sociocultural, behavioral, and situational factors associated with HIV exposure potential. METHODS: The U.S. Army-Wide HIV/AIDS
Prostitute patronage in a high HIV-prevalence environment: male sexual risk-taking in Thailand.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1525). Unique Identifier : AIDSLINE ICA8/92400106; VanLandingham M; Suprasert S; Sittitrai W; Vaddhanaphuti C; Chiang Mai Univ.; OBJECTIVES: The research goals are to assess 1) the degree of under standing among young men in northern Thailand about how AIDS is transmitted & 2) the determinants of risky sexual practices. A major hypothesis to be explored is that close friends influence each other s decision
Psychodynamics in HIV preventive behavior change among sexually vulnerable population.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th70 (abstract no. ThD 1530). Unique Identifier : AIDSLINE ICA8/92400107; Sundararaman S; Narayan H; Daniel A; AIDS Research Foundation Of India, Madras.; INTRODUCTION: Though HIV infection was initially detected among Commercial sex workers in Madras, their clients in fact are the unseen partners in the infection chain. The increase in HIV infection among men involving in multipartner sexual intercourse necessitated a risk reduction intervention program. METHOD: A prel
Features governing nuclear import of HIV-1 preintegration complexes: role in permissiveness, latency and reactivation.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1535). Unique Identifier : AIDSLINE ICA8/92400108; Stevenson M; Bukrinsky MI; Sharova N; Gulizia J; Haggerty S; University of Nebraska Medical Center, Omaha.; The cytopathogenic properties of HIV-1 in permissive CD4 lymphocytes in vitro are difficult to reconcile with the chronic nature of AIDS progression and the gradual decline in CD4 lymphocyte number. Thus, my laboratory has investigated features of the virus and the host which influence HIV-1 latency and reactivation d
Influence of HIV infection on the V beta repertoire in monozygotic twins discordant for HIV: evidence for the effects of a superantigen.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1536). Unique Identifier : AIDSLINE ICA8/92400109; Pantaleo G; Rebai N; Graziosi C; Lane HC; Sekaly RP; Fauci AS; LIR, NIAID, NIH, Bethesda, MD.; OBJECTIVES: To investigate whether perturbations of the V beta repertoire occur in individuals infected with HIV and to determine whether these perturbations are consistent with the effects of a superantigen. METHODS: A quantitative polymerase chain reaction (PCR) assay was used to determine the frequency of expressio
Preference for G----A hypermutation via dislocation mutagenesis by the HIV-1 reverse transcriptase.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1534). Unique Identifier : AIDSLINE ICA8/92400110; Vartanian JP; Meyerhans A; Sala M; Buc H; Henry M; Wain-Hobson S; Laboratoire de Retrovirologie Moleculaire, Institut Pasteur,; Paris.; OBJECTIVES: To characterize in vitro the mechanism of G-greater than A hypermutation by dislocation mutagenesis and to compare the ability of the HIV-1, Moloney MLV and AMV reverse transcriptases (RTase) to tolerate dislocations. METHODS: A 60-mer DNA oligonucleotide was constructed so that both +1 and +2 frameshifts
The central polypurine tract in the HIV-1 genome is important for viral replication.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1533). Unique Identifier : AIDSLINE ICA8/92400111; Grinde B; Jonsrud K; Tjotta E; Hungnes O; National Institute of Public Health, Oslo, Norway.; OBJECTIVES: To understand the function of the central polypurine tract. INTRODUCTION: The reverse transcription of HIV-1 RNA generates a linear, double-stranded DNA with a single-stranded gap. The gap is believed to be the result of plus-strand priming from a second, centrally located polypurine tract (PPT). This PPT
The second origin of HIV DNA plus-strand: structure and role in viral replication.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1532). Unique Identifier : AIDSLINE ICA8/92400112; Charneau P; Clavel F; Unite d'oncologie virale, Institut Pasteur, Paris.; OBJECTIVES: Most retroviruses have a unique, well defined origin site for their DNA plus-strand, determined by a polypurine tract (PPT). By contrast, HIV and some related viruses use an additional origin site, located at the center of the viral genome, and defined by a second copy of the PPT, which result in a discont
Three-dimensional structure of HIV-1 reverse transcriptase complexed with a dsDNA template-primer reveals arrangement of the active sites for polymerization and RNase H.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th71 (abstract no. ThA 1531). Unique Identifier : AIDSLINE ICA8/92400113; Arnold E; Jacobo-Molina A; Nanni RG; Williams RL; Clark AD Jr; Ding J; Lu X; Ferris AL; Clark PK; Hughes SH; Center for Advanced Biotechnology and Medicine (CABM),; Piscataway, NJ.; OBJECTIVES: Knowledge of the three-dimensional structure of HIV reverse transcriptase (RT) in a catalytically relevant complex should potentially enable improved design of RT inhibitors. Molecular mechanisms of catalysis and drug resistance should also be illuminated through studies of the structure. METHODS: We are a
Biased T cell receptor V beta repertoire of peripheral blood derived and intestinal CD8+ T cells in HIV disease.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th72 (abstract no. ThA 1539). Unique Identifier : AIDSLINE ICA8/92400114; Deusch K; Dahne I; Endres N; Reich K; Poppinger J; Jager H; Classen M 2d; Dept. of Medicine, Technical University Munich, Germany.; The hallmark of HIV disease is a progressive depletion of CD4+ T cells. Apart from cytolytic effects imposed by viral infection of CD4 cells other mechanisms such as autoimmune mediated cytotoxicity targeted to gp120 bound to the CD4 molecule or antiidiotypic cell interactions have been discussed. A striking feature d
Conservation of the TCR-V-beta chains repertoire in CD4+ T cells during progression of HIV infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th72 (abstract no. ThA 1541). Unique Identifier : AIDSLINE ICA8/92400115; Gorochov G; Autran B; Debre P; Sigaux F; Lab. Molecular Hematology, Hop. St Louis, Paris, France.; OBJECTIVES: To study the hypothesis of a selective in-vivo deletion of T cell receptor (TCR) V-Beta chains as co-factors for CD4+ cell depletion in HIV disease. We studied the evolution of the usage of Beta chain repertoire during progression of the disease. METHODS: We performed a PCR analysis of the V-Beta segments
HIV-1 acts as a superantigen: TCR V beta expression regulates HIV replication.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th72 (abstract no. ThA 1538). Unique Identifier : AIDSLINE ICA8/92400116; Laurence J; Hodtsev AS; Posnett DN; Department of Medicine, Cornell University Medical College, New; York, New York 10021.; OBJECTIVES: Superantigens (SA), molecules recognized by T cells expressing specific Ag receptor (TCR) V beta gene products, bridge MHC and TCR, variously leading to cell stimulation, deletion or anergy. Mammalian retroviruses, as other pathogens, may encode SAs as a means to block generation of cellular immune reactiv
Positive selection of the V beta 5 TCR gene product in HIV infected individuals.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th72 (abstract no. ThA 1537). Unique Identifier : AIDSLINE ICA8/92400117; Wilson SE; Gompels LC; Coates A; Habeshaw J; Dalgleish A; St. George's Hospital, London, England.; OBJECTIVE: To investigate if HIV infected individuals with normal CD4 counts show selective use of specific V beta TCR gene products. METHODS: PBMC were isolated from both HIV seropositive donors (CDC II) with normal CD4 counts (greater than 600) and healthy volunteers (controls). The percentage of CD3+ T cells bearin
T cell receptor V gene expression on CD4+ and CD8+ peripheral T cells from HIV+ patients.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th72 (abstract no. ThA 1540). Unique Identifier : AIDSLINE ICA8/92400118; Hodara V; Jeddi-Tehrani M; Grunewald J; Andersson R; Scariatti G; Holmberg V; Libonatti O; Wigzell H; Dpt. Immunology, Karolinska Institutet, Sweden.; OBJECTIVES: To analyze T cell receptor (TcR) V beta and J beta gene expression in HIV+ patients and to find out whether there is any relation between the disease progression and the expression of select TcR genes. METHODS: Peripheral blood was obtained from 2 HIV+ patients at clinical stage CDCII; 5 at stage III and 5
