RETROVIRUS RECEPTORS EXPRESSED ON HUMAN CELLS (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

RETROVIRUS RECEPTORS EXPRESSED ON HUMAN CELLS (MEETING ABSTRACT)

Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 102, 1991.. Unique Identifier : AIDSLINE ICDB/92682440
Weiss RA; Chester Beatty Laboratories, Inst. of Cancer Res., London SW3; 6JB, UK

Abstract: Eight distinct receptors have been delineated on human cells for 25 strains of C-type and D-type oncoviruses and lentiviruses. Some receptors are highly expressed in many cell lineages, whereas others are more restricted. The gene determining the receptor for the human and simian T-cell leukemia viruses resides on human chromosome 17, and that for D-type simian viruses on human chromosome 19. The receptor for the gibbon ape leukemia virus also serves for the attachment of feline leukemia virus subgroup B. Bovine leukosis virus and xenotropic and amphotropic murine leukemia viruses each utilize unique receptors. CD4 acts as the high-affinity attachment receptor for human and simian immunodeficiency viruses, but further, type-specific cell surface components are required for virus entry. Most mammalian retroviruses gain entry into cells by a pH-independent route and, in some cases, virion attachment to receptors triggers cell-signalling mechanisms leading to proliferation. The comparative analysis of retrovirus receptors on human cells is relevant to leukemogenesis and to the development of retroviral vectors for gene therapy.

Keywords: Animal Antigens, CD4/METABOLISM Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 9 Human Leukemia/MICROBIOLOGY Leukemia Virus, Bovine/METABOLISM Leukemia Virus, Feline/METABOLISM Leukemia Viruses, Murine/METABOLISM Receptors, Virus/*METABOLISM Retroviridae/*METABOLISM STLV/METABOLISM ABSTRACT
920830
M9281098

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .