Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements.

New Biol. 1989 Dec;1(3):318-28. Unique Identifier : AIDSLINE MED/91120696
Felber BK; Derse D; Athanassopoulos A; Campbell M; Pavlakis GN; Frederick Cancer Research Facility BRI-Basic Research Program, MD; 21701-1013.

Abstract: The Rex regulatory proteins of human T-cell leukemia virus type I (HTLV-I) and bovine leukemia virus (BLV), and the Rev protein of human immunodeficiency virus type 1 (HIV-1), promote the cytoplasmic accumulation and translation of viral messenger mRNAs encoding structural proteins. Rev and Rex act through cis-acting elements on the viral RNA; these elements are named Rev- and Rex-responsive elements, or RRE and RXRE, respectively. We show that the Rex proteins of HTLV-I and BLV are interchangeable, but only the Rex protein of HTLV-I can substitute for Rev of HIV-1. Rex of HTLV-I and Rev of HIV-1 appear to act on RRE by similar mechanisms. Rev of HIV-1 does not act on the RXRE of HTLV-I or BLV. The nonreciprocal action of Rev and Rex suggests that these factors interact directly with the cis-acting RNA elements of the two viruses.

Keywords: Animal Cattle Gene Products, rev/*GENETICS Gene Products, rex/*GENETICS Genetic Complementation Test Human HIV-1/GENETICS HTLV-I/GENETICS Leukemia Virus, Bovine/GENETICS Mutation RNA, Messenger/GENETICS RNA, Viral/*GENETICS Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
910530
M9150916

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