Epidemic Kaposi's sarcoma (EKS) in HIV uninfected (HIV-neg) homosexual (HS) men: clinical course and analysis for known human retroviral genomic sequences by PCR.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th73 (abstract no. ThB 1543). Unique Identifier : AIDSLINE ICA8/92400119; Saltzman BR; Friedman-Kien AE; Huang YQ; Li JJ; N.Y.U. Medical Center, NY.; OBJECTIVES: 1. Describe epidemiology and clinical course of HIV-neg EKS in HS men. 2. Determine presence or absence of known human retroviral genomic sequences in EKS tissue samples via polymerase chain reaction (PCR). METHODS: 1. Identification of HS men with EKS who are HIV-neg. 2. EIA, Western blot HIV p24 Ag, on s
High-dose chemotherapy (LNH84) for HIV associated non-Hodgkin's lymphoma. Prospective study (141 pts). GELA-GICAT Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th73 (abstract no. ThB 1542). Unique Identifier : AIDSLINE ICA8/92400120; Oksenhendler E; Gisselbrecht C; Tirelli U; Gabaree J; Farcet JP; Lepage E; Monfardini S; Hop. St Louis, Paris, France.; OBJECTIVE: To evaluate an intensive combination chemotherapy (LNH84; JCO 08/89) in HIV-NHL and to define the major prognostic factors. PATIENTS: 141 patients with good performance status (PS less than 3) and no uncontrolled opportunistic infection were included from Jan 1988 to Jan 1991. Histology: Burkitt: 59 pts, di
Prospective study with combined low-dose chemotherapy and zidovudine for 37 patients (pts) with poor prognosis HIV-related non-Hodgkin's lymphoma (HIV-NHL). The French-Italian Cooperative Study Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th73 (abstract no. ThB 1544). Unique Identifier : AIDSLINE ICA8/92400121; Tirelli U; Oksenhendler E; Vaccher E; Errante D; Spina M; Crosato IM; Magnani G; Malfltano A; Salassa B; Lombardi F; et al; Centro di Riferimento Oncologico, Aviano, Italy.; Since May 1988, within the French-Italian Cooperative Study Group. 37 consecutive patients with HIV-NHL and poor prognosis, i.e. with PS greater than or equal to 3 and/or opportunistic infections (OI) in the history were prospectively treated with combined low dose chemotherapy CHVmP Vincristine Bleo (50% reduced dosa
HIV-1 infection and modulation of cytokine and growth factor expression in AIDS-Kaposi's sarcoma derived cells.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th74 (abstract no. ThD 1547). Unique Identifier : AIDSLINE ICA8/92400122; Kim K; Huang Y; Li J; Le J; Poiesz B; Friedman-Kien A; NYU Medical Center NYC.; HIV-1 INFECTION AND MODULATION OF CYTOKINE AND GROWTH FACTOR EXPRESSION IN AIDS-KAPOSI S SARCOMA DERIVED CELLS OBJECTIVES: To investigate whether HIV-1 is able to infect AIDS-KS derived cells in vitro and some physiological changes resulting from the infection. METHODS: Two different KS-derived cell lines were used in
Liposomal-encapsulated cytotoxic agent daunorubicin (LD) versus conventional three-drug chemotherapy (CC) in AIDS patients with Kaposi's sarcoma (KS)--preliminary results.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th74 (abstract no. ThD 1545). Unique Identifier : AIDSLINE ICA8/92400123; Dormann A; Gruenewald T; Ross ME; Pohle HD; Ruf B; Schueler W; II. Dept. of Internal Medicine, Rudolf Virchow University; Hospital, Freie Universitaet Berlin, Germany.; OBJECTIVE: To compare efficacy and safety of LD with three-drug regimen using adriamycin, vinblastine and bleomycin in patients with advanced HIV-associated KS. METHODS: Two groups (each n = 7) designed as matched pairs by the degree of the disease and CD4+ lymphocyte counts and compared according to clinical and/or r
Prognostic factors for survival in AIDS patients with pulmonary Kaposi's Sarcoma (KS) treated by chemotherapy (CT).: Int Conf AIDS. 1992 Jul 19-24;8(1):Th74 (abstract no. ThD 1546). Unique Identifier : AIDSLINE ICA8/92400124; Cadranel J; Winter C; Kammoun S; Perrot A; Denis M; Rozenbaum MW; Akoun G; Mayaud C; Hopital Tenon, Paris, France.; AIDS patients (pts) with symptomatic pulmonary KS have spontaneous survival of less than 3 months. Recent reports in small groups of pts have shown that such evolution may be improved by CT. In this study, we have analysed prognostic factors for survival in 30 pts with symptomatic pulmonary KS treated with 3-drug chem
HIV-1 reverse transcriptase mutations in children treated with zidovudine.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th75 (abstract no. ThB 1549). Unique Identifier : AIDSLINE ICA8/92400125; Principi N; Vago T; Massironi E; Tornaghi R; De Pasquale MP; Picco P; Marchisio P; Pediatr Dept 4, University of Milan, Italy.; OBJECTIVE To evaluate the presence of HIV-1 mutations in HIV infected children treated with zidovudine (ZDV) METHODS 19 HIV infected children (9 P2A,4 P2AB,2 P2AC,1 P2AD1,3 P2AF) treated with ZDV (600 mg/m2/day) were prospectively followed-up monthly with clinical and laboratory controls. The presence of mutant HIV-1
