THE TRANSFERRIN RECEPTOR (TFR) IN HIV-ASSOCIATED ANEMIA (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

THE TRANSFERRIN RECEPTOR (TFR) IN HIV-ASSOCIATED ANEMIA (MEETING ABSTRACT)

Proc Annu Meet Am Soc Clin Oncol; 10:A4 1991. Unique Identifier : AIDSLINE ICDB/91671489
Feigal EG; Kornfeld S; Rutherford M; Fullerton S; Taetle R; Univ. of California, San Diego, CA 92103

Abstract: Impaired erythropoiesis is a common manifestation of HIV infection and often limits antiretroviral therapy. In non-HIV infected patients (pts), serum levels of TfR correlate closely with in vivo erythroid hematopoiesis. This study is to correlate TfR, a noninvasive measure of erythropoiesis, with other measures of erythropoiesis and clinical status in HIV infected pts. Methods: IgG anti-Tf receptor MAb T56 is incubated overnight on 96 well tissue culture plates. Duplicate serum samples diluted 1:8, 1:16 and 1:32 are added to the plates and incubated overnight. IgG anti-TfR MAb B3/25 is radiolabeled using 125I and chloramine T and incubated with the diluted serum. Wells are cut from the plates and gamma counted. Clinical status of the pt is abstracted from the database of the AIDS Time Health Oriented Study. Results: TfR was measured in 59 HIV-infected pts (mean = 539 ng/ml, SD = 261). 19% of participants had abnormally high values (greater than 750 ng/ml). Correlation coefficients with other hematology measures were ferritin r = -0.45, Hct r = 0.30, RBC r = 0.28, Hb r = 0.25, serum iron r = 0.22, absolute reticulocytes r = 0.09. Of pts with low absolute retic counts, 12% had high TfR levels. Results are shown in a table. Comment: Impaired erythropoiesis is common in AIDS pts and is multifactorial. Those with MAI infection have the unusual pattern of high TfR levels with low retic counts. Longitudinal studies of change in TfR with time will allow better definition of the effects of drug and HIV-associated conditions on the bone marrow.

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Anemia/BLOOD/*ETIOLOGY Antibodies, Monoclonal/DIAGNOSTIC USE Biological Markers/BLOOD Erythropoiesis Human HIV Infections/*BLOOD/COMPLICATIONS Iodine Radioisotopes/DIAGNOSTIC USE Receptors, Transferrin/*ANALYSIS ABSTRACT
910930
M9190741

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