[The therapy of Candida esophagitis in AIDS patients with fluconazole] NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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[The therapy of Candida esophagitis in AIDS patients with fluconazole]

Mycoses. 1990;33 Suppl 1:32-6. Unique Identifier : AIDSLINE MED/91333666
Heise W; Arasteh K; L'age M; II. Innere Abteilung (Gastroenterologie und Infektiologie),; Auguste-Viktoria-Krankenhaus, Berlin.

Abstract: Esophageal candidosis was found endoscopically in 135 of 496 AIDS patients with upper gastrointestinal symptoms. Vomiting, dysphagia and retrosternal pain were the leading symptoms. Endoscopy showed different stages of esophagitis with Candida patches as early changes up to severe esophagitis with hemorrhage. 36 patients were treated with fluconazole orally or intravenously administered (100 mg per day). In 33 of 36 patients clinical, endoscopic and microbiological results were good with complete cure of the lesions after 7, 14 or 21 days of treatment. In 3 patients with wasting syndrome and severe opportunistic infections a resistance to the drug was discussed because of lack of sufficient therapy results. Maintenance therapy seems to be necessary to prevent relapses.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Candidiasis/COMPLICATIONS/*DRUG THERAPY English Abstract Esophagitis/COMPLICATIONS/*DRUG THERAPY Esophagoscopy Fluconazole/*THERAPEUTIC USE Human Opportunistic Infections/COMPLICATIONS/*DRUG THERAPY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationscandidiasis/complications/KWDdrugtherapyenglishabstractesophagitis/complications/KWDdrugtherapyesophagoscopyfluconazole/KWDtherapeuticusehumanopportunisticinfections/complications/KWDdrugtherapyjournalarticle
911130
M91B0791

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