Association of thrombotic thrombocytopenic purpura and human immunodeficiency virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Association of thrombotic thrombocytopenic purpura and human immunodeficiency virus infection.

Nouv Rev Fr Hematol. 1990;32(4):277-80. Unique Identifier : AIDSLINE MED/91149139
Beris P; Dunand V; Isoz C; Reynard C; Departement de Medecine, Hopital Cantonal Universitaire,; Geneve, Suisse.

Abstract: A 35 year-old HIV-positive male intravenous drug abuser developed thrombotic thrombocytopenic purpura (TTP) during the course of recto-sigmoiditis secondary to Shigella flexneri. Complete remission was achieved by aggressive treatment of a combination of plasma exchange, fresh frozen plasma infusion, continuous prostacyclin perfusion, p.o. administered aspirin-dipyridamol and intravenous injections of vincristine. During acute microangiopathy, an acquired type II von Willebrand disease was diagnosed. TTP is a newly-recognized hematologic manifestation of HIV-1 infection; endothelial damage by endotoxin during course of infection or by high serum levels of circulating immune complexes may be a causative mechanism of microangiopathy causing hemolysis and platelet consumption.
Keywords: von Willebrand Factor/METABOLISM Adult Case Report Ciprofloxacin/THERAPEUTIC USE Human HIV Infections/*COMPLICATIONS Male Proctocolitis/COMPLICATIONS/DRUG THERAPY/MICROBIOLOGY Purpura, Thrombotic Thrombocytopenic/*COMPLICATIONS Shigella flexneri/ISOLATION & PURIF Substance Abuse, Intravenous/*COMPLICATIONS JOURNAL ARTICLEKWDvonwillebrandfactor/metabolismadultcasereportciprofloxacin/therapeuticusehumanhivinfections/KWDcomplicationsmaleproctocolitis/complications/drugtherapy/microbiologypurpura,thromboticthrombocytopenic/KWDcomplicationsshigellaflexneri/isolation&purifsubstanceabuse,intravenous/KWDcomplicationsjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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