Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
Treatment of non-Hodgkin's lymphoma.
Curr Opin Oncol. 1991 Oct;3(5):830-7. Unique Identifier : AIDSLINE MED/92089217 Diaz-Pavon JR; Cabanillas F; University of Texas, MD Anderson Cancer Center, Houston.
Abstract:
Many of the advances in the management of non-Hodgkin's lymphomas have been based on more precise understanding of the various cell types that constitute these disorders. During the past year, we have seen some dramatic changes in the therapeutic approach to low-grade lymphomas. Until recently, the usual approach to these disorders was a purely palliative one, but a number of publications from the past year describe a more intensive approach with the goal of developing a curative modality. The use of combination chemotherapy in addition to radiation therapy for the early Ann Arbor stages as well as the use of high-dose chemotherapy with bone marrow transplantation in patients with high-risk factors has been reported recently. In the area of intermediate-grade lymphomas, most of the recent publications have described prognostic factors associated with various chemotherapy protocols. One of the most interesting recent developments is related to the dose-intensity issue. A consensus appears to be developing in regard to the correlation of dose intensity with clinical outcome. Despite the fact that new third-generation regimens have been associated with cures in 50% to 66% of the patients, a significant fraction of patients require salvage chemotherapy. Some of the new salvage regimens are discussed, as is the use of calcium channel blockers to reverse multiple-drug resistance. Finally, management of the high-grade lymphomas, specifically the small noncleaved cell type, has been associated with a cure rate in the range of 50% in two recently published studies. Patients who are human immunodeficiency virus-positive with small noncleaved cell lymphoma can be cured of their underlying malignancy, but many of them later develop complications of acquired immunodeficiency syndrome, to which they usually succumb.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Antineoplastic Agents, Combined/*THERAPEUTIC USE Bone Marrow Transplantation Calcium Channel Blockers/PHARMACOLOGY Combined Modality Therapy Drug Resistance Human Lymphoma, Non-Hodgkin's/DRUG THERAPY/MORTALITY/PATHOLOGY/ RADIOTHERAPY/SURGERY/*THERAPY Prognosis Remission Induction Salvage Therapy Survival Rate JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL 920430
M9240914
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Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
