DETECTION OF A 90-KD TUMOR-ASSOCIATED ANTIGEN IN HIV INFECTION (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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DETECTION OF A 90-KD TUMOR-ASSOCIATED ANTIGEN IN HIV INFECTION (MEETING ABSTRACT)

Proc Annu Meet Am Soc Clin Oncol; 10:A11 1991. Unique Identifier : AIDSLINE ICDB/91671493
Natoli C; Ghinelli F; D'Egidio M; Sighinolfi L; Tinari N; Bicocchi R; Iacobelli S; Cattedra Oncologia Medica, Univ. G. D'Annunzio, Chieti, Italy

Abstract: Tumor markers are sometimes increased in nonmalignant diseases. A newly developed 90-kD tumor-associated antigen (90K), detected by monoclonal antibody Sp-2, has been reported to be elevated in about 50% of patients (pts) with advanced breast cancer and other malignancies. We measured 90K in sera from 136 asymptomatic anti-HIV seropositive individuals (AHSP), 48 pts with AIDS-related complex (ARC) and 21 pts with frank AIDS. Mean 90K concentrations were higher in AIDS (25.1 +/- 21.7 U/ml) and in ARC (23.0 +/- 13.9 U/ml) than in AHSP (15.2 +/- 12.8 U/ml; p less than 0.0001). 90K positivity (greater than 11.5 U/ml) was as follows: 57% in AHSP, 83% in ARC and 90% in AIDS. 90K levels correlated with CD4+ lymphocytes (r=0.23; p greater than 0.001) and with beta 2-microglobulin serum levels (r+0.53; p greater than 0.0001). Among AHSP with normal CD4+ cells (greater than 500/ug3), 63 (46%) had elevated 90K levels. Though not specific, 90K may represent an early and sensitive marker of progressive HIV infection.
Keywords: beta 2-Microglobulin/ANALYSIS Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY Antigens, CD4/ANALYSIS Antigens, Neoplasm/*ANALYSIS AIDS-Related Complex/*BLOOD/IMMUNOLOGY Biological Markers/BLOOD Comparative Study Human HIV Infections/*BLOOD/IMMUNOLOGY *HIV Seropositivity Lymphocytes/IMMUNOLOGY Molecular Weight Tumor Markers, Biological/*ANALYSIS ABSTRACTKWDbeta2-microglobulin/analysisacquiredimmunodeficiencysyndrome/KWDblood/immunologyantigens,cd4/analysisantigens,neoplasm/KWDanalysisaids-relatedcomplex/KWDblood/immunologybiologicalmarkers/bloodcomparativestudyhumanhivinfections/KWDblood/immunologyKWDhivseropositivitylymphocytes/immunologymolecularweighttumormarkers,biological/KWDanalysisabstract
910930
M9190737

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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