RESPONSE OF CALVES INOCULATED WITH BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV) (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

RESPONSE OF CALVES INOCULATED WITH BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV) (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 32:A1862 1991. Unique Identifier : AIDSLINE ICDB/91674664
Thurmond M; Theilen G; Stott J; Kwon O; Sninsky J; Koyama M; Univ. of California, Davis, CA 95616

Abstract: Calves were inoculated with BIV to determine pathogenesis of this virus under controlled conditions. They were frequently examined for viremia, presence of antibodies to BIV and immunologic changes. Presence of viremia was monitored in vivo by PCR and in vitro by RT assays and syncytia formation. Antibody titers were studied by IFA. Immunologic changes were detected with analysis of Cd4-Cd8 ratio changes and health was monitored by physical examinations and CBCs. IFA antibody titers and syncytia formation appeared before viremia was detected using PCR techniques. Initially there was a Cd4-Cd8 ratio reversal similar to early changes seen in AIDS patients, with return to normal ratios soon thereafter. Inoculated animals have remained physically normal for 2 yr postinoculation. Based on our results, BIV may not be an immunodeficiency-inducing virus.

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Animal Antigens, CD4/ANALYSIS Antigens, Differentiation, T-Lymphocyte/ANALYSIS Cattle Human Immunodeficiency Virus, Bovine/GENETICS/*IMMUNOLOGY Lentivirus Infections/*IMMUNOLOGY Polymerase Chain Reaction ABSTRACT
910730
M9170995

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