Analysis, identification and determination of urinary modified nucleosides of cancer and AIDS patients. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Analysis, identification and determination of urinary modified nucleosides of cancer and AIDS patients.

Nucleic Acids Symp Ser. 1990;(22):31-2. Unique Identifier : AIDSLINE MED/91334215
Nakano K; Yasaka T; Nakao T; Schram KH; Hammargren WM; PL Comprehensive Research Institute, Osaka, Japan.

Abstract: Modified nucleoside levels in urine samples collected before and after surgery from seven patients with malignant gastrointestinal cancer were examined by the reversed-phase HPLC method. Those of an AIDS patient, a breast cancer patient, and pooled normal urines were also compared. To monitor the effects of therapy on cancer patients, the levels of modified nucleosides, especially t6A and MTA, were found to be fairly effective. In an AIDS patient, the levels of most of the nucleosides exhibited remarkable increases compared to normal urine.
Keywords: Acquired Immunodeficiency Syndrome/*URINE Breast Neoplasms/*URINE Chromatography, High Pressure Liquid Gastrointestinal Neoplasms/SURGERY/*URINE Human Nucleosides/*URINE JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDurinebreastneoplasms/KWDurinechromatography,highpressureliquidgastrointestinalneoplasms/surgery/KWDurinehumannucleosides/KWDurinejournalarticle
911130
M91B0787

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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