HIV associated arthropathy: HIV antigen demonstration in the synovial membrane. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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HIV associated arthropathy: HIV antigen demonstration in the synovial membrane.

J Rheumatol. 1990 Sep;17(9):1195-201. Unique Identifier : AIDSLINE MED/91148061
Espinoza LR; Aguilar JL; Espinoza CG; Berman A; Gutierrez F; Vasey FB; Germain BF; Department of Internal Medicine, University of South Florida; College of Medicine, Tampa.

Abstract: Light and electron microscopic studies were performed on the synovial membranes of 5 patients with HIV associated arthropathy. An immunoperoxidase technique with the use of monoclonal antibodies against CD4, CD8, B and DR lymphocytes, and HIV p24 antigen was also used. Mild to moderate nonspecific proliferative changes and increased vascularity of the subsynovial space were seen. Electron dense deposits and viral-like particles were not observed. Immunohistochemical staining revealed HIV p24 positive staining in cells of the synovial lining layer and in the mononuclear cells of the subsynovial space. CD4, CD8, with predominance of CD8, and B and DR cells were also present. The presence of HIV p24 antigen may be indicative of a role, yet to be defined, in the pathogenesis of HIV associated rheumatic disorders.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY Antibodies, Monoclonal/IMMUNOLOGY Antigens, CD4/IMMUNOLOGY Human HIV/IMMUNOLOGY/ULTRASTRUCTURE HIV Antigens/ANALYSIS/IMMUNOLOGY/*ISOLATION & PURIF HLA-B Antigens/IMMUNOLOGY HLA-DR Antigens/IMMUNOLOGY Immunoenzyme Techniques Immunohistochemistry Joint Diseases/ETIOLOGY/IMMUNOLOGY/*MICROBIOLOGY Microscopy, Electron Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY Synovial Membrane/CHEMISTRY/IMMUNOLOGY/ULTRASTRUCTURE JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/complications/immunologyantibodies,monoclonal/immunologyantigens,cd4/immunologyhumanhiv/immunology/ultrastructurehivantigens/analysis/immunology/KWDisolation&purifhla-bantigens/immunologyhla-drantigens/immunologyimmunoenzymetechniquesimmunohistochemistryjointdiseases/etiology/immunology/KWDmicrobiologymicroscopy,electronopportunisticinfections/complications/immunologysynovialmembrane/chemistry/immunology/ultrastructurejournalarticle
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M9160675

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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