Characterization of Mycobacterium avium isolated from multiple sites in AIDS patients. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Characterization of Mycobacterium avium isolated from multiple sites in AIDS patients.

Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:149 (abstract no. U-42). Unique Identifier : AIDSLINE ASM91/0080292
Yakrus M; Brown S; Smith C; Kilburn J; Good RC; Butler W; Centers for Disease Control, Atlanta, GA.

Abstract: Mycobacterium avium can be isolated from a variety of sites in AIDS patients who have disseminated infection. We characterized isolates from multiple sites in 21 AIDS patients to determine if individual infections are due to one or more strains. Specimen sources included blood, sputum, stool, bronchial-alveolar lavage, tissue, urine, and other body fluids. Isolates were characterized by seroagglutination, multilocus enzyme electrophoresis (MEE), and mycolic acid patterns as determined by high-performance liquid chromatography (HPLC). Serotypes isolated were 4 (7 patients), 8 (5 patients), 1 (5 patients), 6 (3 patients), and 9 (2 patients). Isolates from 5 patients were nontypable by seroagglutination. Isolates were categorized into 22 types by MEE. Mycolic acid patterns confirmed if isolates from the same patient were identical. A single strain was isolated from multiple sites in 15 patients. Six patients were infected with more than one strain of M. avium. An AIDS patient may have disseminated infection associated with one or more strains of M. avium. MEE and HPLC can be used to identify strains and may be especially useful when isolates fail to serotype.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*MICROBIOLOGY Body Fluids/MICROBIOLOGY Chromatography, High Pressure Liquid Hemagglutination Tests Human Mycobacterium avium Complex/*ISOLATION & PURIF Mycobacterium avium-intracellulare Infection/COMPLICATIONS ABSTRACTKWDacquiredimmunodeficiencysyndrome/complications/KWDmicrobiologybodyfluids/microbiologychromatography,highpressureliquidhemagglutinationtestshumanmycobacteriumaviumcomplex/KWDisolation&purifmycobacteriumavium-intracellulareinfection/complicationsabstract
920830
M9281075

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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