Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs [see comments]

Blood. 1990 Nov 15;76(10):1924-6. Unique Identifier : AIDSLINE MED/91055087
Gibbons J; Cory JM; Hewlett IK; Epstein JS; Eyster ME; Department of Medicine, Pennsylvania State University College of; Medicine, Hershey.

Abstract: We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
Keywords: Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/ETIOLOGY Blood Transfusion/*ADVERSE EFFECTS DNA, Viral/GENETICS Hemophilia/*COMPLICATIONS Human HIV Seropositivity/*COMPLICATIONS HIV-1/GENETICS/*ISOLATION & PURIF Male Opportunistic Infections/*EPIDEMIOLOGY/METABOLISM/MICROBIOLOGY Polymerase Chain Reaction Prevalence Prospective Studies Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDepidemiology/etiologybloodtransfusion/KWDadverseeffectsdna,viral/geneticshemophilia/KWDcomplicationshumanhivseropositivity/KWDcomplicationshiv-1/genetics/KWDisolation&purifmaleopportunisticinfections/KWDepidemiology/metabolism/microbiologypolymerasechainreactionprevalenceprospectivestudiessupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
Comment in: Blood 1991 Oct 1;78(7):1893-4
910330
M9130586

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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