In vitro synergistic inhibitory effect of ethambutol and vancomycin aginst Mycobacterium avium complex (MAC). NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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In vitro synergistic inhibitory effect of ethambutol and vancomycin aginst Mycobacterium avium complex (MAC).

Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:151 (abstract no. U-56). Unique Identifier : AIDSLINE ASM91/0090292
Berlin OG; Lang HL; Shum AC; UCLA Medical Center, Los Angeles, CA 90024-1713.

Abstract: Fifty clinical isolates of MAC, from AIDS and non-AIDS patients (32 M. avium and 18 M. intracellulare), were tested against Ethambutol (EB) and Vancomycin (VA) individually and in combination. Commercially available antimicrobial disks (BBL Microbiology Systems, Cockeysville, MD) of EB (25 ug) and VA (30 ug) were placed in sterile quadrant plates (Falcon, Lincoln Park, NJ) individually and in combination and 5 ml of 7H10 agar (Difco Laboratories, Detroit, MI) was added to achieve final concentration of 5.0 and 6.0 microgram/ml respectively; the growth quadrant contained only 7H10 agar. The plates were placed in plastic bags, incubated at 37 degrees C with 8% CO2 for 15 days and examined for visible CFUs. Separately, EB and VA had no effect on any of the MAC isolates; however, 47 of 50 (94%) were inhibited by the combination of EB/VA. The three isolates not affected by the combination drug regimen were MA. These results suggest that the synergism of EB/VA may be efficacious in the treatment of infections caused by multiresistant MAC, but additional in vitro studies need to be done.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Drug Synergism Ethambutol/*PHARMACOLOGY Human Microbial Sensitivity Tests Mycobacterium avium Complex/*DRUG EFFECTS Vancomycin/*PHARMACOLOGY ABSTRACTKWDacquiredimmunodeficiencysyndrome/microbiologydrugsynergismethambutol/KWDpharmacologyhumanmicrobialsensitivitytestsmycobacteriumaviumcomplex/KWDdrugeffectsvancomycin/KWDpharmacologyabstract
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M9281074

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