IN VIVO BIOASSAY TO TEST THE BIOAVAILABILITY OF POTENTIAL ANTI-AIDS AGENTS (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

IN VIVO BIOASSAY TO TEST THE BIOAVAILABILITY OF POTENTIAL ANTI-AIDS AGENTS (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 32:A2517 1991. Unique Identifier : AIDSLINE ICDB/91675327
Osborn BL; Buckheit R; Sparks RM; Tomaszewski JE; Page JG; NCI, Bethesda, MD 20892

Abstract: Currently, no HIV-based in vivo animal model exists for testing the efficacy of potential anti-HIV drugs. As a result, candidate compounds are tested in vitro against HIV-infected cells grown in tissue culture. Rationale for evaluating these drugs in initial toxicity studies is to examine multiples of doses capable of producing viral inhibitory concentrations in the plasma of treated animals. Plasma and serum from untreated mice, rats, hamsters, dogs and monkeys were tested in vitro in HIV-infected cells. All of these samples were toxic to the test system, with rat and hamster serum being the least toxic. Rats or hamsters were given iv, sc or po doses of the test drugs, and serum samples were taken at various times after dosing. Six serial dilutions of each serum sample were tested for anti-HIV activity. Results from po and sc doses were compared to iv doses to determine bioavailability. Data will be presented on clinically active drugs and drugs under development.

Keywords: Acquired Immunodeficiency Syndrome/*DRUG THERAPY Administration, Oral Animal Antiviral Agents/ADMINISTRATION & DOSAGE/*BLOOD Biological Availability Cells, Cultured Dogs Hamsters HIV Infections/*DRUG THERAPY Injections, Intravenous Injections, Subcutaneous Mice Rats ABSTRACT
910930
M9190729

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