Mathematical models of HIV infection. I. Threshold conditions for transmission and host survival. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Mathematical models of HIV infection. I. Threshold conditions for transmission and host survival.

J Acquir Immune Defic Syndr. 1990;3(12):1129-34. Unique Identifier : AIDSLINE MED/91056413
Bremermann HJ; Anderson RW; Department of Molecular and Cell Biology, University of; California, Berkeley 94720.

Abstract: This is the second in a series of papers modeling human immunodeficiency virus (HIV) infections at four levels: transmission, interaction with the immune system, gene regulation, and selection of mutants. In the previous paper (1) we described and presented a theory of the HIV cytopathic effect based upon the models (and a review of the literature). In this article we give mathematical equations of threshold conditions that connect infectivity, length of host survival, and frequency of acts conducive to transmission. The formula is derived not only for homogeneous populations but also for populations of an arbitrary number of subgroups with varying frequencies of risk behavior, varying rates of infection and latency periods, and varying frequencies of interaction with other groups.
Keywords: Cytopathogenic Effect, Viral Human HIV/PHYSIOLOGY HIV Infections/MORTALITY/*TRANSMISSION *Models, Biological *Models, Statistical Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDcytopathogeniceffect,viralhumanhiv/physiologyhivinfections/mortality/KWDtransmissionKWDmodels,biologicalKWDmodels,statisticalsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M9130560

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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