RETROVIRUS-INDUCED MURINE LYMPHOMA AND PARANEOPLASTIC SYNDROMES (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


RETROVIRUS-INDUCED MURINE LYMPHOMA AND PARANEOPLASTIC SYNDROMES (MEETING ABSTRACT)

Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 42, 1991.. Unique Identifier : AIDSLINE ICDB/92682397
Jolicoeur P; Kay DG; Simard C; Huang M; Clinical Res. Inst. of Montreal, Montreal, Canada

Abstract: Murine AIDS (MAIDS) shows many similarities with human AIDS. The etiologic agent of MAIDS is a defective retrovirus encoding a precursor gag protein (Pr60gag) which remains uncleaved. Helper-free stocks of this defective virus have been shown to induce disease. Using such helper-free stocks, we have found that the infected target cells proliferated markedly following infection, first as a polyclonal expansion which eventually reaches a stage of clonality. Therefore, this disease appears to be primarily a lymphoproliferative disorder. In diseased mice inoculated with helper-free stocks of tagged defective viruses harboring unique sequences, we have identified the target cells of the defective virus by in situ hybridization/immunocytochemistry techniques. Infection of this target cell population appears necessary and sufficient to induce disease. Our data are discussed in the context of immunodeficiency associated with lymphoproliferative disorders (as a paraneoplastic syndrome), and in the context of superantigens, since Pr60gag appears to exhibit some of the characteristics of a superantigen.
Keywords: Animal Gene Products, gag/*GENETICS Murine Acquired Immunodeficiency Syndrome/*GENETICS/PATHOLOGY Paraneoplastic Syndromes/*GENETICS ABSTRACTKWDanimalgeneproducts,gag/KWDgeneticsmurineacquiredimmunodeficiencysyndrome/KWDgenetics/pathologyparaneoplasticsyndromes/KWDgeneticsabstract
920830
M9281106

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .