Immunology of HIV infection.

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Immunology of HIV infection.

Int Rev Immunol. 1990;7(1):1-13. Unique Identifier : AIDSLINE MED/92113413
Lewis DE; Giorgi JV; Department of Microbiology and Immunology, Baylor College of; Medicine, Houston, Texas 77030.

Abstract: The goal of finding an effective vaccine against the human immunodeficiency virus (HIV) is hampered by our uncertainty of the mechanism(s) responsible for the pathogenesis as well as the lack of knowledge of protective mechanisms. The effects of HIV on the immune system are myriad and thus the truly significant manifestations of the pathology are difficult to dissociate from those more peripheral. In this article we will initially characterize the natural history of HIV infection which shows a chronic and perhaps inexorable course. The second part will deal with the immune response mounted against this assault and the final section is a discussion of the possible unfavorable consequences of the immune response that humans muster against this agent.

Keywords: CD4-Positive T-Lymphocytes/IMMUNOLOGY Human HIV Antibodies/IMMUNOLOGY HIV Infections/ETIOLOGY/*IMMUNOLOGY/PATHOLOGY HIV-1/*IMMUNOLOGY Immunity, Cellular/IMMUNOLOGY Retroviridae Proteins/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC
920430
M9240923

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