[Experimental activation of cryptosporidiosis in mice by immunosuppression]

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

[Experimental activation of cryptosporidiosis in mice by immunosuppression]

Kisaengchunghak Chapchi. 1990 Mar;28(1):31-7. Unique Identifier : AIDSLINE MED/91104646
Chai JY; Shin SM; Yun CK; Yu JR; Lee SH; Department of Parasitology, College of Medicine, Seoul National; University, Korea.

Abstract: Cryptosporidium, a coccidian parasite first described by Tyzzer (1907) from a laboratory mouse, has become an important human enteric pathogen causing overwhelming diarrhea especially in immunocompromised patients such as AIDS. This parasite has been reported from over 20 countries and is recognized as a cosmopolitan species. In Korea, however, there has been no report on human as well as animal cryptosporidiosis. This study was performed so as to verify the presence of Cryptosporidium in Korea by activating the parasite from laboratory mice by immunosuppression. Total 65 conventionally-bred ICR mice including a control (5 mice) and 3 experimental groups (20 each) were used for this study. Group I was immunosuppressed with prednisolone injection (1 mg IM, every other day) for 7 weeks. Group II (prednisolone injection and tetracycline administration) and Group III (prednisolone injection and trimethoprim-sulfamethoxazole administration) were prepared to observe the effect of antibacterial agents on the activation of cryptosporidiosis. In fecal examinations of mice Cryptosporidium oocysts (4-6 microns in size) were detected from 1 week after the start of immunosuppression and the mice began to die. In H-E stained tissue sections of the lower jejunum, numerous very small (2-4 microns), dense, ovoid or spherical, slightly basophilic bodies were seen attached on the free border of mucosal epithelial cells. In scanning and transmission electron microscopic observations, these organisms were identified as various developmental stages of Cryptosporidium. The species is considered to be C. parvum.(ABSTRACT TRUNCATED AT 250 WORDS)

Keywords: Animal Cryptosporidiosis/ETIOLOGY/IMMUNOLOGY/*PARASITOLOGY Cryptosporidium/GROWTH & DEVELOPMENT/*PATHOGENICITY English Abstract Immune Tolerance *Immunosuppression Intestinal Diseases, Parasitic/ETIOLOGY/IMMUNOLOGY/*PARASITOLOGY Mice Mice, Inbred ICR JOURNAL ARTICLE
910530
M9150910

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