HIV-2 infection in macaque species.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

HIV-2 infection in macaque species.

Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:32 (abstract no. 16). Unique Identifier : AIDSLINE PRIM8/900016
Morton WR; McClure J; Schmidt A; Kuller L; Gale M; Hu SL; Regional Primate Research Center, University of Washington,; Seattle, WA 98195

Abstract: Human immunodeficiency virus type 2 (HIV-2) has a high degree of homology to the simian immunodeficiency virus (SIV), which has been shown to cause AIDS in several species of nonhuman primates. Use of HIV-2-infected macaques as an animal model of AIDS has several advantages, and may well limit the need for the use of chimpanzees. Two strains of HIV-2 (ROD and EHO) were obtained that exhibit differing degrees of cytopathogenicity to macaque PMBCs in vitro. Two groups, consisting of 4 Macaca nemestrina (Mn) and 4 M. fascicularis (Mf), received autologous PBMCs that had been infected with either the ROD or EHO strain, along with cell-free virus. In a third study, 10 ml whole blood was transfused from one EHO-infected Mn into each of 2 Mn; likewise, from one ROD-infected Mn into 2 Mn. With the exception of 1 EHO-inoculated M. fascicularis, all animals have become infected, as demonstrated by seroconversion and viremia. The first group of Mn infected is now 56 weeks post-inoculation (PI). One of these animals was euthanized due to an episode of acute gastric distress and collapse; in addition to CD4 cell depletion, findings at necropsy revealed signs similar to SIV-induced AIDS. The remaining 3 animals show signs of persistent fever, but otherwise remain in apparent good health. The Mf of the second group, now 8 weeks PI, are normal at the present time; HIV-2 has been isolated from 3 of the 4 animals. In the whole blood transfusion study, also 8 weeks PI,the two EHO recipients show signs of clinical disease: i.e., fever, weight loss, diarrhea, dehydration and lymphadenopathy. These results indicate that HIV-2 infection of macaques is efficient and is likely to be useful as a disease model for AIDS.

Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS/PATHOLOGY Animal Blood Transfusion Cells, Cultured Cytopathogenic Effect, Viral CD4-Positive T-Lymphocytes/MICROBIOLOGY Disease Models, Animal HIV-2/GROWTH & DEVELOPMENT/*PHYSIOLOGY Macaca fascicularis Macaca nemestrina *Simian Acquired Immunodeficiency Syndrome/COMPLICATIONS/ PATHOLOGY SIV/*PHYSIOLOGY Viremia ABSTRACT
910730
M9170978

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