[New York, N.Y.?] : Global Village, c1988 1 videocassette (17 min.) : sd., col. ; 1/2 in. + 1 leaflet (Young people and AIDS) Unique Identifier : AIDSLINE AV/9100993A
(Producer) If there s currently no cure for the deadly AIDS disease, what can society do to protect itself? According to the experts, teenagers, and AIDS victims interviewed in this documentary, there s only one answer: people must stop sharing drug needles and stop practicing unsafe sex.
[New York, N.Y.?] : Global Village, c1988 1 videocassette (17 min.) : sd., col. ; 1/2 in. + 1 leaflet (Young people and AIDS) Unique Identifier : AIDSLINE AV/9100994A
(Producer) Interviewing AIDS victims and experts from around the world, this program explains that no one is immune to the disease, examines how AIDS is spread, and tells young people what they can do to protect themselves. An animated sequence illustrates how AIDS destroys the immune system.
[New York, N.Y.?] : Global Village, c1988 1 videocassette (18 min., 8 sec.) : sd., col. ; 1/2 in. + 1 leaflet (Young people and AIDS) Unique Identifier : AIDSLINE AV/9100995A
(Producer) This documentary surveys some of the world s regions that have been hardest hit by AIDS. The program explains the kind of conditions and behavior that spread the disease, examines the easy availability of drugs in the Bronx, visits the international sex market in Bangkok, and observes the picking up of ma
(Producer) A multimedia risk management program designed to educate health care professionals about blood-borne pathogenic disease transmission and prevention in a health care setting. This program is intended to complement current training and assist in the documentation of that training.
(Producer) In this software package, the physician is guided through a series of decision-making situations related to managing and coping with AIDS. Case I reviews evaluation of risk for HIV infection and the pros and cons of antibody testing. Case II reviews identification and discussion of generalized lymphadenop
(Producer) The dental professional is guided through a series of decision-making situtations related to managing and coping with AIDS. Case I focuses on the recognition of oral lesions seen in HIV infected individuals and the management of a patient who has undiagnosed AIDS. Case II places the dental professional in
Geneva, Switzerland : Published by the World Health Organization in collaboration with the Bureau of Hygiene & Tropical Diseases, v Unique Identifier : AIDSLINE CAT/9110090
Atlanta, Ga. : Dept. of Health & Human Services, Public Health Service, Centers for Disease Control, 1990- v. : ill Unique Identifier : AIDSLINE CAT/9109784
AIDS Updates; 3(4):1-19 1990. Unique Identifier : AIDSLINE ICDB/91671323
Muul LM; Div. of AIDS, Natl. Inst. of Allergy and Infectious Diseases,; Bethesda, MD
Currently, HIV infection is confirmed by a series of immunologic assays designed to detect specific antibodies against the virus and viral proteins. Since diagnosis by serologic techniques depends on the formation of specific antibodies by infected persons, there is a variable period of time from infection until clini
Proc Annu Meet Am Soc Clin Oncol; 10:A2 1991. Unique Identifier : AIDSLINE ICDB/91671488
Remick S; McSharry J; Wolf B; Blanchard C; Gorman P; Slaga J; Wagner H; Harper G; Horton J; Ruckdeschel J; Albany Medical Coll., Albany, NY 12208
We are administering an oral-based combination CT regimen to patients (pts) with AIDS-related NHL repeated at 6-wk intervals consisting of CCNU 100 mg/m2 day 1 (cycles 1, 3, 5), VP-16 200 mg/m2 days 1-3, cyclophosphamide 100 mg/m2 days 22-31, and procarbazine 100 mg/m2 days 22-31. Nine male pts with good performance s
Proc Annu Meet Am Soc Clin Oncol; 10:A4 1991. Unique Identifier : AIDSLINE ICDB/91671489
Feigal EG; Kornfeld S; Rutherford M; Fullerton S; Taetle R; Univ. of California, San Diego, CA 92103
Impaired erythropoiesis is a common manifestation of HIV infection and often limits antiretroviral therapy. In non-HIV infected patients (pts), serum levels of TfR correlate closely with in vivo erythroid hematopoiesis. This study is to correlate TfR, a noninvasive measure of erythropoiesis, with other measures of ery
Proc Annu Meet Am Soc Clin Oncol; 10:A8 1991. Unique Identifier : AIDSLINE ICDB/91671490
Samuels A; Century of Life Inst., Los Angeles, CA 90048
In a previous report (6th International Conference on Adjuvant Therapy of Cancer, Tucson, AZ, 3/7-10/90), an example of benefit from the simultaneous adjuvant treatment of a hypercoagulable state, and fibrinolytic failure in a 75-yr-old female with terminal disseminated malignant disease (Ca breast) and deep vein th
Proc Annu Meet Am Soc Clin Oncol; 10:A9 1991. Unique Identifier : AIDSLINE ICDB/91671491
Conant M; Roy D; Shepard KV; Plasse TF; Univ. of California, San Francisco, CA 94115
Dronabinol, delta-9-THC in sesame oil (Marinol, Roxane Laboratories , Columbus, OH) has been noted in a past study to cause wt gain in HIV patients (pts). To date 19 symptomatic HIV pts with a history of loss of greater than 5% total body wt over 3 mo prior to study entr
Proc Annu Meet Am Soc Clin Oncol; 10:A10 1991. Unique Identifier : AIDSLINE ICDB/91671492
Grosvenor M; Tai V; Bulcavage L; Kruger S; Beall G; Chlebowski RT; Harbor-UCLA Medical Center, Torrance, CA 90509
An identical, defined nutritional assessment procedure, including a questionnaire of symptoms potentially influencing wt loss was prospectively performed on 124 HIV infected patients (pts) and compared to results from 254 cancer pts (CA). Only favorable performance score (0-2) pts were studied. Those with ascites or c
Tumor markers are sometimes increased in nonmalignant diseases. A newly developed 90-kD tumor-associated antigen (90K), detected by monoclonal antibody Sp-2, has been reported to be elevated in about 50% of patients (pts) with advanced breast cancer and other malignancies. We measured 90K in sera from 136 asymptomatic
Proc Annu Meet Am Soc Clin Oncol; 10:A12 1991. Unique Identifier : AIDSLINE ICDB/91671494
Kahn J; Kaplan L; Northfelt D; Piro L; Beutler E; Carson D; Abrams D; Volberding P; San Francisco General Hosp., San Francisco, CA 94110
Ten patients with AIDS-associated NHL were treated with 2-CDA in a Phase I dose escalation study. All subjects had histologic diagnosis of high grade B-cell lymphoma, including small noncleaved (3), immunoblastic (3), large cell (2), Burkitt s (1), and unclassified (1). All subjects had Stage IV disease. Nine subjects
Proc Annu Meet Am Soc Clin Oncol; 10:A23 1991. Unique Identifier : AIDSLINE ICDB/91671503
Giusti R; Manns A; Hanchard B; Cranston B; Murphy J; Murphy E; Williams E; Fuchs D; Blattner W; et al; NCI, Rockville, MD 20852
Studies in endemic areas suggest a long latent period between HTLV-I infection and ATL with an estimated 3-4% cumulative lifetime risk of ATL among seropositives. The current study was undertaken to evaluate markers of immune activation in HTLV-I infection and disease. Serum B2M and NEOP levels were evaluated by radio
Between 8/82 and 5/90, 26 patients (pts) with SNC lymphoma were treated with an intensive inpatient chemotherapy regimen (mega therapy) which primarily involved two courses of treatment. Course I consisted of cyclophosphamide 1500 mg/m2/day (d) x 2 d and etoposide 400 mg/m2/d x 3 d. Course II began on d 29: cyclophosp
HTLV-I is a human retrovirus associated with Adult T-cell leukemia and a viral-encoded protein, tax, is the potential transforming agent of this virus. The focus of this dissertation is the characterization of this very important viral regulatory protein. In the first part of the thesis a molecular biological approach
The hepatitis B virus (HBV) is a small, human DNA virus that causes acute and chronic hepatitis and is strongly associated with the development of primary hepatocellular carcinoma. In addition to the genes that code for the major structural proteins, and a gene coding for the viral polymerase, the HBV genome contains
Proc Annu Meet Am Assoc Cancer Res; 32:A1678 1991. Unique Identifier : AIDSLINE ICDB/91674479
Cooney AJ; Tsai SY; O'Malley BW; Tsai MJ; Dept. of Cell Biology, Baylor Coll. of Medicine, Houston, TX; 77030
Previous studies have shown that a GGTCA palindrome within the HIV-1 LTR NRE binds a potential member of the steroid receptor superfamily. Mutation of this sequence leads to an increase in LTR-directed transcription compared to the wild type, consistent with this element s being a functional part of the NRE. The palin
Proc Annu Meet Am Assoc Cancer Res; 32:A2286 1991. Unique Identifier : AIDSLINE ICDB/91675085
Nassiri MR; Spurr JJ; Drach JC; Univ. of Michigan, Sch. of Dentistry, Ann Arbor, MI 48109-1078
The MTT assay is frequently used in anti-HIV and antineoplastic drug screening for the evaluation of cell survival and proliferation. The inherent cytotoxicity of MTT itself has either escaped evaluation or has not been examined systematically. Therefore, we have investigated the effects of MTT on cell growth and cell
Currently, no HIV-based in vivo animal model exists for testing the efficacy of potential anti-HIV drugs. As a result, candidate compounds are tested in vitro against HIV-infected cells grown in tissue culture. Rationale for evaluating these drugs in initial toxicity studies is to examine multiples of doses capable of
Proc Annu Meet Am Assoc Cancer Res; 32:A2524 1991. Unique Identifier : AIDSLINE ICDB/91675334
Tsai CH; Chen CH; Vazquez-Padua MA; Cheng YC; Dept. of Pharmacology, Yale Univ. Sch. of Medicine, New Haven, CT; 06510
Deoxynucleoside analogs, such as adenine arabinoside (ara-A), 2-F-ara A,2 ,3 dideoxycytidine ( ddC ), 2 ,3 dideoxyinosine (ddI), and 2 ,3 didehydro-dideoxythymidine (D4T), were shown to exhibit delayed toxicity in clinic after continuous usage. The dela
Proc Annu Meet Am Soc Clin Oncol; 10:A1 1991. Unique Identifier : AIDSLINE ICDB/91671487
Geara F; Le Bourgeois JP; Lepechoux C; Piedbois P; Pavlovich JM; Mazeron JJ; Departement de Cancerologie, Hopital Henri Mondor, 51 Ave De; Lattre De Tassigny, 94000 Creteil, France
Between June 1986 and October 1990, we treated 285 patients (pts) by radiotherapy for AIDS-related EKS. According to Mitsayasu s staging, 59 pts (21%) had Stage I disease, 140 (49%) Stage II, 5 (2%) Stage III and 81 (28%) Stage IV. Of the 285 pts, 30 were treated for mucosal EKS in the head and neck region (group 1),
Proc Annu Meet Am Assoc Cancer Res; 32:A2369 1991. Unique Identifier : AIDSLINE ICDB/91675172
Huang P; Farquhar D; Plunkett W; Univ. of Texas M.D. Anderson Cancer Center, Houston, TX 77030
2 ,3 -Didehydro-2 ,3 -dideoxythymidine (D4T) is a nucleoside analog with potent and selective anti-HIV activity. The action of D4T triphosphate (D4T-TP) on DNA strand elongation catalyzed by HIV reverse transcriptase and human DNA polymerases was evaluated in comparison with the action of 3 -azido-3 -deoxythymidine tr
Never has one disease caused so much fuss in the debate over the rights of the individual and the safety of the community. AIDS has managed to bring out the worst in our irrational fears about the unknown, as well as to crystallise all our bigotry and prejudices. Knowledge about AIDS and how it spreads are essential t
The case of a young male patient who consulted because of his poor oral health is reported. AIDS was suspected to exist by the dentist on account of an oral candidiasis. He was sent to a specialized center and AIDS was confirmed. Dentist must be trained in stomatology diagnosis in order to strongly cooperate with heal
Bernal JN; Martinez MA; Triantafilo VJ; Suarez M; Dabancens A; Hurtado C; Montaldo G; Molina R; Espinoza A; Socias M; et al
We searched in 100 healthy pregnant women by isolation, the presence of Neisseria gonorrhoeae, Herpes simplex, Mycoplasma hominis, Ureaplasma urealyticum and Chlamydia trachomatis. Blood was also taken for examination of specific antibodies to these microorganisms. We studied only for antibodies titled Cytomegalovirus
Lechi A; Cristina S; Majno P; Saginario A; Trabattoni G; Vago L; Tedeschi F; Istituto di Neurologia, Universita degli Studi di Parma.
Brains of AIDS patients do often display characters of HIV specificity, in the presence or not of opportunistic lesions. Mesodermal nodules with giant cells, and a peculiar primary demyelination, the progressive diffuse leukoencephalopathy of Kleihues et al., which can be found only in brains with giant cells, have be
Gokal R; Uttley L; Department of Renal Medicine, Manchester Royal Infirmary,; England.
Several isolated problems, which in magnitude may appear small, yet can be enormous management problems, are discussed. In most instances experience is limited and literature is sparse. An attempt has been made to collate personal experience with that from the literature in arriving at guidelines for management of the
Lacey HB; St Mary's Sexual Assault Centre, Manchester, UK.
Epidemiological data and rates of sexually transmitted diseases (STDs) are presented from a group of 90 women screened following rape. Forty-eight (53%) women knew their assailant. In 6 cases multiple assailants were involved. In 21 (23%) rapes weapons were used. Of 47 women examined within 48 hours of rape, 17 (36%)
Smith E; Kroon S; Gerstoft J; Kvinesdal B; Mathiesen LR; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
In order to describe the risk pattern including sexual behaviour among HIV-infected women in Copenhagen we studied the charts of all women tested seropositive between January 1985 and August 1988 in the three main hospitals handling HIV/AIDS. One hundred and fifteen women were positive for HIV antibodies: 35 (31%) wer
Chapman S; Stoker L; Ward M; Porritt D; Fahey P; Department of Community Medicine, University of Sydney, Westmead; Hospital, Australia.
Four hundred and eight people aged 15-35 years who reported having more than one sexual partner of the opposite sex in the past year or who thought it likely that they would do so in the next year were surveyed about their sexual behaviour, concern about acquired immunodeficiency syndrome and sexually transmitted dise
Mitchell SA; Shukla SR; Thin RN; Department of Genitourinary Medicine, St Thomas's Hospital,; London, UK.
Chlamydia trachomatis can be identified in up to 60% of cases of nongonococcal urethritis (NGU) and the aetiology of most of the remainder is obscure. This paper reports a role for other genitourinary (GU) infections such as candidiasis, warts and herpes simplex, in the causation of NGU. One hundred and ten men fulfil
Ross MW; Department of Community Medicine, University of New South Wales,; Surry Hills, Australia.
Sixty-eight homosexually active men attending an STD clinic were questioned to ascertain the percentage of the time they did not use condoms during anal intercourse, and the reasons for this. Data indicated that the reasons most commonly given were being in a steady relationship (32.8%), being unprepared (19.4%), coul
Riccio M; Burgess A; Hawkins D; Wilson B; Thompson C; Charing Cross and Westminster Medical School, London, UK.
Six homosexual men with a diagnosis of acquired immunodeficiency syndrome (AIDS)-related complex (ARC- CDC IVA/C2) were assessed with a series of neuropsychological and psychiatric tests prior to commencing treatment with zidovudine and again after 5-6 months. Significant improvements were seen in cognitive functionin
Kumar B; Rajagopalan M; Sehgal S; Sharma M; Malhotra S; Department of Dermatology, Postgraduate Institute of Medical; Education and Research, Chandigarh, India.
AIDS and other sexually transmitted diseases are interlinked. VDRL positivity may indicate that the individual has an increased risk of being HIV positive as the epidemiological risk factors for developing syphilis and AIDS are similar. We analysed 323 (5.8%) VDRL positive serum samples (out of 5592 screened) for HIV
Analysis of data on case-management and referral of persons infected by HIV is based upon a cross-sectional study at the national level. The evolution of trends over the last 2 years reveals a rise in the number of AIDS cases undergoing full hospital treatment and a decline in the number of seropositives hospitalised.
Psychological, ethical and political issues of the HIV and AIDS epidemic on one part, the pauperization of people with AIDS on the other have given birth to AIDS organizations and to a creative solidarity amongst PWA. Doctors and nurses in spite of a real professional stress show many proofs of readiness to give more
AIDS, because of the seriousness of its diagnosis, as well as the fact that it is linked with such life-giving symbols such as blood and sperm, has often been presented as the plague of the 1900 s. As is often the case with serious, misunderstood societal calamities, AIDS carries with its attitudes of guilt and denial
Gentilini M; Chieze F; Departement des maladies infectieuses et tropicales et de sante; publique, Unite INSERN 313, Groupe hospitalier; Pitie-Salpetriere, Paris.
The assessment of the socio-economical aspects of the human immunodeficiency virus (HIV) infection is difficult because of the relative scarcity of information. This study addresses mainly the socio-economic aspects of the AIDS pandemic in the inter-tropical zone of Africa, which, at the moment, constitutes the epicen
Int J Addict. 1990 Dec;25(12):1475-83. Unique Identifier : AIDSLINE MED/91244501
Lishner DM; Look MS; Department of Family Medicine, University of Washington, Seattle; 98195.
Sharing of needles by intravenous drug users is known to be one of the major means for the transmission of the HIV virus into the general population. In Seattle, where liberal laws make acquisition of needles relatively easy, it has been assumed that needle sharing is not a significant problem. Results of a survey of
J Chromatogr. 1990 Dec 14;534:109-18. Unique Identifier : AIDSLINE MED/91244921
Remmel RP; Huang SH; Hoff D; Zimmerman CL; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455.
Carbovir is a carbocyclic guanosine analogue with potent in vitro activity against the human immunodeficiency virus. All of the activity resides in the (-)-enantiomer. An ion-paired liquid chromatographic assay for (-)-carbovir was developed on a Spherisorb C8 column with fluorescence detection (275 nm excitation, 345
Toso JF; Ferbas JJ; Rappocciolo G; Armstrong JA; Ho M; Rinaldo CR Jr; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, PA 15261.
Monkey kidney cells CV-1 were infected with recombinant vaccinia virus carrying HIV-1 gag gene with a deletion of 230 nucleotide pairs from the 3 -terminus. The main gene product detected in the lysates of infected cells was the gag precursor rp50. The protein was accumulated on the cell membranes suggesting that it h
Giampalmo A; Buffa D; Quaglia AC; Istituto di anatomia patologica, Universita di Genova.
Our studies on pathology of AIDS point to four major conclusions. 1) The brain is often directly affected by the HIV infection (with the characteristics of subacute microglial encephalitis with pathognomonic multinucleated giant cells) and then by opportunistic infections such as Cytomegalovirus, Herpes-virus, Papova-
Trans Am Ophthalmol Soc. 1990;88:63-86; discussion 86-8. Unique Identifier : AIDSLINE MED/91247157
Gagliuso DJ; Teich SA; Friedman AH; Orellana J; Department of Ophthalmology, Mount Sinai School of Medicine, New; York, New York.
We describe 16 cases of ocular and, in some patients, associated CNS toxoplasmosis in AIDS patients. T gondii is commonly associated with infection in the immunocompromised host. The lesions are most often seen in the CNS and eyes; involvement in the brain, heart, lung, liver, spleen, and lymph nodes may be observed.
Galati F; Sarago A; Viscomi A; Forciniti D; Pizzutti AR; Rajani M; Divisione di Otorinolaringoiatria e Patologia Cervico-Facciale; dell'Ospedale S. Giovanni di Dio di Crotone.
The authors report a case presenting highly complex symptomatology. In fact, when the patient came under observation he had had a cough, dyspnea, dysphagia and dysphonia for approximately three months. The biopsy, taken by direct laryngoscopy, indicated the presence of candidiasis in the subglottic and tracheal areas.
Dreno B; Milpied B; Dutartre H; Litoux P; Department of Dermatology, Hotel Dieu, Nantes, France.
Interleukin 1 (IL-1) in the epidermis plays an important role together with Langerhans cells in the activation of the T cells. To determine whether IL-1 could be located in the normal epidermis of 54 patients with HIV infection and related to the stage of the disease, an indirect immunofluorescence technique was used.
Ghetie V; Till MA; Ghetie MA; Tucker T; Porter J; Patzer EJ; Richardson JA; Uhr JW; Vitetta ES; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235.
In a previous study, we have demonstrated that conjugates containing soluble, recombinant human CD4 (rCD4) and the deglycosylated form of ricin A chain (dgA) (rCD4-dgA) effectively kill a human T cell line infected with the human immunodeficiency virus (HIV) in vitro. In contrast, such conjugates are 100-1000-fold les
Pneumocystis carinii pneumonia is one of the most common and severe infections in patients with human immunodeficiency virus (HIV) infection. Classically, the diagnosis of this condition is made with aggressive techniques such as fibrobronchoscopy (FBS) with bronchoalveolar lavage (BAL) or pulmonary biopsy. Sputum ind
Moran EM; University of California-Irvine Medical Program, Department of; Veterans Affairs Medical Center, Long Beach 90822.
The lymphoma occurring in AIDS patients is characterized by the following features. 1. It is a B-cell malignant neoplasm of high-grade malignancy resulting from a profound T-cell suppression caused by the cytotoxic effect of a retrovirus that has lymphotropism for the T4 subset. 2. The age of lymphoma patients paralle
Speich R; Weber R; Kronauer CM; Opravil M; Luthy R; Russi EW; Department of Internal Medicine, University Hospital of Zurich,; Switzerland.
Sixty episodes of Pneumocystis carinii pneumonia in 59 patients were evaluated for risk factors predicting fatal outcome within 14 days after bronchoscopy. We found significantly higher values for serum lactate dehydrogenase (p less than 0.001), alveolar-arterial oxygen difference (p less than 0.001) and percentage of
Ivo-Dos-Santos J; Mello DL; Couto-Fernandez JC; Passos RM; Dias-Carneiro LA; Castilho EA; Galvao-Castro B; Fundacao Oswaldo Cruz, WHO Collaborating Centre on AIDS, Bahia,; Brazil.
Sera from 472 Brazilian subjects, confirmed to be either positive or negative for HIV antibodies and comprising the total clinical spectrum of HIV infection, were utilized in the evaluation of six commercially available enzyme-linked immunosorbent assays (ELISA), as well as of four alternative assays, namely indirect
Takahashi T; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.
The use of nucleic acid hybridization techniques has expanded into many areas, including studies of gene structure and function, routine diagnosis of human, animal and plant diseases, and also forensic science. In situ hybridization is one of the techniques currently available for nucleic acid hybridization and has so
In 1981 AIDS acquired a lot importance, observing opportunist infections, not common malignant lesion and abnormalities in the immune system which develops in mysterious ways in healthy persons apparently or without pathologic background. The medical and scientific community respond immediately with intensive research
Ortiz de Lejarazu R; Eiros JM; Perlado del Campo E; Palenzuela MS; Reguera JI; Rodriguez-Torres A; Facultad de Medicina y Hospital Clinico, Valladolid.
We have retrospectively investigated the antibodies against type 2 human immunodeficiency virus (Ac HIV-2) in sera from parenteral drug abusers (PDA) who had been previously investigated for HIV-1 and who fulfilled established criteria (trips, sexual contacts, etc.). Enzyme immunoassay (EIA) was positive in 7 individu
Gallagher EJ; Lynn SG; Emergency Department, Bronx Municipal Hospital Center, Albert; Einstein College of Medicine, NY 10461.
Overcrowding of emergency departments in New York City is the most apparent symptom of a crumbling health care system. There is a growing need for the care of a largely impoverished population suffering from an increasing prevalence of AIDS, substance abuse, and psychiatric disease. Institutions crippled by critical s
NIDA Res Monogr. 1990;103:60-91. Unique Identifier : AIDSLINE MED/91260813
Mieczkowski T; Department of Criminology, University of South Florida, St.; Petersburg 33701.
This chapter identified three methods by which crack cocaine is distributed at the retail level: the street-corner or walk-up sales system, the runners and beepermen system, and the crack house. The chapter devoted primary attention to the crack house, because it appears as the most popular method for distribution. In
Rev Med Interne. 1990 May-Jun;11(3):197-200. Unique Identifier : AIDSLINE MED/91262251
Dautzenberg B; Antoun F; Benichou S; Postal MJ; Broussier PM; Sors C; Service de pneumologie, G.H. Pitie-Salpetriere, Paris.
Over a 2 years period, 49 AIDS patients and 3 non AIDS patients were treated for pneumocystosis in our chest department. Forty-six were male and 6 were female. Pneumocystosis was the first opportunistic infection in 77 p 100 of patients. Fever above 38.5 degrees C was the major symptom in 92 p 100. Cough was present
Infectious oesophagitis is the most frequent of digestive tract diseases occurring in patients with AIDS. It is diagnosed by endoscopy which permits brushing and biopsy of mucosal lesions for cytological, histological and microbiological examinations. In 40 to 50 percent of HIV positive patients, Candida is responsibl
Rev Med Interne. 1990 May-Jun;11(3):248-9. Unique Identifier : AIDSLINE MED/91262261
Constans J; Dufau JP; Duriez T; du Bourget F; Service de Medecine Interne et d'Hematologie, Hopital; d'Instruction des Armees Robert Picque, Bordeaux Armees.
We report an observation where a patient suffering HIV related thrombocytopenia was followed up for 23 months. Introduction or reintroduction of azidothymidine obtained a raise of platelet rate. When azidothymidine was stopped, platelet rate climbed down. This observation is in agreement with recent data suggesting ef
Mayaud C; Parquin F; Cadranel J; Dominique S; Denis M; Akoun G; Centre de Pneumologie et de Reanimation respiratoire, Hopital; Tenon, Paris.
Intrathoracic Kaposi s sarcoma (KS) in AIDS is remarkable for its frequency and severity. It is responsible for 10% of pneumonias and almost 50% of pleurisies observed in these patients. The time elapsed between the discovery of the lesion and the patient s death does not exceed a few months on average. The initial ma
Trans R Soc Trop Med Hyg. 1990 Nov-Dec;84(6):800-2. Unique Identifier : AIDSLINE MED/91263157
Wakefield AE; Stewart TJ; Moxon ER; Marsh K; Hopkin JM; Institute of Molecular Medicine and Osler Chest Unit, Oxford, UK.
Pneumocystis pneumonia is rarely identified in the many immunosuppressed individuals with acquired immune deficiency syndrome (AIDS) and malnutrition in Africa. To test whether infection with Pneumocystis carinii occurs in the continent we conducted a comparative serological study, measuring by enzyme-linked immunosor
From a cohort of 162 children born to 161 mothers belonging to risk groups for human immunodeficiency virus (HIV) infection, we have studied 32 asymptomatic HIV seropositive and 19 HIV seronegative mothers and their offspring seropositive mothers when compared with the seronegative group had lower counts of leukocytes
An Esp Pediatr. 1990 Nov;33(5):424-8. Unique Identifier : AIDSLINE MED/91264400
Tuset Ruiz C; Leon Sebastia P; Elorza Arizmendi J; Tuset Ruiz L; Vidal Rico S; Tacons Mateu J; Seccion de Inmunologia del Servicio de Hematologia, Hospital; General y Universitario de Valencia.
We study 37 children with mothers infected by human immunodeficiency virus type 1 (HIV-1) at birth and over the following three years. HIV-1 serology of these patients is reported, i.e., HIV-1 antigen p24 and antibodies using two commercially available enzymatic methods and Western blot. Throughout follow-up, IgG anti
Motawia MS; Pedersen EB; Suwinski J; Nielsen CM; Department of Chemistry, Odense University, Denmark.
Reaction of 1,5-di-O-acetyl-2,3-dideoxy-3-phthalimido-beta-D-erythro-pento-fu- r anose (1) with silylated pyrimidinediones 2a-c using the Lewis acid trimethylsilyl triflate as catalyst afforded nucleosides 3a-c and 4a,c which were deprotected with 33% methylamine/ethanol to give the corresponding 3-aminonucleosides 5a
Motawia MS; Pedersen EB; Nielsen CM; Department of Chemistry, Odense University, Denmark.
Treatment of 3 -amino-3 -deoxythymidine (1) with carboxylic acid anhydrides afforded the corresponding acylamino derivatives 2a-f. Reaction of 1 with a variety of isothiocyanates led to the corresponding thioureido derivatives 3a-i. Also, conversion of 1 into 3 -carbylamino-3 -deoxythymidine (7) is reported. The compo
During the clinical history of HIV infection, haematological abnormalities represent a common finding which not only contributes to worsening the clinical condition but also limit the use of antibacterial as well as antiviral agents. On the basis of the regulatory role played by the immune system on haemopoiesis, in t
Fifty drug addicts, users of intravenous heroin and infected by HIV, with an average age of 28 years, were followed for a period of one year. The purpose was to analyze, as precisely as possible, the medical and social cost of their illness as a function of the stage of the infection to which they belonged. The costs
The impact of AIDS is expected to shift dramatically towards women and children during the next decade. By the year 2000, millions of women and children in Africa will have AIDS or be orphan. In Europe and America, HIV infection is also spreading most rapidly among these populations. In the Paris hospitals, 0.9% of pr
Bez G; Mission SIDA, Ministere, de la Solidarite, de la Sante et de; la Protection sociale, Paris.
It is not easy to identify these costs. One must start by setting out the data of the whole health system, either in hospitals or privately. Furthermore, the statistical disposition is purely administrative, not epidemiological. No budget has been set aside for pathology. However, the total health costs involved are e
Rinaldo CR Jr; Armstrong JA; Kingsley LA; Zhou S; Ho M; Department of Pathology, School of Medicine, University of; Pittsburgh, Pennsylvania 15261.
Homosexual men who were human immunodeficiency virus (HIV) seropositive at enrollment into the Pittsburgh portion of the Multicenter AIDS Cohort Study had elevated titers of serum alpha and gamma interferon (IFN) within 24 months prior to development of AIDS. In contrast, subjects who developed AIDS relatively early a
Hrinda ME; Feldman F; Schreiber AB; Biotechnology Department, Rorer Central Research, King of; Prussia, PA 19406.
The treatment of hemophilia A patients has progressed in the last 30 years. The development of more pure factor VIII concentrates has been encouraged by the appearance of the human immunodeficiency virus in blood supply. Monoclate was the first essentially pure form of factor VIII available for hemophilia therapy. The
Smith KJ; Lusher JM; Cohen AR; Salzman P; Department of Medicine, University of New Mexico School of; Medicine, Albuquerque 87131.
Heat treatment of lyophilized factor VIII and factor IX concentrates has been found to eliminate HIV virus infectivity in plasma-derived products. Pasteurization of factor VIII in solution has recently been used to reduce the risk of hepatitis transmission in concentrates prepared by standard fractionation methods. Th
Pourtois M; Binet C; Van Tieghem N; Courtois P; Vandenabbeele A; Thiry L; Laboratoire de Stomatologie, Faculte de Medecine, Universite; Libre de Bruxelles, Belgium.
HIV aliquots, from a supernatant of ARV-4 cell line, were mixed with an equal volume of a OSCN.generating glucose-glucose oxidase + thiocyanate-lacteroperoxidase solution, and then pre-incubated at 37 degrees C for periods of 30 secs to one hour. These mixtures were then inoculated into cultures of phytohaemagglutinin
Bone Marrow Transplant. 1990 Dec;6(6):371-83. Unique Identifier : AIDSLINE MED/91265903
Wingard JR; School of Medicine, Johns Hopkins University, Baltimore,; Maryland.
An important contribution to the improved survival after bone marrow transplantation (BMT) over the past decade has been the development of strategies to prevent and manage infectious complications. Today, with these advances, deaths from bacterial and fungal infections are uncommon except in the setting of uncontroll
Mori K; Sakai H; Suzuki S; Akutsu Y; Ishikawa M; Imaizumi M; Tada K; Aihara M; Sawada Y; Yokoyama M; et al; Third Department of Internal Medicine, Tohoku University School; of Medicine, Sendai.
Forty-two hemophiliacs with HIV infection were treated with high-dose glycyrrhizin, Stronger Neo-Minophagen C (SNMC). The dose was 100-200 ml of SNMC in 21 patients and 400-800 ml in the other 21. The patients were divided into an asymptomatic carrier (AC) group and AIDS related-complex (ARC)/AIDS group. SNMC was admi
Serraino D; Franceschi S; Vaccher E; Tirelli U; Crosatto I; Crovatto M; Moise M; Servizio di Epidemiologia, Centro di Riferimento Oncologico,; Aviano (PN).
Prevalence and determinants for human immunodeficiency (HIV) virus infection was assessed in 581 heterosexual intravenous drug users, recruited from public drug assistance centers in the northeast of Italy between 1984 and 1988. The overall seroprevalence rate for HIV antibody was 3
Syrjanen K; Yliskoski M; Kataja V; Hippelainen M; Syrjanen S; Saarikoski S; Ryhanen A; Department of Pathology, University of Kuopio, Finland.
The results of the nationwide, population-based cervical cancer screening programme (organized by the Finnish Cancer Society since early 1960s) were analysed to establish the prevalence figures (and their changes) for genital human papillomavirus (HPV) infections in an unselected Finnish female population (aged betwee
Rodgers SJ; Baldwin CA; Oklahoma Animal Disease Diagnostic Laboratory, College of; Veterinary Medicine, Oklahoma State University, Stillwater 74078.
A serologic survey was done on 618 cat sera submitted to the Oklahoma Animal Disease Diagnostic Laboratory between July 1, 1987 and June 30, 1988. The samples were collected from clinically normal and sick cats. The sera were tested for the presence of antibodies to feline immunodeficiency virus by a commercial immuno
J Chromatogr. 1990 Dec 14;534:57-66. Unique Identifier : AIDSLINE MED/91244950
Scappaticci B; Soubeyrand J; Rousseau-Tsangaris M; Desage M; Brazier JL; Coquet B; L.E.A.C.M. Laboratoire d'Etudes Analytiques et Cinetiques du; Medicament, Institut des Sciences Pharmaceutiques et Biologiques,; Lyon, France.
A gas-chromatographic-mass spectrometric method is described to measure the plasma concentration of sodium diethyldithiocarbamate (ditiocarb sodium, DEDTC-Na), the active ingredient of Imuthiol, a drug found to be active in the opportunistic infections occurring in AIDS, and its S-methyl metabolite. Plasma samples are
Lusher JM; Salzman PM; Division of Hematology-Oncology, Children's Hospital of Michigan,; Detroit 48201.
A multicenter study evaluated the potential for transmitting non-A/non-B hepatitis, as well as other viruses, with the use of the factor VIIIC product Monoclate. This product is purified from plasma via the monoclonal process that includes heat treatment for ultra-purification as a final step. Twenty different lots of
Rideout BA; Moore PF; Pedersen NC; Department of Medicine, School of Veterinary Medicine, University; of California, Davis.
A new monoclonal antibody raised against gradient-purified feline immunodeficiency virus was found to recognize a bimolecular complex, comprising 27-29 kD and 32-35 kD subunits, on feline peripheral blood lymphocytes. Immunoperoxidase staining of feline tissues with this antibody, designated 43.2H2, demonstrated a rea
Le Goaster J; Rougeot C; Tekaia F; Dormont D; Boileau G; Montagnier L; Le Magnen J; Hospital Trousseau, University of Paris, France.
Three groups of male homosexuals: AIDS (n = 19), HIV seropositive (n = 15), and seronegative partners of seropositive subjects (n = 15), were compared to a heterosexual seronegative control group (n = 13). Twice daily evaluations (8 A.M. and 5 P.M.) of plasma levels of beta-endorphin, ACTH, and cortisol were done by r
Two naturally occurring lignanolides, isolated from the tropical climbing shrub Ipomoea cairica, (-)-arctigenin and (-)-trachelogenin, were found to inhibit strongly replication of human immunodeficiency virus type 1 (HIV-1; strain HTLV-III B) in vitro. At a concentration of 0.5 microM, (-)-arctigenin and (-)-trachelo
Bone Marrow Transplant. 1990 Dec;6(6):361-9. Unique Identifier : AIDSLINE MED/91265902
Lenarsky C; Parkman R; Division of Research Immunology/Bone Marrow Transplantation,; Children's Hospital, Los Angeles, CA 90027.
The first successful allogeneic bone marrow transplants were performed in children with severe combined immune deficiency (SCID). Bone marrow transplants for patients with SCID have been in the forefront of clinical bone marrow transplantation including the first successful use of T lymphocyte-depleted haploidentical
Kenyon RH; Condie RM; Jahrling PB; Peters CJ; Pathogenesis and Immunology Department, United States Army; Medical Research Institute of Infectious Diseases, Fort Detrick,; Frederick, MD 21702-5011.
Antibody-containing plasma from patients recovered from Argentine hemorrhagic fever (AHF) is of proven value in treatment of the acute disease, but the possibility of transmitting blood-borne organisms such as HIV and hepatitis virus detracts from this approach. Purified human immune plasma fractions IgG1,2,4, IgG1,2,
Our statistics reveal the average patient in our study to be a young black male with a history of IVDA with CAPD as the initial dialysis modality. He was most often trained on a mechanical assist device, but he still developed frequent peritonitis episodes, predominantly gram positive. His survival rate was less than
We report a case of a 68 years old male patient treated for chronic lymphocytic leukaemia, presenting a right inguino-crural tender lymphadenopathy with periadenitis. The histologic changes associated with adenitis were large foci of necrosis with regular crown of epithelioid cells, without giant cell. The presence of
AIDS Educ Prev. 1991 Spring;3(1):1-9. Unique Identifier : AIDSLINE MED/91242225
McKusick L; Hoff CC; Stall R; Coates TJ; Department of Medicine, University of California, San Francisco.
Three groups of San Francisco bar patrons (heterosexual men, heterosexual women, and gay men) were compared on four sexual risk reduction strategies for AIDS: safer sex practices (particularly adoption of the use of condoms), reducing the number of sexual partners, taking the HIV antibody test, and determining the cha
AIDS Educ Prev. 1991 Spring;3(1):10-20. Unique Identifier : AIDSLINE MED/91242226
Feucht TE; Stephens RC; Gibbs BH; Department of Sociology, Cleveland State University, OH 44115.
Increasing intravenous drug users (IVDUs) knowledge about the etiology and symptoms of the human immunodeficiency virus is a first step in controlling the spread of the virus to the general population. A comparison of pretest and posttest measures of knowledge of acquired immune deficiency syndrome among IVDUs partic
AIDS Educ Prev. 1991 Spring;3(1):21-30. Unique Identifier : AIDSLINE MED/91242227
Skurnick JH; Johnson RL; Quinones MA; Foster JD; Louria DB; Department of Preventive Medicine & Community Health, UMDNJ-New; Jersey Medical School, Newark 07103-2757.
In 1988 a questionnaire was administered to 1,793 urban and suburban New Jersey high school students to survey their knowledge, attitudes, and behavior related to the acquisition of acquired immunodeficiency syndrome (AIDS). Knowledge about the disease was high, but exaggeration of risk from social contacts was common
AIDS Educ Prev. 1991 Spring;3(1):31-46. Unique Identifier : AIDSLINE MED/91242228
Shernoff M; Bloom DJ; Chelsea Psychotherapy Associates, NYC, NY 10011.
The authors have developed three AIDS prevention workshops and conducted them for thousands of gay and bisexual men. The workshops evolution, design, and development, as well as their implicit assumptions and values, are presented. The concept of different generations of AIDS prevention efforts is introduced. The goa
AIDS Educ Prev. 1991 Spring;3(1):47-9. Unique Identifier : AIDSLINE MED/91242229
Kotarba JA; Williams ML; Johnson J; Department of Sociology, University of Houston, Texas 77204-3474.
As the prevalence of HIV infection among adolescents increases, public health workers continue to seek media for intervention. An interview-based study conducted with a large sample of adolescent intravenous drug users (AIVDUs) by the National AIDS Demonstration and Research Project in Houston, Texas has located two w
AIDS Educ Prev. 1991 Spring;3(1):50-9. Unique Identifier : AIDSLINE MED/91242230
Brown LK; DiClemente RJ; Reynolds LA; Brown University's Program in Medicine, Providence, RI 02903.
The Health Belief Model (HBM) has been applied to diverse sets of health behaviors. Research that suggests difficulties of the HBM in predicting future behaviors, especially HIV-related, is reviewed. Prominent features of adolescence that influence HIV-related risk behaviors are discussed including: cognitive immaturi
AIDS Educ Prev. 1991 Spring;3(1):60-71. Unique Identifier : AIDSLINE MED/91242231
Cleary PD; Van Devanter N; Rogers TF; Singer E; Avorn J; Pindyck J; Department of Health Care Policy, Harvard Medical School, Boston,; MA 02115.
This paper describes the sociodemographic characteristics of people who donated blood to the New York Blood Center between April 1985 and February 1988 and tested positive for antibodies to HIV. Information on HIV-related risk factors and knowledge of blood screening is presented for seropositive donors who participat
Biochemistry. 1991 May 28;30(21):5195-201. Unique Identifier : AIDSLINE MED/91242426
Fitzgerald DW; Coleman JE; Department of Molecular Biophysics and Biochemistry, Yale; University, New Haven, Connecticut 06510.
The nucleocapsid (NC) protein (p15) of the human immunodeficiency virus (HIV) has been cloned and overproduced (under the control of a phage T7 promoter) in soluble form in an Escherichia coli host. The soluble NC protein is a fusion protein containing 15 amino acids from the T7 gene 10 and 7 amino acids from the HIV
Within the rapidly progressing pandemic of the acquired immunodeficiency syndrome (AIDS) Sub-Saharan Africa plays a disproportionally large role. The reported data indicate that heterosexual transmission is the predominant cause for the rapid spread in this, one of the world s poorest regions. Prostitution, though poo
Hillman R; O'Mara N; Tomlinson D; Harris JR; Division of Sexually Transmitted Diseases, Clinical Research; Centre, Harrow, Middlesex, UK.
The records of 28 male victims of sexual assault were analysed retrospectively. The mean age at time of assault was 21.7 years and the mean number of assailants was 2.8. Sixteen victims (57%) reported skin or mucosal damage and 25 (89%) sustained penetrative anal intercourse. The threat of transmission of HIV was used
Woolley PD; Palfreeman AJ; Patel R; Talbot MD; Samarasinghe PL; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.
The blood-taking practices and prevalence of needle-stick injuries were recorded for 46 house officers working at the two largest teaching hospitals in Sheffield and 38 house officers working at three hospitals in London. Wearing gloves when performing venesection or inserting an intravenous cannula was generally perc
Mandal D; Ray TK; Richmond SJ; Goorney BP; Haye KR; Department of Genitourinary Medicine, Manchester Royal Infirmary,; UK.
Endocervical specimens obtained by cytobrush and conventional cotton wool swabs from 90 women attending a genitourinary medicine clinic were compared for their efficiency in detecting chlamydial infection. Isolation of Chlamydia trachomatis and detection of the chlamydial lipopolysaccharide antigen were attempted on e
Fischer PR; Horton GL; Knight P; Lusi KM; Evangelical Medical Centre, Nyankunde, Zaire.
Human immunodeficiency virus (HIV)-antibody screening of blood donors in northeastern Zaire was reviewed to determine overall seroprevalence in the population and to identify particular subgroups of the population who are at relatively high risk. Six hundred and seventy-five healt
Bloor M; Goldberg D; Emslie J; MRC Medical Sociology Unit, Glasgow University.
Ethnostatistics is the study of the social practices surrounding the construction and interpretation of statistics. This paper considers certain ethnostatistical aspects of the official statistics on AIDS cases--the monthly updated figures on AIDS cases supplied by the Department of Health and derived from the English
Spears R; Abrams D; Sheeran P; Abraham SC; Marks D; Vakgroep Sociale Psychologie, Universiteit van Amsterdam, The; Netherlands.
A questionnaire study (N = 318) examined social judgements of sexually active males and females on positive and negative evaluative dimensions, as a function of the perceiver s gender, and the linguistic frame of judgement. This frame was manipulated by requiring respondents to rate themselves on a number of descripti
Sanders TG; Northup HM; Wilf LH; Department of Radiology, University of Florida Health Science; Center, Jacksonville 32209.
A case of progressive bilateral upper lobe Pneumocystis carinii pneumonia in a patient receiving aerosolized pentamidine is presented. This is a recently recognized pattern in patients with acquired immunodeficiency syndrome on aerosolized pentamidine. Pneumocystis carinii pneumonia must be considered as a possibility
This article highlights current changes in our understanding of HIV infection in children; examines two central concepts--family-centered care and prevention--for the development of child welfare services; and explores certain implications for foster care for HIV-infected children while reviewing the training needed b
Kimes AS; London ED; Szabo G; Raymon L; Tabakoff B; Neuropharmacology Laboratory, National Institute on Drug Abuse,; Baltimore, Maryland 21224.
Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-D-[1-14C] glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral
Gaynor RB; Muchardt C; Diep A; Mohandas TK; Sparkes RS; Lusis AJ; Department of Medicine, University of California, Los Angeles; 90024.
A variety of cellular proteins have been found to bind to related DNA sequences in the enhancer elements of the human immunodeficiency virus, the kappa immunoglobulin gene, the class I major histocompatibility complex gene, and the beta-interferon gene. Recently, lambda gt11 gene expression cloning using ligated oligo
Kinninmonth AW; Hutchinson JD; Orthopaedic Trauma Unit, Royal Infirmary of Edinburgh, UK.
A clear plastic, full-face visor is described which gives face, eye and neck protection during surgery. It has proved comfortable and light to wear, providing excellent, unobstructed vision and, unlike protective goggles and spectacles, it is not prone to condensation.
Health Educ Q. 1991 Spring;18(1):111-23. Unique Identifier : AIDSLINE MED/91244633
Scrimshaw SC; Carballo M; Ramos L; Blair BA; UCLA School of Public Health 90024.
Health education is an essential part of efforts to limit and manage the current AIDS pandemic. The information needed to develop meaningful and culturally appropriate educational interventions is often difficult to obtain because topics related to the prevention and treatment of AIDS are invariably culturally and/or
Health Educ Q. 1991 Spring;18(1):29-37. Unique Identifier : AIDSLINE MED/91244638
Erben R; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.
This article examines how the concept of health promotion can be of value to professionals who have a special responsibility to promote the health of young people and adults. What does it mean to address the issue of AIDS within the broad concept of health promotion? A key message of health promotion is that health ca
Health Educ Q. 1991 Spring;18(1):49-63. Unique Identifier : AIDSLINE MED/91244640
Hagard S; Chambers J; Killoran A; Health Education Authority, London.
The Health Education Authority in England has published its first Strategic Plan, covering the years 1990-1995. The origins and functions of the Authority are described, as are the various factors contributing to the Plan. The strategic objective is defined as being to ensure that by the year 2,000 the people of Engla
We developed an improved microtiter-based assay for the detection of polymerase chain reaction (PCR)-amplified DNA sequences. The synthetic DNA sequences used to prime the PCR were labeled with biotin at their 5 ends so that the specific PCR product was labeled with biotin. Following amplification, an aliquot of the
Holzemer WL; Henry SB; School of Nursing, University of California, San Francisco; 94143-0604.
Examination of four standardized nursing care plans for people with AIDS (PWAs) from four agencies with extensive experience with caring for PWAs revealed that there is little agreement about the nursing care problems of PWAs. Differences in language, conceptual clarity, and level of complexity related to problem iden
Siminoff LA; Erlen JA; Lidz CW; Department of Psychiatry, University of Pittsburgh, Pennsylvania.
Reports of fear and psychological distress on the part of nurses when caring for AIDS patients have drawn attention to the real possibility that care for this very sick group of patients may be less than adequate. This paper reviews what is currently known about the attitudes of nurses and the care provided to HIV-inf
Early neurosyphilis, characterized by meningitis, cranial nerve abnormalities, and cerebrospinal accidents, was first described in patients with syphilis who received inadequate courses of arsphenamine. Although more effective, penicillin at conventional doses does not yield treponemacidal levels in the central nervou
Toltzis P; Marx CM; Kleinman N; Levine EM; Schmidt EV; Department of Pediatrics, Case Western Reserve University School; of Medicine, Cleveland, Ohio.
A novel toxicity associated with zidovudine ( AZT ), the standard antiviral therapy for infection with human immunodeficiency virus, is described. When AZT was administered to mice to evaluate its safety during gestation, the animals failed to complete
Jehuda-Cohen T; Powell JD; Sell KW; Villinger F; Lockwood E; McClure HM; Ahmed-Ansari A; Department of Pathology, Winship Cancer Center, Emory University; School of Medicine, Atlanta, Georgia.
Techniques such as polyclonal B cell activation with pokeweed mitogen (PWM) and polymerase chain reaction (PCR) analysis have documented the existence of simian immunodeficiency virus (SIV)-and human immunodeficiency virus type 1-seronegative but infected humans and nonhuman primates. To establish whether blood from s
Bermudez LE; Young LS; Kuzell Institute for Arthritis and Infectious Diseases, San; Francisco, CA 94115.
Chronic ethanol ingestion predisposes to tuberculosis and bacterial pneumonia. Mycobacterium avium complex (MAC) organisms cause bacteremia in patients with AIDS. Cultured human monocyte-derived macrophages and murine Kupffer cells were exposed to 10-100 micrograms/dl ethanol; significantly greater intracellular growt
Ellner JJ; Goldberger MJ; Parenti DM; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, Ohio.
Note from Dr. Merle A. Sande--The role of Mycobacterium avium as a pathogen in the human immunodeficiency virus-infected population has been confusing and controversial to clinicians who care for AIDS patients. The organism is commonly isolated from respiratory secretions of patients with other infections and often se
Shannon J; Benrubi GI; Department of Obstetrics and Gynecology, University Medical; Center, Jacksonville.
Patients hospitalized with acute pelvic inflammatory disease at University Medical Center of Jacksonville had a mean age of 26.8 years. Contraception use was minimal and mean gravidity was two. Hospitalized patients had a high incidence of peritonitis and tubo-ovarian abscess. N. gonorrhoeae was cultured in 50%. Mean
Med Clin (Barc). 1991 Feb 23;96(7):258-60. Unique Identifier : AIDSLINE MED/91245853
Alvarez R; Pujol A; Graus F; Soriano V; Corachan M; Tolosa E; Servicio de Neurologia, Hospital Clinic i Provincial,; Barcelona.
The first patient with myelopathy associated with T-cell leukemia/lymphoma virus infection (HTLV-I) in Spain is reported. Although this condition is endemic in several areas from the Caribbean Sea, South America, Africa and Japan , some cases have
Hendrickson EA; Liu VF; Weaver DT; Division of Tumor Immunology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
Somatic gene rearrangement of immunoglobulin and T-cell receptor genes [V(D)J recombination] is mediated by pairs of specific DNA sequence motifs termed signal sequences. In experiments described here, retroviral vectors containing V(D)J rearrangement cassettes in which the signal sequences had been altered were intro
Percept Mot Skills. 1991 Feb;72(1):99-102. Unique Identifier : AIDSLINE MED/91246551
Levenson RL Jr; Kairam R; Bartnett M; Mellins CA; Child Neurology/Department of Pediatrics, St. Luke's/Roosevelt; Hospital Center, New York, NY 10025.
The purpose of this preliminary investigation was to assess the equivalence of Forms L and M of the Peabody Picture Vocabulary Test--Revised for a sample of 15 Hispanic and 12 black children diagnosed as having Acquired Immune Deficiency Syndrome (AIDS). The children (15 boys, 12 girls) were administered PPVT-R Forms
Pol Arch Med Wewn. 1991 Jan;85(1):35-40. Unique Identifier : AIDSLINE MED/91246602
Radkowski M; Goch A; Laskus T; Babiuch L; Slusarczyk J; Zakladu Immunopatologii, Akademii Medycznej w Warszawie.
Serological markers of present or past HBV infection were looked for in 69 persons infected with HIV. 40 out of them were clinically asymptomatic, while 29 showed evidence of clinically overt disease related to HIV infection. Most of them were homo- or bisexual men, prostitutes or intravenous drug abusers. Control gro
Coleburn NH; Scholes JV; Lowe FC; Department of Urology, St. Luke's-Roosevelt Hospital Center, New; York, New York.
The acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) can be associated with nephropathy and renal failure. As the number of AIDS and ARC patients continues to increase dramatically, urologists will be called upon more frequently to help evaluate these patients for reversible causes of renal fa
Am J Drug Alcohol Abuse. 1991;17(1):39-48. Unique Identifier : AIDSLINE MED/91247448
Vlahov D; Anthony JC; Celentano D; Solomon L; Chowdhury N; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Maryland 21205.
To assess how injection practices may have changed during the course of the AIDS epidemic, active intravenous drug users (IVDUs) recruited from the community were asked to report year of first injection as well as specific details about the first 3 months after initial injection: frequencies of injection, using steril
Am J Gastroenterol. 1991 Jun;86(6):715-8. Unique Identifier : AIDSLINE MED/91247464
Danzig JB; Brandt LJ; Reinus JF; Klein RS; Department of Medicine, Montefiore Medical Center, Albert; Einstein College of Medicine, Bronx, New York.
To clarify the prevalence and characteristics of gastrointestinal malignancy in patients with AIDS, we reviewed the demographics and clinical features of patients with AIDS and gastrointestinal neoplasms seen at North Central Bronx Hospital and Montefiore Medical Center during the past 8 yr. Malignant neoplasia compli
O'Briain DS; Department of Pathology, St. James's Hospital, Dublin, Ireland.
Details of injuries and exposures to body fluids while handling tissue that were sustained by 36 pathologists (nine residents and 27 staff pathologists) were ascertained by retrospective questionnaire. In the preceding year 56% (20/36) had sustained a cut or needlestick injury. A total of 72 individual injuries occurr
Smith JW; Nichols RL; Department of Surgery, Tulane University School of Medicine, New; Orleans, La 70112-2669.
Surgical gowns are traditionally worn to protect patients from contamination by the surgical team. Blood routinely covers gowns during surgery and often contaminates surgeons undergarments and skin. Because of risks to the surgical team by blood-borne pathogens, disposable and reusable gowns were examined. To quantif
Bol Asoc Med P R. 1991 Jan;83(1):17-8. Unique Identifier : AIDSLINE MED/91248355
Reyes-Iglesias Y; Grant TH; Department of Medicine, University of Puerto Rico, School of; Medicine, San Juan.
A patient with hemiballism-hemichorea as the initial manifestation of the acquired immunodeficiency syndrome is described. Movement disorders in AIDS have not been frequently reported. Possible etiologies and therapeutic trials are presented. To our knowledge this is the first case report of hemiballism-hemichorea as
Bol Asoc Med P R. 1991 Jan;83(1):8-9. Unique Identifier : AIDSLINE MED/91248359
Negron DF; Diaz L; Joglar F; Rivera C; Burgos Calderon R; University of Puerto Rico, School of Medicine, Department of; Medicine, Rio Piedras.
There is controversy on whether or not patients with End Stage Renal Disease (ESRD) on chronic hemodialysis (HD) should be routinely tested for the presence of HIV-antibody (HIV-Ab) in their blood. Several reports have appeared in the literature reporting incidence from 0 to 11%. A total of 227 patients receiving chro
New Biol. 1991 Jan;3(1):82-9. Unique Identifier : AIDSLINE MED/91248828
Lisziewicz J; Rappaport J; Dhar R; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, MD 20892.
Transcriptional activation of gene expression directed by the long terminal repeat (LTR) of the human immunodeficiency virus type 1 (HIV-1) requires both the Tat activation response element (TAR) and the Tat protein. Mutants lacking a functional tat gene are not able to replicate. An approach we have used to suppress
Blood. 1991 Jun 1;77(11):2419-30. Unique Identifier : AIDSLINE MED/91249091
Chadburn A; Athan E; Wieczorek R; Knowles DM; Department of Pathology, Columbia University College of; Physicians and Surgeons, New York, NY 10032.
Human T-cell lymphotropic virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATLL) occurs endemically in southwestern Japan , the Caribbean, and West Africa, but occurs sporadically in most of the rest of the world. However, because ATLL and non-HTLV-I associated T-cell
Cirelli A; Ciardi M; de Simone C; Sorice F; Giordano R; Ciaralli L; Costantini S; Istituto Malattie Infettive, University La Sapienza, Rome, Italy.
The selenium concentration in the serum of 67 patients with HIV infection was measured to determine whether selenium deficiency occurred in the different stages of the disease. In the first stage of the study, patients were divided into four groups: symptom-free subjects, PGL (persistent generalized lymphadenopathy),
Herst JA; Shepherd FA; Liu P; Butany JW; Houle S; Burkes R; Paul K; Department of Medicine, Toronto General Hospital, Ontario.
Prospective evaluation of cardiac function was undertaken in 21 patients with Kaposi s sarcoma (KS) and the acquired immune deficiency syndrome (AIDS) as part of a phase II clinical trial of 4 epirubicin. All patients were homosexual or bisexual males of median age 34 years (range 23-65). All patients had disseminated
MacGregor SN; Department of Obstetrics and Gynecology, Northwestern University; Medical School, Evanston, Illinois.
Many aspects of HIV infection in pregnancy remain unclear. Subsets at increased risk for perinatal transmission, adverse pregnancy outcome, and development of symptomatic HIV infection need to be identified. For instance, relative risks may be quite different in asymptomatic HIV infected patients with T4 lymphocyte co
Albert AE; Hatcher RA; Graves W; Emory University Summer Program in Family Planning and Human; Sexuality, Atlanta, GA.
For those who choose to be sexually active, condoms are the best available means of protection against sexually transmitted diseases including the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). Condoms are also an effective method for preventing pregnancy. Unfortunately, co
The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol
Miller RF; Jarritt PH; Lui D; Kidery J; Semple SJ; Ell PJ; Department of Medicine, University College and Middlesex School; of Medicine, Middlesex Hospital, London, UK.
We report the validation of a new delivery system--aerosol production equipment (known by the acronym APE), which generates a particulate aerosol of technetium 99m diethylene triamine penta-acetic acid (DTPA) with a mass-median aerodynamic diameter of 0.35 microns and a geometric standard deviation of 1.8 Twenty subje
A survey on the family planning behaviour in the Federal Republic of Germany was conducted by interviewers of the EMNID institute in 1985 (n = 1267) and 1989 (n = 950). The survey was carried out with women of 15 to 45 years of age. It was the aim of the 1989 study, to look into c
Allergy Proc. 1991 Jan-Feb;12(1):25-30. Unique Identifier : AIDSLINE MED/91250115
Harrison LF; Shearer WT; Texas Children's Hospital, Department of Allergy/Immunology,; Houston 77030.
Congenital deficiencies that involve the lymphocyte system are complex and represent abnormalities in genetic control or gestational development. Only the more common prototypes of these diseases will be discussed. Diseases of the B cell system presented include X-linked agammaglobulinemia, selective IgA deficiency, I
Bernstein LH; University of Connecticut, School of Medicine, Farmington.
Home intravenous antibiotic therapy (HIVAT) has proven to be a safe, effective, and cost-saving method to treat appropriately selected patients with bone, soft tissue, respiratory, genitourinary, and cardiac infections. Further, the acceptance of HIVAT by both physicians and patients has been enhanced by the availabil
Back NK; Haigwood NL; de Wolf F; de Jongh BM; Goudsmit J; Department of Virology, Academic Medical Centre, Amsterdam, The; Netherlands.
In human immunodeficiency virus type 1 (HIV-1) infected individuals, the antibody response to the external envelope (gp120) is associated with in vitro neutralization. To further characterize the anti-gp120 response, we examined the IgG reactivity of 75 HIV-1-seroconverted and 200 HIV-1-seropositive individuals to del
Luke W; Fendrich C; Schreiner D; Sprenger R; Rietschel J; Hunsmann G; Department of Virology and Immunology, German Primate Center,; Gottingen, FRG.
The structural variability of the external glycoproteins of primate immunodeficiency viruses, has, so far, been investigated exclusively by sequence comparison of the respective proviral genomes. We have examined the structural relationship amount the external glycoproteins from three specific human immunodeficiency v
Juszczak RJ; Turchin H; Truneh A; Culp J; Kassis S; Department of Cell Sciences, SmithKline Beecham Pharmaceuticals,; King of Prussia, Pennsylvania 19406.
The human immunodeficiency virus binds to CD4+ T lymphocytes through the interaction of its envelope glycoprotein (gp120) with the CD4 molecule. The src-related protein tyrosine kinase p56lck is physically associated with CD4 and is co-immunoprecipitated by CD4 monoclonal antibody (mAb). Activators of protein kinase C
Pal R; Nair BC; Hoke GM; Sarngadharan MG; Edidin M; Department of Cell Biology, Advanced BioScience Laboratories,; Inc., Kensington, Maryland 20895.
The envelope glycoprotein (gp120) of HIV-1 was labeled with fluorescein by using 6-[4,6-dichlorotriazinyl]aminofluorescein. The labeled glycoprotein was found to bind to CD4-positive CEM cells. Monoclonal antibody OKT4a but not OKT4 blocked this binding. Similar specific binding of fluorescein-labeled gp120 with CD4 w
Gerberding JL; University of California, San Francisco.
At San Francisco General Hospital and many other institutions in areas of high HIV prevalence, a policy of body substance isolation has proved easier to implement than the CDC s across-the-board recommendations. Prevention of needle-stick injury and use of barrier methods of infection control are emphasized. Preoperat
Sprengers ED; Hellings JA; Theunissen HJ; Ten Kortenaar PB; Organon Teknika B.V., Screening Systems Research Unit, Boxtel,; The Netherlands.
Current anti-HIV-1 screening tests combine an excellent anti-HIV-1 sensitivity with a sensitivity of only 28-93% for anti-HIV-2 positive plasma or serum samples. The reactivity of anti-HIV-2 sera in anti-HIV-1 screening tests is based mainly on the immunological cross-reactivity of the GAG and POL proteins of HIV-1 an
Shibata R; Kawamura M; Sakai H; Hayami M; Ishimoto A; Adachi A; Department of Viral Oncology, Kyoto University, Japan.
We constructed five chimeric clones between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIVMAC) and four SIVMAC mutants by recombinant DNA techniques. Three chimeric clones and all mutants with an alteration in either the vif, vpx, vpr, or nef gene were infectious to human CD4-positi
Niederman TM; Hu W; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110.
The nef gene is conserved among all human and simian lentiviruses. However, the amino acid similarity between simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 NEF is only 38%. To assess the role of SIV NEF on virus replication and compare its activity with that of its human immunodeficiency
Komurian F; Pelloquin F; de The G; Epidemiology of Oncogenic Viruses, Pasteur Institute, Paris,; France.
To investigate the geography- and disease-associated genomic variation of human T-cell leukemia virus type I (HTLV-I), we studied ex vivo DNA from peripheral blood lymphocytes from nine patients by polymerase chain reaction and direct DNA sequencing. For each viral strain, 1,917 bp was sequenced, including parts of th
Thomas DJ; Wall JS; Hainfeld JF; Kaczorek M; Booy FP; Trus BL; Eiserling FA; Steven AC; Laboratory of Structural Biology Research, National Institute of; Arthritis and Musculoskeletal and Skin Diseases, Bethesda,; Maryland 20892.
The molecular masses, carbohydrate contents, oligomeric status, and overall molecular structure of the env glycoproteins of human immunodeficiency virus type 1--gp120, gp160, and gp41--have been determined by quantitative electron microscopy. Using purified gp160s, a water-soluble form of env purified from a recombina
Whitcomb JM; Hughes SH; ABL-Basic Research Program, National Cancer Institute-Frederick; Cancer Research and Development Center, Maryland 21702-1201.
The sequence of the human immunodeficiency virus type 2 circle junction was determined. The most common sequence found between the conserved CA and TG dinucleotides at the ends of the integrated provirus was five bases long (GGTAC). This suggests that the integration of human immunodeficiency virus type 2 DNA is accom
Marcon L; Michaels F; Hattori N; Fargnoli K; Gallo RC; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
Human immunodeficiency virus type 2 (HIV-2) is similar in genetic organization to HIV-1 but contains a unique gene (vpx) that encodes a 16-kDa protein. A replication-competent molecular clone of HIV-2 (HIV-2sbl/isy) that infects human primary cells in vitro and rhesus monkeys was used to generate three mutations in th
Matsumura I; Kiso S; Tago H; Kawakami F; Fushimi H; Aozasa K; Kanakura Y; Tamaki T; Kanayama Y; Yonezawa T; et al; Second Department of Internal Medicine Osaka University Medical; School.
A 48-year-old woman was admitted in September 1987, because of lumbago and galactorrhea. Peripheral blood analysis showed neutrophilia and eosinophilia without abnormal lymphocytes. The antibody to adult T-cell leukemia (ATL) virus-associated antigen was detected and a hyperprolactinemia was observed. The blastogenic
Med Oncol Tumor Pharmacother. 1991;8(1):45-7. Unique Identifier : AIDSLINE MED/91251611
Logan WD Jr; Alonso K; Atlanta Heart & Lung Clinic, GA 30312.
The effect of prolonged exposure to heat on the HIV has had limited exploration. This is the report of a 33-year-old white man with positive tests for HIV and multiple lesions of Kaposi s Sarcoma. The patient was exposed to total body hyperthermia of 42 degrees C for two hours. Three months following hyperthermia the
Med Hypotheses. 1991 Feb;34(2):118-21. Unique Identifier : AIDSLINE MED/91251786
Elomaa E; Telakivi T; Haaga Neurological Rehabilitation Centre, Helsinki, Finland.
The main principles of this hypothesis are very general: (i) signal-detection from background noise is one central issue in electronics; (ii) an important source of misunderstanding at different levels of communication is the fact that a given signal may have different meanings in different contexts; (iii) the unique
Previous reports from an epidemiologic investigation in Florida strongly suggested that three patients (patients A, B, and C) became infected with human immunodeficiency virus (HIV) while receiving dental care from a dentist with acquired immunodeficiency syndrome (AIDS) (1,2). This report describes findings that sugg
Principi N; Marchisio P; Tornaghi R; Massironi E; Onorato J; Picco P; Libretti C; Department of Pediatrics (IV), University of Milan Medical; School, Italy.
To evaluate the occurrence of infections in asymptomatic and symptomatic human immunodeficiency virus (HIV)-infected children we performed a prospective comparative cohort study. Twenty-seven HIV-infected children were individually matched with paired immunocompetent controls and followed up for a total of 543 months
Craigie R; Mizuuchi K; Bushman FD; Engelman A; Laboratory of Molecular Biology, National Institute of Diabetes,; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892.
Retroviruses synthesize a double stranded DNA copy of their RNA genome after infection of a permissive cell and subsequent integration of this DNA copy into the host genome is necessary for normal viral replication. Integration occurs by a specialized DNA recombination reaction, mediated by the viral IN protein. Becau
Pillemer SR; Lawrence RC; Shulman LE; National Institute of Arthritis and Musculoskeletal and Skin; Diseases, National Institutes of Health, Bethesda, Maryland.
Espinoza LR; Aguilar JL; Espinoza CG; Gresh J; Jara J; Silveira LH; Martinez-Osuna P; Seleznick M; Department of Internal Medicine, College of Medicine, University; of South Florida, Tampa.
Inflammatory muscle involvement during the course of human immunodeficiency virus (HIV) infection is described and guidelines are suggested for its differentiation from the myopathy associated with azidothymidine ( AZT ) therapy. Six patients infected w
Calabrese LH; Department of Rheumatic and Immunologic Disease, Cleveland; Clinic, Ohio.
Vasculitic syndromes associated with infection with the human immunodeficiency virus (HIV) would appear to represent a microcosm of the vasculitic spectrum. Reported cases have included polyarteritis nodosa-like illnesses, hypersensitivity vasculitis, lymphomatoid granulomatosis, primary angiitis of the central nervou
Goldenberg DL; Tufts University School of Medicine, Boston, Massachusetts.
Bacterial arthritis has been reported rarely in patients with human immunodeficiency virus infection and generally is associated with other risk factors such as intravenous drug use. Septic arthritis may be caused by opportunistic organisms and may be more common in hemophiliacs when associated with human immunodefici
Solinger AM; Hess EV; Department of Internal Medicine, University of Cincinnati Medical; Sciences Center, Ohio.
Although many of the changes in HIV and AIDS appear to be global, on closer investigation the defects are specific and can be explained by recognized mechanisms. Despite a demonstrated concurrent polyclonal B-cell activation, studies fail to show any evidence to date of significant dysregulation of the immune system l
Furie RA; Department of Medicine, Cornell University Medical College, New; York.
Observations in patients with SLE and RA complicated by HIV-1 infection suggest that the immunodeficient state induced by the virus ultimately leads to improvement of rheumatic symptoms. Although profound CD4 lymphocyte depletion occurred in most of the patients reviewed, it is too simplistic to theorize that CD4 lymp
Keat A; Rowe I; Charing Cross and Westminster Medical School, London, England.
Several distinct arthritic syndromes now have been recognized in HIV-infected persons. These comprise seronegative spondarthritis, including classic Reiter s syndrome and psoriatic arthritis associated with HLA-B27, and undifferentiated arthritis usually confined to the lower limbs, unassociated with other lesions, an
Solomon G; Brancato L; Winchester R; Department of Medicine, Mt. Sinai School of Medicine, New York,; New York.
One of the unanticipated consequences of infection with the human immunodeficiency virus (HIV) is the appearance of various rheumatic syndromes that traditionally have been thought to result from inappropriate overactivity of the immune system. This distinctive spectrum of rheumatic syndromes has been well described;
Arnett FC; Reveille JD; Duvic M; Department of Internal Medicine, University of Texas Medical; School, Houston.
It has been well established that psoriasis, psoriatic arthritis, and Reiter s syndrome can occur in patients with HIV infection. These arthocutaneous diseases tend to occur in temporal proximity to the development of AIDS and ARC, and their clinical manifestations are unusually severe. The appearance or exacerbation
Rynes RI; AMC Division of Rheumatology, Albany Medical College, New York.
Severe pain is a prominent characteristic of many rheumatic conditions occurring in patients with human immunodeficiency virus (HIV) infection. These conditions may affect joints or soft tissues. Some painful syndromes, such as acquired immune deficiency syndrome-associated arthritis, may be unique to HIV-infected ind
Davis P; Stein M; Department of Medicine, University of Alberta, Edmonton, Canada.
Our clinical experience with patients in Zimbabwe suggests that an arthropathy may be a feature of HIV disease. This takes two forms: the first is a reactive arthropathy usually affecting the large, lower limb joints with no other clinical features of a connective tissue disease.
Itescu S; Institute of Molecular Immunology, Hospital for Joint Diseases,; New York, New York.
Certain adults and children with human immunodeficiency virus (HIV) infection develop a syndrome characterized by marked parotid gland enlargement, sicca symptoms and pulmonary insufficiency. Lymphocytic tissue infiltration is accompanied by circulating CD8 lymphocytosis, and autoantibodies are infrequently observed.
Marin Casanova P; Garcia Martos P; Fernandez Gutierrez del Alamo C; Garcia Herruzo J; Escribano Moriana JC; Aznar Martin A; Hospital de la Seguridad Social de Cadiz.
A young drug addict with positive anti-HIV antibodies, OKT4/OKT8 ratio below 1, oropharingeal candidiasis and pulmonary Pneumocystis carinii infection, dies due to a cerebral abscess with a septic status. The postmortem microbiologic study shows pulmonary abscesses and Nocardia asteroides is isolated from lung tissue
Merigan TC; Katzenstein DA; Center for AIDS Research, Stanford University School of Medicine,; California 94305.
This paper reviews functionally important insights into the pathogenesis of human immunodeficiency virus (HIV) infection. The major sequela of this infection is early and progressive involvement of the immune system, with widespread immune dysfunction. This pathogenetic feature has a major impact on strategies for con
Singapore Med J. 1991 Apr;32(2):123-6. Unique Identifier : AIDSLINE MED/91252867
Emmanuel SC; Research & Evaluation Department, Ministry of Health, Singapore.
Singapore had 52 cases of AIDS as at June 1990. This places Singapore in the low-infection-load group of countries. Constant vigilance is necessary however. The Health education programme against AIDS in Singapore was launched in 1985. This first ever National Survey on public a
Siem H; International Organization for Migration, Geneve, Sveits.
Today, there are about 14 million refugees worldwide. The United Nations High Commissioner for Refugees supports them with legal aid, food supplies, housing and preventive health measures, and also tries to find a permanent residence for the refugees. In recent years, there has been increasing awareness about the gre
Tidsskr Nor Laegeforen. 1991 May 10;111(12):1493-5. Unique Identifier : AIDSLINE MED/91252995
Haneberg B; Howlett WP; Det tanzaniansk-norske AIDS-prosjekt (MUTAN), Moshi, Tanzania.
AIDS is now world-wide, and the HIV infection is spreading rapidly via the heterosexual route. Among the Third World countries those in sub-Saharan Africa are the hardest hit, it is estimated that one in 40 of the adult population is already infected. Half of the victims are women, who will give birth to a large numbe
Tidsskr Nor Laegeforen. 1991 May 10;111(12):1496-9. Unique Identifier : AIDSLINE MED/91252996
Bjune G; Avdeling for Vaksine, Statens Institutt for Folkehelse, Oslo.
Infectious diseases are the main cause of mortality and morbidity in developing countries. The Expanded Programme on Immunization, initiated by WHO in 1974, now reaches 60 mill. a year at a cost of less than 2 US $ per immunized child, and saves 2.2 mill. lives annually. The present vaccines, however, have significant
Baylac-Kalabokias H; Astier-Gin T; Moynet D; Hernould M; Mamoun R; Legrand E; Guillemain B; University of Bordeaux, France.
We report the cloning and characterization of a new ecotropic provirus encountered in a radio-induced thymic lymphoma of the C57BL/6 mouse. The provirus with an abnormally long LTR was inserted in the chromosomal DNA within the Pvt-1/MLVi-1/Mis-1 region which is a common integration site for MCF virus in mice and for
Am Fam Physician. 1991 Jun;43(6):2081-5. Unique Identifier : AIDSLINE MED/91253493
Vinson RP; Epperly TD; Martin Army Community Hospital, Fort Benning, Georgia.
The best condoms are made of latex, are lubricated and coated with a spermicide, and have a reservoir tip. Condoms can protect against conception and sexually transmitted diseases, including acquired immunodeficiency syndrome. When condoms are used properly and in combination with vaginal spermicidal foam, the contrac
Van Dyke RB; Department of Pediatrics, Tulane University School of Medicine,; New Orleans, LA.
The number of children infected with the human immunodeficiency virus (HIV) is rapidly increasing. Most infected children acquire their infection by vertical transmission from an infected mother, and this increase in the number of infected children reflects a similar increase in the number of infected women. Many feat
Bargman JM; Wagner C; Cameron R; Department of Medicine, Toronto Hospital, Ontario, Canada.
A 38-year-old man with acquired immunodeficiency syndrome (AIDS) demonstrated atypical nephrocalcinosis on abdominal x-ray. Computed tomography (CT) scanning showed the calcifications to be predominantly in a cortical distribution. The patient had evidence of disseminated Pneumocystis carinii infection, and histologic
Schectman JM; Kimmel PL; Department of Health Care Sciences, George Washington University; Medical Center, Washington, DC 20037.
Hepatitis B virus (HBV) infection has been associated with several renal diseases, the most common being membranous glomerulonephritis (MGN). The role of concurrent human immunodeficiency virus (HIV) infection in affecting the course of the renal involvement is largely unknown. We report the case of a HIV-infected adu
Am J Med. 1991 Jun;90(6):675-7. Unique Identifier : AIDSLINE MED/91253647
Durand JM; Lefevre P; Hovette P; Issifi S; Mongin M; Clinique Medicale B, Pr M. Mongin, CHU Timone, Marseille,; France.
PURPOSE: The purpose of this study was to determine the effect of dapsone on platelet count in patients with human immunodeficiency virus (HIV)-related autoimmune thrombocytopenia. PATIENTS AND METHODS: Eleven patients with HIV-related thrombocytopenia received dapsone (50 to 125 mg/day) for 2 to 43 months. Patients w
Am J Med. 1991 Jun;90(6):678-84. Unique Identifier : AIDSLINE MED/91253648
Miller A; Taub H; Spinak A; Pilipski M; Brown LK; Division of Pulmonary and Critical Care Medicine, Mount Sinai; School of Medicine, City University of New York, New York 10029.
PURPOSE: To determine whether former intravenous drug abusers (IVDAs) demonstrate reductions in pulmonary function, especially in the diffusing capacity (DLCO), after adjustment for the effects of their ubiquitous smoking habit. Knowledge of baseline DLCO in this high-risk group is important in evaluating the effects
We look risk factors (RF) (other than i.v. drug addiction) leading to the suspicion of HIV infection. We have measured (ELISA) HIV antibodies in mothers and their children whenever the following circumstances were present: Maternal age under 22, previous abortions, sexually transmitted disease, uncontrolled pregnancy,
An Esp Pediatr. 1991 Feb;34(2):123-7. Unique Identifier : AIDSLINE MED/91253815
Arcas Cruz R; Figueras Aloy J; Vilanova Juanola JM; Comas Mastmitja L; Jimenez Gonzalez R; Cruz Hernandez M; Subdivision de Pediatria, Hospital Clinico y Facultad de; Medicina, Universidad de Barcelona.
Maternal drug addiction has increased in an alarming way over the last ten years. Therefore, the withdrawal syndrome in the newborn has also increased. 53% of the newborns (of chemical dependent mother) studied from 1985 to 1989 in HCP have presented this syndrome. We have analysed: perinatal, neonatal and maternal fa
An Esp Pediatr. 1991 Feb;34(2):158-60. Unique Identifier : AIDSLINE MED/91253824
de Juan Martin F; Gomez Barrena V; Garcia Vera C; Gresa Munoz M; Arcauz Eguren P; Omenaca Teres M; Martin Moradillo M; Seccion Infecciosos, Hospital Infantil Miguel Servet, Zaragoza.
Ann Neurol. 1991 Mar;29(3):333-6. Unique Identifier : AIDSLINE MED/91254017
Rozenberg F; Lefebvre S; Lubetzki C; Lebon P; Lyon-Caen O; Brahic M; Bureau JF; Unite des Virus Lents, Institut Pasteur, Paris, France.
The polymerase chain reaction was used, in a blind study, to look for retroviral sequences in DNA extracted from the peripheral blood mononuclear cells of 11 patients with the spinal form of multiple sclerosis (MS). Control subjects consisted of 7 patients with other neurological diseases and 5 healthy blood donors. T
Gemson DH; Colombotos J; Elinson J; Fordyce EJ; Hynes M; Stoneburner R; Division of Sociomedical Sciences, Columbia University School of; Public Health, New York, NY 10032.
We conducted a telephone survey of a probability sample of 473 internists, family practitioners, general practitioners, and obstetrician-gynecologists in New York City (NY) in 1988 to assess their knowledge, attitudes, and practices with respect to the prevention of the acquired immunodeficiency syndrome (AIDS). Altho
Calabrese LH; Kelley DM; Cullen RJ; Locker G; Department of Rheumatic and Immunologic Disease, Cleveland Clinic; Foundation, OH 44195-5028.
While there is now evidence that health-promoting education can be effective at reducing transmission of human immunodeficiency virus (HIV) infection, little is known of the role of the practicing physician in this process. We have surveyed 301 practicing physicians in Northeastern Ohio over a 2-year period and we hav
Cohen OJ; Stoeckle MY; Department of Medicine, New York Hospital, Cornell Medical; Center, NY 10021.
Pneumocystis carinii is a frequent cause of interstitial pneumonitis in patients with cell-mediated immunodeficiencies. Extrapulmonary P carinii infection is a rare manifestation of disease caused by this organism. Nevertheless, reports of extrapulmonary P carinii infection are increasing in the setting of the acquire
Biochem Biophys Res Commun. 1991 May 31;177(1):279-85. Unique Identifier : AIDSLINE MED/91254288
Tomiyama T; Lake D; Masuho Y; Hersh EM; Teijin Institute for Biomedical Research, Tokyo, Japan.
Anti-carbohydrate antibodies were isolated from Human immunodeficiency virus (HIV) negative human serum by affinity chromatography using yeast mannan followed by protein A. The purified mannan-binding IgG (MBIgG) bound to HIV glycoproteins gp 160, gp 120 and gp 41 in Western blot. Immunofluorescence revealed that MBIg
Biochem Pharmacol. 1991 Jun 1;41(11):1615-24. Unique Identifier : AIDSLINE MED/91254355
Niedzwicki JG; Abernethy DR; Division of Clinical Pharmacology, Brown University, Providence,; Rhode Island.
Diethylaminoethyl-cellulose chromatography was used to separate the two isoenzymes of adenosine deaminase (EC3.5.4.4), adenosine deaminase1 (ADA1) and adenosine deaminase2 (ADA2), in human plasma. One hundred and fifteen purine base, nucleoside, and nucleotide analogs were tested as inhibitors of this partially purifi
Biochemistry. 1991 Jun 18;30(24):6013-23. Unique Identifier : AIDSLINE MED/91255226
Loret EP; Vives E; Ho PS; Rochat H; Van Rietschoten J; Johnson WC Jr; Department of Biochemistry and Biophysics, Oregon State; University, Corvallis 97331-6503.
Tat protein is a trans-acting transcriptional activator of the human immunodeficiency virus type 1 and is essential for viral transcription. By homology with other transcriptional activators, Tat is expected to possess a nucleic acid binding region and a separate adjacent activating region. In order to localize the ac
Davey FR; Hutchison RE; State University of New York Health Science Center, Syracuse.
Adult T-cell leukemia/lymphoma is a disseminated malignancy of T lymphocytes infected by the human T-lymphotrophic virus type I. It is endemic in southern Japan , the Caribbean basin, the southeastern United States , and central Africa. The virus is tr
Arumainayagam JT; de Silva Y; Shahmanesh M; Department of Genitourinary Medicine, General Hospital,; Birmingham, UK.
One hundred male sexual partners of women with anaerobic vaginosis (AV) were screened for the presence of sexually transmitted diseases (STD). Thirty male partners had evidence of non-gonococcal urethritis (NGU), compared to 5 in the control group (P less than 0.05). Chlamydia trachomatis was isolated from 14 male par
Venegas VS; Madrid JP; Lorenzana I; Grillner L; Cosenza H; Bygdeman S; Department of Microbiology, National Autonomous University of; Honduras, Tegucigalpa DC.
The seroprevalence of human immunodeficiency virus (HIV) infection and syphilis was investigated in 181 female prostitutes in Tegucigalpa, Honduras . One particle agglutination test and two enzyme immunoassays, as well as one immunof
Ramstedt K; Forssman L; Johannisson G; Department of Dermato-venereology, University of Goteborg,; Sweden.
Four different types of contact tracing for partners of Chlamydia trachomatis infected patients were compared with respect to reinfections during two 15-month periods in 1979/80 and in 1983/84. Between the two study periods a gradual improvement in contact tracing occurred. No reduction in overall reinfections was obs
Ahmed HJ; Omar K; Adan SY; Guled AM; Grillner L; Bygdeman S; Department of Pathology and Morphology, Faculty of Medicine and; Surgery, Somali National University, Mogadishu.
A total of 155 prostitutes inhabiting 4 different districts in Mogadishu, Somalia , were enrolled in a 6 month prospective study of syphilis and HIV infection. Blood samples were taken on entry, at 3 months and at 6 months. Differences were seen between the prostitutes in the 4 dis
Jones AJ; Thin RN; Department of Genitourinary Medicine, St Thomas's Hospital,; London, UK.
The presenting complaint in 100 consecutive patients attending the psychosexual session (PSS) attached to the Department of Genitourinary Medicine (GUM) in St Thomas s Hospital was compared with 100 consecutive patients seen at a community PSS attached to a family planning clinic in an outer London district. Patients
Reddy MM; Grieco MH; RA Cooke Institute of Allergy, St Luke's-Roosevelt Hospital; Center, New York, New York 10019.
Levels of erythropoietin and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in sera of 28 HIV-seronegative heterosexual non-intravenous drug using controls, 57 HIV-seronegative and 42 HIV-seropositive asymptomatic intravenous drug users (IVDU) and 36 HIV-seronegative and 36 HIV-seropositive ho
Ross MW; Drew PA; National Centre in HIV Social Research, School of Community; Medicine, University of New South Wales, Sydney, Australia.
Immune function in 97 homosexually active men (none of whom had HIV infection) was assessed. Data revealed that mitogenesis in those who used volatile nitrites compared to those who did not was higher at 72 h but that there was no difference between the groups at 96 h. In those who had high as compared to low nitrite
Zuccati G; Tiradritti L; Mastrolorenzo A; Traversa G; Staderini C; Starnotti L; Institute of Dermatology, Department of Sexually Transmitted; Diseases, University of Florence, Italy.
Lau RK; Pinching AJ; Department of Immunology, St Mary's Hospital Medical School,; London, UK.
To assess the clinical and laboratory workload arising from human immunodeficiency virus (HIV)-related inpatient admissions in a London teaching hospital, a 10-month retrospective audit was performed of the casenotes of all HIV-infected inpatients admitted under the care of one consultant physician. During this period
Can J Psychiatry. 1991 Mar;36(2):118-20. Unique Identifier : AIDSLINE MED/91256115
Schechter JB; Myers MF; Solyom L; Department of Family Practice, University of British Columbia,; Vancouver.
It is well known that delusions, obsessions and phobic reactions may centre on items which are of current topical interest. We report a case of obsessive-compulsive disorder manifested primarily by intrusive thoughts about AIDS. The patient eventually responded to an unusual combination of medications.
Can J Psychiatry. 1991 Mar;36(2):121-3. Unique Identifier : AIDSLINE MED/91256116
Kleinman I; Department of Psychiatry, Mount Sinai Hospital, Toronto, Ontario.
Psychiatrists, particularly psychotherapists, have access to the most intimate details of patients lives. As a result, psychiatrists may face a number of ethical dilemmas, particularly when the issue of potential human immunovirus (HIV) transmission is involved. This paper examines the principle and the limits of con
Cas Lek Cesk. 1991 Mar 8;130(10):292-5. Unique Identifier : AIDSLINE MED/91256282
Svoboda J; I. interni klinika 1. lekarske fakulty Univerzity Karlovy,; Praha.
The author analyzes individual pathophysiological mechanisms which play a part in the development and clinical manifestation of HIV infection. He uses as a basis the CDC classification of HIV infections and explains on different models of clinical situations mechanisms which lead to haematological, neurological, immun
Cas Lek Cesk. 1991 Mar 8;130(10):296-8. Unique Identifier : AIDSLINE MED/91256283
Svoboda J; I. interni klinika 1. lekarske fakulty Univerzity Karlovy,; Praha.
The author pays attention to interindividual differences in the course of HIV infection and its causes. He emphasizes above all the influence of sex life, herpetic infections and the mental state of the patient. He analyzes also individual clinical and laboratory prognostic factors which can be used in clinical practi
Cas Lek Cesk. 1991 Mar 15;130(11):335-9. Unique Identifier : AIDSLINE MED/91256291
Svoboda J; I. interni klinika 1. lekarske fakulty Univerzity Karlovy,; Praha.
The author analyzes different possible therapeutic approaches to HIV infection in different clinical stages. He draws attention to the fact that antiretroviral therapy has always also a certain immunomodulating effect and vice versa. It is in particular necessary to pay attention to the fact that therapeutic activatio
Jeffrey AA; Israel-Biet D; Andrieu JM; Even P; Venet A; Hopital Laennec, Paris, France.
In a study of 75 alveolar cell co-cultures from 55 HIV-seropositive subjects, p24 antigen production was identified by ELISA in 11 out of 26 (42%) of unseparated cell cultures, 15 out of 39 (38%) purified alveolar macrophage cultures and eight out of 10 purified alveolar lymphocyte samples. Positivity in unseparated c
Changes in immune competent tissues of the HIV-1-infected person reflect to a certain extent the kind and intensity of immunological dysregulations. The diagnostic approach, however, must include immunophenotyping of cells, immunovirological studies of virus distribution in diseased tissues, and functional tests in ad
Experientia. 1991 May 15;47(5):437-9. Unique Identifier : AIDSLINE MED/91257219
Rolston KV; Zandvliet SE; Rodriguez S; Nguyen HT; Bodey GP; Department of Medical Specialties, University of Texas, M. D.; Anderson Cancer Center, Houston 77030.
The spectrum of infection with Aeromonas and Plesiomonas included gastroenteritis, bacteremia, biliary tract infection, perirectal infection, and disseminated disease. Most patients (86%) with bacteremia were neutropenic (less than 500 PMN/mm3). Colonization of stools and sputum also occurred. Therapy with aminoglycos
Odujinrin OM; Akinkuade FO; Department of Community Health College of Medicine, University of; Lagos, Nigeria.
Three hundred ninety-eight randomly selected Nigerian adolescents were surveyed using well structured questionnaires to collect all information on their knowledge, attitude, beliefs and practice regarding AIDS. The questionnaires were carefully administered and analysed. Most of the respondents, aged 10-20 years, were
Enel P; Manuel C; Charrel J; Larher MP; Reviron D; San Marco JL; Public Health Department, Faculte de Medecine, Marseille, France.
At present, we can observe an evolution in ideas about the detection of HIV seropositivity through a qualitative analysis of specialised literature on the ethical aspects of AIDS. In the case of this disease, systematic screening of the population does not correspond to epidemiological criteria: it is wasteful, troubl
Enel P; Charrel J; Larher MP; Reviron D; Manuel C; San Marco JL; Public Health Department, Faculte de Medecine, Marseille,; France.
At present questions are being asked world-wide about the risk of the AIDS epidemic. The discovery of an anti-HIV vaccine has become an urgent priority, but it also raises a number of sensitive questions. Ethical problems in this field are particularly delicate, since the perspectives of individual health and public h
Frery N; Chavance M; Valette I; Schaffar L; Neisson-Vernant C; Jouannelle J; Monplaisir N; Recherches en epidemiologie: INSERM U169, Villejuif, France.
A case-control study was performed in Martinique , French West Indies, comparing 66 anti-p24 antibody carriers to 91 seronegative subjects for HTLV-I, matched for age and place of residence. The aim of our study was to identify facto
FEBS Lett. 1991 Jun 3;283(2):180-4. Unique Identifier : AIDSLINE MED/91257297
Jupp RA; Phylip LH; Mills JS; Le Grice SF; Kay J; Department of Biochemistry, University of Wales College of; Cardiff, UK.
Mutations were introduced into the P2 and P1 positions of the junctions, (a) linking reverse transcriptase (RT) and integrase (IN) (-Leu*Phe-) and (b) between the p51 and RNase H domain (-Phe*Tyr-) within p66 of RT in the HIV-1 pol polyprotein. Processing by HIV proteinase (PR) in cis was monitored upon expression of
Eskerud JR; Hoftvedt BO; Laerum E; Department of General Practice, University of Oslo, Norway.
To investigate the layman s knowledge, perception and attitudes regarding normal body temperature, fever, infections and the effect of penicillin on virus infections a representative sample of the Norwegian population (619 women and 592 men over the age of 15) was interviewed in 1988 as part of a monthly national opin
Holtedahl KA; Doumenc M; Steinert S; Roghell PK; Kvaloysletta health centre, University of Tromso, Norway.
Since patients with sexually transmitted disease (STD) form the most apparent risk group for HIV infection in general practice, differences in sexual behaviour in patients with and without STD were studied. Patients fulfilling at least one of four clinical criteria for suspicion of STD were offered four microbiologica
Kochen MM; Hasford J; Department of General Practice, University of Gottingen, FRG.
To evaluate the knowledge on infection with the human immunodeficiency virus (HIV) a questionnaire survey was carried out in West German medical students attending general practice courses. Lecturers of 19 medical schools agreed to participate and 1665 completed questionnaires were returned. The analysis of students
Fortschr Med. 1991 Feb 20;109(5):129-31. Unique Identifier : AIDSLINE MED/91257706
Bocker FM; Psychiatrische Klinik mit Poliklinik, Universitat; Erlangen-Nurnberg.
Is the medical prescription of narcotics an adequate way to treat opiate addiction? This question has been controversial in Germany for the last two decades. In 1987, a clinical trial of levomethadone treatment has been started in North-Rhine-Westfalia. Recently, aspects of public
Fortschr Med. 1991 Feb 20;109(5):132-5. Unique Identifier : AIDSLINE MED/91257707
Bocker FM; Psychiatrische Klinik mit Poliklinik, Universitat; Erlangen-Nurnberg.
On the basis of epidemiological findings, it is shown that methadone programs are unsuitable to prevent the spread of HIV infection, and that the AIDS epidemic among intravenous drug users does not justify the introduction of such programs. Abstinence from all psychotropic substances should remain the overriding aim o
Int Nurs Rev. 1991 Mar-Apr;38(2):49-52. Unique Identifier : AIDSLINE MED/91258076
Sarr F; Gambia College, School of Nursing & Midwifery.
HIV/AIDS education for nurses worldwide received impetus from the WHO/ICN Guidelines for Nursing Management of People Infected with Human Immunodeficiency Virus, which stresses that information about HIV infection and its implication for nursing management should be planned for and integrated into formal and continuin
By entering the medical profession, physicians have consented to accept a standard level of risk of infection. In most instances, the risk of contracting HIV does not exceed this level.
Hoekman P; van de Perre P; Nelissen J; Kwisanga B; Bogaerts J; Kanyangabo F; Department of Orthopedics and Traumatology, Centre Hospitalier de; Kigali, Rwanda.
In a prospective study of 214 patients who had elective extensive operations for fractures, we compared the relative frequencies of postoperative infections in the seventeen patients who were seropositive for human immunodeficiency virus and had associated clinical symptoms, in the twenty-six patients who were seropos
In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited
Glynn AA; Central Public Health Laboratory, London.
Current laboratory practice in testing for HIV antibodies in western Europe was investigated by means of a questionnaire addressed to the 12 EC countries and Finland , Norway ,
Roy TM; Dow FT; Puthuff DL; University of Louisville School of Medicine, Kentucky 40292.
Kaposi s sarcoma occurs in the head and neck region, commonly in patients with the acquired immunodeficiency syndrome. This tumor may also involve oromucosal surfaces, but only rarely leads to upper airway obstruction. When such obstruction develops, the emergency physician must be aware of the attendant problems of s
Cydulka RK; Mathews JJ; Born M; Moy A; Parker M; Department of Medicine, Northwestern University Medical School,; Northwestern Memorial Hospital, Chicago, Illinois.
We surveyed 420 paramedics employed by a large metropolitan fire department to determine the effects of educational seminars on their knowledge base, perceptions, and attitudes about AIDS and hepatitis B. All surveys were completed on an anonymous, voluntary, and confidential basis. Our educational efforts improved th
Zambruno G; Mori L; Marconi A; Mongiardo N; De Rienzo B; Bertazzoni U; Giannetti A; Department of Dermatology, University of Modena, Italy.
Langerhans cells (LC) are bone marrow-derived, HLA-DR+, CD1a+, dendritic antigen-presenting cells found in stratified squamous epithelia. Within resident epidermal cells (EC), LC are the only cells expressing the CD4 antigen and are, therefore, a possible target for human immunodeficiency virus (HIV) infection. To dat
de Wit R; Raasveld MH; ten Berge RJ; van der Wouw PA; Bakker PJ; Veenhof CH; Department of Medicine, University of Amsterdam, The Netherlands.
Interleukin-6 (IL-6) levels were determined in the serum of 14 HIV-1-infected patients with Kaposi s sarcoma, 10 HIV-1-infected patients without symptoms, and 10 healthy male subjects. IL-6 levels were also determined in the serum of the 14 patients with Kaposi s sarcoma during treatment with high-dose human recombina
Vernon SK; Murthy S; Wilhelm J; Chanda PK; Kalyan N; Lee SG; Hung PP; Biotechnology and Microbiology Division, Wyeth-Ayerst Research,; Philadelphia, Pennsylvania 19101.
The human immunodeficiency virus type 1 (HIV-1) Gag protein was expressed in A549 cells infected with recombinant adenovirus types 4 and 7, each carrying the HIV-1 gag and pro genes. The Gag protein was assembled into enveloped virus-like particles that budded from plasma and vacuolar membranes. The particles, isolate
Zachar V; Norskov-Lauritsen N; Juhl C; Spire B; Chermann JC; Ebbesen P; Danish Cancer Society, Department of Virus and Cancer, Aarhus C.
Primary cultures of essentially pure human term trophoblasts were studied to determine their ability to support the expression of complete proviral clones of human immunodeficiency virus (HIV) and their permissiveness to this virus. Transient expression of molecular clones derived from two biologically distinct strain
Bolmstedt A; Hemming A; Flodby P; Berntsson P; Travis B; Lin JP; Ledbetter J; Tsu T; Wigzell H; Hu SL; et al; Department of Clinical Virology, University of Goteborg, Sweden.
Site-directed mutagenesis was used to study the biological significance of a disulphide bridge and two N-linked oligosaccharides in the CD4-binding region of the envelope glycoproteins of human immunodeficiency virus type 1. Mutagenesis was performed in a phage M13 system at sites corresponding to the cysteine residue
Pepler CJ; Lynch A; Department of Nursing, Royal Victoria Hospital, Montreal, Quebec,; Canada.
When dying patients are young adults or have a contagious disease, nursing staff may feel acutely uncomfortable and the patients may become isolated and alone. Nurses who work in palliative care units (PCU) develop special interactive skills that are generally acknowledged but not clearly defined or understood. Admiss
Blaney NT; Goodkin K; Morgan RO; Feaster D; Millon C; Szapocznik J; Eisdorfer C; Department of Psychiatry, University of Miami School of Medicine,; FL 33136.
A stress moderator framework was employed to investigate the relationship of negative life events, hardiness and social support to psychological distress among 67 asymptomatic HIV-1 seropositive gay males. Both main effects and stress moderator (interaction) models were evaluated. Main effects were found for negative
J Psychosoc Nurs Ment Health Serv. 1991 Apr;29(4):6-12. Unique Identifier : AIDSLINE MED/91259527
Cowles KV; Rodgers BL
1. The significant others of persons with AIDS, whether they assume the role of primary caregiver or not, have a number of unique experiences, concerns, and needs specifically related to their situations. 2. During the initial period following the diagnosis of a loved one, the significant others indicated their primar
JAMA. 1991 Jun 26;265(24):3275-9. Unique Identifier : AIDSLINE MED/91259643
Schuchat A; Broome CV; Hightower A; Costa SJ; Parkin W; Meningitis and Special Pathogens Branch, Centers for Disease; Control, Atlanta, GA 30333.
We used population-based surveillance in New Jersey in 1986 to quantify the risk of invasive pneumococcal disease in persons with the acquired immunodeficiency syndrome (AIDS) and in those who went on to develop AIDS. Using pneumococcal surveillance, we also devised a method to estimate the size of the immunosuppresse
Friedman Y; Franklin C; Freels S; Weil MH; Department of Medicine, Cook County Hospital, Chicago, Ill 60612.
OBJECTIVE.--To evaluate the long-term survival of patients admitted to the medical intensive care unit, Cook County Hospital, Chicago, Ill, with Pneumocystis carinii pneumonia and acute respiratory failure. DESIGN.--Cohort study over a 4-year period. SETTING.--Municipal teaching hospital. PATIENTS.--Seventy-three cons
Fowler NO; Department of Internal Medicine, University of Cincinnati (Ohio); College of Medicine 45267.
Tuberculosis is responsible for approximately 4% of cases of acute pericarditis, 7% of cases of cardiac tamponade, and, in older studies, 6% of instances of constrictive pericarditis. However, in some nonindustrialized countries, tuberculosis is a leading cause of pericarditis. The diagnosis is based on demonstration
Med Clin (Barc). 1991 Mar 16;96(10):361-3. Unique Identifier : AIDSLINE MED/91260136
Muga R; Tor J; Solsona L; Villanueva C; Pol M; Jacas C; Sabria M; Rey-Joly C; Foz M; Unidad de Enfermedades infecciosas (Servicio de Medicina; Interna), Hospital Germans Trias i Pujol, Badalona, Barcelona.
BACKGROUND: To evaluate the usefulness of serum immunoglobulin A (IgA) as a prognostic marker of human immunodeficiency virus type 1 (HIV-1) in parenteral drug abusers (PDA). METHODS: The serum IgA levels and HIV-1 antibodies were assessed in 374 PDAs admitted for infective diseases or for treatment of addiction. RESU
Busch MP; Eble BE; Khayam-Bashi H; Heilbron D; Murphy EL; Kwok S; Sninsky J; Perkins HA; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143-0134.
BACKGROUND. Reports of transmission of the human immunodeficiency virus type 1 (HIV-1) from transfusions of screened blood and reports of silent, antibody-negative HIV-1 infections in persons at high risk continue to foster concern about the safety of the blood supply. Previous estimates of the risk of HIV-1 range fro
Nature. 1991 Jun 6;351(6326):479-82. Unique Identifier : AIDSLINE MED/91260850
Aldovini A; Young RA; Whitehead Institute for Biomedical Research, Cambridge,; Massachusetts 02142.
Several viral and bacterial live recombinant vaccine vehicles are being developed to produce a new generation of vaccines against a broad spectrum of infectious diseases. The human tuberculosis vaccine Mycobacterium bovis bacillus Calmette-Guerin (BCG) has features that make it a particularly attractive live recombina
Thornton CA; Latif AS; Emmanuel JC; Department of Medicine, University of Zimbabwe School of; Medicine, Harare.
We studied the clinical features and human immunodeficiency virus (HIV) serology of 32 consecutive adults with inflammatory demyelinating polyneuropathy (IDP) admitted to the teaching hospitals in Harare, Zimbabwe . Twenty-nine of the IDP patients had Guillain-Barre syndrome (GBS)
McKendall RR; Oas J; Lairmore MD; Department of Neurology, University of Texas Medical Branch,; Galveston 77550.
We report three Texas-born patients with spastic paraparesis and well-documented infection with HTLV-I. CSF examination showed moderate pleocytosis, protein elevation, and elevated IgG index. Oligoclonal bands were present in two patients. On MRI, one patient had frontal lobe lesions that were low intensity on T1- and
Keane JR; Department of Neurology, Los Angeles County/University of; Southern California Medical Center.
In 50 hospitalized patients with acquired immunodeficiency syndrome, signs of central eye movement limitation (28 cases) were most common. Peripheral eye movement limitations (18), abnormalities of vision (18), and abnormal spontaneous eye movements (15) occurred with about equal frequency. Meningitis (17), usually du
N Y State J Med. 1991 Mar;91(3):93-7. Unique Identifier : AIDSLINE MED/91261293
Brown LS Jr; Chu A; Allain JP; Lee H; Cerney M; Nemoto T; Division of Medical Services, Addiction Research and Treatment; Corporation, Brooklyn, NY 11201.
To define further the magnitude, epidemiology, and clinical features of human T-cell lymphotropic/leukemia virus type I/II (HTLV-I/II) infection in 454 intravenous drug users in New York City, we evaluated previously frozen aliquots of sera for HTLV-I/II antibodies using enzyme-linked immunoassay, Western blot, and ra
The cumulative seroprevalence was 5.21% among the homo/bisexual men in the four years. As well as in Budapest, we experienced the increase of seroprevalence in the country, too, after a decrease in 1988. The cumulative seroprevalence was 0.44% with men and 0.04% with women in the group of the voluntary reporters in th
Cohen FL; Department of Medical-Surgical Nursing, University of Illinois; College of Nursing, Chicago.
Despite the still bleak picture of HIV infection and AIDS, there has been progress in pharmacologic therapeutic approaches. These comprise both direct and indirect approaches. Direct approaches include treatment aimed at the HIV whereas indirect approaches include boosting the immune system and treating or preventing
Zuckerman G; Metrou M; Bernstein LJ; Crain EF; Department of Pediatrics, Albert Einstein College of Medicine,; New York.
Cutaneous manifestations of HIV infections in childhood are common but are not the dermatologic lesions associated with HIV infection in adults. For example, Kaposi s sarcoma, a common finding in adults with AIDS, is rare in children. Other cutaneous manifestations, including bacterial and fungal lesions and viral exa
Mod Pathol. 1991 Mar;4(2):232-8. Unique Identifier : AIDSLINE MED/91261871
Cornford ME; Said JW; Vinters HV; Department of Pathology, UCLA Medical Center.
Immunohistochemical localization of human immunodeficiency virus type 1. (HIV-1) in central nervous system lymphoma lesions and uninvolved regions of the brain in seven patients with AIDS revealed evidence of frequent association of HIV-labeled macrophages and multinucleated giant cells with the lesions. Five of seven
Gonzalez Cocina E; Espinosa Caliani JS; Cabrerizo Comitre E; Arana Romero C; Perez Peinado M; Gonzalez Santos P; Servicio de Cardiologia, Hospital Clinico-Universitario Virgen; de la Victoria, Malaga.
We present 1 case of right sided endocarditis caused by Fusobacterium nucleatum in a patient with intravenous drug addiction and human immunodeficiency. The clinical features were fever, anemia, and pulmonary embolism. The echocardiogram showed a giant vegetation originated from the right atrial wall prolapsing in dia
Sherlock S; Department of Surgery, Royal Free Hospital School of Medicine,; London, United Kingdom.
The diagnosis of primary sclerosing cholangitis is made on cholangiographic appearances supported by liver histologic findings. Clinical features may be compatible but are not diagnostic and there is no specific diagnostic test. Immunologic mechanisms have been proposed as pathogenetic, but the evidence is far from co
This ethnographic study describes part of the social context in which heterosexual transmission of the human immunodeficiency virus (HIV) may be taking place. Based on interviews with sex partners of intravenous (IV) drug users in an urban, African American community of the United States
Ankrah EM; Department of Social Work and Social Administration, Makerere; University, Kampala, Uganda.
The presence of AIDS in epidemic proportions in the African context can directly and indirectly affect the health of the majority of people. AIDS highlights the social side of health, those factors of a social nature that enhances or potentially weakens the health status of individuals and whole communities. Attention
Weiblen BJ; Schumacher RT; Garrett PE; Hoff R; Massachusetts State Laboratory, Boston.
Detection of antibodies to the human immunodeficiency virus (HIV) in recently infected donors is crucial to prevent the transmission of HIV infection via blood products. To determine whether specific antibodies of the IgA or IgM class are present as markers of recent infection in donor specimens that have borderline r
Mayo DJ; Rose AM; Matchett SE; Hoppe PA; Solomon JM; McCurdy KK; American Institutes for Research, Washington, DC.
Even though all blood donated for transfusion is tested for the presence of human immunodeficiency virus (HIV) antibodies, there exists a period of time after infection by the virus before these antibodies can be detected. Blood donated during this window period is capable of transmitting the virus. Therefore, the blo
The acquired immune deficiency syndrome (AIDS) presents a global problem of XX century medicine. The speed with which this pathology spreads is great and the number of AIDS patients is increasing in geometric progression. At present AIDS is a real threat to the health and life of millions of people. It is very difficu
Women Health. 1991;17(1):21-37. Unique Identifier : AIDSLINE MED/91263407
Shayne VT; Kaplan BJ; Social Science Research Laboratory, American University,; Washington, DC 20016-8019.
Women constitute the fastest growing group of people with AIDS; a disproportionate number of poor minority women are affected. Education and prevention campaigns have not been directed at this population. Though intravenous drug users have been identified as at risk, many American women have been identified as HIV pos
Scadden DT; Bering HA; Levine JD; Bresnahan J; Evans L; Epstein C; Groopman JE; Department of Medicine, New England Deaconess Hospital, Harvard; Medical School, Boston, Massachusetts.
Combined zidovudine (ZDV) and interferon-alpha (IFN) is an appealing therapy for AIDS-associated Kaposi s sarcoma because of the antiretroviral as well as antitumor potential of this combination. Overlapping myelotoxicity of these agents, however, frequently complicates their clinical use. This phase I/II study was un
Am J Nephrol. 1991;11(1):61-3. Unique Identifier : AIDSLINE MED/91264011
Elsey RM; Carson RW; DuBose TD Jr; Department of Internal Medicine, University of Texas Medical; Branch, Galveston.
Pasteurella multocida has been reported only once previously as a cause of peritonitis in a patient undergoing chronic peritoneal dialysis. The present report describes findings associated with a case of P. multocida peritonitis in a human immunodeficiency virus (HIV)-positive patient in which renal replacement therap
Am J Orthopsychiatry. 1991 Apr;61(2):168-78. Unique Identifier : AIDSLINE MED/91264078
Christ GH; Siegel K; Mesagno FP; Langosch D; Memorial Sloan-Kettering Cancer Center, New York.
A brief, standardized intervention program to facilitate children s adjustment to the terminal illness and death of a parent posed the following implementation problems: estimation of patient life expectancy; engagement of the family in crisis; adhesion to the parental guidance model; and termination of formal clinica
Monfort-Gouraud M; Duyckaerts V; Boccara F; de Boissieu D; Guillou MA; Badoual J; Service de Pediatrie B, Hopital Saint-Vincent-de-Paul, Paris.
A case of hyperalgesic pseudothrombophlebitis in an hemophilic child with acquired immune deficiency syndrome (AIDS) is reported. Known causes such as associated blood clotting defect, collagen vascular disease, infection and homocystinuria were ruled out. Five similar cases were reported in 1985, in homosexual Americ
Kienzle N; Broker M; Harthus HP; Enders M; Erfle V; Buck M; Muller-Lantzsch N; Abteilung Virologie, Institut fur Medizinische Mikrobiologie und; Hygiene, Homburg, Federal Republic of Germany.
We constructed and expressed different overlapping fusion proteins with the nef gene of HIV-1 and generated specific polyclonal rabbit and monoclonal mouse antibodies against these recombinant proteins. The rabbit antisera, one of the monoclonal antibodies as well as a serum from a HIV-1 infected patient recognized th
Shimoyama M; Hematology-Oncology and Medical Oncology Division, National; Cancer Center Hospital, Tokyo, Japan.
T-lymphoma, including adult T-cell leukemia-lymphoma (ATL) accounted for 75% of non-Hodgkin s lymphoma in the Kyushu district of Japan and for 43% in the nation as a whole. Human T-cell leukemia/lymphoma virus type I (HTLV-I) is closely associate
Int Immunol. 1991 Mar;3(3):245-54. Unique Identifier : AIDSLINE MED/91265461
Nishida J; Yoshida M; Arai K; Yokota T; Department of Molecular Biology, DNAX Research Institute of; Molecular and Cellular Biology, Palo Alto, CA 94304-1104.
The human IL-3 gene, located on chromosome 5, contains several cis-acting DNA sequences, i.e. CLE (conserved lymphokine element) and a GC-rich region, similar to the GM-CSF gene. To investigate the role of these elements, the 5 flanking region of the IL-3 gene was attached to a bacterial chloramphenicol acetyltransfe
Ann Hematol. 1991 May;62(5):151-5. Unique Identifier : AIDSLINE MED/91265697
Geissler RG; Ottmann OG; Eder M; Kojouharoff G; Hoelzer D; Ganser A; University of Frankfurt/Main, Department of Hematology, Federal; Republic of Germany.
With progressive disease, the majority of patients with human immunodeficiency virus (HIV) infection develop bone marrow failure with anemia, leukopenia, and thrombocytopenia, the cause of which has not yet been clarified. Besides direct infection of bone marrow progenitor cells and immune-mediated cytolysis, the acti
Ann Hematol. 1991 May;62(5):165-8. Unique Identifier : AIDSLINE MED/91265700
de la Salle C; Baas MJ; Laustriat D; Guy B; Bordes E; Wiesel ML; Grunebaum L; Lutz P; Partisani M; Lang JM; et al; Centre Regional de Transfusion Sanguine, Service d'Hemostase et; de Thrombose, INSERM U. 311, Strasbourg, France.
We evaluated the validity of DNA enzymatic amplification (PCR) in a population at risk for HIV-1 infection, consisting of hemophiliacs and children born to seropositive mothers. All but one of the seropositive hemophiliacs and controls were found positive with the three sets of primers. All the seronegative patients a
Bull N Y Acad Med. 1991 Mar-Apr;67(2):184-6. Unique Identifier : AIDSLINE MED/91265946
Barondess JA; Farber SJ; Rogers DE; Adler KP; Cohen JJ; Finberg L; Kase NG; Pardes H; Purpura DP; Shires GT; et al; New York Academy of Medicine, New York.
Can J Public Health. 1991 Mar-Apr;82(2):87-91. Unique Identifier : AIDSLINE MED/91266181
Northcott HC; Reutter L; Department of Sociology, University of Alberta, Edmonton, Canada.
This study examines public attitudes toward AIDS issues and tests the extent to which fear of contracting AIDS and attitude toward homosexuality influence opinions regarding the screening of potentially infected persons and the isolation of those already identified as infected. The data for this study are drawn from a
Acquired Immune Deficiency Syndrome (AIDS) is a devastating medical illness of epidemic proportions with cases continuing to increase at an alarming rate. Hospital nurses at all levels and in all specialized areas of practice are affected by the challenge of caring for AIDS patients, who have overwhelming physical and
Poplin EA; Gordon CJ; Piskorowski TJ; Chandrasekar PH; Division of Hematology and Oncology, Harper Hospital, Wayne State; University, Detroit, MI.
Pneumocystis carinii pneumonia (PCP) developed in two patients with solid tumors without acquired immune deficiency syndrome (AIDS). In patients with neoplastic solid tumors, as in those with hematologic malignancies, Pneumocystis is a possible cause of pneumonia. Management protocols evaluating pulmonary infiltrates
Cassulis P; Magasic MV; DeBari VA; Department of Medicine, Seton Hall University, School of Graduate; Medical Education.
We purified IgG by an automated chromatographic procedure, using a recombinant DNA-produced Protein G ligand bound to silica as the solid phase. The IgG can be separated from human serum in approximately 20 min with little operator manipulation. Recovery studies indicate that unconcentrated eluates contain 77-100% of
Farley TA; Pomputius PF; Sabella W; Helgerson SD; Hadler JL; Department of Health Services, Hartford, CT.
To measure the effect of school-based education on adolescents AIDS knowledge and attitudes, we conducted surveys in two high schools and compared them to a baseline survey conducted in the same schools the previous year. One month before the follow-up survey, students in one of the two schools (the intervention scho
Checko PJ; Miller JW; Averbach C; AIDS Section, Connecticut Department of Health Services, Hartford; 06106.
From 1980 to 30 September 1990, 1,769 Connecticut cases of AIDS have been diagnosed and reported. The epidemiology of AIDS in Connecticut continues to differ from national patterns in several important ways. Intravenous drug users (IVDUs) have been the most prominent source of new cases since 1986 and made up 49% of a
Checko PJ; Abshire JP; Roach AI; Markowski M; Backman L; AIDS Section, Connecticut Department of Health Services.
A seroprevalence survey of human immunodeficiency virus (HIV) among childbearing women in Connecticut is being conducted as one of the family of HIV seroprevalence surveys funded by the Centers for Disease Control (CDC). Between 1 April 1989 and 30 March 1990 dried blood specimens submitted from all newborns (45,890)
To identify the characteristic features of lues in patients infected with HIV, 402 HIV-positive patients were examined for serological and clinical signs of lues. 141 patients (133 male, 8 female, mean age 36 [18-69] years) had a positive lues serology. Treatment for lues was required in 20 of the 141 cases (14%). In
Donnet A; Harle JR; Cherif AA; Gastaut JA; Weiller PJ; Clinique de Neurologie, CHU La Timone, Marseille.
Maccario et al. described, in 1987, the case of an HIV-positive patient whose psychotic symptomatology was the expression of right centrum semi-ovale lesion. We report the case of a patient who suffered a sudden delirium, expression of a probable right lenticular cerebral toxoplasmosis. This 35-year-old male homosexua
EMBO J. 1991 Jul;10(7):1733-9. Unique Identifier : AIDSLINE MED/91266901
Mann DA; Frankel AD; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
The human immunodeficiency virus-1 (HIV-1) Tat protein has previously been shown to transactivate the HIV-1-LTR when added exogenously to HeLa, H9 lymphocytic and U937 promonocytic cells growing in culture. Here we show that Tat enters these cells by adsorptive endocytosis. Tat appears to bind non-specifically to the
Crosby DL; Berger TG; Woosley JT; Resnick SD; Department of Dermatology, Medical College of Wisconsin,; Milwaukee.
Kaposi s sarcoma (KS) is an important finding in patients infected with human immunodeficiency virus (HIV), with a distinctive spectrum of clinical presentations. Three cases of dermatophytosis in HIV-infected patients are presented which clinically mimic the appearance of KS. This new observation underscores the impo
Since 1986 the notation Human Immunodeficiency Virus (HIV) is used for the retroviral agent of the Acquired Immunodeficiency Syndrome (AIDS). At the beginning of the therapeutical interest in the immunodeficiency syndrome have been primarily focussed in the internal complications. 1982 one reported for the first time
Hosp Community Psychiatry. 1991 Apr;42(4):347-9. Unique Identifier : AIDSLINE MED/91267494
Rosen MI; Kosten TR; Substance Abuse Treatment Unit, Connecticut Mental Health Center,; New Haven 06511.
This month s guest authors are affiliated with the substance abuse treatment and treatment research unit of the Connecticut Mental Health Center and the department of psychiatry at Yale University School of Medicine, where Dr. Rosen is instructor and Dr. Kosten is associate professor. They discuss a promising new trea
Through epidemiological considerations we conclude that full-blown AIDS may occur only if the index patient is infected by the human immunodeficiency virus (HIV) and, in addition, by some other infectious coagent. Since the dynamical behavior of the spread of AIDS cases with manifestation of Kaposi s sarcoma differs f
Weimer CE Jr; Sahn EE; Department of Dermatology, Medical University of South Carolina,; Charleston 29425-2215.
Palpable purpura in a follicular localization developed in association with acute epididymitis in a white man who was seropositive for the human immunodeficiency virus (HIV). Biopsy specimens revealed a leukocytoclastic vasculitis with follicular accentuation. With antibiotic therapy the vasculitis resolved, but it re
Moritz DL; Elmets CA; Department of Dermatology, Case Western Reserve University,; University Hospitals of Cleveland, OH 44106.
Eosinophilic pustular folliculitis is characterized by the spontaneous development of recurrent, sterile papules, pustules, and plaques on the face, trunk, arms, and occasionally the palms and soles. Although the large majority of the reported cases have occurred in Eastern Asians, most patients in the
Slonim-Nevo V; Ozawa MN; Auslander WF; Spitzer Department of Social Work, Ben-Gurion University of the; Neger, Beer Shera, Israel.
This study assesses the level of knowledge about and attitudes toward AIDS among youth residing in residential centers. It also assesses the degree to which they engage in high risk behaviors related to AIDS. The study evaluates the impact of a short educational intervention on the youth s knowledge, attitudes, and be
Desmond-Hellmann SD; Mbidde EK; Kizito A; Hellmann NS; Ziegler JL; Uganda Cancer Institute, Makerere University, Kampala.
Kaposi s sarcoma (KS) in African adults can present in endemic (non-HIV-related) and epidemic (HIV-related) forms. We evaluated the usefulness of a clinical case definition for epidemic KS in predicting HIV seropositivity. A total of 235 patients with KS presenting to the Uganda Ca
Greenspan D; Greenspan JS; Overby G; Hollander H; Abrams DI; MacPhail L; Borowsky C; Feigal DW Jr; Oral AIDS Center, School of Dentistry, UCSF 94143-0512.
To determine risk factors for early progression from oral hairy leukoplakia to AIDS, this case-control study compared 27 patients who had not progressed to AIDS within 1,000 days of diagnosis of hairy leukoplakia with 28 patients who progressed rapidly. The risk factors that proved most predictive fell into two catego
Northfelt DW; Mayer A; Kaplan LD; Abrams DI; Hadley WK; Yajko DM; Herndier BG; Department of Medicine, San Francisco General Hospital, CA 94110.
To determine the utility of bone marrow examination for the diagnosis of opportunistic infections and lymphoma in patients with known or suspected human immunodeficiency virus (HIV) infection, we retrospectively reviewed the medical and laboratory records of all patients undergoing diagnostic bone marrow examinations
Dawson JD; Lagakos SW; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115.
Repeated measurements of laboratory markers of immunologic or disease status, such as CD4 lymphocyte counts and HIV p24 antigen levels, can be important end points in comparative clinical trials. In this report, we consider comparison of treatment groups with respect to such markers, focusing on a distribution-free ap
In this study we raised antibodies against Candida albicans mannans of serotype A and B which comprise mannose alpha(1----2)-and mannose alpha(1----3)-linked residues. These antibodies inhibited human immunodeficiency virus type IIIB (HIV-IIIB) infection of H9 cells in vitro; 5 micrograms/ml of antibodies against mann
Read SE; Major CJ; Coates RA; Francis A; Raboud J; McLaughlin BJ; Shepherd FA; Fanning MM; Calzavara LM; MacFadden DK; et al; Department of Pediatrics, Faculty of Medicine, University of; Toronto, Ontario, Canada.
HIV antigen detection kits are available from a number of commercial sources. Abbott, Coulter, and Du Pont antigen kits were used to test 661 sera collected sequentially from 65 members of the Toronto Sexual Contact Study (TSCS). The sera had been collected at 3-month intervals over 4 years from nine persistently HIV-
J S C Med Assoc. 1991 Mar;87(3):113-50. Unique Identifier : AIDSLINE MED/91269742
Bryan CS
Management of the early stages of HIV infection has become relatively straightforward. Therapy with AZT (Retrovir) should be instituted when the CD4 count is consistently between 400 and 500 per cmm, and prophylaxis against Pneumocystis carinii pneumo
de Quiros JF; Telenti M; Fleites A; Moreno Torrico A; Figueroa E; Servicio de Medicina Interna, Hospital General de Asturias,; Oviedo.
A male patient of 33 years of age with AIDS developed pneumonia with abscess formation and a slow clinical course. The sputum, bronchoalveolar lavage and blood cultures yielded a Gram-positive, partially acid-alcohol resistant bacillus which was identified as Rhodococcus equi. This organism has been uncommonly implica
BACKGROUND: A clinical, histologic, immunohistochemical, serological and evolutive review was carried out in 12 cases of Kaposi s sarcoma, representing 5.5% (12/217) of the HIV positive patients consecutively seen during an 18 month period. METHODS: The patients were clinically examined and staging was assessed. Skin
Sanchez-Toril F; Robles A; Lopez M; Berbegal J; Pasquau F; del Campo F; Seccion de Neumologia, Hospital Marina Alta, Denia, Alicante.
Pulmonary infection by Pneumocystis carinii in patients with acquired immunodeficiency syndrome (AIDS) can result in different radiological patterns with an ever expanding spectrum. A 40-year-old male, infected with the human immunodeficiency virus (HIV), presented with toxic symptoms and multiple pulmonary cystic les
Jansen RW; Molema G; Pauwels R; Schols D; De Clercq E; Meijer DK; Department of Pharmacology and Therapeutics, Groningen; University, The Netherlands.
A series of neoglycoproteins was synthesized by coupling of thiophosgene-activated p-aminophenyl derivatives [Biol. Cell. 47:95-110 (1983); J. Histochem. Cytochem. 32:1091-1094 (1984)] of various sugars to human serum albumin. The compounds were evaluated for their in vitro activity against human immunodeficiency viru
Greenberg AE; Nsa W; Ryder RW; Medi M; Nzeza M; Kitadi N; Baangi M; Malanda N; Davachi F; Hassig SE; Division of Parasitic Diseases, Centers for Disease Control,; Atlanta, GA 30333.
BACKGROUND. It is uncertain whether Plasmodium falciparum malaria is more frequent or more severe in children with perinatally acquired human immunodeficiency virus type 1 (HIV-1) infection and whether P. falciparum infection accelerates the progression of HIV-related disease. METHODS. We conducted a prospective, long
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4616-20. Unique Identifier : AIDSLINE MED/91271244
Watanabe M; Levine CG; Shen L; Fisher RA; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
Since the CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV), it has been suggested that a soluble truncated form of CD4 may compete with cell-surface CD4 for HIV binding and thus be of use in the therapy of AIDS. We have utilized the simian immunodeficiency virus of macaq
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5326-30. Unique Identifier : AIDSLINE MED/91271382
Luria S; Chambers I; Berg P; Department of Biochemistry, Beckman Center, Stanford University; Medical Center, CA 94305.
Stable transformants of the Jurkat T-cell line have been obtained that express either of two distinct forms of the type 1 human immunodeficiency virus nef gene: the nef-1-encoded protein (Nef-1) contains alanine, glycine, and valine at positions 15, 29, and 33, respectively; the protein specified by nef-2 (Nef-2) has
Teixidor HS; Godwin TA; Ramirez EA; Department of Radiology, New York Hospital-Cornell Medical; Center, NY 10021.
Cryptosporidiosis of the biliary system was studied retrospectively in 13 patients with acquired immunodeficiency syndrome (AIDS). The diagnosis was made by means of histologic examination (n = 9) or imaging studies and the presence of intestinal cryptosporidiosis (n = 4). Imaging studies were done in 10 patients. Ult
Sant'Anna GD; Franche GL; Tabajara LM; Favero RM; Kuhl G; Universidade Federal do Rio Grande do Sul, Departament of; Otolaryngology, School of Medicine, Porto Alegre, Brazil.
In this study, the authors analysed retrospectively 161 patients with acquired immunodeficiency syndrome interned at the Hospital de Clinicas de Porto Alegre. 115 (71.4%) presented with otolaryngologic lesions. 92.2% were male. The great majority were white and aged between 20 and 50 years of age (88.7%). Homosexual a
Clumeck N; Departement de Medecine interne, l'Hopital Saint-Pierre.
HIV epidemic is still expanding all over the world. Heterosexual transmission into the general population is of particular concern mostly in Africa and Western countries. So far, pathogenesis of the syndrome is best explained by the likely role of co-factors that interfere with the latency phase of the virus. In this
Rev Med Brux. 1991 Apr;12(4):127-34. Unique Identifier : AIDSLINE MED/91271723
Legrand JC; Bastin F; Denachtergael C; Departement d'Hematologie-Oncologie et Maladies Infectieuses,; Hopital Civil de Charleroi.
When more and more health care workers are involved in treatment of patients infected with HIV, the fear of professional acquisition has to be met. Data about real risk and the type of recommended prophylactic measures are reviewed. A realistic approach of this problem in our health care settings is attempted.
Schweiz Rundsch Med Prax. 1991 May 21;80(21):580-3. Unique Identifier : AIDSLINE MED/91271738
Michel B; Rheumaklinik, Universitatsspital, Zurich.
The seronegative spondyloarthropathies are a group of mostly chronic diseases sharing many clinical, radiologic, and genetic features. Described are the main characteristics of the different subsets. Growing evidence of new disease associations will lend new impulses to research of pathogenesis.
South Med J. 1991 Jun;84(6):733-5, 739. Unique Identifier : AIDSLINE MED/91271974
Dull JS; Sen P; Raffanti S; Middleton JR; Raritan Bay Medical Center, Perth Amboy, NJ.
All reported clinical characteristics of acute retroviral illness with the human immunodeficiency virus (HIV) are nonspecific. Signs and symptoms described are associated with a variety of acute infections. We report the cases of three patients in whom the acute retroviral illness was characterized by transient oral c
South Med J. 1991 Jun;84(6):796-8. Unique Identifier : AIDSLINE MED/91271994
Villamil A; Hammer RA; Rodriguez FH; Department of Medicine, Tulane University School of Medicine, New; Orleans, La.
A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreatitis should be empha
South Med J. 1991 Jun;84(6):799-800. Unique Identifier : AIDSLINE MED/91271995
Deer T; Rosencrance JG; Chillag SA; Department of Internal Medicine, West Virginia University School; of Medicine, Charleston 25304.
This study shows that conduction abnormalities may occur frequently in Reiter s syndrome of new onset or short duration. Since these conduction defects may be initially life threatening or may progress to life-threatening abnormalities, anyone with RS should be followed up. Because of the strong association between RS
Hadden JW; Immunopharmacology Division, University of South Florida Medical; College, Tampa 33612.
HIV infection results in the destruction of the thymus-dependent cellular immune system and death due to opportunistic infection and malignancy. Immunosuppressive influences (other sexually or blood-transmitted viruses, HIV-derived peptides, semen, poor nutrition, drugs, etc.) favor the progression of the disease. Alt
Imamura A; Kitagawa T; Ohi Y; Osame M; Department of Urology, Faculty of Medicine, Kagoshima University,; Japan.
Patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) sometimes have accompanying voiding disturbances. We performed clinical surveys and urodynamic examinations on 25 untreated patients with HAM. Although 4 cases (16%) were entirely aware of urinary symptoms, the onset of urinary s
Angulo JC; Lopez JI; Unda-Urzaiz M; Larrinaga JR; Zubiaur CL; Flores NC; Department of Urology, Santo Hospital Civil de Bilbao, Spain.
Kaposi s sarcoma of the penis is an initial manifestation of AIDS and the practising urologist should be aware of this form of presentation. We report 2 young intravenous drug abusers with this tumor in the male genitourinary system. The clinical course is unfavorable; therefore prompt diagnosis and management, based
Nebreda AR; Bryan T; Segade F; Wingfield P; Venkatesan S; Santos E; Laboratory of Molecular Microbiology, NIAID, National Institutes; of Health, Bethesda, Maryland 20892.
Human immunodeficiency virus type 1 (HIV-1) NEF protein has been reported to share certain biochemical and structural properties with known oncoproteins like src or rats. To determine whether this is a general property of NEF from various HIV isolates, three different NEF proteins were expressed in Escherichia coli us
Expression, ribosomal frameshifting, and proteolytic processing of HIV-1 GAG and POL proteins were investigated in heterologous mammalian cells in order to elucidate the influence of the cellular background on these events. DNA fragments encoded by the gag and pol region were expressed in two rodent cell lines, LTK- a
Friedrich R; Friedrich U; Maennle G; Division of Molecular Oncology, Justus Liebig University,; Giessen, Germany.
The replication-defective Friend spleen focus-forming virus (F-SFFV) induces acute erythroblastosis in adult mice. The envelope-related (env) gene and LTR are the only functional elements of the viral genome. The env-coded glycoprotein gp55 has been shown to be responsible for target cell specificity and for the short
Ranta K; Tuominen R; Department of Cariology, University of Helsinki, Finland.
The purpose of this investigation was to study the knowledge about HIV infection and AIDS among dental students in Helsinki, Finland , and in Dar es Salaam, Tanzania . All respondents knew that H
This report describes four patients who presented with masses in the tail of the parotid gland and who were seropositive for antibody to the human immunodeficiency virus. Two had unilateral gland enlargement and the other two had bilateral disease. A characteristic cyst appearance and a benign lymphoepithelial infiltr
Havlichek DH Jr; Greenman E; Plaisier K; Department of Medicine, Michigan State University, East Lansing.
To determine the prevalence of risk factors for blood-borne infections in a city with a low prevalence of human immunodeficiency virus (HIV), we confidentially surveyed 397 adult inpatients in three community hospitals. Twenty-one percent of inpatients reported one or more risk factors, 56% denied risks, 15% were unab
Gan To Kagaku Ryoho. 1991 Jun;18(7):1112-7. Unique Identifier : AIDSLINE MED/91273378
Takatsuki K; Hattori T; Yamaguchi K; Matsuzaki H; Asou N; Kiyokawa T; Maeda Y; Suzushima H; Second Dept. of Internal Medicine, Kumamoto University Medical; School.
ATL (adult T-cell leukemia) is the first human cancer known to be caused by a retrovirus. ATL cells show usually positive for CD2, CD3, CD4, CD25 and HLA-DR, but negative for CD8. They produce a variety of cytokines, including IL-1, IL-2 , TNF, ADF and PTHrP. PTHrP is c
Bolton-Maggs PH; Rogan PD; Duguid JK; Mutton KJ; Ball LM; Royal Liverpool Children's Hospital, Alder Hey.
Eleven haemophiliac boys infected with HIV were screened for irregular red cell antibodies and were compared with nine haemophiliac boys who did not have antibodies to HIV. Seven (64%) of the children who had antibodies to HIV also had cold agglutinins, mostly of anti-I specificity, compared with one (11%) of those wh
Sato K; Maruyama I; Maruyama Y; Kitajima I; Nakajima Y; Higaki M; Yamamoto K; Miyasaka N; Osame M; Nishioka K; Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Ten patients with chronic inflammatory arthropathy and the human T lymphotropic virus type I (HTLV-I) are described. These patients showed chronic persistent oligoarthritis, associated with proliferative synovitis, in large joints. The place of birth or residence of these patients was within the area endemic for adult
Med Clin (Barc). 1991 Feb 23;96(7):245-7. Unique Identifier : AIDSLINE MED/91245849
Diaz Portillo J; Garcia-Martos P; Alvarez Rojas C; Castano Lopez MA; Gonzalez Borrachero ML; Martinez-Pais Romani R; Servicios de Analisis Clinicos, Hospital del Servicio Andaluz; de Salud, Cadiz.
BACKGROUND: Human immunodeficiency virus (HIV) shares transmission mechanisms with some hepatotropic viruses, such as hepatitis B (HBV), C (HCV) and delta (HDV) viruses. METHODS: To evaluate the prevalence of infection in a group of 100 male prisoners, carriers of the human immunodeficiency virus, the serologic marker
Hollister WS; Canning EU; Willcox A; Department of Biology, Imperial College, London.
The enzyme-linked immunosorbent assay (ELISA) was used to survey human sera for antibodies to Encephalitozoon cuniculi using spores obtained from in vitro cultures as antigen. Sera were obtained from patients with tropical diseases, neurological and renal disorders, patients who were HIV positive and those who had bee
Ammar A; Cibert C; Bertoli AM; Tsilivakos V; Jasmin C; Georgoulias V; Unite d'Oncogenese Appliquee, Institut National de la Sante; et de la Recherche Medicale Unite 268, Hopital Paul Brousse,; Villejuif, France.
Adherent cells from human immunodeficiency virus (HIV)-infected subjects but not from normal blood donors, patients with Gram-positive or -negative bacteremia, active tuberculosis, toxoplasmosis, pulmonary aspergillosis, and cytomegalovirus infection produce spontaneously an activi
Moriyama EN; Ina Y; Ikeo K; Shimizu N; Gojobori T; National Institute of Genetics, Mishima, Japan.
Human immunodeficiency viruses (HIVs) show extensive genetic variation. This feature is the fundamental cause of pathogenicity of HIVs and thwarts efforts to develop effective vaccines. To understand the mutation mechanism of these viruses, we analysed nucleotide sequences of env and gag genes of the viruses by use of
Grassmann R; Berchtold S; Aepinus C; Ballaun C; Boehnlein E; Fleckenstein B; Institut fur Klinische und Molejulare Virologie, Universitat; Erlangen-Nurnberg, Federal Republic of Germany.
Human T-cell leukemia virus (HTLV-I, HTLV-II) rex protein function is required for the cytoplasmic expression of incompletely spliced viral transcripts encoding structural proteins. The effect is mediated by a cis-acting rex-response element (RRX) which is located near the 3 end of all viral mRNAs. We show that rex p
STUDY OBJECTIVE: To determine forms of malnutrition and basal metabolism at different stages of immunological impairment in clinically stable patients infected with Human Immunodeficiency Virus (HIV). DESIGN: Cross sectional study. SETTING: 53 outpatients with HIV-infection classified according to the Walter Reed stag
Murthy AR; Ho D; Goetz MB; Department of Medicine, Sepulveda Veterans Administration Medical; Center, California 91343.
Infection due to the human immunodeficiency virus (HIV) has been complicated by the development of acute nonlymphocytic leukemia in five patients whose cases have previously been reported; other manifestations, including preleukemia, myelofibrosis, and myeloid hyperplasia, have also been reported in patients infected
In the last few years, the treatment of HIV infection has advanced considerably due to the development of active antiretroviral compounds. Many substances with different mechanisms of action show strong activity against HIV in vitro and many of them are now under clinical investigation. But immense effort is needed to
Finfer M; Perchick A; Burstein DE; Department of Pathology, Bellevue Hospital, New York, New York.
All Bellevue Hospital cases from a recent 27-month period whose fine needle aspiration (FNA) samples of cervical or supraclavicular masses showed acute and/or granulomatous inflammation were reviewed. The 30 patients included 8 with the acquired immune deficiency syndrome (AIDS), 3 with the AIDS-related complex (ARC),
Fujino R; Kawato K; Ikeda M; Miyakoshi H; Mizukoshi M; Imai J; Diagnostic Research Laboratories, Fujirebio Inc., Tokyo.
Partial modifications of antigen components were made to improve the gelatin particle agglutination (PA) test for the detection of antibodies against human T cell leukemia virus type-I. Envelope glycoproteins prepared by lentil lectin affinity chromatography were further added to the purified viral antigens to be coat
Kontio S; Labsystems Research Laboratories, Helsinki, Finland.
An enzyme immunoassay (EIA) with a single incubation step has been developed to detect the HIV-1 major core polypeptide p24 in human blood specimens and in cell culture supernatants. In this assay, the solid phase is coated with monoclonal antibodies to p24, and the specimen is incubated simultaneously with peroxidase
Nature. 1991 Jun 6;351(6326):456-60. Unique Identifier : AIDSLINE MED/91260847
Stover CK; de la Cruz VF; Fuerst TR; Burlein JE; Benson LA; Bennett LT; Bansal GP; Young JF; Lee MH; Hatfull GF; et al; MedImmune Incorporated, Gaithersburg, Maryland 20878.
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been develop
Friedland LR; Bell LM; Rutstein R; Division of General Pediatrics, Children's Hospital of; Philadelphia, PA.
A retrospective review was conducted of 22 human immunodeficiency virus type 1 (HIV-1)-infected children under 13 years of age presenting to an inner city pediatric emergency department to determine their clinical manifestations of disease and utilization of emergency department services. When compared with a populati
Science. 1991 Jun 21;252(5013):1703-5. Unique Identifier : AIDSLINE MED/91262653
Finberg RW; Wahl SM; Allen JB; Soman G; Strom TB; Murphy JR; Nichols JC; Laboratory of Infectious Diseases, Dana-Farber Cancer Institute,; Boston, MA.
Infection by human immunodeficiency virus type 1 (HIV-1) is associated with cellular activation and expression of the interleukin-2 ( IL-2 ) receptor. A genetically engineered fusion toxin, DAB486 IL-2, that contains the enzymatic site and translocation domain of diphthe
Hickey MS; University of California, San Francisco.
Investigators are now predicting that nearly 100% of the estimated 12 million HIV-positive persons in the world will develop AIDS. Most persons with AIDS will experience progressive weight loss and malnutrition prior to death. Because nutritional therapy clearly has a beneficial effect on the clinical course and immun
Polonis VR; Anderson GR; Vahey MT; Morrow PJ; Stoler D; Redfield RR; Department of Retroviral Research, Walter Reed Army Institute of; Research, Rockville, Maryland 20850.
The effects of oxygen deprivation, or anoxia, on human immunodeficiency virus (HIV-1) expression in chronically (ACH.2) and acutely (H9/HIV-1-IIIB) infected cell lines was investigated. Temporary cellular anoxia has previously been shown to activate transcription of endogenous type C leukemia virus sequences, resultin
The acquired immunodeficiency syndrome and (human immunodeficiency virus) infection loom as our major public health priorities for at least the next two decades. Despite the recent exciting early development of vaccines and newer drug therapies, we are all faced with a reservoir of almost one-quarter million cases in
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4723-7. Unique Identifier : AIDSLINE MED/91271265
Berg J; Lotscher E; Steimer KS; Capon DJ; Baenziger J; Jack HM; Wabl M; Department of Microbiology and Immunology, University of; California, San Francisco 94143-0414.
Although AIDS patients lose human immunodeficiency virus (HIV)-specific cytotoxic T cells, their remaining CD8-positive T lymphocytes maintain cytotoxic function. To exploit this fact we have constructed bispecific antibodies that direct cytotoxic T lymphocytes of any specificity to cells that express gp120 of HIV. Th
Public Health Rep. 1991 May-Jun;106(3):297-304. Unique Identifier : AIDSLINE MED/91271514
Schilling RF; el-Bassel N; Schinke SP; Gordon K; Nichols S; Columbia University School of Social Work, New York, NY 10025.
Although most women infected with HIV are intravenous drug users, some contact the virus through sexual contact with IV drug users. To reach at-risk women, public health officials must develop a range of prevention strategies. One approach, skills training, holds promise as a means of altering risk-related sexual beha
In an AIDS patient who had repeated successful treatment with acyclovir in his history, erosive herpes perianalis with herpes proctitis appeared, which persisted over several weeks. High-dose intravenous administration on of acyclovir (500-750 mg, 3 x daily, over 7 weeks) did no
Jacobsen MA; van der Horst C; Causey DM; Dehlinger M; Hafner R; Mills J; Department of Medicine, University of California, San Francisco.
Zidovudine and foscarnet each have antiretroviral activity against human immunodeficiency virus (HIV) and, when combined in vitro, inhibit HIV replication in an additive or synergistic fashion. To determine if an in vivo additive or synergistic antiretroviral effect might result from combined therapy, six symptomatic
Stellbrink HJ; Albrecht H; Loning T; Greten H; Medizinische Kernklinik und Poliklinik, Universitatskrankenhaus; Eppendorf, Hamburg.
The case of a 25-year-old homosexual man with large inguinal and perianal ulcers is reported. He had been pretreated extensively with acyclovir . Herpes simplex virus (HSV) was identified in the ulcer tissue by in-situ hybridization. No clinical improvement with acyclovir but a p
Weinstein BD; Keyes GG; Center for Health Ethics and Law, West Virginia University Health; Sciences Center, Morgantown 26506.
This article provides an ethical and legal analysis of a previously reported case involving an HIV-positive dental student at the Medical College of Georgia . We conclude that the college acted appropriately from an ethical point of view and probably exceeded its legal obligations
C R Acad Sci III. 1991;312(5):197-202. Unique Identifier : AIDSLINE MED/91256032
Autran B; Sadat-Sowti B; Debre P; Laboratoire d'Immunologie cellulaire et tissulaire, U.A.-C.N.R.S.; n. 186, Paris.
We report a new suppressor function of CD8+CD57+ lymphocytes from HIV-seropositive patients or allotransplanted recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha beta. A pre
Yamagoe S; Kohda T; Oishi M; Institute of Applied Microbiology, University of Tokyo, Japan.
Gene expression of human immunodeficiency virus type 1 (HIV-1) is induced not only by trans activation mediated through a gene product (tat) encoded by the virus but also by treatment of virus-carrying cells with DNA-damaging agents such as UV light. Employing an artificially constructed DNA in which the chloramphenic
628 pupils from both the northern and southern parts of West Germany (Baden-Wurttemberg, Bavaria, Lower Saxony, Schleswig-Holstein) were interviewed via an infectious diseases questionnaire: 44 questions dealt with vaccination (vaccination history, opinions of efficiency of differ
Poizot-Martin I; Lafeuillade A; Dhiver C; Xeri L; Bouabdallah R; Gamby T; Gastaut JA; Hopital de jour du CISIH, Hopital Salvator, Marseille.
Four cases of pigmentation of the skin and mucous membranes in homosexuals of the IVC1 group (CDC classification) are reported. The aetiological investigation, although incomplete, pointed to a medicinal origin which could not be formally confirmed. The drugs suspected were azidothymidine, pyrimethamine and ketoconazo
Maruta H; Holden J; Sizeland A; D'Abaco G; Melbourne Tumor Biology Branch, Ludwig Institute for Cancer; Research, Victoria, Australia.
The oncogenic transformation of a normal fibroblast by mutated Ras genes can be reversed by overexpression of a Ras-related gene called Rap1A (or Krev1). Both Ras and Rap1A proteins are G proteins and appear to serve as signal transducers only in the GTP-bound form. Therefore, GAP1 and GAP3, which stimulate the intrin
Clerici M; Tacket CO; Via CS; Lucey DR; Muluk SC; Zajac RA; Boswell RN; Berzofsky JA; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.
Healthy, human immunodeficiency virus seronegative (HIV-) volunteers were multiply immunized with a recombinant gp160 (rgp160) candidate acquired immunodeficiency syndrome (AIDS) vaccine. Peripheral blood lymphocytes from volunteers immunized with 40 micrograms or with 80 micrograms (two volunteers per group) of rgp16
Mansour AM; Uchida T; Rodenko G; Dutt R; Department of Ophthalmology, University of Texas Medical Branch,; Galveston 77550.
