Humoral response to Mycobacterium avium complex disease in AIDS and non-AIDS populations.

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Humoral response to Mycobacterium avium complex disease in AIDS and non-AIDS populations.

Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:148 (abstract no. U-33). Unique Identifier : AIDSLINE ASM91/0050292
Morris S; Armoa G; Rouse D; Chaparas S; Center for Biologics Evaluation and Research, FDA, Bethesda, MD; 20892.

Abstract: Disease resulting from Mycobacterium avium, M. intracellulare complex (MAC) infections has become a serious complication for patients with acquired immmunodeficiency syndrome (AIDS). Because the detection of MAC disease is difficult and time-consuming, we have examined sera taken from AIDS and non-AIDS patients with M. avium disease for anit-MAC serodiagnostic indicators. The MAC specific antibody concentrations, quantitated by enzyme-linked immunosorbent assay (ELISA), were essentially equivalent for AIDS patients with MAC disease and controls without mycobacterial disease, the anti-MAC antibody levels in non-AIDS patients with MAC disease were significantly higher. Only minor differences in the immunoblot reactivity profiles were detected among the three patient populations. The seroreactivity of nontuberculus mycobacterial recombinant antigens was also evaluated by immunoblot assays. A recombinant antigen derived from a 35 kDa mycobacterial protein was recognized by sera from 4 of 5 non-AIDS MAC patients, 19 of 20 AIDS MAC patients, 10 of 10 tuberculosis patients, and 5 of 20 control patients. A complete epitope map of this immunogenic protein is currently being constructed. A molecular definition of the 35 kDa protein's humoral reactivity in humans should then be possible.

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY Antibodies, Bacterial/ANALYSIS *Antibody Formation Blotting, Western Enzyme-Linked Immunosorbent Assay Epitopes/IMMUNOLOGY Human Mycobacterium avium-intracellulare Infection/*COMPLICATIONS/ IMMUNOLOGY ABSTRACT
920830
M9281078

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