Virucidal efficacy of various lens cleaning and disinfecting solutions on HIV-I contaminted contact lenses. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Virucidal efficacy of various lens cleaning and disinfecting solutions on HIV-I contaminted contact lenses.

Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:334 (abstract no. T-2). Unique Identifier : AIDSLINE ASM91/0150292
Amin RM; Dean MT; Poiesz BJ; Zaumetzer LE; VA Medical Center and SUNY Health Science Center at Syracuse, NY.

Abstract: The isolation of Human Immunodeficiency Virus (HIV-I) from tears, cornea, conjuctival epithelium and contact lenses has raised significant concern about the possible transmissibility of this virus during routine opthalmologic procedures such as trial contact lens fittings. Because of this, we sought to determine virucidal efficacy of various contact lens cleaning regimens on HIV-1 contaminated Softlens contact lens using either cursory or meticulous cleaning with a rubber policeman. In order to detect infectious HIV-1 remaining on individual contact lenses, the lenses were cultivated with target HUT 78 cells over a 28 day period and subsequently the cultures were analyzed for the production of HIV-1 p24 by antigen culture and for HIV-1 gag gene DNA content by the polymerase chain reaction. Results of our study indicate that all but one of the lens care regimens tested in the meticulous cleaning group were capable of safely decontaminating the contact lenses and reducing more than 10 log of infectious HIV-I on the lenses as compared to the standard controls. Thus, we suggest that most tested lens care regimens, if properly followed, would virtually eliminate any chance of the lens as a vector for HIV.
Keywords: *Contact Lenses *Disinfection Genes, gag Human HIV Core Protein p24/ANALYSIS HIV-1/*ISOLATION & PURIF Polymerase Chain Reaction ABSTRACTKWDcontactlensesKWDdisinfectiongenes,gaghumanhivcoreproteinp24/analysishiv-1/KWDisolation&purifpolymerasechainreactionabstract
920830
M9281068

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .