Pathogenesis of HIV-related malignancies. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Pathogenesis of HIV-related malignancies.

Curr Opin Oncol. 1991 Oct;3(5):867-71. Unique Identifier : AIDSLINE MED/92089221
Gill PS; University of Southern California School of Medicine, Los; Angeles.

Abstract: Human immunodeficiency virus (HIV)-1 infection is associated with increased frequency of Kaposi's sarcoma and high-grade B-cell lymphoma. Several other cancers in HIV-1-infected individuals have been reported, although without statistically significant increase in their respective occurrences. Although HIV-1 does not infect either Kaposi's sarcoma-derived spindle cells or B lymphocytes in vivo, viral proteins in vitro have been shown to be mitogenic to both Kaposi's sarcoma-derived spindle cells and B lymphocytes. Furthermore, several cytokines influence directly and indirectly the proliferative differentiation capacity of these cells. These cytokines include interleukin-1, interleukin-4, interleukin-6, and tumor necrosis factor. Many of these cytokines also are regulated by HIV-1 infection of T lymphocytes and monocyte/macrophage. Furthermore, elevated levels of interleukin-1, interleukin-6 and tumor necrosis factor have been observed in patients with HIV-1 infection, particularly in advanced stages, when these tumors often manifest. Thus, it appears that although HIV-1 does not directly transform cells permissive to its infection, viral proteins directly and through regulation of cellular genes exert activities that may lead to the development of Kaposi's sarcoma and B-cell lymphoma.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS B-Lymphocytes/PATHOLOGY Cell Division Cytokines/BIOSYNTHESIS/PHYSIOLOGY Female Gene Expression Regulation, Viral Human HIV Infections/*COMPLICATIONS Incidence Lymphoma, Non-Hodgkin's/EPIDEMIOLOGY/*ETIOLOGY Male Retroviridae Proteins/PHYSIOLOGY Sarcoma, Kaposi's/EPIDEMIOLOGY/*ETIOLOGY Tumor Stem Cells/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/complicationsb-lymphocytes/pathologycelldivisioncytokines/biosynthesis/physiologyfemalegeneexpressionregulation,viralhumanhivinfections/KWDcomplicationsincidencelymphoma,non-hodgkin's/epidemiology/KWDetiologymaleretroviridaeproteins/physiologysarcoma,kaposi's/epidemiology/KWDetiologytumorstemcells/pathologyjournalarticlereviewreview,tutorial
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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