Activation of NF-kappa B by the HTLV-I trans-activator protein Tax requires an additional factor present in lymphoid cells. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Activation of NF-kappa B by the HTLV-I trans-activator protein Tax requires an additional factor present in lymphoid cells.

New Biol. 1989 Dec;1(3):275-84. Unique Identifier : AIDSLINE MED/91120692
Ruben SM; Perkins A; Rosen CA; Department of Molecular Oncology and Virology, Roche Research; Center, Nutley, NJ 07110.

Abstract: The Tax protein of human T-cell leukemia virus is a potent transcriptional activator of viral and cellular genes, including the genes for interleukin 2 and interleukin 2 receptor alpha chain (IL2R alpha). The NF-kappa B protein has been implicated in Tax-mediated activation of IL2R alpha gene expression. We show that activation of NF-kappa B by Tax is an indirect process that requires prior activation of a preexistent factor that is present in lymphoid cells. Deletion mutagenesis revealed that the carboxyl-terminal acidic region of Tax is required for activation of IL2R alpha-directed gene expression but dispensable for activation of the long terminal repeat (LTR). Our findings suggest that activation of viral and cellular gene expression by Tax is achieved through a cascade of events that involves multiple protein-protein associations and that the specificity of these associations is conferred through different domains of the Tax protein.
Keywords: B-Lymphocytes/IMMUNOLOGY Base Sequence Cell Line DNA/GENETICS Gene Expression Regulation Gene Products, tax/*GENETICS Human HTLV-I/*GENETICS Molecular Sequence Data Mutation NF-kappa B/*GENETICS Receptors, Interleukin-2/GENETICS JOURNAL ARTICLEKWDb-lymphocytes/immunologybasesequencecelllinedna/geneticsgeneexpressionregulationgeneproducts,tax/KWDgeneticshumanhtlv-i/KWDgeneticsmolecularsequencedatamutationnf-kappab/KWDgeneticsreceptors,interleukin-2/geneticsjournalarticle
910530
M9150926

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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