Risk factors for the development of acyclovir-resistant herpes simplex virus (HSV) infection.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th75 (abstract no. ThB 1548). Unique Identifier : AIDSLINE ICA8/92400126; Safrin S; Elbaggari A; Elbeik T; San Francisco General Hospital, University of California 94110.; OBJECTIVES: We performed a case-control study to determine the risk factors associated with the development of acyclovir-resistant HSV infection in HIV-infected patients. METHODS: The Research Virology Laboratory at San Francisco General Hospital has served as a reference laboratory for testing of antiviral susceptibi
'Frontloading' is associated with HIV infection among drug injectors in New York City.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th76 (abstract no. ThC 1551). Unique Identifier : AIDSLINE ICA8/92400127; Jose B; Friedman SR; Neaigus A; Curtis R; Des Jarlais DC; Narcotic and Drug Research, Inc., NY, NY.; OBJECTIVE: To assess the extent to which frontloading is associated with exposure to HIV among injecting drug users (IDUs). Frontloading is a drug sharing practice in which an injector s syringe is used to measure drugs and to give a fair share to another injector by spouting the drug into another s syringe. M
High risk of HIV seroconversion among street intravenous drug users in Montreal.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th76 (abstract no. ThC 1550). Unique Identifier : AIDSLINE ICA8/92400128; Soto J; Lamothe F; Bruneau J; Vinceiette J; Brabant M; Fauvel M; Saint-Luc Hospital, Quebec, Canada.; OBJECTIVES: To evaluate the incidence of HIV seroconversion in a cohort of intravenous drug users (IVDU) and to determine factors associated with the risk of HIV infection. METHODS: We considered eligible for inclusion any adult using intravenous drugs in the last 6 months. Subjects were referred by several treatment
HIV-1 infection among female injection drug users (IDU) in the San Francisco Bay Area, California, 1989-1991: increased seroprevalence rates for IDU who are lesbian/bisexual, racial/ethnic minorities or cocaine injectors. California HIV Seroprevalence Surveys Coordinating Group.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th76 (abstract no. ThC 1553). Unique Identifier : AIDSLINE ICA8/92400129; Reardon J; Wilson MJ; Lemp GF; Gaudino JA; Snyder D; Elcock M; Nguyen S; OBJECTIVES: To determine HIV-1 seroprevalence rates and demographic and additional factors associated with HIV-1 infection among women with a history of injection drug use entering treatment in the San Francisco Bay Area. METHODS: During the period October 1, 1989--September 30, 1991 we conducted HIV-1 unlinked serosu
Incidence of HIV infection in intravenous drug users from Milan and northern Italy, 1987-91. (NISDA Study).: Int Conf AIDS. 1992 Jul 19-24;8(1):Th76 (abstract no. ThC 1552). Unique Identifier : AIDSLINE ICA8/92400130; Ciaffi L; Nicolosi A; Correa Leite ML; Musicco M; Molinari S; Lazzarin A; University of Milan.; OBJECTIVE: To monitor time trends of HIV infection s incidence and risk factors among intravenous drug users (IVDU) and study the dynamics of seroconversion rates in relation to behaviors, prevalence of the infection and other variables influencing the rate of parenteral and sexual HIV transmission. METHODS: All IVDU
Mortality predictors in a 7 year IVDA cohort study: roles of HIV, HTLV-2, age, gender and entry symptoms.: Int Conf AIDS. 1992 Jul 19-24;8(1):Th76 (abstract no. ThC 1555). Unique Identifier : AIDSLINE ICA8/92400131; Weiss SH; French J; Klein CW; Mayur RK; Altman R; UMD-NJ School of Medicine, Newark.; OBJECTIVES: Examine predictors of mortality in an ongoing study of injection drug users (IDU), particularly among those HIV seronegative (SN) on enrollment. METHODS: We administered an extensive questionnaire, and obtained blood for HIV and HTLV testing and storage, on 963 IDU from New Jersey in 1984. SN have been per
Rapid spread of HIV among injecting drug users of north-eastern India: a new risk group of transmission in India.