Individual-specific patterns of human variable genomic regions detected by a DNA probe from the HIV-1 env gene. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Individual-specific patterns of human variable genomic regions detected by a DNA probe from the HIV-1 env gene.

Biomed Sci. 1991;2(3):311-3. Unique Identifier : AIDSLINE MED/92089508
Rogaev EI; Shlenskii AB; Spoode AYa; National Mental Research Centre, Academy of Medical Sciences of; the USSR, Moscow.

Abstract: It was postulated that similar genetic elements that are 'hot spots' for genetic variation might exist in both the HIV-1 and the human genome. To test this possibility a short repeated sequence from a region of variability in the HIV-1 glycoprotein (env) gene was amplified and used as a probe for blot hybridization with human genome DNA. Human genomic regions were hybridized and characterized by a set of polymorphic restriction DNA fragments. The pattern of the restriction fragments was individual specific. Thus a DNA probe from the HIV-1 env gene can serve as a genetic marker for hybridization with human genome regions and for the identification of individuals.
Keywords: Amino Acid Sequence Base Sequence Binding Sites *DNA Probes DNA, Viral/CHEMISTRY *Genes, env *Genome, Viral Human HIV-1/*GENETICS Molecular Sequence Data Polymorphism (Genetics) Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid *Variation (Genetics) JOURNAL ARTICLEKWDaminoacidsequencebasesequencebindingsitesKWDdnaprobesdna,viral/chemistryKWDgenes,envKWDgenome,viralhumanhiv-1/KWDgeneticsmolecularsequencedatapolymorphism(genetics)repetitivesequences,nucleicacidsequencehomology,nucleicacidKWDvariation(genetics)journalarticle
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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