We analysed the correlation between ophthalmic and systemic findings in 125 subjects with AIDS and 50 subjects with AIDS-related complex (ARC). Positive eye findings were defined as the presence of cotton-wool spots (CWS) or cytomegalovirus (
Law CL; Merianos A; Grace J; Rose BR; Thompson CH; Cossart YE; STD Centre, Sydney Hospital, Australia.
To determine the significance of overt anogenital warts as indicators of human papillomavirus (HPV) infection of the cervix, 177 women attending a Sydney STD clinic were screened for evidence of cervical HPV infection using clinical criteria together with cytology and HPV DNA dot hybridization. HPV DNA probing was als
Chow VT; Tay SK; Tham KM; Lim-Tan SK; Bernard HU; Institute of Molecular and Cell Biology, National University of; Singapore.
In 25 partners of women with genital human papillomavirus (HPV) infection or cervical intraepithelial neoplasia, colposcopic examination revealed the existence of subclinical HPV infection of the male lower genital tract in 22 cases. It manifested either as short papillae tipped with acetowhite changes, or flat acetow
Jacobson MA; Drew WL; Feinberg J; O'Donnell JJ; Whitmore PV; Miner RD; Parenti D; Department of Medicine, University of California, San Francisco.
Infections caused by cytomegalovirus ( CMV ) resistant in vitro to ganciclovir, defined as requiring greater than 6 mumols of ganciclovir for ED50 have developed in some AIDS patients with progressive CMV retinitis despite chro
Visna, a lingering meningo-encephalitis in sheep, was one of the diseases on which B. Sigurdsson based his theory of a special group of disorders called slow infections. The cause of the disease, a retrovirus, was isolated in 1957. Visna is now classified in a subgroup of retroviridae, lentivirinae, together with viru
Balzarini J; Schols D; Neyts J; Van Damme E; Peumans W; De Clercq E; Laboratory of Chemotherapy, Rega Institute for Medical Research,; Katholieke Universiteit Leuven, Belgium.
The alpha-(1-3)-D-mannose- and alpha-(1-6)-D-mannose-specific agglutinins (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, and Listera ovata inhibited infection of MT-4 cells by human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus at concentrati
Biochem Biophys Res Commun. 1991 May 15;176(3):985-92. Unique Identifier : AIDSLINE MED/91248270
Balsano C; Avantaggiati ML; Natoli G; De Marzio E; Will H; Perricaudet M; Levrero M; I Clinica Medica, Policlinico Umberto I, Rome, Italy.
The products of the human hepatitis B virus (HBV) and woodchuck hepatitis B virus X genes (pXs) transactivate homologous and heterologous genes including the HBV-X and core promoters, the human immunodeficiency viruses 1 (HIV-1) and 2 (HIV-2) long terminal repeats and the beta interferon regulatory sequences. We repor
Kanitakis J; Euvrard S; Lefrancois N; Hermier C; Thivolet J; Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
Oral hairy leukoplakia (OHL) is seen almost exclusively in patients infected with HIV. A case is reported of OHL occurring in a patient who was seronegative for HIV and who had a renal graft. This occurred following an increase in his treatment with immunosuppressive drugs.
Hutchings DE; Dow-Edwards D; Department of Developmental Psychobiology, Columbia University; College of Physicians and Surgeons, New York, New York.
A traditional concern with drugs administered during pregnancy has been teratogenicity or the production of gross structural malformations. Beginning in the 1970s, it became increasingly evident that the issue of drug safety and risk assessment went far beyond structural defects. During the 1980s, the newly emerged re
Griffin TC; Squires JE; Timmons CF; Buchanan GR; Department of Pediatrics, University of Texas Southwestern; Medical Center, Children's Medical Center, Dallas 75235-9063.
Carroll R; Martarano L; Derse D; Laboratory of Viral Carcinogenesis, NCI-Frederick Cancer Research; and Development Center, Maryland 21702-1201.
The structural regions that comprise the functional domains of lentivirus Tat proteins were examined. Chimeric tat genes and chimeric viral promoters were constructed between the distantly related human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia virus (EIAV). These exchange experiments revealed
Carvalho M; Derse D; Laboratory of Viral Carcinogenesis, National Cancer Institute,; Frederick, Maryland 21702-1201.
A hairpinlike structure is predicted to exist at the 5 end of equine infectious anemia virus (EIAV) RNA which is similar in many ways to the human immunodeficiency type 1 (HIV-1) Tat-responsive element (TAR). In EIAV, this structure has a shorter stem than in HIV-1 and lacks the uridine bulge. Primer extension analys
Tiley LS; Malim MH; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Visna virus encodes a posttranscriptional regulatory protein that is functionally analogous to the Rev trans activator of human immunodeficiency virus type 1. Here, we demonstrate that the known functional organization of the human immunodeficiency virus type 1 Rev trans activator is shared by the distantly related vi
Oberste MS; Greenwood JD; Gonda MA; Laboratory of Cell and Molecular Structure, Program Resources,; Inc., NCI-Frederick Cancer Research and Development Center,; Maryland 21702-1201.
The bovine immunodeficiency-like virus (BIV) genome contains the obligatory structural genes of all retroviruses and, in addition, the complex central region of lentiviruses; this novel region may code for at least five nonstructural/regulatory genes in BIV (K.J.Garvey, M.S. Oberste, J.E. Elser, M.J. Braun, and M.A. G
Marquet R; Baudin F; Gabus C; Darlix JL; Mougel M; Ehresmann C; Ehresmann B; Laboratoire de Biochimie, Institut de Biologie Moleculaire et; Cellulaire du CNRS, Strasbourg, France.
The retroviral genome consists of two identical RNA molecules joined close to their 5 ends by the dimer linkage structure. Recent findings indicated that retroviral RNA dimerization and encapsidation are probably related events during virion assembly. We studied the cation-induced dimerization of HIV-1 RNA and result
Michaels FH; Banks KL; Reitz MS Jr; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland.
Two lentiviruses that infect sheep and goats have been shown to be closely related to the human immunodeficiency virus (HIV). These ungulate lentiviruses cause a spectrum of diseases, including arthritis in their natural hosts. The molecular and cellular biology of these viruses as well as possible pathogenic mechanis
Jabs DA; Enger C; Haller J; de Bustros S; Wilmer Ophthalmological Institute, Department of Ophthalmology,; Johns Hopkins University School of Medicine, Baltimore, Md 21205.
Retinal detachments are a recognized complication of cytomegalovirus retinitis. In a series of 145 patients with cytomegalovirus retinitis, 38 (26%) developed retinal detachments. The cumulative probability of a retinal detachment 1 year after the diagnosis of cytomegalovirus retin
Neckers LM; Medicine Branch, NCI, NIH, Bethesda, Md.
Transferrin receptor expression is vital for the continuous growth of most cells. Although iron plays a key role in modulating transferrin receptor expression, other physiological factors are also capable of affecting receptor expression. In hematopoietic cells, these include interleukin-2, interleukin-6, calcium chan
Wikstrom A; Lidbrink P; Johansson B; von Krogh G; Department of Dermatology and Venereology, Karolinska Hospital,; Stockholm, Sweden.
Using the polymerase chain reaction (PCR) technique, we found that up to 84% of 228 men consecutively attending two Swedish STD clinics harboured human papillomavirus (HPV) types 6 or 16. Mean age of the patients was 28 years (range 17-58); 70% were between 17 and 30 years old. Among men without a previous history of,
Clarke J; Terry RM; Lacey CJ; Department of Genito-urinary Medicine, General Infirmary, Leeds,; UK.
Respiratory tract papillomas are associated with human papillomavirus (HPV) types 6 and 11; these HPV types are also commonly associated with genital warts (condyloma acuminata). Although most commonly seen in young children, the incidence of respiratory tract papillomas in young adults is increasing. It has been post
Valerdiz-Casasola S; Pardo-Mindan FJ; Department of Pathology, University Clinic, University of; Navarra, Pamplona, Spain.
Disseminated cytomegalovirus infection occurs predominantly in immunocompromised hosts. Involvement of the gastrointestinal tract in the acquired immunodeficiency syndrome is frequent, but to our knowledge there is only one report of involvement of the appendix. In this study, a pa
In 28 cases of cytomegalovirus retinitis being treated with ganciclovir we examined the relative value of planimetry and conventional investigative methods, such as visual field examination and serial fundus photographs in determination of the development of retinitis. Planimetric
Thuluvath PJ; Connolly GM; Forbes A; Gazzard BG; AIDS Unit, Westminster Hospital, London.
The causes of abdominal pain in patients with AIDS are different from those of the general population, and there are no guidelines as to which investigations are optimal. We reviewed our experience of 63 patients who presented with abdominal pain as the main reason for admission to the AIDS unit at St Stephen s and We
The effect of pepsin treatment at pH 4 on the infectivity of several enveloped viruses was assessed under the conditions used during the production of intravenous immunoglobulins. It was shown that the prototypes of four virus families--human immunodeficiency virus (Lentivirinae), herpes simplex virus type 1 and human
Safrin S; Berger TG; Gilson I; Wolfe PR; Wofsy CB; Mills J; Biron KK; University of California, San Francisco.
OBJECTIVE: To determine whether foscarnet has potential efficacy in the treatment of acyclovir-resistant mucocutaneous varicella-zoster infection in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Open-label study. SETTING: Three university medical centers. PATIENTS: Five patients with AIDS who we
Pluda JM; Yarchoan R; Broder S; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
The incidence of non-Hodgkin s lymphoma (NHL) has increased by over 50% in the United States since 1973. There is epidemiologic evidence that some of this increase is the result of AIDS-related lymphoma and that this component is increasing. Prolong
Hirabayashi K; Iwata S; Matsumoto H; Mori T; Shibata S; Baba M; Ito M; Shigeta S; Nakashima H; Yamamoto N; Research Laboratory, Minophagen Pharmaceutical Co., Kanagawa,; Japan.
Chemically modified compounds of glycyrrhizin have been synthesized and evaluated for their inhibitory effect on the replication of human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). Among them, the 11-deoxo compound having a heteroannular diene structure at the C and D rings proved a
Dodd LG; McBride JH; Gitnick GL; Howanitz PJ; Rodgerson DO; Department of Pathology, University of California, Los Angeles,; Center for Health Sciences 90024.
Quality-assurance sera (QAS) are prepared from pooled sera composed of thousands of individual donations. Previous studies documented that a substantial percentage of individual QAS test positive for viral disease markers, including antibodies to human immunodeficiency virus and to hepatitis B surface antigen. We test
Makino M; Davidson WF; Fredrickson TN; Hartley JW; Morse HC 3d; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
Mice of certain strains are highly sensitive to development of a severe immunodeficiency disease following inoculation as adults with LP-BM5 murine leukemia viruses (MuLV) whereas others are extremely resistant. These strain-dependent differences in response to infection have been shown to be genetically determined wi
Int J Immunopharmacol. 1991;13(4):411-7. Unique Identifier : AIDSLINE MED/91267670
Specter S; Lancz G; Westrich G; Friedman H; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa 33612.
Delta-9-tetrahydrocannabinol (THC), the major psychoactive component in marijuana, and the murine retrovirus, Friend leukemia virus (FLV), have been demonstrated to depress cellular immune function, including lymphocyte blastogenic transformation and natural killer cell activity. The present study demonstrates tht the
Kanaya S; Katsuda-Nakai C; Ikehara M; Protein Engineering Research Institute, Osaka, Japan.
The handle region (residues 84-99) in ribonuclease HI (RNase HI) from Escherichia coli, which is rich in basic amino acid residues, was altered by alanine-scanning mutagenesis. Fifteen mutant proteins were purified to homogeneity and analyzed for the enzymatic activity. A mutation of either of 2 tryptophan residues at
Toome BK; Bowers KE; Scott GA; Dermatology Department, University of Rochester, NY 14642.
Cytomegalovirus infections are a major source of morbidity and mortality in immunocompromised patients. We report a case of cutaneous cytomegalovirus in a patient with the acquired immunodeficiency syndrome, in which routine light microscopy was suggestive but not diagnostic of cyt
Dhawan S; Streicher HZ; Wahl LM; Miller N; Louie AT; Goldfarb IS; Jackson WL; Casali P; Notkins AL; Laboratory of Oral Medicine, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892.
Purified human T cell leukemia virus type I (HTLV-I) was biotinylated and used to study its attachment to human PBMC. The use of biotinylated HTLV-I (biot-HTLV-I) in conjunction with mouse mAb specific for selected cell-surface molecules and flow cytometric analysis allowed us to positively identify virus-binding cell
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4776-80. Unique Identifier : AIDSLINE MED/91271276
Partin K; Zybarth G; Ehrlich L; DeCrombrugghe M; Wimmer E; Carter C; Department of Microbiology, State University of New York, Stony; Brook 11794.
Human immunodeficiency virus type 1 expresses structural proteins and replicative enzymes within gag and gag-pol precursor polyproteins. Specific proteolytic processing of the precursors by the viral proteinase is essential for maturation of infectious viral particles. We have studied the activity of proteinase in its
We investigated the correlation between the prevalence of antibodies against human cytomegalovirus (HCMV) early proteins and the state of infection. Two hundred and twenty-eight HCMV-IgG-positive (HCMV late-antigen ELISA) sera, drawn from subjects with active and non-active HCMV in
Morikawa S; Booth TF; Bishop DH; NERC Institute of Virology and Environmental Microbiology,; Oxford, United Kingdom.
Feline immunodeficiency virus (FIV) gag gene was expressed in baculovirus vectors to investigate its potential for the assembly of virus-like particles. The unprocessed 50-kDa FIV gag precursor made in infected insect cells by recombinant AcFIVGAG-1 was myristoylated, assembled at the cell surface into virus-like part
Biegalke BJ; Geballe AP; Department of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98104.
Human cytomegalovirus ( CMV ) alters the growth and expression of human immunodeficiency virus-1 (HIV-1) in cell culture and may accelerate the course of AIDS in HIV-1 infected patients. CMV infection or the expression of the C
The antiviral mechanism of action and intracellular metabolism of 2 ,3 -dideoxycytidine (ddCyd), 3 -azido-2 ,3 -dideoxythymidine ( AZT ) and 2 ,3 -didehydro-2 ,3 -dideoxythymidine (D4T) has been investigated. Marked differences in the affinity of these
Conte D; Mandelli C; Cesana BM; Barbera R; Aimo GP; Piubello W; Bianchi PA; Patologia Medica III, Istituto di Scienze Mediche, University of; Milan, Italy.
We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease (n = 81) or with persistent generalized lymphadenopathy (n = 172) in a prospective study to evaluate clinical progression to AIDS related complex (ARC) or AIDS and to identify factors of possible prognostic relevance. Follow-up lasted bet
Buti M; Esteban R; Espanol MT; Malagelada A; Jardi R; Rodriguez-Frias F; Roget M; Guardia J; Liver Unit, Hospital General Vall d'Hebron, Barcelona, Spain.
To determine whether the abnormalities of cell-mediated immunity described in chronic D hepatitis are associated with hepatitis D virus (HDV) infection or concomitant human immunodeficiency virus (HIV) infection, serologic and tissue hepatitis B virus (HBV) and HDV markers and T lymphocyte subsets were studied in seru
Fraser VJ; Keath EJ; Powderly WG; Division of Infectious Diseases, Washington University School of; Medicine, St. Louis, MO 63110.
Two friends, one with AIDS, developed severe pulmonary blastomycosis but differed markedly in clinical course. The human immunodeficiency virus-negative patient responded completely to ketoconazole; the patient with AIDS died of progressive disseminated infection despite treatment with fluconazole and amphotericin B.
Lancet. 1991 Jun 8;337(8754):1378-9. Unique Identifier : AIDSLINE MED/91245865
Wakefield AE; Guiver L; Miller RF; Hopkin JM; Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.
DNA amplification and silver staining were used to identify Pneumocystis carinii in bronchoscopic lavage and induced sputum samples during 51 episodes of respiratory illness in 47 subjects with HIV infection. In 20 episodes, in which the clinical diagnosis was pneumocystis pneumonia (PCP), silver stain was positive in
Lancet. 1991 Jun 8;337(8754):1397-9. Unique Identifier : AIDSLINE MED/91245873
Kouri YH; Shepard DS; Borras F; Sotomayor J; Gellert GA; Harvard Institute for International Development, Harvard; University, Cambridge, MA 02138.
In an era of decreasing availability of funds and increasing demand, the AIDS epidemic threatens to overwhelm health-care services in some countries. We describe a comprehensive model for the treatment of AIDS in San Juan, Puerto Rico , and compare it with traditional hospital-b
Gendelman HE; Ehrlich GD; Baca LM; Conley S; Ribas J; Kalter DC; Meltzer MS; Poiesz BJ; Nara P; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland 20852.
Studies of lentivirus infection in ruminants, nonhuman primates, and humans suggest that virus infection of macrophages plays a central role in the disease process. To investigate whether human immunodeficiency virus type 1 (HIV-1) can infect chimpanzee macrophages, we recovered monocytes from peripheral blood mononuc
Srivastava KK; Fernandez-Larsson R; Zinkus DM; Robinson HL; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655.
Single-cycle infections have been used to study the human immunodeficiency virus type 1 (HIV-1) life cycle in CD4+ T-cell lines that differ in their permissiveness for infection. In single-cycle infections of highly permissive C8166 cells, 50% of the infectious units escaped being blocked by a monoclonal antibody agai
Rev Med Interne. 1991 Jan-Feb;12(1):47-51. Unique Identifier : AIDSLINE MED/91252621
Conri C; Mestre C; Constans J; Vital C; Service de Medecine Interne, Hopital Haut Leveque, Pessac.
The human immunodeficiency virus (HIV) may be responsible for several types of vasculitis: leucocytoclastic vasculitis, granulomatous angiitis, angiitis associated with lymphoproliferative syndromes or necrotizing vasculitis including periarteritis nodosa (PAN). We report a case of PAN in a 62-year old HIV1-positive w
Wis Med J. 1991 Apr;90(4):161-5. Unique Identifier : AIDSLINE MED/91253224
Ebert S; Gockel K; Horowitz S; Weber P; Vogelman B; Graziano F; University of Wisconsin Hospital and Clinics, Madison.
Zidovudine is the only anti-retroviral drug approved by the FDA for treatment of HIV infection. We have examined the clinical and laboratory efficacy of this drug for 4 years in a cohort of HIV-infected patients from Wisconsin. Overall, we have found that individuals with AIDS will ha
Bol Asoc Med P R. 1991 Feb;83(2):65-8. Unique Identifier : AIDSLINE MED/91254430
Garrido Davila JI; Ramirez Ronda CH; Infectious Diseases Program, University of Puerto Rico School of; Medicine, San Juan DVA.
Cryptosporidium is a protozoal coccidian parasite that produces among other diseases chronic watery diarrhea. The extent of the diseases is mostly dependent on the immune status of the individual. Mortality in immunosuppressed and AIDS individuals due to the diarrhea illness is nearly 80%. Although no effective treatm
Melino C; Venza F; Istituto di Igiene G. Sanarelli, Universita degli Studi di Roma; La Sapienza.
This is the first of three articles on AIDS, in which the story of HIV infection, its etiology and pathogenesis, its pathology and clinical features, and finally its hygienic-prophylactic measures will be reviewed in the light of our present knowledge. Although the subject has been amply illustrated by many writers, i
Lancet. 1991 Jun 15;337(8755):1435-9. Unique Identifier : AIDSLINE MED/91260189
Lee HH; Swanson P; Rosenblatt JD; Chen IS; Sherwood WC; Smith DE; Tegtmeier GE; Fernando LP; Fang CT; Osame M; et al; Abbott Laboratories Diagnostic Division, North Chicago, IL 60064.
The clinical significance of human T-cell lymphotropic virus type II (HTLV-II) infection, unlike that of HTLV-I, is unknown, and the major known association of HTLV-II seropositivity is with intravenous drug abuse. Screening of blood donors for HTLV-I, now routine in North America, does not distinguish this retrovirus
Maiman M; Tarricone N; Vieira J; Suarez J; Serur E; Boyce JG; Department of Obstetrics and Gynecology, Brooklyn Hospital, New; York.
To determine the effect of human immunodeficiency virus (HIV) infection on cervical histology, 32 known HIV-seropositive women underwent cervical colposcopic evaluation. All had cervical cytology, colposcopically directed biopsy, and T-cell studies performed. Thirteen of 32 patients (41%) had cervical intraepithelial
Iwata J; Oka T; Furihata M; Sonobe H; Matsubayashi K; Uemura Y; Miyoshi I; Ohtsuki Y; Department of Pathology, Kochi Medical School, Japan.
Two cell lines, CNS-5 and CNS-6, were established by cocultivation of sedimented cells in cerebrospinal fluid (CSF) from two anti-human T-lymphotropic virus type I (HTLV-I) antibody-positive male patients with encephalopathy and HTLV-I-associated myelopathy, respectively, with peripheral blood mononuclear cells from a
Su IJ; Chang IC; Cheng AL; Department of Pathology and Hematology/Oncology, National Taiwan; University Hospital and College of Medicine, Taipei, R.O.C.
This study was designed to investigate the biologic and molecular basis of the aggressive behavior of high-grade post-thymic T-cell malignancies. Freshly frozen tumor tissues from (1) human T-cell leukemia/lymphoma virus type I (HTLV-I)-positive adult T-cell lymphoma (ATL) (7 cases), (2) HTLV-I-negative aggressive T-c
EMBO J. 1991 Jul;10(7):1827-32. Unique Identifier : AIDSLINE MED/91266912
Logeat F; Israel N; Ten R; Blank V; Le Bail O; Kourilsky P; Israel A; Unite de Biologie Moleculaire du Gene, U.277 Inserm-U.A. 535; CNRS, Paris, France.
The KBF1 factor, which binds to the enhancer A located in the promoter of the mouse MHC class I gene H-2Kb, is indistinguishable from the p50 DNA binding subunit of the transcription factor NF-kappa B, which regulates a series of genes involved in immune and inflammatory responses. The KBF1/p50 factor binds as a homod
Schols D; Wutzler P; Klocking R; Helbig B; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Polyhydroxycarboxylates (MW: 3,800-14,000) derived from phenolic (PDP) compounds have been found to inhibit the cytopathicity of HIV-1 and HIV-2 in MT-4 cells at concentrations that are not toxic to the host cells. The PDP compounds also inhibited syncytium formation in cocultures of MOLT-4 cells with HIV-1- or HIV-2-
Sheppard HW; Ascher MS; McRae B; Anderson RE; Lang W; Allain JP; Viral and Rickettsial Disease Laboratory, California Department; of Health Services, Berkeley 94704.
A study was conducted to assess the relative contribution of the HIV-1-specific immune response and -nonspecific immune activation to HIV disease progression. The titer of antibody to the p24 core protein and the concentration of serum neopterin were measured in 238 HIV-1-seropositive subjects in a prospective cohort
Lang W; Osmond D; Samuel M; Moss A; Schrager L; Winkelstein W Jr; San Francisco Men's Health Study, Children's Hospital of San; Francisco, CA 94118.
From the San Francisco Men s Health Study (SFMHS) and the San Francisco General Hospital Cohort we derived partially population-based estimates of zidovudine (ZDV) use in San Francisco from 1987 to 1989. Data from the SFMHS alone were used to make estimates of aerosol pentamidine (AP) use in 1989. From 1987 to 1989, z
Rhoads JL; Birx DL; Wright DC; Brundage JF; Brandt BL; Redfield RR; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Washington, D.C.
Twenty-one asymptomatic adults who had recently received multiple polysaccharide, live viral, and protein-derived vaccines were identified as being infected with human immunodeficiency virus (HIV). The mean subject age was 24 years (range 18-33); 20 of 21 (95%) were male. The mean T4 count was 523/mm3 with a mean T4/T
Lancet. 1991 Jun 29;337(8757):1562-5. Unique Identifier : AIDSLINE MED/91269927
Ades AE; Parker S; Berry T; Holland FJ; Davison CF; Cubitt D; Hjelm M; Wilcox AH; Hudson CN; Briggs M; et al; Epidemiology and Biostatistics Unit, Institute of Child Health; and Hospitals for Sick Children, London, UK.
