Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
Immunologic investigation of Chinese hemophiliacs with and without human immunodeficiency virus infection.
Chin Med J (Engl). 1991 Oct;104(10):803-7. Unique Identifier : AIDSLINE MED/92090146 Tang DJ; Pang XG; Institute of Hematology, Zhejiang Medical University, Hangzhou.
Abstract:
Cellular and humoral immune functions in Chinese hemophiliacs with and without human immunodeficiency virus (HIV) infection were compared with those of healthy controls. There was a significant increase in peripheral T8 cells and a significant decrease of peripheral T4 cells as well as the T4/T8 ratio in 3 hemophiliacs with HIV infection when compared with 26 hemophiliacs without HIV infection and 18 healthy controls (P less than 0.005, P less than 0.05 and P less than 0.002, respectively). In contrast, there were no statistical differences in the above mentioned parameters between hemophiliacs without HIV infection and healthy controls. All the three HIV seropositive hemophiliacs had anergy for 1:2000 OT test whereas among the 15 HIV seronegative hemophiliacs, only two had anergy for 1:2000 OT test. These results demonstrate that the immunological abnormalities of the 3 HIV seropositive hemophiliacs were attributed to HIV infection, and that even though hemophiliacs without HIV infection had been treated with blood products, their immune functions are generally normal. These findings are somewhat different from those reported abroad. This difference may be due to the fact that Chinese hemophiliacs are often treated with much smaller dose of blood products as a part of the treatment of their coagulative defects.
Keywords: von Willebrand's Disease/IMMUNOLOGY/THERAPY Adolescence Adult Child Christmas Disease/IMMUNOLOGY/THERAPY CD4-CD8 Ratio Factor VIII/ADVERSE EFFECTS Female Hemophilia/*IMMUNOLOGY/THERAPY Human HIV Seropositivity/*IMMUNOLOGY Immunoglobulins/BLOOD Male Middle Age T-Lymphocyte Subsets/*IMMUNOLOGY JOURNAL ARTICLE 920430
M9240895
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Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.
