AIDS-ASSOCIATED T-CELL LYMPHOMA: EVIDENCE FOR HIV-1-ASSOCIATED TRANSFORMATION (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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AIDS-ASSOCIATED T-CELL LYMPHOMA: EVIDENCE FOR HIV-1-ASSOCIATED TRANSFORMATION (MEETING ABSTRACT)

FASEB J; 5(4):A883 1991. Unique Identifier : AIDSLINE ICDB/91676432
Herndier BG; Shiramizu BT; Aldape KD; Jewett NE; McGrath MS; Dept. of Pathology, San Francisco General Hosp., San Francisco,; CA 94110

Abstract: The majority of non-Hodgkin's lymphomas in AIDS are B-cell in origin. We describe a CD4+ T-cell lymphoma that expresses HIV-1 p24 antigen and appears to be the first case described with clonally integrated HIV sequence. Such integration may indicate a direct transforming role of the virus. Multiple sites of tissue were isolated at autopsy from a 45-yr-old man who died of a fulminant large-cell lymphoma. The immunophenotype of the lung tumor was LCA+, CD4+, CD25+, CD8-, CD3-. Tumor cells expressed HIV-1 p24. Southern blot analysis for rearrangement of the T-cell receptor gene (C[T]beta) indicated a monoclonal pattern. DNA probed with a 3.5-kb 3'-HIV fragment digested with BamH1 showed two distinct bands at 6 kb but only a single 9.6-kb band on XbaI digest, as well as a larger fragment with undigested DNA. The presence of two distinct bands in the BamH1 digest but a single fragment on XbaI, suggest integration of HIV-1 (internal BamH1 site with flanking XbaI sites). Probes for HTLV-1 genes were negative. Further gene mapping and sequencing will determine if there are structural analogies to transforming retroviruses described in animals.
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Cell Transformation, Neoplastic/*PATHOLOGY Cell Transformation, Viral/PHYSIOLOGY Gene Products, gag/ANALYSIS Human HIV-1/*ISOLATION & PURIF Immunophenotyping Lung/PATHOLOGY Lung Neoplasms/*PATHOLOGY Lymphoma, Large-Cell/PATHOLOGY Lymphoma, T-Cell/*PATHOLOGY Male Middle Age Viral Core Proteins/ANALYSIS ABSTRACT

KWDacquiredimmunodeficiencysyndrome/KWDpathologycelltransformation,neoplastic/KWDpathologycelltransformation,viral/physiologygeneproducts,gag/analysishumanhiv-1/KWDisolation&purifimmunophenotypinglung/pathologylungneoplasms/KWDpathologylymphoma,large-cell/pathologylymphoma,t-cell/KWDpathologymalemiddleageviralcoreproteins/analysisabstract
911130
M91B0821

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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