DIAGNOSIS OF HUMAN T-CELL LEUKEMIA VIRUS INFECTION

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

DIAGNOSIS OF HUMAN T-CELL LEUKEMIA VIRUS INFECTION

HIV Detection by Genetic Engineering Methods. Luciw PA and Steimer KS, eds. New York, Marcel Dekker, p. 275-92, 1989.. Unique Identifier : AIDSLINE ICDB/90660266
Chen IS; Slamon DJ; UCLA Sch. of Medicine, Los Angeles, CA

Abstract: Human T-cell leukemia virus (HTLV)-I infection is a major health problem in certain regions of the world, including Japan, the Caribbean, and Africa. Recent studies suggest that the incidence of HTLV-I is increasing elsewhere, including the United States. At least four categories have been proposed as stages in HTLV-I-associated disease: a preleukemic stage (pre-adult T-cell leukemia [ATL]), smoldering ATL, chronic ATL, and subacute/acute ATL. Diagnosis of HTLV infection is reviewed under the following headings: seroepidemiology of HTLV-I-associated ATL, HTLV-I association with diseases other than ATL, HTLV-II-associated malignancies, features of HTLV infection relevant to HTLV diagnostics, genome structure of HTLV, HTLV gene products antigenic in patients and asymptomatic individuals, other assay methods for HTLV, and HTLV genomic variation. Diagnostic approaches to HTLV-I and HTLV-II should be readily feasible along the same lines as those used for HIV. Molecular clones and recombinant constructs of the viral genome are available and could be adapted readily to diagnosis. However, the natural history of HTLV-I infection and disease occurrence requires further study to determine the feasibility of various diagnostic approaches. (84 Refs)

Keywords: Cloning, Molecular Genes, Viral Human HTLV-I/GENETICS HTLV-I Antibodies/ANALYSIS HTLV-I Antigens/IMMUNOLOGY HTLV-II/GENETICS HTLV-II Antibodies/ANALYSIS HTLV-II Antigens/IMMUNOLOGY Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*DIAGNOSIS Leukemia, T-Cell, HTLV-II-Associated/*DIAGNOSIS Proviruses/GENETICS Variation (Genetics)/GENETICS MONOGRAPH REVIEW

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M91B0840

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