Acute syphilitic posterior placoid chorioretinitis. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Acute syphilitic posterior placoid chorioretinitis.

Ophthalmology. 1990 Oct;97(10):1288-97. Unique Identifier : AIDSLINE MED/91057002
Gass JD; Braunstein RA; Chenoweth RG; Department of Ophthalmology, Bascom Palmer Eye Institute, Miami,; FL 33101.

Abstract: Six patients with evidence of secondary syphilis presented with visual loss in both eyes caused by large, placoid, yellowish lesions with faded centers at the level of the pigment epithelium in the macula and juxtapapillary areas. All eyes had vitreitis. All of the lesions showed a similar fluorescein angiographic pattern of early hypofluorescence and late staining. Five patients had mucocutaneous lesions typical of secondary syphilis. All five patients treated with antibiotics had prompt improvement in visual function and resolution of the fundus lesions. The ophthalmoscopic and angiographic appearance of these posterior fundus lesions was sufficiently characteristic to suggest a diagnosis of secondary syphilis. Modification of the host response to syphilis by human immune deficiency virus (HIV) infection may be partly responsible for this peculiar fundus picture. Three of the four patients tested positive for HIV.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Acute Disease Adult Antibiotics/THERAPEUTIC USE Case Report Chorioretinitis/DRUG THERAPY/*ETIOLOGY Fluorescein Angiography Fundus Oculi Human HIV Seropositivity/COMPLICATIONS Male Middle Age Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Syphilis/*COMPLICATIONS/DRUG THERAPY Syphilis Serodiagnosis Syphilis, Cutaneous/COMPLICATIONS/PATHOLOGY Vision Disorders/ETIOLOGY Visual Acuity JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/complicationsacutediseaseadultantibiotics/therapeuticusecasereportchorioretinitis/drugtherapy/KWDetiologyfluoresceinangiographyfundusoculihumanhivseropositivity/complicationsmalemiddleagesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDsyphilis/KWDcomplications/drugtherapysyphilisserodiagnosissyphilis,cutaneous/complications/pathologyvisiondisorders/etiologyvisualacuityjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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