Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
LYMPHOMA, AN OPPORTUNISTIC NEOPLASIA OF AIDS: A MULTIPARAMETER STUDY OF 111 CASES (MEETING ABSTRACT)
Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 37, 1991.. Unique Identifier : AIDSLINE ICDB/92682393 Ioachim HL; Dept. of Pathology, Lenox Hill Hosp., New York, NY
Abstract:
The incidence of lymphomas in HIV-infected persons has increased progressively since the beginning of the AIDS epidemic. In the United States there were, by 1989, 3000 cases of AIDS-associated non-Hodgkin's lymphomas (NHL) out of 100,000 cases of AIDS, an incidence of 3%, 60 times higher than in the general population. A series of 111 patients, 108 men and 3 women (average age 39 yr), with male homosexuality the predominant risk factor, comprised 11 cases of Hodgkin's lymphoma (HL) and 100 cases of NHL, a distribution in sharp contrast to that in the general population where, in this age group, HL is prevalent. The ratio of 11:1, NHL vs HL, is also different from that of only 2:1 in European series, explainable by the predominance of homosexuals over iv drug users among the risk groups of AIDS in the US vs Europe. In the general population, NHL originate mainly in lymph nodes, whereas in patients with immune deficiencies, visceral lymphomas are more common. In this series there were 39 nodal and 61 extranodal NHL. The digestive tract was most frequently involved, including unusual oral and anal primary locations possibly related to specific risk factors. The CNS was the primary site of NHL in 15% of cases, as compared to its incidence of 0.1% among the lymphomas of the general population. The majority of NHL were to high histologic grades, particularly Burkitt and immunoblastic types, which represented most of the cerebral and gastrointestinal tumors. All NHL were of B-cell immunophenotype. The predominance of high-grade B-cell NHL may be related to the uncontrolled proliferation of B cells secondary to T-cell impairment. Probing for EBV genome was more frequently positive in HL (100%) than in NHL (40%). Lymphadenopathies with the histologic features of HIV infection, particularly of the late stage (type C), often preceded NHL. Immunologic evaluations showed severely depressed T-cell counts and CD4/CD8 cell ratios, as well as markedly increased levels of antilymphocyte antibodies. Reflecting the profound immune deficiency, AIDS-associated HL and NHL were characterized by high aggressiveness, early tendency to generalization, frequent post-treatment relapses and short survivals.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/TRANSMISSION Adult Brain Neoplasms/ETIOLOGY CD4-CD8 Ratio Female Gastrointestinal Neoplasms/COMPLICATIONS Homosexuality Human Lymphoma, AIDS-Related/COMPLICATIONS/IMMUNOLOGY/*PATHOLOGY Male Substance Abuse, Intravenous ABSTRACT 920830
M9281107
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Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
