Influence of the infectious dose of SIV on the acute infection in cynomolgus monkeys and on the effect of treatment with 3'-fluorothymidine. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Influence of the infectious dose of SIV on the acute infection in cynomolgus monkeys and on the effect of treatment with 3'-fluorothymidine.

Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:102 (abstract no. 81). Unique Identifier : AIDSLINE PRIM9/1490292
Bottiger D; Oberg B; Department of Virology, Karolinska Institute; Stockholm, SWEDEN.

Abstract: Objective: To study whether the infectious dose of simian immunodeficiency virus (SIVsm) influences the acute infection and the response to antiviral treatment of 3'-fluorothymidine (FLT). Methods: Cynomolgus monkeys treated s.c. with FLT (3 x 5 mg/kg/d for 10d) were inoculted with 3 different doses of SIVsm i.v. and the time of viral antigen appearance was determined. Treatment started 8 hours to virus inoculation. Each treatment group included 4 monkeys. Results: The appearance of viral antigen in the control monkeys was delayed when the virus dose was decreased. The effect of FLT treatment on the appearance of viral antigen was dependent on the virus dose given. When 500-2500 monkey infectious doses (MID50) was inoculated no marked influence of treatment on viral antigen was seen as compared to the controls whereas a virus inoculum of 10-50 MID50 significantly delayed the appearance of viral antigen. At the lowest virus dose given, 2-10 MID50, treatment with FLT prevented SIV infection in 2/4 animals as determined by virus isolation and seroconversion. All control animals became infected. Conclusion: Decreasing the SIV inoculum dose delayed viral antigen appearance in the acute infection. The response to antiviral treatment was dependent on the multiplicity of the infection. No significant treatment effect was seen when a high virus inoculum was used whereas the same treatment had a prophylactic effect when a low dose of virus was used.
Keywords: Animal Antigens, Viral/ANALYSIS Dideoxynucleosides/*THERAPEUTIC USE Macaca fascicularis Simian Acquired Immunodeficiency Syndrome/DRUG THERAPY/IMMUNOLOGY/ *PHYSIOPATHOLOGY SIV/ISOLATION & PURIF ABSTRACTKWDanimalantigens,viral/analysisdideoxynucleosides/KWDtherapeuticusemacacafascicularissimianacquiredimmunodeficiencysyndrome/drugtherapy/immunology/KWDphysiopathologysiv/isolation&purifabstract
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