The oncogenicity of jun. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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The oncogenicity of jun.

Princess Takamatsu Symp. 1989;20:127-34. Unique Identifier : AIDSLINE MED/91170143
Vogt PK; Bos TJ; Mitsunobu F; Nishimura T; Monteclaro FS; Su HY; Department of Microbiology, Univeristy of Southern California; School of Medicine, Los Angeles 90033-1054.

Abstract: The oncogenic transforming potential of the jun oncogene was investigated with viral constructs that contain various terminal deletions of v-jun, c-jun and recombinants between the viral and cellular genes. Cellular jun can induce transformation of chicken embryo fibroblasts with a low efficiency. High efficiency transformation is dependent on alterations in the major transactivator domain. A jun deletion that lacks the transactivator domain is non-transforming. These observations are compatible with the conclusion that transcriptional regulation plays an important part in jun oncogenesis. In cells transformed by viral jun and expressing high levels of viral jun expression of the cellular jun is not constitutively upregulated. Cellular jun may therefore not contribute to transformation in these cells.
Keywords: Animal Cell Transformation, Viral Chick Embryo Chickens/GENETICS DNA-Binding Proteins/GENETICS/*PHYSIOLOGY Fibroblasts Gene Products, gag/GENETICS Genes, Synthetic Genetic Vectors *Oncogenes Proto-Oncogenes Recombinant Fusion Proteins/PHYSIOLOGY Recombination, Genetic Retroviridae Proteins, Oncogenic/GENETICS/*PHYSIOLOGY Sarcoma Viruses, Avian/*GENETICS Sequence Homology, Nucleic Acid Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Trans-Activators/GENETICS/PHYSIOLOGY Transcription Factors/GENETICS/*PHYSIOLOGY JOURNAL ARTICLEKWDanimalcelltransformation,viralchickembryochickens/geneticsdna-bindingproteins/genetics/KWDphysiologyfibroblastsgeneproducts,gag/geneticsgenes,syntheticgeneticvectorsKWDoncogenesproto-oncogenesrecombinantfusionproteins/physiologyrecombination,geneticretroviridaeproteins,oncogenic/genetics/KWDphysiologysarcomaviruses,avian/KWDgeneticssequencehomology,nucleicacidsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDtrans-activators/genetics/physiologytranscriptionfactors/genetics/KWDphysiologyjournalarticle
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M9160717

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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