RADIATION MUCOSITIS IN AIDS: PAST EXPERIENCE AND A NEW PROPOSAL (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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RADIATION MUCOSITIS IN AIDS: PAST EXPERIENCE AND A NEW PROPOSAL (MEETING ABSTRACT)

Br J Cancer; 64(Suppl 15):14 1991. Unique Identifier : AIDSLINE ICDB/92679216
Hughes-Davies LT; Sebag-Montefiore D; Knowles S; Spittle M; Middlesex Hosp., London, UK

Abstract: The unexpected sensitivity of oropharyngeal mucosa in patients (pts) with AIDS limits the use of radiotherapy in oral Kaposi's sarcoma. We present our experience with 23 pts. Daily fractionation is hazardous. The risk of mucositis appears to increase with time from the AIDS-defining diagnosis. We have recently used weekly fractionation which is safer. 16 pts received daily treatment to the palate and 4 later required treatment to the larynx, yielding 20 evaluable treatment episodes. A range of doses were used: 1200 cGy in 3 (n=7), 1600 cGy in 4 (n=4) and 1500 cGy in 10 (n=7). Two pts were prescribed 3000 cGy in 10 for acute airway obstruction, one of whom was withdrawn at 1800 cGy. Only 2/20 treatments were uncomplicated by mucositis and 9/20 (45%) led to a reaction of grade 2 or above. Pts treated within 9 mo of an AIDS-defining diagnosis had less severe mucositis (mean score 0.88, range 0-2) than those treated later in the course of the illness (mean score 2.0, range 0-4). Seven pts received weekly fractionation (1200-1600 cGy in 4 wk). No mucositis was encountered. Six out of 7 pts had complete palliation of symptoms. Weekly fractionation is safe and effective in pts with a long-standing AIDS diagnosis. Daily fractionation may be used with caution earlier in the disease.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Human Mouth Mucosa/PATHOLOGY/*RADIATION EFFECTS Radiotherapy Dosage Sarcoma, Kaposi's/ETIOLOGY/*RADIOTHERAPY Stomatitis/*ETIOLOGY ABSTRACT CLINICAL TRIALKWDacquiredimmunodeficiencysyndrome/KWDcomplicationshumanmouthmucosa/pathology/KWDradiationeffectsradiotherapydosagesarcoma,kaposi's/etiology/KWDradiotherapystomatitis/KWDetiologyabstractclinicaltrial
920430
M9240939

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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