Early encephalopathy in the SIV model.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

Early encephalopathy in the SIV model.

Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:30 (abstract no. 14). Unique Identifier : AIDSLINE PRIM8/900014
Hurtrel B; Chakrabarti L; Hurtrel M; Maire MA; Dormont D; Montagnier L; Institut Pasteur, Paris, France

Abstract: The development of non human primate models is crucial for the understanding of the first stages of HIV-CNS infection. Rhesus macaques were inoculated by intravenous (IV) or intracerebral (IC) routes with SIV mac 251 and regularly sacrificed (7, 15 days,1,2 and 3 months). CNS was studied by light microscopy, immunohistochemical and in situ hybridization analyses. In IC injected animals, although SIV could be detected by in situ hybridization in all the brains, the CNS showed only slight gliosis sometimes associated with perivascular infiltrates. These results indicate that there is no direct neuropathogenicity of SIV and that progression of infection towards the AIDS dementia complex involves the role of coinfections, or immunodeficiency, or an immunopathological process. The CNS of IV injected animals showed gliosis and perivascular infiltrates; white matter lesions and glial nodules with multinucleated giant cells were found in 2 animals with immunological deficiency (T4 decrease, antibody defect). SIV could be characterized in the CNS by in situ hybridization very early (7 days) after IV inoculation. Using immunochemistry procedures, infiltrating cells were identified as macrophages, T, and B cells; using combined immunochemistry and in situ hybridization, we showed that infected cells express macrophage markers. Using different genomic probes, hypotheses concerning SIV RNA expression during early brain infection were tested. It was shown that the latent brain infection is not due to a complete transcription block but rather to a productive replication of SIV at a low level, in a small number of target cells in the brain.

Keywords: Animal AIDS Dementia Complex/*MICROBIOLOGY B-Lymphocytes/MICROBIOLOGY Biological Markers Central Nervous System/ULTRASTRUCTURE *Disease Models, Animal *Macaca mulatta Macrophages/MICROBIOLOGY RNA, Messenger/BIOSYNTHESIS Simian Acquired Immunodeficiency Syndrome/*COMPLICATIONS SIV/GROWTH & DEVELOPMENT/GENETICS T-Lymphocytes/MICROBIOLOGY Transcription, Genetic Virus Replication ABSTRACT
910730
M9170980

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