To monitor the spread of human immunodeficiency virus (HIV) in the heterosexual population, residues of blood samples collected routinely on absorbent paper for neonatal screening (Guthrie cards) in NE, NW, and SW Thames Regions in England have been tested for antibodies to HIV-1 since June, 1988. 323,369 dried blood
Lancet. 1991 Jun 29;337(8757):1565-7. Unique Identifier : AIDSLINE MED/91269928
Tappin DM; Girdwood RW; Follett EA; Kennedy R; Brown AJ; Cockburn F; Department of Child Health, Royal Hospital for Sick Children,; Glasgow, UK.
Dried blood spot samples from newborn babies have been successfully tested for HIV-1 antibody by the particle agglutination method to assess the prevalence of infection in the mothers. In January, 1990, unlinked anonymous testing of Guthrie cards for HIV antibody was begun in Scotland. 99.6% of Scottish births were te
BACKGROUND. Serious recurrent bacterial infections are a major cause of morbidity and mortality in children infected with the human immunodeficiency virus (HIV). Because intravenous immune globulin has been shown to prevent bacterial infection in patients with primary immunodeficiency and in uncontrolled studies of HI
Agy MB; Foy K; Gale MJ; Benveniste RE; Clark EA; Katze MG; Department of Microbiology, University of Washington, Seattle; 98195.
Our laboratory has undertaken an analysis of cellular and viral gene expression in CD4+ human lymphoid cell lines infected by the human and simian immunodeficiency viruses, HIV-1 and SIV/Mne, respectively. The purpose of the current study was to: (i) examine the effects of SIV/Mne infection on host macromolecular synt
Kirchhoff F; Voss G; Nick S; Stahl-Hennig C; Coulibaly C; Frank R; Jentsch KD; Hunsmann G; German Primate Centre, Department of Virology and Immunology,; Gottingen.
The antibody response to structural and regulatory viral proteins was studied in 14 rhesus (Macaca mulatta) and 6 cynomolgus (Macaca fascicularis) macaques experimentally infected with HIV-2 or SIVMAC. To investigate the humoral antibody response to the negative regulatory factor (nef), the recombinant protein was exp
Biochemistry. 1991 May 21;30(20):4831-5. Unique Identifier : AIDSLINE MED/91242378
Tan CK; Civil R; Mian AM; So AG; Downey KM; Department of Medicine, University of Miami School of Medicine,; Florida 33101.
The effects of AZTMP and other nucleoside 5 -monophosphates on the RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase have been investigated. Both activities are sensitive to inhibition by millimolar concentrations of AZTMP with MgCl2 as divalent cation activator. Substituti
Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 1990 Dec;12(6):391-5. Unique Identifier : AIDSLINE MED/91243215
Tang X; Institute of Medicinal Biotechnology, Beijing.
Thirty-three chinese medicinal herbs reputed by ancient chinese folklore to have anti-infective properties were extracted. The extracts and their compounds were tested for inhibitory activity against the human immunodeficiency virus RT in vitro. 8 of the 33 extracts were found to be active. Of these, MBAA9045 was stud
FEBS Lett. 1991 May 6;282(2):231-4. Unique Identifier : AIDSLINE MED/91243801
Lowe DM; Parmar V; Kemp SD; Larder BA; Department of Molecular Sciences, Wellcome Research Laboratories,; Beckenham, Kent, U.K.
Two conserved sequence motifs, occurring in HIV-1 reverse transcriptase at residues 110-116 and 183-190, have been studied using site-directed mutagenesis of the cloned gene. In particular, aspartates at positions 185 and 186 have each been mutated to either asparagine or glutamate. The resulting mutant proteins were
Fabris F; Cordiano I; Casonato A; Zanon E; Luzzatto G; Girolami A; University of Padua Medical School, Institute of Medical; Semeiotics, Italy.
We have studied anti platelet antibodies and circulating immunocomplexes in 16 haemophiliacs with mild thrombocytopenia eight of which were infected by human immunodeficiency virus (HIV). No difference in platelet count was observed between HIV+ (143 +/- 31 x 10(9)/l) and HIV- patients (148 +/- 30 x 10(9)/l). On the c
Janvier B; Baillou A; Archinard P; Mounier M; Mandrand B; Goudeau A; Barin F; Departement de Microbiologie Medicale et Moleculaire, URA CNRS; 1334, CHRU Bretonneau, Tours, France.
A sequential inhibition enzyme-linked immunoassay (SIEIA) using a peroxidase-conjugated monoclonal antibody reacting to the sequence AAEWDRVHP of p24HIV-1 (amino acids 209 to 217 of p55) was developed in order to detect and determine the titer of antibody to this epitope in various populations of human immunodeficienc
Lau AS; Williams BR; Division of Infectious Diseases, Hospital for Sick Children,; Toronto, Ontario, Canada.
Cytokines including interferon (IFN) and tumor necrosis factor (TNF) are potent modulators of immune processes. They are synthesized in response to microbial infections and inflammation. TNF and IFN interact with other cytokines to elicit differentiation and cellular responses of specific target cells. In view of thei
5 -Phosphites (5 -hydrogenphosphonates) of 3 -azido-2 -, 3 -dideoxynucleosides are shown to be effective inhibitors of the human immunodeficiency virus (HIV-1) in MT4 cell culture. 5 -Phosphite of 3 -azido-2 , 3 -dideoxythymidine was the most active among these compounds and even a little more active as compared to th
Pedersen M; Permin H; Bindslev-Jensen C; Bendtzen K; Norn S; Laboratory of Immunology, University Clinic for Infectious; Diseases M, Copenhagen, Denmark.
Basophil leukocytes obtained from AIDS patients, allergic patients and healthy controls were stimulated in vitro with interleukin 4, lymphotoxin, tumour necrosis factor alpha and interferon gamma to examine the histamine releasing effect. The cytokines caused histamine release from the basophils of approximately half
J Immunol. 1991 Jun 15;146(12):4315-24. Unique Identifier : AIDSLINE MED/91250725
Pincus SH; Cole RL; Hersh EM; Lake D; Masuho Y; Durda PJ; McClure J; Laboratory of Microbial Structure and Function, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Hamilton, MT 59840.
Six different anti-HIV envelope antibodies and one irrelevant control antibody were coupled to ricin A chain and tested for their efficacy in inhibiting HIV tissue culture infections. The anti-HIV antibodies consisted of five monoclonals, three of murine and two of human origin, and one polyclonal preparation prepared
J Immunol. 1991 Jun 15;146(12):4325-32. Unique Identifier : AIDSLINE MED/91250726
Posner MR; Hideshima T; Cannon T; Mukherjee M; Mayer KH; Byrn RA; Department of Medicine, Roger Williams Medical Center,; Providence, RI 02908.
A human mAb (HmAb) termed F105 was obtained by fusion of antibody-producing EBV-transformed cells with the HMMA2.11TG/O cell line. F105 is an IgG1 kappa antibody that binds to the surfaces of cells infected with all HIV-1 strains tested: MN, RF, IIIB, and SF2, but not uninfected cells. The HmAb immunoprecipitates GP12
Wills JW; Craven RC; Weldon RA Jr; Nelle TD; Erdie CR; Department of Biochemistry and Molecular Biology, Louisiana State; University Medical Center, Shreveport 71130.
The molecular mechanism by which retroviral Gag proteins are directed to the plasma membrane for the formation of particles (budding) is unknown, but it is widely believed that the MA domain, located at the amino terminus, plays a critical role. Consistent with this idea, we found that small deletions in this segment
Fernie BF; Poli G; Fauci AS; Department of Microbiology, Georgetown University, Rockville,; Maryland 20852.
Alpha interferon (IFN-alpha) is effective in preventing the release of human immunodeficiency virus (HIV) from chronically infected T-lymphocytic (ACH-2) and promonocytic (U1) cell lines stimulated with the phorbol ester phorbol-12-myristate-13 acetate (PMA). In the present study, we observed that together with partic
Klin Wochenschr. 1991 Feb 26;69(4):143-5. Unique Identifier : AIDSLINE MED/91251597
Paloczi K; Ujhelyi E; Fuchs D; Mihalik R; Banhegyi D; Berkessy S; Salavecz V; Wachter H; Hollan SR; Fust G; National Institute of Haematology and Blood Transfusion,; Budapest, Hungary.
The percentage of activated, CD3+ DR+ and CD8+ Leu7+ lymphocytes and the serum neopterin concentration were determined in 17 HIV-seropositive and 10 HIV-seronegative haemophiliacs and in 11 healthy control subjects. All three parameters tested were found to be significantly higher in the seropositive patients than in
Sarria L; Cisterna R; Gorrino MT; Malave C; Sunen E; Departamento de Microbiologia e Immunologia, Hospital Civil de; Bilbao, Universidad del Pais Vasco.
The diagnosis of human immunodeficiency virus infection is sometimes difficult or nonspecific, both in early and late stages, as the patients may be seronegative at the time of testing. Although serologic testing usually suffices to identify infected individuals and to follow up the course of the infection, in some ca
An IL-2 autocrine growth circuit has been proposed as a major mechanism in HTLV-I-related leukaemogenesis. We have developed a polymerase chain reaction combined with reverse transcription RT-PCR to detect IL-2 transcripts and a sensitive immunostaining method for IL-2
Haas G; David R; Frank R; Gausepohl H; Devaux C; Claverie JM; Pierres M; Centre d'Immunologie, INSERM-CNRS de Marseille-Luminy, France.
Delineation of major T helper cell recognition sites of human immunodeficiency virus (HIV-1) proteins represents one important step in the design of an efficient acquired immune deficiency syndrome (AIDS) vaccine. Towards this end, we have explored the immunogenicity of HIV-1BRU proteins in the mouse model. Preliminar
Healey DG; Dianda L; Buck D; Schroeder K; Truneh A; Sattentau QJ; Beverley PC; Academic Department of G-U Medicine, University College and; Middlesex School of Medicine, London, GB.
Anti-CD4 antibodies directed to the N terminus of CD4 can inhibit human immunodeficiency virus (HIV) infection. Therefore, it has been proposed that some of these reagents may contain idiotypic determinants which conformationally model the binding site expressed on gp120. In this report, we have selected a panel of an
FEBS Lett. 1991 Jun 3;283(2):298-302. Unique Identifier : AIDSLINE MED/91257327
Stammers DK; Tisdale M; Court S; Parmar V; Bradley C; Ross CK; Department of Molecular Sciences, Wellcome Research Laboratories,; Beckenham, Kent, UK.
The C-termini of p66 and p51 forms of HIV-1 reverse transcriptase have been engineered to contain a Glu-Glu-Phe sequence recognized by a monoclonal antibody to alpha-tubulin, YL1/2. Mutated RTs were purified in a single step using peptide elution from columns of immobilized YL1/2. The known sequence requirements of th
Int J Cancer. 1991 Jun 19;48(4):623-30. Unique Identifier : AIDSLINE MED/91258038
Tanaka Y; Yoshida A; Tozawa H; Shida H; Nyunoya H; Shimotohno K; Department of Immunology, School of Hygienic Sciences, Kitasato; University, Japan.
A 42-kDa recombinant protein, PX141, consisting of the trans-activator protein encoded by human T-cell leukemia virus (HTLV-1) (tax1 antigen) and the amino-terminal fusion peptide of 12 amino acid residues of the alpha-peptide encoded by the plasmid pUC19 was produced. In order to investigate the immunogenicity of the
de Wolf F; Meloen RH; Bakker M; Barin F; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Centre, University; of Amsterdam, The Netherlands.
Antibody-reactive peptide scanning (Pepscan) using overlapping nonapeptides and human sera as probes allows the identification of amino acids contributing significantly to antigen-antibody interaction. Five-hundred and two overlapping nonapeptides derived from the human immunodeficiency virus type 2 strain Rod (HIV-2R
Tan GT; Pezzuto JM; Kinghorn AD; Hughes SH; Program for Collaborative Research in the Pharmaceutical; Sciences, College of Pharmacy, University of Illinois, Chicago.
Inhibition of human immunodeficiency virus reverse transcriptase is currently considered a useful approach in the prophylaxis and intervention of acquired immunodeficiency syndrome (AIDS), and natural products have not been extensively explored as inhibitors of this enzyme. We currently report that the reverse transcr
Hirsch S; Rudi A; Kashman Y; Loya Y; Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv; University, Israel.
Six new avarol and avarone derivatives, 3 -hydroxyavarone [3], 3 ,6 -dihydroxyavarone [4], 6 -hydroxyavarol [5], 6 -acetoxyavarol [6], 6 -acetoxyavarone [7], and 6 -hydroxy-4 -methoxyavarone [8], are reported from the Red Sea sponge Dysidea cinerea. The structures of the new compounds were determined by spectroscopic
Levine AM; Wernz JC; Kaplan L; Rodman N; Cohen P; Metroka C; Bennett JM; Rarick MU; Walsh C; Kahn J; et al; University of Southern California School of Medicine, Los Angeles; 90033.
OBJECTIVE.--To ascertain if low-dose multiagent chemotherapy, with central nervous system prophylaxis and antiretroviral therapy, might be associated with increased efficacy and decreased risk of intercurrent infection in patients with malignant lymphoma related to the acquired immunodeficiency syndrome (AIDS). DESIGN
Ono M; Department of Molecular Biology, School of Medicine, Kitasato; University, Kanagawa, Japan.
Intracisternal A particles (IAPs) are retrovirus-like structures consistently observable in a variety of mouse tumor cells such as myeloma and hybridoma and in early embryonic cells derived from rodents but nothing is known of their infectivity. Mouse IAPs contain a gag-like protein, a reverse transcriptase and a poly
Mod Pathol. 1991 Mar;4(2):187-90. Unique Identifier : AIDSLINE MED/91261863
Fukunaga M; Silverberg SG; Department of Pathology, Jikei University School of Medicine,; Tokyo, Japan.
Hyaline globules (HG) were detected in 51 of 54 Kaposi s sarcoma (KS) lesions (94.4%), including all four non-acquired immunodeficiency syndrome (AIDS) cases of cutaneous KS in this group of cases. Thus, there was no correlation between the presence of HG and the presence or absence of AIDS, nor could we demonstrate a
Dionisio D; Di Lollo S; Orsi A; Pecile P; Tortoli E; Gabbrielli M; Vivarelli A; Mecocci L; Caresia C; Divisione di Malattie infettive, Policlinico di Careggi, Firenze.
Microbial isolates from 60 diarrheic AIDS patients hospitalized to the Infectious Disease Division of Careggi hospital (Florence) are described. Clinical, microbiological and diagnostic features of each case are discussed with emphasis to some rare or underestimated entities in Europe: Campylobacter laridis bacteremia
Ann Ig. 1990 Jul-Aug;2(4):213-21. Unique Identifier : AIDSLINE MED/91265098
Nicolosi A; Molinari S; Musicco M; Amendola M; Arici C; Bono G; Camisani AM; Cernuschi M; Ciaci D; Correa Leite ML; et al; Amb. Malat, Inf., USSL 75/18 di Milano.
Fagerstam LG; Frostell A; Karlsson R; Kullman M; Larsson A; Malmqvist M; Butt H; Pharmacia Biosensor AB, Uppsala, Sweden.
Surface plasmon resonance (SPR) detection requires no labeling of antigen or antibodies and allows quantification of two or more interacting molecular species. The automated SPR instrument used here consists of an optical detection unit, an integrated liquid handling unit, and an autosampler. A first molecule is immob
Monfardini S; Tirelli U; Vaccher E; Foa R; Gavosto F; Division of Medical Oncology, Centro di Riferimento Oncologico,; Aviano (PN), Italy.
Sixty-three cases of Hodgkin s disease in intravenous drug users (IVDUs) have been collected by the Italian Cooperative Group on AIDS-Related Tumors (GICAT). In most patients (74%) the histological pattern was that of mixed cellularity and lymphocyte depletion. In 39% of patients the initial symptom was a persistent l
4000 sera were tested for antibodies against hepatitis C virus (HCV) by means of an ELISA using the C100-3 antigen. 38.9% of patients with non-A, non-B hepatitis following blood transfusion (n = 108) had HCV antibodies. Among patients with chronic liver damage of unknown origin (n = 316) 30.4% were anti-HCV positive,
Tosteson MT; Tosi PF; Nicolau C; Tosteson DC; Department of Cellular and Molecular Physiology, Harvard Medical; School, Boston, Massachusetts 02115.
gp120, the coat glycoprotein of the human immunodeficiency virus type 1 (HIV1) binds to a molecule on the surface of a class of T-lymphocytes, CD4, which is also the receptor for major histocompatibility complex class II (MHCII). To study the events that follow the interaction of gp120 with CD4, we have incorporated C
Hostetler KY; Carson DA; Richman DD; Department of Medicine, University of California, San Diego; 92093.
Dimyristoylphosphatidylazidothymidine has been shown to inhibit human immunodeficiency virus (HIV) replication in CEM or U937 cells infected with the LAV-1 strain in vitro, but its metabolism and mechanism of antiretroviral activity have not been determined (Hostetler, K. Y., Stuhmiller, L. M., Lenting, H. B. M., van
Zoulim F; Vitvitski L; Bouffard P; Pichoud C; Rougier P; Lamelin JP; Trepo C; Hepatitis and AIDS Research Unit, INSERM U271, Lyon, France.
The presence of pre-S1 proteins in peripheral blood mononuclear cell (PBMC) samples from 115 patients with different forms of hepatitis B virus (HBV) infection was investigated by Western blot. Among 67 chronic HBsAg carriers, HBV antigens were detected in the PBMC in 80% for HBsAg, 27% for HBc/e Ag and 34% for pre-S1
Miller MD; Yamamoto H; Hughes AL; Watkins DI; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
Infection of macaque monkeys with the simian immunodeficiency virus of macaques (SIVmac) results in disease similar to human AIDS. Therefore, the macaque monkey is proving to be an important model for testing the effectiveness of various AIDS vaccine approaches. A detailed analysis of the cellular immune responses is
Tanaka Y; Zeng L; Shiraki H; Shida H; Tozawa H; Department of Immunology, School of Hygienic Sciences, Kitasato; University, Kanagawa, Japan.
We have generated a number of mAb against various epitopes on the external envelope glycoprotein, gp46, of human T cell leukemia virus type I (HTLV-I) from a WKA rat immunized with a recombinant vaccinia virus containing the HTLV-I env gene. Among these mAb, one group of mAb, represented by a mAb designated LAT-27, co
J Med Virol. 1991 Feb;33(2):106-13. Unique Identifier : AIDSLINE MED/91268742
Goswami KK; Kaye S; Miller R; McAllister R; Tedder R; Department of Medical Microbiology, University College and; Middlesex School of Medicine, London, England.
The CSF/serum immune response to HIV 1 was studied in 24 patients admitted for investigation. The level of antibody to HIV-1 and specificity of oligoclonal IgG were determined in blood and cerebrospinal fluid (CSF). The majority of patients demonstrated elevated levels of intrathecal IgG synthesis, with levels of HIV-
Stein CA; Neckers LM; Nair BC; Mumbauer S; Hoke G; Pal R; Medicine Branch, National Cancer Institute, Bethesda, Maryland.
In addition to their properties as sequence-specific inhibitors of gene expression, sequence nonspecific phosphorothioate oligodeoxynucleotides have been shown to protect against the cytopathic effects of HIV-1. Although these compounds are effective inhibitors of HIV-1 reverse transcriptase in vitro, it is not certai
Baba M; De Clercq E; Tanaka H; Ubasawa M; Takashima H; Sekiya K; Nitta I; Umezu K; Walker RT; Mori S; et al; Department of Bacteriology, Fukushima Medical College, Japan.
In the search for novel derivatives of 1-[2-(hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT), we have found that several 5-ethyl-6-(3,5-dimethylphenylthio)uracil and 5-ethyl-6-(3,5-dimethylbenzyl)uracil analogues are exquisitely potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replicat
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4596-600. Unique Identifier : AIDSLINE MED/91271240
Hu YW; Kang CY; Department of Microbiology and Immunology, University of Ottawa,; Faculty of Medicine, ON, Canada.
Five cassettes of the pol gene of human immunodeficiency virus 1 were constructed and inserted under the control of the polyhedrin gene promoter of Autographa californica nuclear polyhedrosis virus by homologous recombination. The first cassette polF contains the full-length pol open reading frame; the second cassette
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4961-5. Unique Identifier : AIDSLINE MED/91271312
Balzarini J; Holy A; Jindrich J; Dvorakova H; Hao Z; Snoeck R; Herdewijn P; Johns DG; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A new class of compounds, 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] [(RS)-FPMP] derivatives of purines, is described that has selective activity against a broad spectrum of retroviruses [including human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)] but not other RNA or DNA viruses. This activity spectru
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5011-5. Unique Identifier : AIDSLINE MED/91271322
Klotman ME; Kim S; Buchbinder A; DeRossi A; Baltimore D; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20815.
The genome of human immunodeficiency virus type 1 (HIV-1) encodes at least six proteins involved in regulation as well as the structural proteins Gag, Pol, and Env. The interplay of the various regulators generates early and late transcriptional phases in the HIV-1 life cycle; the earliest RNA is enriched in subgenomi
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5262-66. Unique Identifier : AIDSLINE MED/91271369
Hafkemeyer P; Ferrari E; Brecher J; Hubscher U; Department of Pharmacology and Biochemistry, University of; Zurich-Irchel, Switzerland.
The reverse transcriptase of human immunodeficiency virus type 1 is a heterodimeric protein consisting of two polypeptides with masses of 66 and 51 kDa and has, as a second enzymatic activity, RNase H activity. The 66-kDa polypeptide can be cleaved by the virus-encoded protease to yield polypeptides of 51 and 15 kDa.
Banapour B; Marthas ML; Munn RJ; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616.
The significance of infection of mononuclear phagocytes by immunodeficiency lentiviruses of primates is not clearly established. To explore the relationship of macrophage tropism and pathogenesis, conditions to culture and infect monocyte-derived macrophages from rhesus macaques were established and the growth propert
Takenaka T; Kishi S; Tsujimoto M; Maeda J; Department of Laboratory Medicine, Wakayama Medical School.
Although it is well-known that Leu3a-epitope on CD4 molecule functions as a receptor for human immunodeficiency virus (HIV), the function of OKT4-epitope is still obscure. In order to learn the significance of OKT4-epitope, we performed immunological and functional studies on lymphocytes obtained from individuals with
Culp JS; Johansen H; Hellmig B; Beck J; Matthews TJ; Delers A; Rosenberg M; Department of Protein Biochemistry, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.
We have established a stable, continuous culture Drosophila Schneider 2 cell line that efficiently expresses a secreted, truncated form of the HIV envelope gp120 protein in a regulated manner. The Drosophila produced recombinant gp120 protein is highly glycosylated, is recognized by gp120-specific monoclonal antibodie
LeVee, William N., ed. New Perpectives on HIV-Related Illnesses: Progress in Health Services Research. Conference Proceedings. Rockville, Md.: National Center for Health Services Research and Health Care Technology Assessment, 1989 Sep :170-179. Unique Identifier : AIDSLINE KIE/32607
Community-Based Care of Persons with AIDS: Developing a Research Agenda. AHCPR Conference Proceedings, Minneapolis, 15-16 Aug 1989. Rockville, Md.: U.S. Agency for Health Care Policy and Research, 1990 Apr :117-126. Unique Identifier : AIDSLINE KIE/32650
Community Based Care of Persons with AIDS: Developing a Research Agenda. AHCPR Conference Proceedings, Minneapolis, 15-16 Aug 1989. Rockville, Md.: U.S. Agency for Health Care Policy and Research, 1990 Apr :127-131. Unique Identifier : AIDSLINE KIE/32651
Federal Rules Decisions. 1990 Apr 4 (date of decision);130:360-363. Unique Identifier : AIDSLINE KIE/32897
Cheryl Coleman became infected with the human immunodeficiency virus (HIV) after receiving a blood transfusion. Alleging that the blood she received was infected, she sued its supplier, the American Red Cross, to compel discovery of the donor s identity. Coleman asserted that without discovery of the donor s name, it
California Reporter. 1990 Dec 28 (date of decision);276:660-667. Unique Identifier : AIDSLINE KIE/32909
The petitioners, April Love and others, were convicted of soliciting acts of prostitution, and were ordered to undergo AIDS testing and counseling in compliance with the California Penal Code. Love challenged the mandatory testing as unconstitutional under the Fourth Amendment and the Fourteenth Amendment s due proce
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