Use of DNA probes to further characterize Mycobacterium avium complex (MAC) strains isolated from patients with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Use of DNA probes to further characterize Mycobacterium avium complex (MAC) strains isolated from patients with AIDS.

Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:145 (abstract no. U-20). Unique Identifier : AIDSLINE ASM91/0040292
Yajko DM; Sanders CA; Kirihara JM; Nassos PS; Hadley WK; Gonzalez PC; Univ. of California, San Francisco Gen. Hosp. Med. Ctr., San; Francisco, CA.

Abstract: Thirty stains of MAC isolated from AIDS patients (25 from blood, 4 from sputum, 1 from bile), that were previously characterized with regard to serotype and antimicrobial susceptibility patterns, were tested for reactivity with the 3 DNA probes in the SNAP (TM) (Syngene Inc, San Diego, CA) M. avium complex kit. The probes identify strains of M. avium, M. intracellulare, and M. X (a possible third species of MAC). Strains belonging to serotype 1 (1 strain), serotype 4 (11 strains), and serotype 9 (2 strains), reacted with the M. avium (MA) probe, as did the one serotype 13 strain, and a strain that had been characterized by serotype as M. xenopi. Two strains having serotype 43 reacted with the M. intracellulare (MI) probe. The remaining 12 MAC strains were untypable. Of these, 10 reacted with the MA probe and 2 reacted with the MI probe. Eight of the 30 isolates had previously been shown to be susceptible to several beta-lactam antimicrobial agents. Seven of these belonged to serotype 4 and one was untypable. All 8 reacted with the MA probe.
Keywords: Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Anti-Infective Agents/PHARMACOLOGY *DNA Probes Human Microbial Sensitivity Tests Mycobacterium avium Complex/DRUG EFFECTS/*GENETICS/ISOLATION & PURIF ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDmicrobiologyanti-infectiveagents/pharmacologyKWDdnaprobeshumanmicrobialsensitivitytestsmycobacteriumaviumcomplex/drugeffects/KWDgenetics/isolation&purifabstract
920830
M9281079

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .