1991

Daily life of an AIDS patient. [videorecording]: Princeton, N.J. : Films for the Humanities, c1987 1 videocassette : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9100722A; Hyman H
Just a regular kid : an AIDS story. [videorecording]: [United States] : Diana Kerew Productions, c1987 1 videocassette : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9100754A; Henderson F; (Producer) This program edited for educational use, puts the critical need for AIDS education before the teenage audience. With concern for the spread of AIDS crossing into all segments of society, it is important to know how the disease is transmitted. This drama presents important information on AIDS and confronts
Treating and preventing AIDS. [videorecording]: Princeton, N.J. : Films for the Humanities, c1988 1 videocassette : sd., col. ; 1/2 in (Facts for life) Unique Identifier : AIDSLINE AV/9100762A; (Producer) AIDS leaves its victim with no defenses against infection. In this very frank program, a heterosexual drug user describes life with AIDS, as doctors seek delaying tactics, treating the infections to which victims are prone. AIDS victims make clear recommendations to those who still have a choice: proper u
AIDS. [videorecording]: Bloomington, MN : Health Education Video, [1989] 1 videocassette (12 min., 34 sec.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9100765A
6th International Conference on AIDS, San Francisco. [sound recording]: North Hollywood, CA : Professional Programs, 1990 121 sound cassettes : 1 7/8 ips Unique Identifier : AIDSLINE AV/9100685A
AIDS in Africa. [videorecording]: [Canada] : Roger Pyke Productions, c1990 1 videocassette (51 min., 35 sec.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9100716A; (Producer) This documentary is the most comprehensive report from the frontlines of the war on AIDS. The disease is especially rampant in Central Africa where it is estimated that several million may be dead by the year 2000. Unlike Europe and the United States , where 90% of AIDS vi
AIDS : ABC News special assignment. [videorecording]: Deerfield, IL : MTI Film & Video, [1990] 1 videocassette (13 min., 21 sec.) : sd., col. ; 1/2 in. + 1 leaflet Unique Identifier : AIDSLINE AV/9100751A; (Producer) This program gives the most recent facts about AIDS: where it came from, how it is spread, what is being done to combat it. This program helps fight some of the fear-inspired myths about AIDS and leads to a more realistic and compassionate understanding of the disease and its victims.
The:Family physician's guide to HIV infection and AIDS. [videorecording]: Kansas City, Mo. : American Academy of Family Physicians, c1990 1 videocassette : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9100753A; Tudor JM; Felmar EA
AIDS/HIV clinical trial handbook.: New York, N.Y. (Suite T-3601 1515 Broadway, New York 10036) : American Foundation for AIDS Research, [between 1985 and 1991] 20 p Unique Identifier : AIDSLINE CAT/9106886
AIDS : facts and fiction.: Accra : Ghana Universities Press, 1986 30 p Unique Identifier : AIDSLINE CAT/9106098; Neequaye AR
The:AIDS/HIV epidemic.: [St. Paul, Minn. : The Dept., 1988] 92 p. : ill Unique Identifier : AIDSLINE CAT/9106100
Drug-nutrient interactions in AIDS guidebook.: Fremont, Calif. : Cutting Edge, c1988 58, 24, 11 p Unique Identifier : AIDSLINE CAT/9107798; Newman CF; Horn B
[El:SIDA en Mexico : los efectos sociales.] 1. ed.: [Mexico] : Ediciones de Cultura Popular, 1988 399 p. : ill Unique Identifier : AIDSLINE CAT/9107680; Galvan Diaz F
AIDS treatment research and approval : hearing before the Committee on Labor and Human Resources, United States Senate, One Hundredth Congress, second session, on examining what progress has been made, what is needed to make progress more rapid, and what barriers stand in the way of better research and swifter distribution of hopeful therapies, July 13, 1988.: Resources Washington : U.S. G.P.O. ; For sale by the Supt. of Docs., Congressional Sales Office, U.S. G.P.O., 1988 iii, 198 p. : ill (S. hrg. ; 100-821) Unique Identifier : AIDSLINE CAT/9107742
[AIDS : powstawanie, obraz kliniczny, proby leczenia, epidemiologia.]: Wroclaw : Zaklad Narodowy im. Ossolinskich, 1988 181 p. : ill Unique Identifier : AIDSLINE CAT/9107743; Skotnicki AB
[AIDS : een nieuwe verantwoordelijkheid voor gezondheidszorg en onderwijs.]: Amsterdam : Swets & Zeitlinger, c1989 200 p. : ill Unique Identifier : AIDSLINE CAT/9106099; Noordhof A
[AIDS, medisch en sociaal : een evaluatie van een TELEAC-cursus.]: Delft : Eburon, 1989 123 p. : ill (NISSO studies (nieuwe reeks) ; nr. 1) Unique Identifier : AIDSLINE CAT/9106101; Lodewijkx H
[Diagnostiek en behandeling van patienten met een HIV-infectie : een protocollaire benadering.]: Utrecht : Bohn, Scheltema & Holkema, 1989 63 p Unique Identifier : AIDSLINE CAT/9106166; Danner SA
[Schwarze Angst, Leben mit AIDS.] 1. Aufl.: Stuttgart : Quell, 1989 240 p. : ill Unique Identifier : AIDSLINE CAT/9106778; Becker-Kolle C
[SIDA en Colombia : nunca me imagine que podria infectarme testimonios.] 2. ed.: [Colombia? : s.n.], 1989. -- (Medellin, Colombia : Editorial Colina) 283 p. : ill Unique Identifier : AIDSLINE CAT/9106791; Gomez Gomez S
Public and professional attitudes toward AIDS patients : a national dilemma.: Boulder : Westview Press, 1989 viii, 136 p Unique Identifier : AIDSLINE CAT/9107174; Rogers DE; Ginzberg E
Education for the prevention and control of AIDS.: Bangkok : Unesco Principal Region Office for Asia and the Pacific, 1989 iii, 121 p (Abstract-bibliography series ; 10) Unique Identifier : AIDSLINE CAT/9106951
AIDS and young people.: Eastbourne : Kingsway Publications, 1989 127 p Unique Identifier : AIDSLINE CAT/9107358; Dixon P
AIDS education, care, and drug development : hearing before the Committee on Labor and Human Resources, United States Senate, One Hundred First Congress, first session, on examining the adequacy of the federal government efforts to combat AIDS, with regard to education, care, and drug development, February 7, 1989.: Resources Washington : U.S. G.P.O. ; For sale by the Supt. of Docs., Congressional Sales Office, U.S. G.P.O., 1989 iv, 219 p. : ill (S. hrg. ; 101-22) Unique Identifier : AIDSLINE CAT/9107359
[Sida espoir : ce que nous apprennent les vainqueurs du sida.]: Chene-Bourg, Geneve : Editions Soleil, c1990 235 p. : ill Unique Identifier : AIDSLINE CAT/9106782; Docteur Soleil
AIDS litigation project : a national survey of federal, state, & local cases before courts & human rights commissions.: Washington, DC : Dept. of Health and Human Services, Public Health Service, Office of the Assistant Secretary for Health, Office of PHS HIV/AIDS Coordination, 1990 viii, 172 p Unique Identifier : AIDSLINE CAT/9106884; Gostin LO; Porter L; Sandomire H; Gostin LO
Resources for teaching about the social impact of AIDS in Africa.: Bloomington, IN : African Studies Program, Indiana University, [1990] 24 p Unique Identifier : AIDSLINE CAT/9106761; Schmidt NJ
[AIDS und Sozialleistungen : Leitfaden fur Betroffene und Betreuer bei HIV-Infektion und AIDS-Erkrankung.] 1. Aufl.: Sankt Augustin : Asgard-Verlag, 1990 112 p Unique Identifier : AIDSLINE CAT/9107360; Lichtenberg P
[Tiempos del SIDA : relatos de la vida real.]: San Jose, Costa Rica : Euroamericana de Ediciones, 1990 printing 117 p Unique Identifier : AIDSLINE CAT/9107244; Francis M
[Le:S.I.D.A.] 3. ed. mise a jour.: Paris : Presses universitaires de France, 1990 127 p. : ill (Que sais-je? ; 2332) Unique Identifier : AIDSLINE CAT/9107191; Cassuto J
Providers of health care services, 1984/85-1987/88.: [Sacramento, Calif.] : Dept. of Health Services, [1990] ii, 16 p. : ill (Medi-Cal studies in AIDS ; no. 3) Unique Identifier : AIDSLINE CAT/9107167
AIDS and ethics : a bibliography.: Services Silver Spring, MD : National Center for Social Policy & Practice, Information Services, c1990 Unique Identifier : AIDSLINE CAT/9107740; The National Center for Social Policy & Practice created this bibliography about AIDS and ethics as a balanced and extensive source of current published literature on the range of issues pertaining to the ethical dimensions of AIDS. Citations were derived from searches of 21 databases from various fields, such as s
Cancer and AIDS : a psychogenic theory and case report.: Frankfurt am Main : Haag + Herchen, c1990 375 p. : ill Unique Identifier : AIDSLINE CAT/9107763; Simmons HE
AIDS/HIV treatment directory. Vol. 4, no. 1 (June 1990)-: New York, NY : The Foundation, c1990- v. : ill Unique Identifier : AIDSLINE CAT/9107362
[Ergebnisse sozialwissenschaftlicher Aids-Forschung.] Bd. 1-: Berlin : Edition Sigma, c1990- v. : ill Unique Identifier : AIDSLINE CAT/9107450
Pediatric AIDS and HIV infection. Vol. 1, no. 1-: New York, NY : Mary Ann Liebert, Inc., c1990- v. : ill Unique Identifier : AIDSLINE CAT/9107942
Genetic structure and regulation of HIV.: New York : Raven Press, c1991 xix, 537 p. : ill (Harvard AIDS Institute series on gene regulation of human retroviruses ; v. 1) Unique Identifier : AIDSLINE CAT/9106203; Haseltine WA; Wong-Staal F
AIDS practice manual : a legal and educational guide. 3rd ed.: San Francisco, CA : National Lawyers Guild AIDS Network in conjunction with AIDS Law Project of Pennsylvania, Gay Men's Health Crisis, Whitman-Walker Clinic, c1991 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9106522; Albert P
AIDS.: New York : Facts on File, c1991 viii, 248 p (Library in a book) Unique Identifier : AIDSLINE CAT/9106885; Flanders SA; Flanders CN; Discusses the AIDS epidemic, including a chronology of major events, a summary of important court cases, a biographical listing of key individuals, and a reference guide to further research.
A:Community approach to AIDS intervention : exploring the Miami outreach project for injecting drug users and other high risk groups.: New York : Greenwood Press, 1991 xii, 234 p. : ill (Contributions in medical studies, ISSN 0886-8220 ; no. 33) Unique Identifier : AIDSLINE CAT/9106551; Chitwood DD
AIDS : abstracts of the psychological and behavioral literature, 1983-1991. 3rd ed.: Arlington, Va. : American Psychological Association, c1991 ix, 301 p (Bibliographies in psychology ; no. 6) Unique Identifier : AIDSLINE CAT/9107744; Anderson JR; Landry CP; Kerby JL
HIV testing & quality control : a guide for laboratory personnel.: Durham, N.C., USA : AIDSTECH, Family Health International, 1991 xii, 165 p. : ill., forms Unique Identifier : AIDSLINE CAT/9107500; Constantine NT; Callahan JD; Watts DM; Mitchell S; Gringle R; Archbold E
Prospects for antisense nucleic acid therapy of cancer and AIDS.: New York : Wiley-Liss, c1991 xiv, 269 p. : ill Unique Identifier : AIDSLINE CAT/9107966; Wickstrom E
Neuropathology and ophthalmologic pathology of the acquired immunodeficiency syndrome : a color atlas.: East Hanover, N.J. : Sandoz ; Boston : Butterworth-Heinemann, c1992 ix, 165 p. : ill Unique Identifier : AIDSLINE CAT/9107578; De Girolami U
AIDS prevention and treatment : hope, humor, and healing.: New York : Hemisphere Pub. Corp., c1992 xiii, 276 p. : ill (The Series in health psychology and behavioral medicine, ISSN 8756-467X) Unique Identifier : AIDSLINE CAT/9107741; Seligson MR; Peterson KE
HIV/AIDS : a guide to nursing care. 2nd ed.: Philadelphia : Saunders, c1992 xiii, 515 p. : ill Unique Identifier : AIDSLINE CAT/9107501; Flaskerud JH; Ungvarski PJ
AIDS : an African perspective.: Boca Raton : CRC Press, c1992 363 p. : ill Unique Identifier : AIDSLINE CAT/9107361; Williams AO
EPSTEIN-BARR VIRUS (EBV) GENOTYPES IN AIDS-ASSOCIATED LYMPHOMAS ARE SIMILAR TO THOSE IN ENDEMIC BURKITT'S LYMPHOMAS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1320 1991. Unique Identifier : AIDSLINE ICDB/91674135; Goldschmidts W; Bhatia K; Gutierrez M; Carolan M; Akar N; Magrath I; Pediatric Branch, NCI, Bethesda, MD 20892; Recent data have suggested that both the major EBV subtypes (type A and type B) are equally prevalent in the US. This is in contrast to the infrequent association of the type B virus in sporadic EBV-positive Burkitt s tumors. To characterize the distribution of the two EBV strains in EBV-associated neoplasms, we scree
ANTISENSE-MEDIATED SPECIFIC INHIBITION OF P120 PROTEIN EXPRESSION AND CELL PROLIFERATION (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1642 1991. Unique Identifier : AIDSLINE ICDB/91674438; Fonagy A; Wilson A; Busch H; Freeman JW; Dept. of Surgery, Univ. of Kentucky Medical Center, Lexington, KY; 40536; Monoclonal antibodies, cDNAs, and the genomic DNA have been obtained for the proliferation-associated nucleolar antigen P120 (Freeman et al, Cancer Res 48:1244-51, 1988; Fonagy et al, Cancer Comm 1:243-51, 1989; and Larson et al, Cancer Comm 2:63-71, 1990). In this study, we report that transfection of a pentadecadeox
PHORBOL DIESTER STIMULATED HL-60 CELL DIFFERENTIATION IS ASSOCIATED WITH THE ACTIVATION OF SPECIFIC DNA BINDING PROTEINS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1751 1991. Unique Identifier : AIDSLINE ICDB/91674552; Rogers M; Small GW; Samples L; Daniel LW; Dept. of Biochemistry, Bowman Gray Sch. of Medicine, Wake Forest; Univ., Winston-Salem, NC 27103-2796; TPA-stimulated differentiation of HL-60 cells to macrophagelike cells is accompanied by morphological and biochemical changes, including cellular adhesion and expression of the lymphocyte cell adhesion molecule subunit cd 11b. Using cellular adhesion assays and direct immunofluorescence microscopy of cd 11b, we observ
MUTATIONS INTRODUCED ALONG THE HTLV-1 ENVELOPE GENE RESULT IN A NONFUNCTIONAL PROTEIN: A BASIS FOR ENVELOPE CONSERVATION (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1846 1991. Unique Identifier : AIDSLINE ICDB/91674648; Dokhelar MC; Pique C; Tursz T; Institut G. Roussy, Villejuif, France; The envelope protein of the human T leukemia virus type I (HTLV-I) is highly conserved among the isolates sequenced so far, as opposed to what is observed for the human immunodeficiency virus envelope. By linker insertion scanning, we have produced 33 random mutations along the HTLV-I envelope gene, cloned into a euka
HUMAN GLIAL CELLS FROM FETAL BUT NOT ADULT HUMAN BRAIN ACTIVATE THE EXPRESSION OF HIV IN CHRONICALLY INFECTED MONOCYTES (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1860 1991. Unique Identifier : AIDSLINE ICDB/91674662; Kalebic T; Helman L; Pizzo P; Lab. of Molecular Genetics, Pediatric Branch, NCI, Bethesda, MD; 20892; The purpose of this study was to investigate whether human glial cell lines derived from fetal brain release soluble factors which induce the expression of latent HIV in chronically infected monocytes. As a cellular model for HIV latency, we used the promonocytic U1 cell line, harboring in its genome 2 copies of provi
IMMUNOELECTRON MICROSCOPIC STUDY OF HTLV-I-PRODUCING HUMAN LYMPHOCYTES IN VITRO (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1861 1991. Unique Identifier : AIDSLINE ICDB/91674663; Ohtsuki Y; Iwata J; Oka T; Furihata M; Sonobe H; Miyoshi I; Dept. of Pathology, Kochi Medical Sch., Kochi 783, Japan; HTLV-I-producing human lymphoid cell lines, derived from ATL and HAM patients, and lymphocytes from HTLV-I carriers and seronegative healthy individuals were tested for lymphocyte markers, on the viral envelope and the plasma membrane. Short-term cultured lymphocytes from HTLV-I carriers, but not the virus were labele
RESPONSE OF CALVES INOCULATED WITH BOVINE IMMUNODEFICIENCY-LIKE VIRUS (BIV) (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A1862 1991. Unique Identifier : AIDSLINE ICDB/91674664; Thurmond M; Theilen G; Stott J; Kwon O; Sninsky J; Koyama M; Univ. of California, Davis, CA 95616; Calves were inoculated with BIV to determine pathogenesis of this virus under controlled conditions. They were frequently examined for viremia, presence of antibodies to BIV and immunologic changes. Presence of viremia was monitored in vivo by PCR and in vitro by RT assays and syncytia formation. Antibody titers were
THE OXYGEN FREE RADICAL-ASSOCIATED DNA ADDUCT 8-OXOGUANINE CAUSES G-C TO T-A TRANSVERSIONS DURING IN VIVO DNA REPLICATION (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 32:A895 1991. Unique Identifier : AIDSLINE ICDB/91673722; Cheng KC; Cahill DS; Kasai H; Nishimura S; Loeb LA; Dept. of Pathology, Univ. of Washington, Seattle, WA 98195; A major product of oxygen damage to DNA is 8-oxoguanine. The mutagenic potential of this adduct was tested in the M13G assay, a site-specific assay for in vivo mutations caused by guanine adducts inserted into the E coli lacZ gene. Site-specific insertion of 8-oxoguanine using the DNA polymerase activity of HIV-1 reve
Molecular diversity of SIVsm/PBj and a cognate variant (SIVsm/PGg).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:17 (abstract no. 1). Unique Identifier : AIDSLINE PRIM8/900001; Novembre FJ; Hirsch VM; McClure HM; Johnson PR; Department of Microbiology, Georgetown University, and Laboratory; of Infectious Diseases, NIAID/NIH, Rockville, Md.; Experimental inoculation of SIVsm/PBj (PBj) into pig-tail macaques induces an acute syndrome characterized by fulminant diarrhea, acid-base imbalance, and death. This outcome is in distinct contrast to the more protracted immunodeficiency syndrome (AIDS) caused by other SIVsm isolates, including the PBj parental strai
Both in vitro culture and in vivo passage lead to selective replication of SIV variants.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:18 (abstract no. 2). Unique Identifier : AIDSLINE PRIM8/900002; Villinger F; De B; Jehuda-Cohen T; Powell JD; Neckelmann N; McClure HM; Folks TM; Ansari AA; Yerkes Regional Primate Research Center, Dept. of Pathology,; Emory University School of Medicine, Atlanta, GA 30322; A set of oligo primers was prepared based on the sequence shared by various SIV isolates from a variety of nonhuman primate species. This primer pair was used to amplify and sequence the middle third of the gag region of the endogenous SIVsmm (SIVsmm-e) present in the DNA prepared from the PBMC of naturally infected c
The fate of molecularly cloned SIV in vivo: patterns of genetic evolution associated with AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:19 (abstract no. 3). Unique Identifier : AIDSLINE PRIM8/900003; Johnson PR; Hamm TE; Hirsch VM; Department of Microbiology, Georgetown University, and Laboratory; of Infectious Diseases, NIAID/NIH, Rockville, Md. 20852; One potential obstacle to the development of an effective AIDS vaccine is the inordinate genetic heterogeneity of HIV isolates. The basis for this genetic diversity appears to be the extreme plasticity of the HIV genome. Although highly informative, studies presented to date on the genetic variation of HIV-1 from infe
Genetic determinants of SIVmac macrophage tropism map to env.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:20 (abstract no. 4). Unique Identifier : AIDSLINE PRIM8/900004; Mori K; Sehgal P; Ringler D; Desrosiers R; New England Regional Primate Research Center; A molecular clone of SIVmac239 produces virus which causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. This cloned virus replicates well in primary PBL cultures and in CD4+ lymphoid cell lines but it replicates poorly in cultured macrophages. We have used primary alveolar macrophages
Nucleotide sequence of the pathogenic SIV239 clone and analysis of nef function.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:21 (abstract no. 5). Unique Identifier : AIDSLINE PRIM8/900005; Kestler H; Regier D; Mori K; Kodama T; Daniel M; Desrosiers R; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, MA, USA; The SIVmac239 infectious molecular clone yields virus that induces AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome, including both LTRs, is 10,279 base pairs. Nine open reading frames, previously identified in other HIV-2/SIVmac/SIVsmm isolates, were also present in th
Biological characterization of SIV molecular clones from tissue of an immunodeficient macaque.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:22 (abstract no. 6). Unique Identifier : AIDSLINE PRIM8/900006; Hirsch VM; Dapolito G; Goldstein S; Johnson PR; Department of Microbiology, Georgetown University and Laboratory; of Infectious Diseases, NIAID, NIH, Rockville, MD; Tissues of immunodeficient macaques experimentally infected with SIVsm contain multiple diverse genotypes, best described as a proviral swarm. We wished to assess the biologic relevance of these multiple genomes. For this purpose, we used PCR to derive molecular clones of the 3 half (4.3 kb) of the proviral genome fr
Molecular analysis of SIV from stumptailed macaque indicates two distinct origins of infection of captive monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:23 (abstract no. 7). Unique Identifier : AIDSLINE PRIM8/900007; Khan AS; Galvin T; Gardner MB; Lowenstine LJ; NIAID, NIH, Bethesda, MD; The natural hosts of simian immunodeficiency viruses (SIVs) are African monkeys including sooty mangabeys, mandrills and African green monkeys. SIVs, however, have also been isolated from captive Asian macaques such as pigtailed, rhesus and stumptailed macaques. The Asian monkeys are thought to have acquired SIVs in c
Natural infection of West African green monkeys with a unique SIVAGM subtype.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:24 (abstract no. 8). Unique Identifier : AIDSLINE PRIM8/900008; Allan JS; Short M; Taylor M; Su S; Hirsch V; Johnson P; Shaw G; Hahn B; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas; African green monkeys harbor a lentivirus related to human AIDS viruses in genomic organization, their gene products, cellular tropism and cytopathology for CD4 bearing T lymphocytes. In contrast to HIV-1, the simian viruses (SIVagm) vary to a much greater degree in nucleotide sequence than HIV-1 strains. African gree
Type-specific neutralizing determinant in the SIVmac transmembrane protein.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:25 (abstract no. 9). Unique Identifier : AIDSLINE PRIM8/900009; Kodama T; Burns D; Silva D; di Marzo Veronese F; Desrosiers R; Department of Microbiology and Molecular Genetics, New England; Regional Primate Research Center, Harvard Medical School,; Southborough, MA, USA; Monoclonal antibody SF8/5E11, which recognizes the transmembrane protein (TMP) of simian immunodeficiency virus of macaque monkeys (SIVmac), displayed strict type-specificity. It reacted with cloned and uncloned SIVmac251 but not with cloned SIVmac142 and SIVmac239 on immunoblots. This monoclonal antibody neutralized
Receptor binding mediates activation of fusogenic events in viral penetration.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:26 (abstract no. 10). Unique Identifier : AIDSLINE PRIM8/900010; Allan JS; Short M; Bradford D; Whitehead E; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas; Recent studies have suggested that events involved in viral entry are initiated by receptor binding to the viral membrane. Based on our previous studies we proposed that CD4, either as soluble form or as a cell membrane constituent, activates the viral membrane by inducing conformational changes leading to viral fusio
Influence of cytokines on SIV replication in macrophages.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:27 (abstract no. 11). Unique Identifier : AIDSLINE PRIM8/900011; Horvath CJ; Walsh DG; Daniel MD; Sehgal PK; Desrosiers RC; Ringler DJ; Harvard Medical School, New England Regional Primate Research; Center, 1 Pine Hill Dr., Southborough, Mass., USA; We and others have previously shown that tissue macrophages represent important targets for SIV replication in vivo and in vitro. Control of lentiviral replication within macrophages is likely influenced by a variety of viral and cellular factors; of these cellular factors, cytokines have received significant attentio
Viral and cellular gene expression in CD4 positive lymphoid cells infected by the simian immunodeficiency virus, SIV/Mne: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:28 (abstract no. 12). Unique Identifier : AIDSLINE PRIM8/900012; Agy MB; Foy K; Gale MJ; Clark EA; Katze MG; Department of Microbiology and Regional Primate Research Center,; University of Washington, Seattle WA 98195; Our laboratory has undertaken an analysis of cellular and viral gene expression in human CD4 positive cells infected by the human and simian immunodeficiency viruses. The purpose of our current study was two-fold: (i) To examine the effects of SIV/Mne infection on cellular gene expression in susceptible human CD4 posi
Induction of infection of rhesus monkeys with topical instillation of SIV/B670 into the conjunctival sac.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:29 (abstract no. 13). Unique Identifier : AIDSLINE PRIM8/900013; Conway MD; Murphey-Corb M; Davison-Fairburn B; Martin L; Delta Regional Primate Research Center, Tulane University,; Covington, LA; Laboratory accidents in which HIV is accidently instilled into the conjunctival cul de sac provide a means by which the retrovirus comes in contact with a mucous membrane and may provide a route for systemic infection. We tested the ability of SIV, a lentivirus immunologically and antigenically related to HIV, to indu
Early encephalopathy in the SIV model.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:30 (abstract no. 14). Unique Identifier : AIDSLINE PRIM8/900014; Hurtrel B; Chakrabarti L; Hurtrel M; Maire MA; Dormont D; Montagnier L; Institut Pasteur, Paris, France; The development of non human primate models is crucial for the understanding of the first stages of HIV-CNS infection. Rhesus macaques were inoculated by intravenous (IV) or intracerebral (IC) routes with SIV mac 251 and regularly sacrificed (7, 15 days,1,2 and 3 months). CNS was studied by light microscopy, immunohis
Characterization of simian immunodeficiency virus fusion peptide.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:31 (abstract no. 15). Unique Identifier : AIDSLINE PRIM8/900015; Lambrecht B; Brasseur R; Bex F; Burny A; Horth M; Department of Molecular Biology, University of Brussels, 67 rue; des Chevaux, 1640 Rhode-St-Gen/gese, Belgium; The aim of our work is the study of the fusogenic domain of SIV glycoproteins: this highly hydrophobic region is located just after the cleavage site at the amino-terminus of the transmembrane glycoprotein. The tridimensional conformation in a lipid bilayer, of fusion peptides of 30 syncytia-inducing viruses including
HIV-2 infection in macaque species.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:32 (abstract no. 16). Unique Identifier : AIDSLINE PRIM8/900016; Morton WR; McClure J; Schmidt A; Kuller L; Gale M; Hu SL; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; Human immunodeficiency virus type 2 (HIV-2) has a high degree of homology to the simian immunodeficiency virus (SIV), which has been shown to cause AIDS in several species of nonhuman primates. Use of HIV-2-infected macaques as an animal model of AIDS has several advantages, and may well limit the need for the use of
Maternal-fetal transmission of SIV in macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:33 (abstract no. 17). Unique Identifier : AIDSLINE PRIM8/900017; Ochs HD; Morton WR; Zhu Q; Kuller LD; Wu YP; Thouless ME; Benveniste RE; Department of Pediatrics, University of Washington, Seattle, WA; Infants and children have become the fastest growing HIV-infected segment in the U.S. and world-wide, reflecting an increase in HIV-infected women of childbearing age. To study the mechanisms of maternal-fetal transmission and to test strategies to prevent infection of the fetus, we have developed a model of maternal-
Maternal transmission of SIVsmm in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:34 (abstract no. 18). Unique Identifier : AIDSLINE PRIM8/900018; McClure H; Anderson DC; Fultz PN; Ansari AA; Jehuda-Cohen T; Villinger F; Klumpp SA; Switzer W; Lockwood E; Brodie A; Yerkes Primate Research Center and Department of Pathology, Emory; University, Altanta, GA; Studies to evaluate the perinatal transmission of SIVsmm were initiated by infecting 15 timed pregnant rhesus monkeys with SIVsmm during various stages of gestation and monitoring the offspring for evidence of virus infection. Three groups of five animals were experimentally infected with SIVsmm during early (day 28-3
Interactions of rhesus cytomegalovirus (CMV) and simian immunodeficiency virus (SIV) in co-infected macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:35 (abstract no. 19). Unique Identifier : AIDSLINE PRIM8/900019; Alcendor DJ; Vogel PJ; Martfeld DJ; Barry PA; Dandekar S; Luciw PA; Departments of Medical Pathology and Internal Medicine,; University of California, Davis, CA 95616; Infection of rhesus macaques with rhesus cytomegalovirus ( CMV ) is widespread at the California Primate Research Center (CPRC). As with infection with CMV in the majority of healthy humans, infection of healthy macaques with r
Serial pathogenesis study of SIV brain infection.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:36 (abstract no. 20). Unique Identifier : AIDSLINE PRIM8/900020; Sharer LR; Michaels J; Murphey-Corb M; HU FS; Kuebler DJ; Baskin GB; New Jersey Medical School, Newark, NJ; In order to determine the early sequence of events in the central nervous system (CNS) following experimental SIV infection, in situ hybridization (ISH) using a radiolabeled RNA probe of SIV/Delta D915 was performed on snap frozen brain tissue from 24 juvenile rhesus macaques. Twenty animals (nursery reared and
Transmission of SIV infection by transfusion of seronegative blood in nonhuman primates.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:37 (abstract no. 21). Unique Identifier : AIDSLINE PRIM8/900021; Jehuda-Cohen T; Villinger F; McClure HM; Lockwood E; Powell JD; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322; Our laboratory has provided several lines of evidence that document the existence of SIVsmm and HIV-1 infected vet seronegative nonhuman primates and humans, respectively. These findings prompted us to determine whether blood and blood products from such seronegative monkeys could transmit infection and disease in nai
Numbers of functional bone marrow colony-forming cells decrease late in SIV infection of rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:38 (abstract no. 22). Unique Identifier : AIDSLINE PRIM8/900022; Beltz LA; Narayan O; Adams RJ; Zink MC; Donnenberg AD; The Johns Hopkins University, School of Medicine, Baltimore, MD; We have used a long term bone marrow (BM) culture system to estimate progenitor frequency by limiting dilution analysis (LDA) in 7 Rhesus macaques studied before and after infection with SIV251. BM cells were first separated on a Ficoll/Hypaque gradient, then depleted of T lymphocytes plus early and mature monocyte/ma
Autoimmune hemolytic anemia in SIVsmm infected macaca mulatta.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:39 (abstract no. 23). Unique Identifier : AIDSLINE PRIM8/900023; Hillyer CD; Brodie AR; Ansari AA; Anderson DC; McClure HM; Department of Pathology, School of Medicine, Emory University,; Atlanta, Georgia; Rhesus macaques (n=15) were infected with 10(4) TCID SIVsmm9 (documented by serologic conversion and reverse transcriptase activity). Blood counts (Sysmex CC-180) were obtained and differential counts were determined on blood smears stained with Wright-Giemsa. Direct antiglobulin tests (DAT) were done using mouse anti
Simian immunodeficiency virus infection of macaques: end-stage disease is characterized by widespread distribution of proviral DNA in tissues.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:40 (abstract no. 24). Unique Identifier : AIDSLINE PRIM8/900024; Hirsch VM; Zack PM; Vogel AP; Johnson PR; Department of Microbiology, Georgetown University and Laboratory; of Infectious Diseases, NIAID, NIH, Rockville, Md; A key to the development of new therapeutic modalities and vaccine strategies for AIDS is a more thorough understanding of the natural history and pathogenesis of immunosuppressive lentiviral infections in animal model systems. The most relevant model for AIDS currently available is simian immunodeficiency virus (SIV)
Soluble CD4 and the treatment of AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:41 (abstract no. 25). Unique Identifier : AIDSLINE PRIM8/900025; Letvin NL; Watanabe M; Harvard Medical School, New England Regional Primate Research; Center, One Pine Hill Drive, Southborough, MA 01772; Since the CD4 molecule is a high affinity cell surface receptor for the human immunodeficiency virus (HIV), it has been suggested that a soluble truncated form of CD4 may compete with cell surface CD4 for HIV binding and thus be of use in the therapy of AIDS. We have utilized the simian immunodeficiency virus of macaq
A CD8+, MHC class II+ lymphocyte lacking CTL function appears in rhesus monkey lymph nodes early after SIVmac infection.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:42 (abstract no. 26). Unique Identifier : AIDSLINE PRIM8/900026; Reimann KA; Snyder GB; Chalifoux LV; Miller MD; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772; An alteration in lymphocyte subset distribution in the peripheral blood is one of the earliest manifestations of HIV infection in humans. We have characterized the coincident changes in the secondary lymphoid organs early after virus infection utilizing the SIVmac/rhesus monkey model. In a prospective study of 4 monke
CD8+ T-cell-induced inhibition of retroviral replication is mediated at the transcriptional level.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:43 (abstract no. 27). Unique Identifier : AIDSLINE PRIM8/900027; Powell JD; Bednarik DP; Folks TM; Jehuda-Cohen T; Villinger F; McClure HM; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322; There is increasing evidence that CD8+ T cells play a crucial role in controlling HIV infection in vivo. Via et al. (Immunology Today, 11(7):250) propose that the clinical transition from the asymptomatic to disease state may be secondary to the quantitative loss of such CD8+ cells. Previously, our laboratory has show
Phenotypic and functional alterations in primate lymphoid organs following SIV and HIV infection.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:44 (abstract no. 28). Unique Identifier : AIDSLINE PRIM8/900028; Rosenberg YJ; White BD; Lewis M; Mosca J; Papermaster SF; Kersey K; Eddy GA; Burke DS; Henry M. Jackson Foundation, Rockville, MD; The aim of the present study is to examine the susceptibility of lymphoid organs to infection with HIV and SIV and to compare alterations in the phenotypic and functional properties of those T cell subsets which may be differentially affected by infection. The anti-CD45RA MAb ALB11 delineates human and monkey T cells
Antibody dependent enhancement and neutralization pattern of sera of SIV infected or HIV2 vaccinated rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:45 (abstract no. 29). Unique Identifier : AIDSLINE PRIM8/900029; LeGrand R; Vogt G; Dormont D; SSA/DPTE/DSV/CEA,BP 6, 92265 Fontenay aux Roses, France; OBJECTIVE: To evaluate the antibody dependent enhancement (ADE) and the neutralizing titer of sera of rhesus monkeys infected with SIVMAC251 or immunized with Vaccinia-HIV2ROD recombinant viruses and purified HIV2 proteins. METHODS: -Animals: 1) Six Maccaca mulata were infected with 1000 TCID50 of SIVMAC251. 2) Five m
Virus neutralizing antibodies in SIV and type D vaccinated macaques, and in animals infected with SIV/Mne.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:46 (abstract no. 30). Unique Identifier : AIDSLINE PRIM8/900030; Benveniste R; Mann D; Kuller L; Morton W; Hu SL; Eddy G; Shafferman A; Lewis M; National Cancer Institute and Southern Research Institute,; Frederick, MD; An EBV transformed human cell line (AA-2) had previously been shown by us to be very sensitive to the replication of SIV s isolated from mangabeys, African green monkeys and macaques, as well as to HIV-1 and HIV-2. Multiple single-cell clones have now been obtained that differ markedly in their ability to replicate th
SIV external envelope glycoprotein is the target of neutralizing antibodies.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:47 (abstract no. 31). Unique Identifier : AIDSLINE PRIM8/900031; Collignon C; Kent K; Desrosiers R; DeWilde M; Bruck C; Thiriart C; To investigate the antigenic and biological properties of SIV envelope glycoproteins, antibodies to SIV envelope antigen (molecular clone BK28) were obtained: i) a panel of monoclonal antibodies was isolated from a mouse immunized with SIV GP150 expressed in mammalian cells and ii) polyclonal antibodies were raised to
Cloning and expression of primate CD4 molecules: diversity of the cellular receptor for SIV/HIV.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:48 (abstract no. 32). Unique Identifier : AIDSLINE PRIM8/900032; Fomsgaard A; Hirsch VM; McClure HM; Novembre FJ; Johnson PR; Department of Microbiology, Georgetown University and Laboratory; of Infectious Diseases, NIAID/NIH, Rockville, Md.; The pathogenic properties of non-human primate lentiviruses (SIV) are varied, and may depend in part on host-specific factors. Biologic disparity among SIVs also extends to infection of cells in culture, where significant differences in cellular tropisms and cytopathic effects are observed. One potential determinant o
SIV vaccine protection of rhesus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:49 (abstract no. 33). Unique Identifier : AIDSLINE PRIM8/900033; Carlson JR; McGraw TP; Keddie E; Yee JL; Rosenthal A; Langlois AJ; Dickover R; Donovan R; Luciw PA; Jennings MB; et al; Departments of Pathology and Internal Medicine, School of; Medicine, California Primate Research Center, University of; California, Davis; Rhesus macaques (M.mulatta) immunized with an inactivated whole SIVmac vaccine and muramyl dipeptide (MDP) incomplete Freund s adjuvant (IFA) or aqueous suspension were challenged intravenously with 10 animal infectious doses (ID) (0.1 TCID/50) of cell free SIVmac. Whereas virus was readily recovered from the PBLs of
Neutralizing antibodies generated in macaques immunized with live recombinant vaccinia virus boosted with recombinant-made SIVmne gp160.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:50 (abstract no. 34). Unique Identifier : AIDSLINE PRIM8/900034; Hu SL; Abrams K; Barber G; Moran P; Zarling JM; Kuller L; Morton WR; Benveniste RE; Oncogen, Seattle WA; We showed previously that immunization with HIV-1 envelope glycoprotein gp160 resulted in significantly enhanced immune responses and anti-HIV-1 neutralizing antibodies in mice and in humans primed with live recombinant vaccinia virus expressing the same antigen. In the present work, we aimed to determine, first, whet
Vaccination against primate lentiviruses in cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:51 (abstract no. 35). Unique Identifier : AIDSLINE PRIM8/900035; Putkonen P; Thorstensson R; Biberfeld G; Department of Immunology, National Bacteriological Lab,; Stockholm, Sweden; The related SIVsm and HIV-2 can infect cynomolgus monkeys, but only SIV causes an immunosuppressive disease. At NBL two vaccine studies have been done. In the first experiment, three macaques were preinfected and immunized with live HIV-2 (SBL-K135) and 168 days later challenged with 10-100 animal ID50 of SIV to study
Protection of rhesus macaques from infection with SIVMAC using a formalin inactivated whole virus preparation.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:52 (abstract no. 36). Unique Identifier : AIDSLINE PRIM8/900036; Cranage MP; Cook N; Thompson A; Greenaway PJ; Baskerville A; Public Health Laboratory Service Centre for Applied Microbiology; and Research, Porton Down, Salisbury SP4 OJG, United Kingdom; Eight rhesus macaques were inoculated with formalin inactivated SIVMAC251 (32H isolate) prepared from cell free supernatant of infected C8166 cells by gel filtration chromatography. Each animal received a total of four intramuscular inoculations of 500 mug administered in threonyl muramyl dipeptide adjuvant (kindly pr
A vaccine of conserved SIV envelope peptides protects macaques against SIV challenge.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:53 (abstract no. 37). Unique Identifier : AIDSLINE PRIM8/900037; Eddy GA; Shafferman A; Jahrling PB; Benveniste RE; Lewis MG; Phipps TJ; Eden-McCutchan F; Sadoff J; Burke DS; Jackson Foundation Research Lab, Rockville, MD; Rhesus monkeys were immunized with a cocktail of four recombinant-origin fusion proteins of beta-galactosidase (beta-gal) and simian immunodeficiency virus (SIV) envelope peptides, SIV-88, SIV-500, SIV-582 and SIV-647. The peptides are 10 to 21 residue segments of conserved, hydrophilic regions of SIV gp120 and transm
Protective responses against HIV-1 elicited by immunization of chimpanzees.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:54 (abstract no. 38). Unique Identifier : AIDSLINE PRIM8/900038; Fultz PN; Pinter A; Nara P; Muchmore E; Kaczorek M; Girard M; University of Alabama at Birmingham; Candidate HIV-1 vaccines, consisting of either whole inactivated virus, purified recombinant antigens (gp160env, p18gag, p27nef p23vif) or peptides conjugated to KLH, and corresponding to the V3 neutralizing epitope, were generated with the HIV-1 (LAV(BRU) strain) and used to immunize chimpanzees. Immunization resulte
Immunization of healthy SIV-infected macaques with a formalin inactivated whole virus vaccine has no apparent effect on disease progression and survival.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:55 (abstract no. 39). Unique Identifier : AIDSLINE PRIM8/900039; Murphey-Corb M; Davison-Fairburn B; Ohkawa S; Martin L; Baskin G; Delta Regional Primate Research Center, Tulane University,; Covington, LA; The association of the decline in HIV-specific antibody titers, specifically with respect to core determinants, to disease progression in infected humans, coupled with the relatively long latency between virus infection and the onset of disease, promotes the concept that immunization of healthy seropositive individual
Effects of 28 day treatment with azidothymidine (AZT) initiated 1 to 72 hours after infection with simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:56 (abstract no. 40). Unique Identifier : AIDSLINE PRIM8/900040; Martin LN; Murphey-Corb M; Soike KF; Davison-Fairburn B; Delta Regional Primate Research Center, Tulane University,; Covington, LA, U.S.A.; We have studied the effects of AZT treatment initiated 1, 8, 24 or 72 hr. postinfection (PI) with 10 ID-50 SIV/Delta B670 using 5 monkeys per group. After initiation, the animals were treated every 6 hr. with 25 mg/kg (100 mg/kg/day) for 28 days. AZT
Inhibition of SIVmac by zidovudine (AZT) and 2', 3' Dideoxy-2', 3'-didehydrothymidine (D4T) in combination with the membrane-active drug dipyridamole (DPM).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:57 (abstract no. 41). Unique Identifier : AIDSLINE PRIM8/900041; Fridland A; Robbins B; Connelly MC; Gould R; Marx PA; St. Jude Children's Research Hospital, 332 North Lauderdale, Box; 318, Memphis, TN 38101; D4T and AZT are two major drugs used in the treatment of HIV infections. However the anti-viral activity of these drugs is limited by their ability to form the 5 triphosphate derivatives which are believed to act as chain terminators of reverse trans
The immunobiological properties of a recombinant SRV-1 envelope protein and a neutralizing monoclonal antibody directed against it.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:58 (abstract no. 42). Unique Identifier : AIDSLINE PRIM8/900042; Werner LL; Torres JV; Kwang HS; Leung CY; Benjamini E; Department of Clinical Pathology, School of Veterinary Medicine,; and Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis, CA; A synthetic peptide representing residues 142-167 contains a unique envelope region of the Simian (Type D) Retrovirus serotype 1 (SRV-1) and constitutes an antigenic site for the binding of murine and rhesus neutralizing antibodies to the SRV-1 strain. A murine monoclonal antibody, C11B8, produced by immunizing with a
The induction of anti-simian retrovirus-1 (SRV-1) neutralizing antibodies by synthetic peptides and studies on the cell receptor to the virus.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:59 (abstract no. 43). Unique Identifier : AIDSLINE PRIM8/900043; Torres J; Werner L; Malley A; Benjamini E; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis; We have recently demonstrated that rhesus monkey antibodies which neutralize SRV-1 are directed to an area encompassing residues 147-162 of the viral envelope protein. Although immunization of mice with the synthetic peptide-KLH conjugate induced antibodies which bind with the peptide, with the viral protein and with
Characterization of T and B cell epitopes of a simian retrovirus (SRV-2) envelope protein.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:60 (abstract no. 44). Unique Identifier : AIDSLINE PRIM8/900044; Malley A; Werner L; Benjamini E; Leung CY; Torres J; Pangares N; Shiigi S; Axthelm M; Oregon Regional Primate Research Center, Beaverton OR; Previously, we reported that the insoluble SRV-2 envelope peptide 92-106 represented the epitope involved in the formation of SRV-2 neutralizing antibodies. Soluble SRV-2 peptide 92-99 and peptide 100-106 were prepared and used to further define the epitope responsible for the induction of SRV-2 neutralizing antibody.
Further studies on SRV-2 positive retroperitoneal fibromatosis (RF) derived cell lines from macaques with simian AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:61 (abstract no. 45). Unique Identifier : AIDSLINE PRIM8/900045; Roodman ST; Tsai CC; Tsai CC; Woon MD; St. Louis University School of Medicine, St. Louis, MO; Several cell lines were derived from Kaposi s Sarcoma (KS) like-RF lesions obtained from pigtailed macaques (Macaca nemestrina) infected with SRV-2. SRV-2 antigens were detected on these cell lines by flow cytometric (FCM) and whole cell ELISA using either SRV-2 infected monkey serum or monoclonal anti gp44 antibodies
Genomic organization, transcriptional regulation, and transactivation of simian foamy virus type 1: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:62 (abstract no. 46). Unique Identifier : AIDSLINE PRIM8/900046; Mergia A; Shaw KE; Pratt-Lowe E; Barry PA; Luciw PA; Department of Medical Pathology, University of California, Davis,; CA 95616; The three subfamilies of retroviruses are oncoviruses, lentiviruses, and spumaviruses. The latter, also designated foamy or syncytium-forming viruses, are found in a variety of species and are highly cytopathic in tissue culture systems. In the animal, spumaviruses appear to establish latency; a clear connection with
Functional analysis of the major homology region (MHR) of M-PMV capsid protein using saturation mutagenesis: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:63 (abstract no. 47). Unique Identifier : AIDSLINE PRIM8/900047; de Castillia CS; Hunter E; University of Alabama at Birmingham, Department of Microbiology,; Birmingham, AL. 35294; The major capsid protein (CA) of avian and mammalian retroviruses is thought to play a critical role in: 1) capsid assembly and release from the cell, 2) maturation of the released virus particles, 3) uncoating of the viral genome early after infection, 4) proviral DNA transport to the nucleus and integration in the c
Baboon: an animal model for human retroviral diseases.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:64 (abstract no. 48). Unique Identifier : AIDSLINE PRIM8/900048; Mone J; Hubbard G; Whitehead E; Allan JS; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas; The baboon (Papio sp.) is an old-world primate which is a natural host for simian T-cell leukemia virus type 1 (STLV-1), a virus very similar to human T-cell leukemia virus type 1 (HTLV-1), the etiologic agent of adult T-cell leukemia/lymphoma. Furthermore, STLV-1 has been associated with malignant lymphomas in baboon
Biological characterization of HIV-IFN-gamma fusion proteins expressed in vaccinia virus: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:65 (abstract no. 49). Unique Identifier : AIDSLINE PRIM8/900049; Yilma T; Gibson HL; Lee Ng CT; Barr PJ; Giavedoni L; Lab of Mol. Bio. Trop. Dis., School of Veterinary Medicine,; University of California, Davis, CA; We have evaluated the adjuvant effects of interferon gamma (IFN-gamma) on heterologous antigens expressed in vaccinia virus recombinants, and also determined the attenuating effects of the lymphokine on vaccinia virus virulence in nude (nu/nu) mice. Antigens expressed included murine IFN-gamma (vMuIFN-g), human IFN-ga
A non-hazardous HIV-1 envelope glycoprotein expression vector system for development of anti-HIV therapy.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:66 (abstract no. 50). Unique Identifier : AIDSLINE PRIM8/900050; Roberts SJ; Dubay JW; Hunter E; Department of Microbiology, University of Alabama at Birmingham,; Birmingham, Alabama; A useful SV40 late promoter based expression vector, pSRH, has been developed and used successfully for the high-level expression of the HIV-1 envelope glycoprotein. The vector contains the SV40 origin of replication, the early genes (T and t) and the early and late promoters. Polyadenylation sequences are from the 3
High titers of HIV-1 reverse transcriptase inhibitory antibodies in the sera of African green monkeys vaccinated with a prototype HIV-1 vaccine: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:67 (abstract no. 51). Unique Identifier : AIDSLINE PRIM8/900051; Bestwick RK; Yoshihara P; Martin L; Leslie G; Hodges W; Benelli-LeMoine M; Ferro A; Epitope, Inc. 15425 SW Koll Parkway, Beaverton, OR 97006; Other than antibodies against the gp41 transmembrane glycoprotein, antibodies against reverse transcriptase are the most prevalent in HIV-infected individuals. The level of antibodies that inhibit reverse transcriptase decrease in patients that progress to AIDS and the presence or absence of these inhibitory antibodie
Vaccination of cynomolgus monkeys against simian immunodeficiency virus: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:68 (abstract no. 52). Unique Identifier : AIDSLINE PRIM8/900052; Stott EJ; Cranage MP; Chan WL; Mills K; Page M; Taffs F; Greenaway P; Kitchin P; National Institute for Biological Standards and Control, Blanche; Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK.; Cynomolgus monkeys were vaccinated with either glutaraldehyde-fixed SIV-infected cells using Quil A as adjuvant or with formalin-fixed whole SIV using tMDP as adjuvant. They were subsequently challenged intravenously with 10 fifty per cent monkey infectious doses (MID50) of 11/88 pool of SIVmac251. The vaccinated anim
Biochemical and antigenic properties of SIVMne gp160 expressed in insect cells by a baculovirus vector.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:69 (abstract no. 53). Unique Identifier : AIDSLINE PRIM8/900053; Barber G; Gale M; Clark EA; Hu SL; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; A cDNA encoding the full-length precursor envelope glycoprotein of SIVMne has been inserted into the genome of Autographica californica nuclear polyhedrosis virus (AcNPV) under control of the viral polyhedrin gene promotor. Infection of cultured Spodoptera frugiperda cells with recombinant virus resulted in the synthe
Development of potential prophylactic and immunotherapeutic agents against SIV: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:70 (abstract no. 54). Unique Identifier : AIDSLINE PRIM8/900054; Rud EW; Yon JR; Cranage MP; Francis MJ; Larder BA; Clarke BE; Wellcome Biotechnology Ltd., Dept of Virology, Beckenham, Kent,; U.K.; Simian Immunodeficiency Virus (SIV) is, in many respects, the best animal model for the study of human AIDS. In order to develop candidate subunit vaccines against SIV, we started by cloning the vaccine challenge strain, SIVmac32H, used by the British M.R.C. AIDS Directed Programme. We made three molecular clones, dif
Mutations in the cysteine array of the nucleic acid binding protein of SIV/MNE: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:71 (abstract no. 55). Unique Identifier : AIDSLINE PRIM8/900055; Powell PJ; Henderson LE; Heidecker G; Benveniste RE; Arthur LO; AIDS Vaccine Program, Program Resources Inc., Frederick MD 21702; Recent studies have shown that vaccines composed of whole inactivated preparations of simian immunodeficiency virus (SIV) gave protection against SIV challenges. These preparations should be considered as candidates for vaccine and immunotherapy for AIDS. Ideally the vaccine should contain all the viral proteins in a
The efficient expression of simian immunodeficiency virus envelope protein by a recombinant human adenovirus host-range mutant: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:72 (abstract no. 56). Unique Identifier : AIDSLINE PRIM8/900056; Sheau-Mei C; Ronchetti-Blume M; Hum W; Politis-Virk K; Mizutani S; Davis A; Lee S; Hung P; Hirsch V; Johnson P; Wyeth-Ayerst Research, Radnor, PA; SIV infection of macaques is a valuable animal model for AIDS vaccine studies. Our research focus is the development of Ad-HIV vaccine by using the Ad-SIV recombinant virus infection of macaques as a model system. Recombinant human adenoviruses (Ads) that replicate in the intestinal tract offer a novel, yet practical,
Immunological properties of recombinant SIV gp130 expressed in genetically engineered mammalian cells: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:73 (abstract no. 57). Unique Identifier : AIDSLINE PRIM8/900057; Planelles V; Haigwood N; Scandella C; Mann K; Shuster J; Marthas M; Marx P; Gardner M; Luciw P; University of California, Davis; The simian immunodeficiency virus (SIV) envelope glycoprotein consists of two major domains, the extracellular domain (gp130) and the transmembrane domain (gp30). Gp130 is (i) the major viral element responsible for attachment to the cell receptor, CD4 and (ii) the main target against which anti-viral immune responses
The effect of recombinant human alpha interferon on SIV infection in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:74 (abstract no. 58). Unique Identifier : AIDSLINE PRIM8/900058; Niphuis H; Schellekens H; Slachmuylders JF; Hochkeppel HK; Heeney JL; Dept. of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The; Netherlands; The activities of recombinant hybrid human interferon alpha-BDBB (HuIFNa-BDBB) and recombinant human interferon alpha-2 (HuIFNa-2) were compared on their ability to inhibit infection with SIVDeltaB670 in rhesus macaques. Four groups of two animals were treated with different doses of HuIFNa (5.10(6) or 1.10(6)units/da
Applications of the SIV/rhesus model for the sexual transmission of HIV: comparison of various contraceptive formulations containing nonoxynol-9 on the genital transmission of SIV in rhesus macaques and the relationship between viremia humoral immune response and the shedding of SIV in semen.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:75 (abstract no. 59). Unique Identifier : AIDSLINE PRIM8/900059; Miller CJ; Alexander NJ; Gettie A; Hendrickx AG; Marx PA; California Primate Research Center and Department of Medical; Pathology, University of California, Davis, CA; Recent in-vitro studies in which HIV was inactivated by low concentrations (0.05% v/v) of nonoxynol-9 (N-9) suggest that the heterosexual transmission of human immunodeficiency virus (HIV) can be prevented by the use of spermicides that contain N-9. However there have been no studies to assess the anti-viral activity
Use of SIV-infected monkeys in the evaluation of drugs against HIV/AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:76 (abstract no. 60). Unique Identifier : AIDSLINE PRIM8/900060; Bottiger D; Ljungdahl-Stahle E; Norrby E; Putkonen P; Wahren B; Oberg B; Department of Virology, Karolinska Institute, Stockholm, Sweden; Many new compounds are being synthesized with the aim of treating AIDS. Several of these compounds show good inhibitory effects against HIV in cell cultures and this requires a further selection in a relevant animal model in order to select the few compounds possible to evaluate in patients. Simian immunodeficiency vi
Prophylactic effect of HOE/BAY 946, a new anti-viral agent, on SIV and simian AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:77 (abstract no. 61). Unique Identifier : AIDSLINE PRIM8/900061; Cheung AT; Lerche NW; Schrinner EJ; Schlumberger HD; Young LJ; Yee JL; Department of Medical Pathology and California Primate Research; Center, University of California, Davis, California, USA; HOE/BAY 946, a disodium salt of xylanpoly-hydrogen sulphate, shows significant in vitro inhibitory activities against the reverse transcriptases of retroviruses, including SIV, HIV, AMV, and FLV. The pharmacokinetic profile of this compound is known and it is currently used for other indications with no significant ad
Bone marrow progenitor cells in SIV infected rhesus monkeys remain uninfected despite hematologic abnormalities in AIDS.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:78 (abstract no. 62). Unique Identifier : AIDSLINE PRIM8/900062; Slachmuylders JF; Wagemaker G; Visser TP; Dubbes R; Niphuis H; Bentvelzen PA; Heeney JL; Institute of Applied Radiobiology and Immunology TNO, P.O. Box; 5815, 2280 HV Rijswijk, The Netherlands; Macaca mulatta experimentally infected with SIVDeltaB670 or SIVmac32H develop a spectrum of hematological abnormalities including thrombocytopenia, anemia and generalized marrow hypoplasia in advanced disease. The underlying nature of these lesions in HIV infected patients or SIV infected Rhesus monkeys with AIDS is u
HLA-DR antigen in neuroendothelium is detected during SIVSM encephalitis.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:79 (abstract no. 63). Unique Identifier : AIDSLINE PRIM8/900063; Beilke MA; Gravell M; Jordan EK; Riding In D; Hamilton R; Nusbaum W; Stone G; Laboratory of Central Nervous System Studies, NINDS, NIH,; Bethesda, MD; Major histocompatibility complex class 2 (MHC II, HLA-DR) antigens generally are not expressed in primate brain. Cerebral microvessels were isolated by dextran gradient centrifugation from two animals with SIVsm encephalitis, from one infected animal without CNS involvement and from two uninfected animals. Neuroendoth
Pathogenesis of simian immunodeficiency virus infection in the central nervous system of rhesus monkeys: cellular localization of virus.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:80 (abstract no. 64). Unique Identifier : AIDSLINE PRIM8/900064; Lackner AA; Smith MO; Munn RJ; Martfeld DJ; Marx PA; Dandekar S; California Primate Research Center and Department of Internal; Medicine, University of California, Davis, California; Simian immunodeficiency virus (SIV), like the human immunodeficiency virus (HIV), is a lentivirus that is both immunosuppressive and neurovirulent. Rhesus macaques (Macaca mulatta) inoculated with SIV often develop a giant cell encephalitis similar to that seen in humans infected with HIV. We examined SIV expression b
Ultrastructural pathology of the acutely lethal primate lentivirus SIVSM-PBj, in pigtailed and cynomolgus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:81 (abstract no. 65). Unique Identifier : AIDSLINE PRIM8/900065; Brown CR; Lewis MG; Jahrling PB; Elkins WR; Zack PM; US Army Medical Research Institute of Infectious Diseases, Fort; Detrick, MD 21702; SIVSM-PBj uniformly produces acutely fatal disease associated with severe metabolic acidosis in pigtailed and cynomolgus macaques. All lymphoid organs and gut-associated lymphoid tissue (GALT) show similar histologic changes including hyperplasia of T-cell areas containing up to 50% lymphoblasts, atrophy of B-cell are
Pathogenesis of enteropathy in SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:82 (abstract no. 66). Unique Identifier : AIDSLINE PRIM8/900066; Dandekar S; Heise C; Martfeld D; Marx P; Miller C; Halsted C; Department of Internal Medicine, University of California, Davis,; CA 95616; Diarrhea with intestinal malabsorption can occur early in the course of HIV infection, often in the absence of opportunistic enteric infections. We have used SIV-infected rhesus macaques as an animal model to determine the pathogenic mechanisms of enteropathy in HIV infection. The major objectives were (1) to evaluate
SIV/Delta-induced arthritis in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:83 (abstract no. 67). Unique Identifier : AIDSLINE PRIM8/900067; Roberts ED; Martin LN; The joint tissues from thirty-six rhesus infected with SIV/Delta were graded into 4 groups and then correlated with the following systemic immunologic parameters: numbers of CD4+, CD4+ plus CD29+, CD8+, CD20+ cells and SIV/Delta antigenemia. Grade I (N=16) Consisted of normal synovial membrane. Grade II (N=8) Consiste
Role of rhesus cytomegalovirus (CMV) and simian immunodeficiency virus (SIV) in SIV-associated pneumonia.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:84 (abstract no. 68). Unique Identifier : AIDSLINE PRIM8/900068; Vogel AP; Lackner AA; Alcendor DJ; Martfeld DJ; Marx PA; Dandekar S; Department of Veterinary Pathology, University of California,; Davis, CA 95616; Animals infected with SIV may be clinically normal for an extended period before developing an acquired immune deficiency syndrome. Individual variation in the responses to infection by SIV suggests the involvement of multiple cofactors in determining disease course and clinical outcome. Several in vitro studies sugge
Preliminary observations on the immunophenotyping of mononuclear cells and the detection of viral antigens using formalin-fixed, paraffin-embedded sections from SIV-infected macaque monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:85 (abstract no. 69). Unique Identifier : AIDSLINE PRIM8/900069; Ribas JL; Sesterhenn IA; McClure HM; Anderson DC; Frizzera G; Benton CS; Armed Forces Institute of Pathology, Washington, DC; The localization of specific antigens in tissues and cells by immunohistochemical methods has become a powerful tool in diagnostic and experimental pathology. Since the simian immunodeficiency virus (SIV) infects mainly CD4-bearing cells of the immune system of susceptible macaque monkeys, immunophenotyping of mononuc
Infection of macaques with SIV or HIV-2 induces a virus-specific increase of urinary neopterin.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:86 (abstract no. 70). Unique Identifier : AIDSLINE PRIM8/900070; Stahl-Hennig C; Fendrich C; Lu\uke W; Fuchs D; Reibnegger G; Wachter H; Hunsmann G; German Primate Center, Go\uttingen, FRG; Neopterin is known as a marker for the activated immune system. Increased neopterin concentrations have been observed in HIV-infected humans and also in SIV-infected macaques. To extend the latter data preinfection and postinfection urinary neopterin concentrations were measured in rhesus (Mm) and fascicularis (Mf) ma
Mapping viral determinants of SIV pathogenesis.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:87 (abstract no. 71). Unique Identifier : AIDSLINE PRIM8/900071; Marthas M; Ramos R; Lohman B; Banapour B; Marx P; Luciw P; Pedersen N; California Regional Primate Research Center, University of; California, Davis, CA 95616; Two molecular clones of simian immunodeficiency virus with different disease potential in rhesus macaques have been characterized. SIVmac-1A11 induces a transient viremia and no disease, while SIVmac-239 induces persistent viremia and a fatal AIDS-like disease in about 50% of experimentally infected macaques within on
Structure of tat-, rev-, and env- specific transcripts of a cloned simian immunodeficiency virus from rhesus macaques (SIVmac1A11).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:88 (abstract no. 72). Unique Identifier : AIDSLINE PRIM8/900072; Unger RE; Stout MW; Luciw PA; School of Medicine, Department of Medical Pathology, University; of California, Davis, CA; Simian immunodeficiency virus from rhesus macaques (SIVmac) produces an immunosuppressive disease in these animals that is similar to that caused by human immunodeficiency virus (HIV-1), the etiologic agent of acquired immunodeficiency syndrome in humans. SIVmac, like HIV-1, has a complex genetic organization characte
Identification of a highly variable region in SIV envelope in macaques inoculated with SIV/MNE clone 8.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:89 (abstract no. 73). Unique Identifier : AIDSLINE PRIM8/900073; Rudensey L; Papenhausen M; Benveniste R; Morton WR; Overbaugh J; Regional Primate Research Center, University of Washington,; Seattle, WA.; The study of retroviral pathogenesis, especially that of HIV, is complicated by the presence of multiple virus variants within an infected individual. In the case of HIV, the contribution of specific variants to the development of AIDS is unclear. Analysis of feline leukemia virus (FeLV) variants cloned directly from
Genetic variation of the SIVagm transmembrane glycoprotein in naturally and experimentally-infected non-human primates.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:90 (abstract no. 74). Unique Identifier : AIDSLINE PRIM8/900074; Fomsgaard A; Johnson PR; Dapolito G; Kitov S; London WT; Hirsch VM; Department of Microbiology, Georgetown University, Washington, DC; Premature truncation of the gp40 transmembrane glycoprotein (TMP) is commonly manifested by some SIV strains when propagated in human cells in culture. However, previous studies with SIVmac indicate that the natural form of the TMP is the full-length form predicted from the entire env open reading frame. To further in
Expression of SIV in CD4+ lymphocytes.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:91 (abstract no. 75). Unique Identifier : AIDSLINE PRIM8/900075; Park IW; Steen R; Regier D; Li Y; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Both simian immunodeficiency viruses (SIVs) and human immunodeficiency viruses (HIVs) belong to the lentivirus sub-family of Retrovirudae. One of the hallmarks of these primate lentiviruses is the presence of at least five or six additional open reading frames (orfs) or genes. The functions of some of the orfs are unc
Disruption of the nef gene in a cloned simian immunodeficiency virus from rhesus macaques (SIVmac1A11) does not effect macrophage tropism in vitro.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:92 (abstract no. 76). Unique Identifier : AIDSLINE PRIM8/900076; Unger R; Padrid P; Marthas M; Pratt-Lowe E; Mulvaney T; Planelles V; Banapour B; Cross C; Luciw P; University of California, Davis, CA; Substantial sequence polymorphism has been detected among nef genes from different cloned isolates of SIVmac. In some, the nef gene is intact and in others an in-frame termination codon is present within the nef gene sequence. nef has been reported to down-regulate viral replication, since in both HIV and SIV, viruses
Simian immunodeficiency virus (SIVmac) infection of monocyte-derived macrophages from rhesus macaques: an in vitro infectivity system.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:93 (abstract no. 77). Unique Identifier : AIDSLINE PRIM8/900077; Banapour B; Vogel P; Marthas M; Unger R; Luciw P; Department of Medical Pathology, School of Medicine, University; of California at Davis. Davis, California 95616; We have developed an in vitro system for infection of primary cultures of monocyte-derived macrophages from rhesus macaques with various strains of SIVmac. This system has been utilized to study cell tropism of pathogenic and nonpathogenic clones of SIVmac. Data will be presented on the extent of infection and cytopat
Granulocyte macrophage-colony stimulating factor stimulates persistently infected U1 cells to produce infectious human immunodeficiency virus (HIV).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:94 (abstract no. 78). Unique Identifier : AIDSLINE PRIM8/900078; Krugner-Higby L; Iyer N; Kucera L; Department of Comparative Medicine, Bowman Gray School of; Medicine, 300 S. Hawthorne Rd. Winston-Salem NC 27103; U1 is a clone of the promonocytic cell line U937 persistently infected with HIV. It produces little or no virus unless stimulated. U1 may be stimulated to productive infection by phorbol esters such as TPA, but the presence of these agents in tissue culture supernatants and cell lysates causes cytotoxic effects in syn
The effect of cytokines on the replication of pathogenic and nonpathogenic isolates of SIV/Delta in monocytes.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:95 (abstract no. 79). Unique Identifier : AIDSLINE PRIM8/900079; St Cyr-Coats K; Murphey-Corb M; Dept. of Biological Sciences, Mississippi State University,; Mississippi State, MS; Neurotropic lentiviruses such as Visna-Maedi, caprine arthritis-encephalitis virus, and certain isolates of human immunodeficiency virus (HIV) replicate preferentially in cells of monocyte origin, and latently infected monocytes may be responsible for the spread of the viruses to the central nervous system. One isolat
Tumor necrosis factor alpha (TNF alpha) production by alveolar macrophages (M phi) infected in vitro or in vivo with SIV.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:96 (abstract no. 80). Unique Identifier : AIDSLINE PRIM8/900080; Horvath CJ; Desrosiers RC; Sehgal PK; Ringler DJ; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772; We studied the release of TNF alpha, a vital immunoregulatory cytokine, by M phi infected with SIV in vitro or collected from SIV-infected macaques. For in vitro studies, M phi were harvested by bronchoalveolar lavage of 5 normal animals and infected in flasks with SIVmacMTV (TCID50=10(4)/2.5x10(6) M phi). After 7-10
Species variation of interleukin production associated with infection with an acutely fatal simian immunodeficiency virus isolate (SIVsm/pbj).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:97 (abstract no. 81). Unique Identifier : AIDSLINE PRIM8/900081; Lewis MG; Birx DL; Zack PM; Vahey MA; Redfield RR; Burke DS; Jahrling PB; Southern Research Inst., Fort Detrick, MD 21702; SIV/sm/pbj causes acute death of susceptible macaques within 10 days of infection. The disease is associated with a rapid onset and high levels of virus production. The virus is mostly localized in the lymph nodes spleen and lower intestinal tract, with titers as high as 10(5) infections units/gram of tissue or millil
Evidence that the seronegative sooty mangabeys in our colony are infected with SIVsmm.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:98 (abstract no. 82). Unique Identifier : AIDSLINE PRIM8/900082; Vuchetich M; Jehuda-Cohen T; Villinger F; Powell JD; McClure HM; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322; Several lines of evidence have been provided by our laboratory to indicate that the seronegative sooty mangabeys in our colony are, in fact, infected with SIVsmm. The findings include (a) the synthesis and secretion of readily detectable SIV-reactive antibodies in the supernatant fluid of PBMC cultured in vitro with p
Effect of synthetic peptide homologous to retrovirus transmembrane protein sequences on calcium second messenger signalling in Macaca nemestrina lymphocytes.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:99 (abstract no. 83). Unique Identifier : AIDSLINE PRIM8/900083; Wright KA; Marr JM; Kanda P; Lafrado LJ; Center for Retrovirus Research, 1925 Coffey Rd., Columbus, Ohio; 43210; CKS-17 is a synthetic peptide homologous to a conserved, immunoactive sequence of p15E in feline leukemia virus and murine leukemia virus, and gp21 of the human T-cell leukemia virus. We assayed the effect of this synthetic peptide on the basal intracellular free calcium (IFC) concentration and transient IFC concentra
Selective preparative isolation of primary blood-brain barrier [endothelial, choroid plexus] and central nervous system supporting [astrocyte] cells from macaques: preliminary in vitro simian immunodeficiency virus [SIV] infection studies.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:100 (abstract no. 84). Unique Identifier : AIDSLINE PRIM8/900084; Brooks BR; Madden RM; Stone CM; Schultz KT; Neurology and Research Services, William S Middleton Memorial VA; Hospital, Madison, Wisconsin, Department of Neurology and Medical; Microbiology, University of Wisconsin, Madison; The mode of entry of SIV into the central nervous system [CNS] is poorly understood. In order to better define the virus-cell interactions which might occur at the blood-brain barrier in different CNS regions, we developed a serial Dextran - Percoll Step Gradient technique to selectively isolate non-neuronal cells fro
The use of rhesus heparinized or defibrinated blood as target cells in in vitro assays for simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:101 (abstract no. 85). Unique Identifier : AIDSLINE PRIM8/900085; Lohman BL; Higgins J; Marthas ML; Marx PA; Pedersen NC; California Primate Research Center, Davis, CA, USA; In vitro assays for viral neutralization, virus titration, and virus isolation are critical for evaluation of animal model vaccine trials. We developed a novel method for in vitro simian immunodeficiency virus (SIV) assays for neutralization, titrations, and isolations using rhesus heparinized or defibrinated blood as
Inhibition of a reverse transcriptase assay for simian retroviruses by different types of mycoplasma.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:102 (abstract no. 86). Unique Identifier : AIDSLINE PRIM8/900086; Ohmann S; Thouless M; Kenny G; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; While screening Macaca fasicularis for type D simian retrovirus (SRV), we assayed supernatant from co-cultures of peripheral blood mononuclear cells with Raji cells for reverse transcriptase activity. We obtained negative results for co-cultures which showed formation of syncytial cells and which were virus positive b
Effects of heat shock on the infectivity of SIV in vitro.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:103 (abstract no. 87). Unique Identifier : AIDSLINE PRIM8/900087; Follis KE; Tsai CC; Hall B; Washington Regional Primate Research Center, University of; Washington, Seattle, WA 98195; Cocultivation of human AA-2 and C-8166 cell lines with simian immunodeficiency virus (SIV) is an appropriate in vitro model for studying the cytopathic effects of lentiviruses. Using this in vitro system we studied the effects of heat shock on the activation of SIV251 and SIVMne infectivity. We also examined the effec
Characterization and in vitro titration of a large, homogeneous SIVmac251 virus pool.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:104 (abstract no. 88). Unique Identifier : AIDSLINE PRIM8/900088; Harrison RE; Eichberg JW; Southwest Foundation for Biomedical Research, San Antonio, Texas,; 78228; A large, homogeneous pool of SIVmac251 was generated by establishing a chronic infection in the H9 cell line. Virus was harvested, pooled, and characterized by western blot, PCR, and host range analysis. An in vivo titration was undertaken using pooled virus in Rhesus monkeys in order to establish the infectivity and
Comparative efficacy of methods used for isolation of HIV-1 from a large cohort of infected chimpanzees.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:105 (abstract no. 89). Unique Identifier : AIDSLINE PRIM8/900089; Murthy KK; Piazza PA; Cobb EK; Tuck P; Eichberg JW; Dept. of Virology/Immunology, Southwest Foundation for Biomedical; Research, San Antonio, TX 78227.; In this study we have evaluated several methods to optimize the recovery of HIV-1 from peripheral blood mononuclear cells (PBMC) of experimentally infected chimpanzees (N=35). The methods used were (1) cocultures of chimp PBMC with PHA induced human blasts and DEAE-Dextran. (2) cocultures of PHA stimulated chimp PBMC
Cell proliferative responsiveness in SIV infected or recombinant SIV envelope immunized monkeys.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:106 (abstract no. 90). Unique Identifier : AIDSLINE PRIM8/900090; Ohkawa S; Wilson L; Murphy-Corb M; Martin L; Delta Regional Primate Research Center, Covington, LA 70433; Antigen specific blastogenic cell responsiveness was assessed in mononuclear cells(MNC) from infected or immunized monkeys. Monkeys immunized with recombinant glycoprotein140(rGP140) in Freund complete adjuvant showed good blastogenic responsiveness to rGP140 1 month after immunization without booster immunization. Bl
Definition of T cell subsets in macaques using quantitative three color flow cytometry.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:107 (abstract no. 91). Unique Identifier : AIDSLINE PRIM8/900091; Axberg I; Gale MJ; Afar B; Clark EA; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; Monitoring changes of T lymphocyte subsets in SIV and HIV-infected individuals can provide important information about immune and clinical status. Two color flow cytometry using fluorescein (FITC)-conjugated monoclonal antibodies (mAb) (GREEN) and R-phycoerythrin (PE)-conjugated mAB (ORANGE) has been used e.g., to mon
Cellular and cytokine requirements for the in vitro synthesis of SIV-reactive antibodies by polyclonal activation of PBMC from infected yet seronegative nonhuman primates.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:108 (abstract no. 92). Unique Identifier : AIDSLINE PRIM8/900092; Ansari AA; Jehuda-Cohen T; Powell JD; Villinger F; Mayne A; Lockwood E; Gordon T; McClure HM; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322; In vitro polyclonal activation of PBMC from seronegative sooty mangabeys led to the secretion of antibodies that specifically react with SIV. This finding not only led to the subsequent observation that such seronegative mangabeys are indeed infected with SIV yet remain seronegative, but a similar study of a cohort of
Seroreactivity to Nef in three species of SIV/Mne-infected macaques at the Washington Regional Primate Research Center.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:109 (abstract no. 93). Unique Identifier : AIDSLINE PRIM8/900093; Heidecker G; Hill R; Morton W; Benveniste R; National Cancer Institute, Frederick, MD 21702; To investigate the immune response to non-structural viral proteins in SIV infected macaques we have studied the antibody response to the regulatory Nef protein. The Nef protein of SIV/Mne clone8 was expressed to high levels in the Sf9/baculovirus expression system. Only extracts from Sf9 cells infected with virus car
Monoclonal antibody mapping and strain-distribution of six epitopic regions of SIVmac(Davis).: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:110 (abstract no. 94). Unique Identifier : AIDSLINE PRIM8/900094; Higgins J; Pedersen N; Sutjipto S; Hansen D; Gettie A; Marx PA; Department of Veterinary Medicine, University of California,; Davis, CA 95616; The immunogenicity of the p27 major core antigen of Simian Immunodeficiency Virus from rhesus macaques (SIVmac) is well established in animal models. The role of this immune response is hypothesized to be important in both cell-mediated and humoral immunity. The characterization of epitopes of SIV p27 provide useful i
Monoclonal antibodies to SIV proteins.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:111 (abstract no. 95). Unique Identifier : AIDSLINE PRIM8/900095; Kent K; Stallard G; Gritz L; Cranage M; Thiriart C; Collignon L; Silvera P; Corcoran T; Stott J; National Institute for Biological Standards and Control, Potters; Bar, Herts, UK.; Eighteen MAbs to env and 16 MAbs to gag were produced and characterised. ELISA titres of ascites of the env MAbs were between 2.4 and 5.8 log10. Eleven of the env MAbs recognize gp160 and gp120 in Western blot (WB), 5 react with gp160 and gp41 and 2 MAbs did not react with denatured antigen. All env MAbs precipitated
A simple, rapid immunoassay for the detection of simian immunodeficiency virus antibodies.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:112 (abstract no. 96). Unique Identifier : AIDSLINE PRIM8/900096; Yee JL; Jennings MB; Carlson JR; Lerche NW; Department of Medical Pathology, University of California, Davis; The detection of Simian Immunodeficiency Virus (SIV) antibodies has proven to be useful for a wide variety of research studies, including estimating prevalence and directing efforts to obtain new virus isolates. However, the requirements of conventional assays for refrigeration, electricity supply, sophisticated equip
Improved detection of SIV p27 by antigen capture ELISA.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:113 (abstract no. 97). Unique Identifier : AIDSLINE PRIM8/900097; Toedter G; Stoner S; Pearlman S; Brewer K; Charie L; Cueto C; Marquez M; Hofheinz D; Coulter Immunology, Hialeah, Florida 33010; The limited sensitivity of HIV-1 p24 antigen capture ELISA systems for SIV core antigens has been documented. A murine monoclonal antibody-based antigen capture ELISA has been developed to detect SIV p27. This assay has been demonstrated to have greater sensitivity for SIV than existing antigen capture assays or rever
Differences in T cell function in rhesus and pigtailed monkeys: implications regarding susceptibility to SIV infection.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:114 (abstract no. 98). Unique Identifier : AIDSLINE PRIM8/900098; Rosenberg YJ; White BD; Lewis M; Papermaster SF; Kersey K; de Crombrugghe I; Eddy GA; Burke DS; Henry M. Jackson Foundation, Rockville, MD; Circulating T lymphocytes in primates are usually divided into two subsets: CD45RA+, CD29-, CD45RO- antigen naive resting cells and CD45RAlo/-, CD29+ CD45RO+ memory cells which also express other activation markers e.g. CD44, CD11a (LFA-1) and CD54 (ICAM-1). Using the anti-CD45RA MAb ALB11, a third CD45RAhi subset can
Immunopathogenesis studies on monkeys infected with simian retroviruses.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:115 (abstract no. 99). Unique Identifier : AIDSLINE PRIM8/900099; van Kuyk R; Acevedo R; Munn R; Unger R; Gardner MB; Luciw PA; Department of Medical Pathology, University of California, Davis,; CA 95616; Simian acquired immunodeficiency syndrome (SAIDS) is a fatal disease in rhesus macaques caused by a type D retrovirus designated SAIDS retrovirus (SRV). The SRV-induced syndrome resembles the acquired immunodeficiency syndrome (AIDS) in humans in clinical manifestations and overall immunodeficiency; thus it is a usefu
Natural killer cell activity in HIV-1 infected chimpanzees.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:116 (abstract no. 100). Unique Identifier : AIDSLINE PRIM8/900100; Javadian A; Couch R; Lafrado L; Department of Biochemical Toxicology, Primate Research Institute,; New Mexico State University, P.O. Box 1027, Holloman AFB, NM; 88330; We evaluated in vitro the natural killer (NK) cell activity of human immunodeficiency virus type-1 (HIV-1) infected chimpanzees. Peripheral blood mononuclear cells from HIV-1 infected chimpanzees were separated from whole heparinized blood by Ficoll-hypaque density gradient centrifugation. To evaluate the NK cell acti
Investigations of viral cofactors: molecular interactions of type D simian retrovirus (SRV-1) with cytomegalovirus, simian immunodeficiency virus and simian foamy virus.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:117 (abstract no. 101). Unique Identifier : AIDSLINE PRIM8/900101; Unger RE; Barry PA; Pratt-Lowe E; Luciw PA; School of Medicine, Department of Medical Pathology, University; of California, Davis, CA; Strong evidence supports the notion that cytomegalovirus ( CMV ) may be a cofactor for disease progression in simian immunodeficiency virus (SIV) infected rhesus macaques. SRV-1 like SIV, induces a fatal immunosuppressive disea
The transactivator of human foamy virus maps to the BEL1 genomic region.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:118 (abstract no. 102). Unique Identifier : AIDSLINE PRIM8/900102; Rethwilm A; Erlwein O; Baunach G; Maurer B; ter Meulen V; Institute f\uur Virologie, Versbacher Str. 7, 8700 W\uurzburg,; F.R.G.; The genome organization of human foamy virus (HFV) is characterized by three open reading frames (ORFs) between env and 3 LTR (bel1-3) which are additional to the classical retroviral gag, pol and env genes. Amino acid homology to HIV-2 regulatory genes indicate that the bel ORFs might encode for regulatory proteins s
Retroviral screening service at the London Zoo.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:119 (abstract no. 103). Unique Identifier : AIDSLINE PRIM8/900103; McCLure MO; Simpson GR; Kluge JD; Lerche N; Chrystie IL; Ali M; Stott J; Kirkwood JK; Marx P; Weiss RA; Chester Beatty Labs, ICR, London, UK; A retroviral screening service was offered to the London Zoo and to other institutions housing captive primates. No animal was bled specifically for this exercise. In the case of the London Zoo, a heparinised blood sample (less than 5 ml) was taken from every Old World and New World primate admitted to the Zoo hospita
Natural transmission of SRV-2/Wa in M. nemestrina in an infant primate nursery.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:120 (abstract no. 104). Unique Identifier : AIDSLINE PRIM8/900104; Thouless ME; Moazed TC; Kuller L; Tsai CC; Regional Primate Research Center SJ-50, University of Washington,; Seattle, WA 98195; Thirty-one percent of 113 Macaca nemestrina in the infant nursery at the UWRPRC became antibody positive by ELISA to SAIDS Retrovirus Type D (SRV) in 1988. With the ultimate objective of preventing the natural transmission of SRV in this nursery, a study was initiated to monitor infants in the nursery on a monthly bas
Phenotypic characterization of Kaposi's sarcoma-like tumor associated with SAIDS-D retrovirus in pigtailed macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:121 (abstract no. 105). Unique Identifier : AIDSLINE PRIM8/900105; Tsai CC; Wu H; Tsai CC; Regional Primate Research Center, University of Washington,; Primate Field Station, Medical Lake, WA; D-type simian retrovirus serotypes 1 and 2 (SRV-1 and SRV-2) are etiologically linked to the simian acquired immunodeficiency syndrome (SAIDS) in captive macaques in U.S. primate centers. SRV-2 has been identified as the major cause of morbidity and mortality in the pigtailed macaques (Macaca nemestrina) at the Washin
High incidence of SAIDS-D retrovirus-associated neoplasms in pigtailed macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:122 (abstract no. 106). Unique Identifier : AIDSLINE PRIM8/900106; Tsai CC; Regional Primate Research Center, University of Washington,; Seattle, WA; A D-type simian retrovirus serotype 2 (SRV-2) has been identified as the most important etiological agent for morbidity and mortality in pigtailed macaques (Macaca nemestrina) at the Washington Regional Primate Research Center. Macaques infected with SRV-2 show a simian acquired immunodeficiency syndrome (SAIDS). The
Mutagenesis of leucine zipper within transmembrane protein of Mason-Pfizer monkey virus.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:123 (abstract no. 107). Unique Identifier : AIDSLINE PRIM8/900107; Brody B; Hunter E; University of Alabama at Birmingham, Department of Microbiology,; Birmingham, AL 35294; The leucine zipper was initially hypothesized to be a structure involved in protein: protein interactions via interdigitation of leucine side chains. More recently, the actual structure of the leucine zipper has been shown to be a coiled coil, with the leucines providing a hydrophobic environment for interaction. Evid
Determining the role of the gag polypeptide p12 in the assembly and release of the prototype D-type retrovirus, M-PMV.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:124 (abstract no. 108). Unique Identifier : AIDSLINE PRIM8/900108; Sommerfelt MA; Rhee S; Hunter E; University of Alabama at Birmingham, Department of Microbiology,; Birmingham AL 35294; B-type and D-type retroviruses differ from other retroviruses in that they preassemble immature intracytoplasmic A-type particles (ICAPs) within the infected cell cytoplasm. These particles are comprised of Gag-precursor proteins which then migrate to the plasma membrane where they are released by budding. The gag-gen
CD8+ associated suppression of in vitro SRV-1 production is mediated by a non-specific soluble factor.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:125 (abstract no. 109). Unique Identifier : AIDSLINE PRIM8/900109; Lasarow RM; Marx P; Kluge JD; Gardner MB; Department of Medical Pathology, University of California Davis; Lymphocytes with CD8+ phenotypes have been reported to suppress production of SIV and HIV viruses in respective simian and human systems. We have demonstrated a CD8+ associated activity that is capable of suppressing the production of SRV-1 in vitro. Mononuclear cells from peripheral blood (PBMC) of SRV-infected rhesu
Comparative studies of infection of rhesus macaques and African green monkeys with SIVAGM and SIVMAC strains.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:126 (abstract no. 110). Unique Identifier : AIDSLINE PRIM8/900110; Mone J; Short M; Bradford D; Eichberg J; Allan JS; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas; While SIV strains from naturally infected sooty mangabeys induce AIDS in experimentally infected Asian macaques, little is known of the pathogenicity of the SIVagm viruses which naturally infect African green monkeys. SIVagm is a nonpathogenic virus found in almost 50% of African green monkeys. This study was undertak
A nonhuman primate model for AIDS and AIDS dementia complex.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:127 (abstract no. 111). Unique Identifier : AIDSLINE PRIM8/900111; Rausch DM; Lendvay J; Sharer L; Eiden LE; Murray EA; N.I.M.H.; Juvenile rhesus macaques inoculated with the B670 isolate of simian immunodeficiency virus (SIV) develop AIDS which is similar to the human disease in symptoms, course and outcome, but in general considerably more rapidly. In addition, the B670 isolate shows neurotropism as manifested by evidence of viral encephalitis
Immunodeficiency and lymphoproliferative disease in an African green monkey dually infected with SIV and STLV-I.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:128 (abstract no. 112). Unique Identifier : AIDSLINE PRIM8/900112; Traina-Dorge V; Blanchard J; Martin L; Murphey-Corb M; Delta Regional Primate Research Center, Tulane University,; Covington, LA; Human T cell leukemia virus (HTLV-I) is a type C exogeneous retrovirus associated with adult T cell leukemia. Seroepidemiological evidence suggests almost all species of Old World monkeys are naturally infected with the closely related simian virus, STLV-I. STLV-I can immortalize monkey cells in vitro. However, no dir
Disease in mangabey monkeys associated with simian immunodeficiency virus and simian T-lymphotropic virus type I.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:129 (abstract no. 113). Unique Identifier : AIDSLINE PRIM8/900113; Klumpp SA; Anderson DC; Fultz PN; Ribas JL; Ansari AA; McClure HM; Yerkes Primate Research Center, Emory University, Atlanta, GA; Following the isolation of simian immunodeficiency virus (SIVsmm) from 14 of 15 healthy mangabey monkeys (Cercocebus atys) in a colony at the Yerkes Primate Center, we reviewed necropsy records for all mangabey deaths between 1969 and 1986 for opportunistic infections or other evidence of immunosuppressive disease. Po
Presence of antibodies to SIV in newly imported baboons.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:130 (abstract no. 114). Unique Identifier : AIDSLINE PRIM8/900114; Watanabe R; Kuller L; Morton WR; Benveniste RE; Washington Regional Primate Research Center, University of; Washington SJ-50, Seattle WA 98195; Sixteen Papio cynocephalus were imported form Addis Ababa Ethiopia in April 1990. All the animals were screened for antibodies to Simian Hemorrhagic Fever within one week of arrival and were found to be negative. Two weeks following arrival, one animal developed marked weight los
Transmission of the molecular clone, SIV(Mne) CL8, in macaques.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:131 (abstract no. 115). Unique Identifier : AIDSLINE PRIM8/900115; Clark EA; Kuller L; Tsai CC; Benveniste R; Shearer GM; Clerici M; Ledbetter JA; Gallatin WM; Morton WR; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; Three transmission studies using a molecular clone of SIV(Mne) were undertaken at the University of Washington Regional Primate Research Center. In an initial study, SIV(Mne) CL8 was demonstrated to be infectious in vivo and caused an AIDS-like disease with mortality in pigtailed macaques (Macaca nemestrina). In a sec
Isolation from African sykes' monkeys (Cercopithecus mitis) of a lentivirus related to human and simian immunodeficiency viruses.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:132 (abstract no. 116). Unique Identifier : AIDSLINE PRIM8/900116; Emau P; McClure HM; Isahakia M; Else J; Fultz P; Yerkes Primate Center, Emory Univ., Atlanta, GA 30322; Immunoassay analysis for antibody in sera from 100 captive Sykes monkeys (Cercopithecus mitis) in Kenya showed that 60 had antibodies to human immunodeficiency virus type-2 (HIV-2). Of these positive sera, 59 were confirmed to have antibodies to HIV-2 by radioimmunoprecipitation ass
Naturally occurring SIV infection in a colony of Macaca arctoides.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:133 (abstract no. 117). Unique Identifier : AIDSLINE PRIM8/900117; Anderson DC; Fultz PN; Ansari AA; Klumpp SA; Ribas JL; McClure HM; Yerkes Primate Research Center, Emory University, Atlanta, GA; A colony of Macaca arctoides at the Yerkes Center was established in 1964 and was maintained as a closed colony until 1981 when four animals obtained from another colony were introduced into the group. One animal died shortly after introduction due to fight wounds. The three other animals remained in the colony until
Persistent HIV 2 infection of rhesus monkey.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:134 (abstract no. 118). Unique Identifier : AIDSLINE PRIM8/900118; Nicol I; Livartowsky J; Chamaret S; Dwyer D; Montagnier L; Dormont D; Commissariat \ga l'Energie Atomique and Centre de Recherches du; Service de Sant\ae des Arm\aees, Fontenay aux Roses, France; OBJECTIVE: To establish an animal model for human HIV infection. Methods: Inoculation: Eight rhesus monkeys were inoculated 3 years ago first IV and IC by 107 in vitro HIV2 ROD-infected cells, then, 1 year ago, IV reinoculated with supernatant of PBL coculture of an infected monkey which presented clinical signs of AI
Virological, immunological and clinical evaluation of Gibbon apes (Hyblobates lar) four years after experimental infection by HIV-1IIIB.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:135 (abstract no. 119). Unique Identifier : AIDSLINE PRIM8/900119; Markham P; Gard E; Robert-Guroff M; Franchini G; Lusso P; Gallo R; Advanced BioScience Laboratories, Kensington, MD; In 1986, four Gibbon apes, three of which had been preimmunized with ISCOM preparations containing HIV-1IIIB or HIV-1RF, core proteins were inoculated i.v. with approximately 10(6) tissue culture infectious units of HIV-1IIIB. All four animals rapidly developed antibody to HIV-1 env proteins and an elevated titer to H
Downregulation of CD28 expression by Tat protein from HIV-1.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:136 (abstract no. 120). Unique Identifier : AIDSLINE PRIM8/900120; Kashiwamura SI; Garcia V; Agy M; Gale M; Katze M; Ledbetter JA; Clark EA; Regional Primate Research Center, University of Washington,; Seattle, WA 98195; The tat gene products of immunodeficiency viruses including HIV-1, HIV-2 and SIV are essential for replication and bind to tat-responsive regions at the 5 of the viral RNA leading to transactivation of genes expressed from the HIV or SIV promoters. Tat may also regulate viral gene expression by post-transcriptional m
Phenotype associated sequence variation both within and around the fusion domain of clonal HIV-1 isolates with varying syncytium inducing capacities.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:137 (abstract no. 121). Unique Identifier : AIDSLINE PRIM8/900121; Andeweg AC; Groenink M; Leeflang P; de Goede RE; Osterhaus AD; Tersmette M; Bosch M; Lab. of Immunobiology, Nat. Inst. of Publ. Health and Env.; Protection, Bilthoven; Immunodeficiency virus-induced syncytium formation is mediated by the fusion peptide located at the amino terminus of the transmembrane glycoprotein. We have shown previously that mutations that change the hydrophobic character of the fusion domain of SIVmac change the ability of the envelope proteins to induce syncyt
Initial characterization of the reverse transcriptase of a human intracisternal A-type retroviral particle associated with Sj\uogren's Syndrome.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:138 (abstract no. 122). Unique Identifier : AIDSLINE PRIM8/900122; Hart DJ; Garry RF; Department of Microbiology and Immunology, Tulane Medical School,; New Orleans, LA 70112; Individuals infected with HIV or SIV often develop symptoms that resemble classic autoimmune diseases. Sj\uogren s Syndrome (SS), also known as autoimmune exocrinopathy, is characterized by dry eyes and mouth, and the infiltration of lymphoid cells into salivary and lacrimal glands. Similar symptoms and glandular path
Psychosocial factors and disease progression in SAIDS: a preliminary report.: Symp Nonhum Primate Models AIDS. 1990 Nov 28-30;8:139 (abstract no. 123). Unique Identifier : AIDSLINE PRIM8/900123; Capitanio JP; Lerche N; Department of Psychology, University of California, Davis, CA; 95616; SIV infection in macaques, like HIV infection in humans, is characterized by a variable time course to progression to clinical disease. A considerable body of research conducted with humans has implicated psychosocial factors in progression in diseases such as cancer and coronary disease. More recently, persisting imm
Alga associated with diarrhea in AIDS patients and in travelers.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:118 (abstract no. D-227). Unique Identifier : AIDSLINE ASM90/905001; Long EG; Ebrahimzadeh A; White EB; Swisher B; Callaway CS; Centers for Disease Control, Atlanta, GA; Spherical bodies resembling coccidian oocysts and measuring 8.0 - 9.0 um in diameter, were seen in stools from 8 persons with explosive, watery diarrhea. Seven of these patients had traveled to tropical countries, mostly in the Carribbean, and 4 of the patients suffered from AIDS. The structures were easily discernibl
Lack of in vitro activity of silver sulfadiazine against HIV.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:18 (abstract no. A-103). Unique Identifier : AIDSLINE ASM90/905002; Sawyer L; Weber P; Hanson CV; California Dept. of Health Services, Berkeley, CA; Up to 10% of burn patients admitted to an urban medical center have been shown to be positive for HIV. The care of these patients may entail frequent exposure to large amounts of blood and body fluids, placing health care workers at increased risk. Silver sulfadiazine (SSD), a topical antimicrobial agent, is used exte
In vitro activity of CI-978 (AT-4140) against AIDS-derived strains of mycobacterium avium complex (MAC).: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:6 (abstract no. A-31). Unique Identifier : AIDSLINE ASM90/905003; Yajko DM; Nassos PS; Sanders CA; Hadley WK; Univ. of California, San Francisco Gen. Hosp. Med. Ctr., San; Francisco, CA; At present, there is no known clinically effective therapy for treatment of disseminated MAC infection in patients with AIDS. Some strains of MAC are susceptible to quinolone antimicrobial agents, with ciprofloxacin (CIP) being the most active. We compared the in vitro activity of CIP with that of a new fluoroquinolon
Characterization of mycobacterium avium complex isolates from AIDS patients by multilocus enzyme electrophoresis.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:145 (abstract no. U-26). Unique Identifier : AIDSLINE ASM90/905004; Yakrus M; Reeves M; Centers for Disease Control, Atlanta, GA; Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are major opportunistic pathogens isolated from AIDS patients. Sero-agglutination has demonstrated that most isolates are either serotype 4 or 8. Direct transmission has not been documented, and infection is probably caused by either environmenta
Possibility for rapid diagnosis of tuberculous meningitis in HIV positive and AIDS patients by FPEC-GLC analysis of CSF.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:146 (abstract no. U-32). Unique Identifier : AIDSLINE ASM90/905005; Brooks J; Daneshvar M; Johnson A; Fields B; Centers for Disease Control, Atlanta, GA; Frequency-pulsed electron-capture gas-liquid chromatography (FPEC-GLC) techniques for detection of free (non-bound) carboxylic acids were applied to the analysis of trichloroethanol esterified acidic chloroform extracts of serum and cerebrospinal fluid (CSF) from 16 patients with human immunodeficiency virus (HIV) and
Incidence of M. tuberculosis in blood cultures from intravenous drug users with AIDS.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:152 (abstract no. U-67). Unique Identifier : AIDSLINE ASM90/905006; Delfin H; Lue YA; Torres J; Berrios A; Auguste P; Luten IE; Lincoln Medical Center, New York Medical College, Bronx, New York; In 1988 acid fast bacilli (AFB) were isolated from 202 patients, at Lincoln Medical and Mental Health Center. Both bone marrow and blood cultures of eight of these patients and only the bone marrow of one patient grew AFB. M. tuberculosis (MTB) was isolated from blood cultures of 2 patients. One patient had a history
Mycobacterium tuberculosis bacteremia.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:152 (abstract no. U-68). Unique Identifier : AIDSLINE ASM90/905007; Tonnessen G; Slim J; Smith L; Guarton A; St. Michael's Medical Center, Newark, N.J.; Since the Bactec system 460 has been introduced for the isolation of mycobacteria from blood culture we identified 18 patients with MTB bacteremia at an inner city hospital in Newark. We are presenting the epidemiological, clinical laboratory findings and outcome of these patients in a retrospective chart review study
Ultrastructural evidence of conjugation in the life cycle of Pneumocystis carinii.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:219 (abstract no. J-12). Unique Identifier : AIDSLINE ASM90/905008; Itatani C; Mack D; Marshall GJ; California State University, Long Beach; Pneumocystis carinii (PC) is an important opportunist of the immunosuppressed condition, whose life cycle and taxonomic position have not been established. We have found evidence of conjugation in PC comparable to that seen in the yeast, Saccharomyces cerevisiae. Rats with fully developed PC pneumonia were injected wi
Detection of enzymatic activity in pneumocystis carinii using 4-Methylumbelliferyl substrates.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:228 (abstract no. K-50). Unique Identifier : AIDSLINE ASM90/905009; Shaw MM; Paulsrud JR; Bartlett MS; Smith JW; Indiana University School of Medicine, Indianapolis, IN; A method of yeast enzyme detection using 10 4-methylumbelliferyl substrates was applied to P. carinii from culture and from rat lung. Substrates are hydrolyzed by preformed enzymes to produce 4-methylumbelliferone which fluoresces when exposed to light of 365 nm. The 10 substrates used were: beta-D-fucoside, beta-L-fu
A semi-automated assay to screen microbial metabolites for inhibitors of HIV-1 protease.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:263 (abstract no. O-1). Unique Identifier : AIDSLINE ASM90/905010; Lingham RB; Hsu A; Darke P; Koch G; Huang L; Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065; The human immunodeficiency virus (HIV), the etiological agent of the acquired immunodeficiency syndrome (AIDS), selectively infects the immune system rendering the host susceptible to opportunistic infections and neoplasms. The HIV protease participates in the viral life cycle by processing the core protein of 55 kDa
Development of a gene probe procedure for the detection of HIV in hospital wastewaters.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:324 (abstract no. Q-218). Unique Identifier : AIDSLINE ASM90/905011; Richardson KJ; Abbaszadegan M; Rose JB; Univ. of Arizona, Tucson, AZ; Since the recognition of Acquired Immune Deficiency Syndrome (AIDS), the water industry has been concerned with the possible presence of Human Immunodeficiency Virus (HIV) in hospital wastewaters, primarily through the disposal of blood, semen, urine and other contaminated waste to the sewer. Using seeded studies, met
Cytomegalovirus infection as a candidate cofactor in AIDS.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:337 (abstract no. T-7). Unique Identifier : AIDSLINE ASM90/905012; Smith K; Ratner J; Boswell N; Ludwig J; The University of Texas Health Science Center at San Antonio, San; Antonio, TX; The purpose of this long-term study is to test the hypothesis that coinfection with human immunodeficiency virus (HIV) and cytomegalovirus ( CMV ) results in more rapid progression of immunosuppression and AIDS than infection w
Blind perioral esophageal brushing versus esophagogastroduodenoscopy in AIDS patients with esophagitis.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:337 (abstract no. T-8). Unique Identifier : AIDSLINE ASM90/905013; Soroko T; Scrobola C; DePasquale J; Perez G; Saint Michael's Medical Center, Newark, NJ, USA; Blind perioral esophageal brushing is an easy and inexpensive diagnostic tool in isolating microorganisms from suspected cases of esophagitis. We studied ten patients with AIDS that had symptoms of esophagitis not improving after two weeks of oral ketoconazole therapy. Patients signed an informed consent and had blind
Tissue distribution of p24 antigen in HIV-infected athymic mice.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:337 (abstract no. T-9). Unique Identifier : AIDSLINE ASM90/905014; Eiring A; McLaughlin RL; Wetherall NT; Vanderbilt University School of Medicine, Nashville, TN; Irradiated immunedeficient (athymic) mice are capable of supporting replication of HIV. Antigen levels in plasma vary over time, peaking at 6 weeks and remaining elevated for at least 9 weeks. We investigated the levels of p24 antigen in kidney, spleen, and tumor tissue at various time points during a nine week study.
In vitro infection of lamina propria mononuclear cells (LPMC) with human immunodeficiency virus (HIV): evidence of increased viral replication.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:337 (abstract no. T-10). Unique Identifier : AIDSLINE ASM90/905015; Yen-Lieberman B; Sierra-Madero J; Proffitt MR; Fiocchi C; Cleveland Clinic Foundation, Cleveland, Ohio 44195; HIV infection of the gastrointestinal mucosa can be demonstrated in some patients with HIV enteropathy. HIV infected LPMC have been identified in some patients, although the pathogenic significance of this finding is unclear. Perhaps LPMC represent the first cellular targets encountered by HIV during anal intercourse.
Intestinal malabsorption: association with HIV and SIV infections in human and simian AIDS.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-11). Unique Identifier : AIDSLINE ASM90/905016; Dandekar S; Heise C; Martfeld D; Miller C; Marx P; Donovan R; Halsted C; Department of Internal Medicine and California Primate Research; Center, University of California, Davis, CA 95616; Diarrhea and weight loss are frequent manifestations of HIV infection and often occur without any detectable enteric pathogens. The pathogenesis of intestinal abnormalities is not well defined. To understand the etiology of intestinal malabsorption in ARC and AIDS, clinical, pathological, morphometrical, functional, v
Human immunodeficiency virus (HIV-1) infection in rabbits as a model for therapy.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-12). Unique Identifier : AIDSLINE ASM90/905017; Carlson JR; Dickover RE; Dandekar S; Jennings MB; Donovan RM; School of Medicine, Univ. California, Davis; HIV-I infections in rabbits may prove to be an important model. We report the results of experiments that confirm the susceptibility of rabbits for HIV-1. Ten New Zealand White rabbits were challenged with cell-associated HIV-1. The rabbits were tested by a newly developed, qua
Protection for macaques against SIVmac challenge using an inactivated whole virus vaccine.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-13). Unique Identifier : AIDSLINE ASM90/905018; Carlson JR; McGraw TP; Keddie E; Jennings MB; Vowels B; Gardner MB; Med. Pathology, Univ. California, Davis; Rhesus monkeys were immunized by multiple inoculations with purified, inactivated SIVmac (ISIV). Experimental groups included animals that received the SIVmac immunogen in muramyl dipeptide, incomplete Freund s adjuvant, or in aqueous suspension. ISIV immunized animals developed anti-SIV antibodies and positive, SIV s
Protection of zidovudine (AZT)-induced bone marrow toxicity and potentiation of anti-HIV activity with vitamin E.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-14). Unique Identifier : AIDSLINE ASM90/905019; Gogu SR; Rangan SR; Agrawal KC; Dept. of Pharmacol., Tulane Univ. Sch. Med. New Orleans, LA 70112; Significant dose-related anemia has been a limiting factor in the treatment of AIDS patients with AZT . We have investigated the ability of vitamin E (a) to stimulate erythroid progenitor cells, and (b) to inhibit HIV replication. Alpha-D-Tocopherol su
Vaginal transmission of retroviral immunodeficiency disease in mice.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-15). Unique Identifier : AIDSLINE ASM90/905020; Traun K; Hopkins W; Univ. of Wisconsin Med. Sch., Madison, Wisconsin 53792; An acquired immunodeficiency disease is induced when the murine leukemia virus LP-BM5, a retrovirus, is injected intraperitoneally (IP) in mice. We have challenged C57B1/6 mice with LP-BM5 via injection into the peritoneal cavity or inoculation of the vaginal introitus. The vaginal mucosal mode of infection serves as
Human monoclonal antibody reactive with the envelope glycoprotein (gp 120) of HIV-1.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:338 (abstract no. T-16). Unique Identifier : AIDSLINE ASM90/905021; Myers RA; Falkler WA Jr; Patel JD; Joseph JM; State of MD Dept. of Health & Mental Hygiene, Lab. Adm. and Univ.; of MD Dental School, Baltimore, MD; The development of human monoclonal antibodies (HmAb) may be useful in the characterization of the host immune response during infection with HIV-1. HmAb would allow the elucidation of biologically relevant epitopes and may have potential diagnostic or therapeutic applications. Peripheral lymphocytes from an HIV-1 inf
In vivo sequence heterogeneity of human immunodeficiency virus env sub-regions.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:340 (abstract no. T-24). Unique Identifier : AIDSLINE ASM90/905022; Howell RM; Fitzgibbon JE; Noe M; Ren Z; Gocke D; Schwartzer TA; Dubin DT; UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ; Sequence analysis of cloned HIV proviral DNA has shown that HIV isolates consist of many molecular variants (e.g., Goodenow et al, J. Acq. Imm. Def. 2:344). These variants display heterogeneity particularly within the gp120 portion of the env gene. To compare these findings with the extent of heterogeneity occurring i
Human immunodeficiency virus (HIV) infection of human placenta.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:340 (abstract no. T-25). Unique Identifier : AIDSLINE ASM90/905023; Amirhessami-Aghili N; Spector SA; Department of Pediatrics and Center for Molecular Genetics,; University of California, San Diego, La Jolla, CA 92093; Transplacental transmission of HIV is an important route of neonatal infection. To examine the potential role of the placenta in transmission of HIV from mother to fetus, we examined the ability of human first trimester placental tissue to support HIV infection. Human placental explant cultures obtained from first tri
Overexpression and purification of the HIV-1 rev protein from E. coli.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:340 (abstract no. T-26). Unique Identifier : AIDSLINE ASM90/905024; Doten RC; Ellam I; Donner AL; Daly TJ; Repligen Corp., Cambridge, MA 02139; The HIV-1 Rev protein is required for viral replication and functions to promote the nuclear export of unspliced and singly spliced viral mRNA. We have obtained high level expression of the rev gene in E. coli by coupling rev translation to the translation of the E. coli beta-glucuronidase (BG) gene in an operon fusio
Rapid serological detection of HTLV-I/II antibodies.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:340 (abstract no. T-28). Unique Identifier : AIDSLINE ASM90/905025; Ng VL; Yajko DM; Gonzalez P; Lipka J; Chun P; Foung SK; Chu A; Hadley WK; Univ. of California, San Francisco Gen. Hosp.; A new assay utilizing rapid serum flow through and trapping of antigen-specific antibodies on filters was tested for its ability to reliably detect HTLV I/II antibodies. One microgram of purified HTLV-I antigen (Hillcrest Biologicals) solubilized in 0.1% SDS was applied to the filters and 100 mul of serum was filtered
Microelisa detection of antibodies to human T-lymphotropic virus type I.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-29). Unique Identifier : AIDSLINE ASM90/905026; Long MR; Chetty C; Crout FV; Organon Teknika Corp., Durham, NC, USA; Human T-lymphotropic virus type I (HTLV-I) infection has been associated with clinical diagnoses of adult T-cell leukemia/lymphoma (ATL) and tropical spastic paraparesis (TSP)/HTLV-1-associated myelopathy (HAM). Transfusion of infectious whole blood or blood cellular components is a recognized means of virus transmiss
Multiple primer pairs for the identification of adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP) by polymerase chain reaction (PCR).: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-30). Unique Identifier : AIDSLINE ASM90/905027; Williams L; Lairmore M; Cardona N; Folks T; De B; The Centers for Disease Control, Atlanta, GA; The exogenous retrovirus human T-cell leukemia virus type-I (HTLV-I) has been established as the etiologic agent for ATL and is associated with the neurological disease, TSP, also known as HTLV-I associated myelopathy (HAM). To identify these specific diseases, we utilized PCR with several primer pairs complementary t
Accuracy of Western blot testing for human immunodeficiency virus type 1 (HIV-1) infection.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-31). Unique Identifier : AIDSLINE ASM90/905028; Schalla WO; Cross GD; Hearn TL; Blumer SO; Taylor RN; Valdiserri RO; Centers for Disease Control, Atlanta, Georgia; Approximately 90% of the more than 1,300 United States laboratories enrolled in the Centers for Disease Control Model Performance Evaluation Program furnished results after testing specimens sent them in May 1988, September 1988, and April 1989. Of the laboratories reporting results, 2
Nucleic acid hybridization for HIV susceptibility testing using peripheral blood mononuclear cells (PBMCs).: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-32). Unique Identifier : AIDSLINE ASM90/905029; Cohen SH; Scholl DR; Bolton V; Ishizaki G; Jennings M; Carlson JR; Univ. California, Davis; We have developed an approach for antiviral susceptibility testing using a rapid method for nucleic acid hybridization called wicking. Using this method we have successfully tested HIV versus AZT with CEM cells. Because only a minority of clinical iso
Comparison of nested vs non-nested polymerase chain reaction assays for the detection of HIV proviral DNA.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-33). Unique Identifier : AIDSLINE ASM90/905030; Porter-Jordan K; Comerford J; Keiser J; Nasim S; Garrett CT; George Washington Univ. Med. Ctr., Washington DC 20037; We can detect proviral DNA sequences of the human immunodeficiency virus (HIV) with the polymerase chain reaction (PCR), a technique of enzymatic amplification of specifically targeted DNA. Nested PCR is a two-step procedure in which a long DNA sequence containing the target is amplified in a first round of PCR, follo
Analysis of dually reactive HIV-1 and HIV-2 sera from Cote d'Ivoire.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:341 (abstract no. T-34). Unique Identifier : AIDSLINE ASM90/905031; Lee-Thomas S; Pau C; Granade T; Phillips S; Schochetman G; Heyward W; George R; Porter A; De Cock K; Odehouri K; Center for Disease Control, Atlanta, GA; Approximately 45% of HIV positive sera collected during seroprevalence studies in Cote d Ivoire were dually reactive by EIA and Western blot to HIV-1 and HIV-2. Dual reactivity could be caused by double infection, cross-reacting antibody, or infection with a third virus contai
Impact of dried blood spot elution buffers on HIV-1 Western blot banding patterns.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-35). Unique Identifier : AIDSLINE ASM90/905032; Phillips S; Granade T; Lee-Thomas S; Pau C; George R; The Centers for Disease Control, Atlanta, GA; In support of the national HIV Seroprevalence Survey of Childbearing Women, five enzyme immunoassays (EIA) and a Western blot procedure for antibodies to HIV-1 in serum were modified to test samples eluted from dried blood spots (DBS). Testing for antibodies extracted from DBS required buffers with strong blocking age
Quantitation of antibody reactivity to HIV-1 proteins and glycoproteins on Western blots by scanning densitometry.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-36). Unique Identifier : AIDSLINE ASM90/905033; Hardy CT; Damrow TA; Kenny GE; University of Washington, Washington State Public Health; Laboratories, Seattle, WA; Scanning densitometry was studied as a method for quantitating specific HIV-1 antibodies on Western Blots. Serum samples displaying varying reactivity to HIV-1 antigens were diluted in two fold steps ranging (1:80-1:2,600,000) and tested with commercially available Western Blotting strips. The staining intensity as me
Detection of HIV IgM in recent seroconverters.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-37). Unique Identifier : AIDSLINE ASM90/905034; Srugo I; Brunell PA; Cedars-Sinai Medical Center, Los Angeles, CA; Screening of donated blood for HIV has markedly diminished but not eliminated the risk of transfusion acquired HIV infection. Many of the remaining cases are due to failure of the IgG ELISA to detect antibody shortly after the onset of infection. For this reason, an antibody capture ELISA to detect IgM antibody direct
Development of a rapid test for the detection of antibodies to human immunodeficiency virus type 1 and 2 using recombinant proteins.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-38). Unique Identifier : AIDSLINE ASM90/905035; Garcia L; Morrisette J; Mantha G; Hung CH; Young E; Beltz J; Stella M; Cambridge BioScience Corporation, Worcester, MA; OBJECTIVE: We have developed a ten minute test to screen serum and plasma for the presence of antibodies to HIV-1 and HIV-2 in a self-contained unit called the Rapid Test Device (RTD). There are three reactive areas on the RTD membrane surface; two contain recombinant proteins for HIV-1 and HIV-2, respectively, and th
Clinical performance of a recombinant protein used in an EIA for the detection of HIV-1 antibodies in patients' samples.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-39). Unique Identifier : AIDSLINE ASM90/905036; Stella M; Hung CH; Beltz J; Yi A; Thorn R; Cambridge BioScience Corporation, Worcester, MA 01605; The Recombigen HIV-1 EIA is an in vitro assay utilizing recombinant proteins for the detection of HIV-1 antibodies in serum or plasma. The genetically engineered proteins, gp 120 (env) and p24 (gag) are expressed in E. Coli, purified to remove contaminating bacterial proteins and adsorbed onto polystyrene microwells f
Evaluation of a rapid immunoassay for HIV-1 in a high prevalence environment.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:342 (abstract no. T-40). Unique Identifier : AIDSLINE ASM90/905037; Totino E; Lopez L; Perez E; Perez G; St. Michael's Medical Center, Newark, NJ; The number of cases of HIV-1 infection in the United States continue to grow but certain areas still show a higher incidence of infection. Newark, because of its proximity to New York City and high proportion of intravenous drug users continues to be one such area. During a 1 month per
Sensitivity comparison of Beckman ASQ HIV Recombinant ELISA and Organon Teknika Western Blot.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-41). Unique Identifier : AIDSLINE ASM90/905038; Condie T; Mottice S; Bureau of Microbiology, Utah State Health Laboratory, 44 Medical; Drive S.L.C., UT, 84113; A comparison of sensitivity was made between the Beckman ASQ HIV Recombinant ELISA assay, which tests for a panel of the six viral peptides, p24, kp55, kp41, kp66/31, kp120N and kp 120CC, and the Organon Teknika HIV Western Blot. Serum specimens showing strong antibody reaction to viral proteins p17, p24, gp41, p51, p
Characterization of monoclonal antibodies recognizing HIV-1 p24.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-42). Unique Identifier : AIDSLINE ASM90/905039; Watson PM; Nigida SM Jr; Arthur LO; Program Resources, Inc., NCI-Frederick Cancer Research Facility,; Frederick, MD; Monoclonal antibodies (MAb) were prepared using spleen cells from mice immunized with purified HIV(IIIb) p24, selected by enzyme immunoassay (EIA), and propagated as ascites tumors. Thirteen MAb were identified; nine had EIA titers greater than or equal to 1:1000 and recognized, by western blot, a 24,000 dalton molecu
Comparison of three ELISA kits for the determination of antibodies to HIV-1.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-43). Unique Identifier : AIDSLINE ASM90/905040; Fonseca K; Anand CM; Walle R; King R; McKendrick B; Gaffney D; Provincial Laboratory of Public Health, Calgary, Alberta, Canada,; T2N 4N1; The performance of 3 enzyme-linked immunoassay (ELISA) kits, each using different antigens and principles, were compared for their relative ability to detect antibodies to Human Immunodeficiency Virus type 1 (HIV-1). The kits selected were Genetics (GEN), Wellcozyme (WEL) and I.A.F. BioChem (IAFB). A total of 350 samp
PCR analysis in HIV-positive drug addicts and in partners of HIV-positive subjects.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-44). Unique Identifier : AIDSLINE ASM90/905041; Zella D; Mori L; Sala M; Achilli G; Cattaneo E; Casoli C; Magnani G; Ferrantes P; Lori F; Bertazzoni U; IGBE/CNR, Pavia; The evaluation by several laboratories of Polymerase Chain Reaction (PCR) in HIV-positive homosexuals resulted in good concordance with the HIV antibody test (Western Blot). We conducted blinded PCR analysis in a cohort of drug addicts whose clinical and HIV-antibody status is well known. The PCR test was performed us
Rapid enzyme immunoassay for the detection of antibodies to human immunodeficiency virus type 1 (HIV-1).: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-45). Unique Identifier : AIDSLINE ASM90/905042; Killion JW; Saewert MD; Schanzenbach H; Trass KG; Achord D; Bunyagidj C; HYBRITECH INC., La Jolla, CA; An eight minute test has been developed for the detection of antibodies to HIV-1 present in serum, plasma, and whole blood. The format is based on the ImmunoConcentration(TM) principle. Each test has three reference zones which include a negative control, internal positive control, and a test zone which consists of in
The effect of primer length on the amplification of the DNA of human immunodeficiency virus (HIV).: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:343 (abstract no. T-46). Unique Identifier : AIDSLINE ASM90/905043; Brown V; Robbins K; Schochetman G; Ou CY; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA; Peripheral blood mononuclear cells from infected persons contain low levels of HIV genetic information which can be directly detected by the polymerase chain reaction. Primer pair SK38/39 specific for the gag gene of HIV-1 has been widely used for direct amplification. To optimize this assay, we examined the effect of
Flow cytometric detection of p24 antigen positive PBMC obtained from HIV-seropositive children.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:345 (abstract no. C-7). Unique Identifier : AIDSLINE ASM90/905044; McSharry J; Lehman JM; Albany Medical College, Albany, New York 12208; Babies born to HIV-seropositive mothers are HIV-seropositive due to maternal antibody. But, only about 1/3 of these HIV-seropositive babies are infected with the virus. To use the currently available antiviral chemotherapy, one must be able to determine which of the HIV-seropositive babies are actually infected with t
Evaluation of a rapid 7 minute ELISA for the determination of antibody status to HIV-1.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:349 (abstract no. C-32). Unique Identifier : AIDSLINE ASM90/905045; Aarnaes S; MacDonald R; Friedly G; de la Maza L; Peterson E; Dept. of Pathology, Univ. of Calif. Irvine Med. Ctr., Orange,; Calif.; The serocard HIV Antibody Test Kit (SC, Disease Detection International, CA) is a rapid, 7 min, ELISA performed on a chromatographic solid support matrix that uses as the antigen a synthetic peptide made to gp41. This kit was compared to a 4 h EIA ( Abbott Laboratories , IL) for thee
Comparison of direct monoclonal antibody stain with modified Toluidine Blue O stain for the rapid diagnosis of Pneumocystis carinii pneumonia.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:373 (abstract no. C-179). Unique Identifier : AIDSLINE ASM90/905046; Zubairi SQ; Ryskewich NJ; Veterans Affairs Medical Center, Washington, DC; The Pneumocystis carinii Immunofluorescence Test Kit (Genetics Systems Corp. Seattle, WA.) is a direct murine monoclonal antibody stain, labeled with fluorescein isothiocynate. We evaluated this kit by using 35 clinical specimens of bronchoalveolar lavage and compared the sensitivity, specificity and readability of the
Evaluation of Fungifluor for the detection of Pneumocystis carinii in respiratory exudates.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:375 (abstract no. C-187). Unique Identifier : AIDSLINE ASM90/905047; Stager CE; Fraire AE; Kim HS; Estrada R; Davis JR; Greenberg SD; McBride R; Department of Pathology, Ben Taub General Hospital and Baylor; College of Medicine, Houston, TX; Pneumocystis carinii pneumonia is a leading cause of morbidity and mortality in the immunocompromised host. Calcofluor white (Fungifluor, Polysciences, Inc., Warington, PA) has been reported to consistently stain unique parenthesis-like polysaccharide structures in the cysts of P. carinii, within two minutes. Seventy-e
Organotropism of mycobacteria in acquired immunodeficiency syndrome patients.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:405 (abstract no. C-371). Unique Identifier : AIDSLINE ASM90/905048; Varricchio F; Nadimpalli V; Hubbard-Shepard M; Panovic S; Swiatlo AL; Kocka FE; Cook County Hospital-Hektoen Institute, Chicago, IL; Mycobacterial infections are common in acquired immunodeficiency syndrome (AIDS) patients. In addition to Mycobacterium tuberculosis, M. avium complex (MAI) and M. kansasii have been reported. Postmortem findings were compared with antemortem cultures on eight patients. Three patients had positive cultures for M. tubee
Impact of aerosolized pentamidine on the laboratory diagnosis of Pneumocystis carinii pneumonia.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:406 (abstract no. C-374). Unique Identifier : AIDSLINE ASM90/905049; Ng VL; McGinty E; Geaghan S; Fahey J; Schnapp L; Yajko DM; Leoung G; Hopewell PC; Hadley WK; Univ. of California and San Francisco General Hospital, San; Francisco, CA; It has been speculated that the use of prophylactic aerosolized pentamidine (AP) may lower the sensitivity for the laboratory detection of Pneumocystis carinii (PC) in respiratory specimens obtained from individuals at risk for or with AIDS. To address this issue, we compared the PC detection rates in respiratory spece
Impact of a clinic for adult patients with HIV infection on the microbiology laboratory at a county hospital.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:406 (abstract no. C-376). Unique Identifier : AIDSLINE ASM90/905050; McGowan JE Jr; Thompson SE 3d; Morriss C; Vroon DH; Grady Memorial Hospital and Emory University School of Medicine,; Atlanta, Georgia; Our Infectious Diseases Clinic (IDC) serves adult patients with AIDS, ARC and others seropositive for HIV. During a 3-month period, 747 patients were active at this clinic; for a random sample of one-third, we reviewed lab records for microbiology tests during the study period (August 1 - October 31, 1989). Reviewed pe
A protocol for microbiologic analysis of bronchoalveolar lavage samples: experience with 235 specimens from compromised patients.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:406 (abstract no. C-377). Unique Identifier : AIDSLINE ASM90/905051; Hall C; Baselski V; Bugg F; Robison M; Hayes M; Ashe S; Reg. Med. Ctr., Baptist Reg. Lab., and Univ. Tenn., Memphis, TN; A protocol was established for detection of opportunistic pulmonary infections using bronchoalveolar lavage samples from compromised patients. Analyzed were 235 samples from 213 patients, primarily with HIV infection, organ transplantation, or malignancy. Cultures of concentrated sediments and stains on cytocentrifugee
Oligoclonal IgG detection in unconcentrated CSF of multiple sclerosis and of CNS HIV-infected patients using a sensitive IEF-EITB method.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:434 (abstract no. V-2). Unique Identifier : AIDSLINE ASM90/905052; Ferrante P; Maccarana M; Caputo D; Saresella M; Achilli G; Cazzullo CL; Multiple Sclerosis Ctr Don C. Gnocchi, Milan, Italy; IgG oligoclonal bands (OCB) in CSF are of great importance in diagnosis and pathogenesis of several neurological disorders, particularly in MS and CNS HIV infection. For these reasons we developed a method based on isoelectrofocusing in poliacrylamide gel followed by electroblot and immunostaining (PAG-IEF EITB). Dilue
HIV-1 antibody testing using recombinant antigens with latex and enzyme immunoassays on African sera.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:434 (abstract no. V-4). Unique Identifier : AIDSLINE ASM90/905053; Proulx A; Stella M; Georges MC; Lapage C; Riggin C; Georges AJ; Cambridge BioScience Corporation, Worcester, Massachusetts 01605; We evaluated the performance of Recombigen HIV-1 Latex Agglutination (LA), and Recombigen HIV-1 EIA (E &G) relative to viral lysate EIA and Western blot (WB) on African sera. The LA test consists of latex particles coated with recombinant env, CBre3. LA is a 5 minute test performed upon a card, which is easy to use
A novel peptide based immunoassay for antibodies to human immunodeficiency virus, types 1 and 2.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:434 (abstract no. V-5). Unique Identifier : AIDSLINE ASM90/905054; Whiteley G; Wong P; Conte K; Freeley P; Dray-Lyons K; Desplaines K; Metzmann E; PB Diagnostic Systems, Westwood, MA 02090; We have developed a 20-minute unitized immunoassay to detect antibodies from individuals infected by HIV 1 or 2. All reagents are contained in a small test module designed to be run on the PB Diagnostic Systems OPUS(TM) automated random access analyzer. The assay is based on liquid phase binding of HIV 1 and 2 antibo
Evaluation of faster and more economical assays for HTLV-I/II antibody detection.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:434 (abstract no. V-6). Unique Identifier : AIDSLINE ASM90/905055; Cahoon-Young B; Chandler A; Gaudino J; Livermore T; Benjamin R; Alameda County Health Care Services Agency, Oakland, CA; Seven different assays for HTLV-I/II antibody (Ab) were used to test 361 serum specimens from a drug treatment center population in Alameda County (northern California). Three enzyme linked immunosorbent assays (ELISA) were compared for initial screening of specimens, while immunofluorescent antibody assay (IFA), West
Enzyme immunoassay for the detection of antibody to human T-lymphotropic virus type-I (HTLV-I) in serum or plasma.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:434 (abstract no. V-7). Unique Identifier : AIDSLINE ASM90/905056; Butwell T; Wescott J; Waksal H; Kissinger R; ImClone Systems Inc., New York, NY; Human T-Lymphotropic Virus Type I (HTLV-I) is the etiologic agent associated with Adult T-Cell Leukemia (ATL), Tropical Spastic Paraparesis (TSP), and HTLV-I-Associated Myelopathy (HAM). The FDA now recommends that whole blood and cellular components donated for transfusion be screene
A comparison of Gomori methenamine silver stain with three immunofluorescent kits for Pn. carinii detection.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:437 (abstract no. V-22). Unique Identifier : AIDSLINE ASM90/905057; Donaldson G; Wild L; Amsterdam D; Erie Cty. Med. Ctr. and SUNY at Buffalo, Buffalo, NY; We studied conventional Gomori methenamine silver stain (GMS) versus 3 immunofluorescent kits [Genetic Systems DFA (GS); Disease Detection International s IFA, Fluorslide (DDI); and Meridian Diagnostic s IFA, Merifluor Pneumocystis (MD)] for Pneumocystis carinii (PC) detection. A total of 49 specimens (34 induced spu
Epidemics and AIDS, a general education non-majors science course.: Abstr Annu Meet Am Soc Microbiol. 1990 May 13-17;90:439 (abstract no. ED-6). Unique Identifier : AIDSLINE ASM90/905058; Aloisi R; Coleman W; Barrett K; Ghnassia J; Birden H; Carveth R; Ciarcia P; Depts. of Biology and Health Professions, University of Hartford,; West Hartford, CT; A four credit laboratory science course, Epidemics and AIDS, was developed at the University of Hartford for non-science majors. The overall goal of the course was to provide accurate information about AIDS while teaching students basic concepts of microbiology, immunology and epidemiology. Included in the course obje
HIV counselling: problems and opportunities in defining the new agenda for the 1990s [editorial]: AIDS Care. 1989;1(2):117-23. Unique Identifier : AIDSLINE MED/91175823; Carballo M; Miller D
Needle-exchange in central London: operating philosophy and communication strategies.: AIDS Care. 1989;1(2):125-34. Unique Identifier : AIDSLINE MED/91175824; Hart G; Woodward N; Carvell A; Academic Department of Genito-Urinary Medicine, University; College & Middlesex School of Medicine, Middlesex Hospital,; London, United Kingdom.; Despite a large number of needle-exchange schemes in the U.K., there are few accounts of how particular agencies attract injecting drug users. This paper describes a busy scheme in London, the take-up of services by clients, and the operating philosophy of the staff. From November 1987 to October 1988 The Exchange saw
The impact of the AIDS-education programme on Ugandan schoolchildren.: AIDS Care. 1989;1(2):135-6. Unique Identifier : AIDSLINE MED/91175825; Muller O; Lubega J; Senoga J; League of Red Cross and Red Crescent Societies, Geneva,; Switzerland.; The knowledge and attitudes of young people towards AIDS prevention and AIDS patient care have been evaluated through an investigation of posters sent to a nationwide poster competition by urban schoolchildren in Uganda . The contents of these posters may reflect the current state o
Prejudice and AIDS: the views and experiences of people with HIV infection.: AIDS Care. 1989;1(2):137-43. Unique Identifier : AIDSLINE MED/91175826; King MB; Academic Department of Psychiatry, Royal Free Hospital, London,; United Kingdom.; Discrimination against people on the basis of physical or mental infirmity is common and creates a considerable burden for sufferers. There has been considerable debate about the prejudice against people with disease resulting from human immunodeficiency virus (HIV) infection. This study reports on the views and exper
The Italian AIDS 'hot-line': providing information to the people.: AIDS Care. 1989;1(2):145-52. Unique Identifier : AIDSLINE MED/91175827; Benedetti P; Zaccarelli M; Giuliani M; Di Fabio M; Valdarchi C; Pezzotti P; Tumbarello M; Greco D; Centro Operativo AIDS (AIDS Operational Centre), Istituto; Superiore di Sanita (National Institute for Health) Roma, Italy.; The Italian AIDS hot-line has recently completed its first two operational years. Established as an emergency service, it was initially overloaded with calls, under the emotional impact of a new disease. As the average number of calls settled to around a hundred per day, a wider approach aimed at the concerns raised b
Treatment dilemmas for HIV infected haemophiliacs.: AIDS Care. 1989;1(2):153-8. Unique Identifier : AIDSLINE MED/91175828; Lee CA; Miller R; Goldman E; Haemophilia Centre, Royal Free Hospital, London, United Kingdom.; A description of a structured group, held for anti-HIV positive haemophiliacs and their relatives, to discuss the implications of participating in the MRC/INSERM double-blind control trial of zidovudine is given. The group discussion is used to define, evaluate and rank the many treatment dilemmas inherent in particip
AIDS strategies and human rights obligations: a discussion paper.: AIDS Care. 1989;1(2):159-64. Unique Identifier : AIDSLINE MED/91175829; Kirby M; Court of Appeal, Sydney, Australia.
HIV testing in antenatal clinics: the impact on women.: AIDS Care. 1989;1(2):165-71. Unique Identifier : AIDSLINE MED/91175830; Stevens A; Victor C; Sherr L; Beard R; Department of Public Health, St Mary's Hospital, London, U.K.; One hundred and fifty-five women attending antenatal clinics in an inner city area where the rate of AIDS reporting is high were interviewed to examine the acceptability of different modes and purposes of antenatal HIV testing. Eighty-two per cent of women felt the test should be available in antenatal clinics, but on
AIDS and community-based care in Uganda: the AIDS support organization, TASO.: AIDS Care. 1989;1(2):173-5. Unique Identifier : AIDSLINE MED/91175831; Kalibala S; Kaleeba N; TASO-Uganda, Kampala.; TASO is an organization set up by Ugandans who are personally, in one way or another, concerned about AIDS. Its work in Uganda is an attempt to bridge the gap between the African approach to disease and the western, hospital-based, approach. The result is a service providing community-based care to those affected by A
World Health Organization Global AIDS Statistics.: AIDS Care. 1989;1(2):229-32. Unique Identifier : AIDSLINE MED/91175844
Injecting drug use, HIV and AIDS [editorial]: AIDS Care. 1989;1(3):237-45. Unique Identifier : AIDSLINE MED/91175845; Hart GJ
Knowledge of AIDS, use of condoms and results of counselling subjects with asymptomatic HIV2 infection in The Gambia.: AIDS Care. 1989;1(3):247-56. Unique Identifier : AIDSLINE MED/91175846; Wilkins HA; Alonso P; Baldeh S; Cham MK; Corrah T; Hughes A; Jaiteh KO; Oelman B; Pickering H; Medical Research Council Laboratories, Fajara, The Gambia.; A questionnaire administered to subjects seen during a serological survey in The Gambia revealed that knowledge of AIDS and HIV infection was limited. Males, those with a secondary education and people who lived in urban areas had a better understanding but only 17% of women seen i
Prevention in practice: obstacles and opportunities.: AIDS Care. 1989;1(3):257-67. Unique Identifier : AIDSLINE MED/91175847; Rhodes T; Gallagher M; Foy C; Philips P; Bond J; Department of Politics and Sociology, Birkbeck College,; University of London, United Kingdom.; General Practitioners are excellently placed within the community to provide health education and advice in relation to HIV infection and AIDS. This paper will report on some of the findings from the first national study of HIV infection and general practice in England and Wales. The findings cast light on the prepare
Sex worker, client sex behaviour and condom use in Harare, Zimbabwe.: AIDS Care. 1989;1(3):269-80. Unique Identifier : AIDSLINE MED/91175848; Wilson D; Chiroro P; Lavelle S; Mutero C; Department of Psychology, University of Zimbabwe, Harare.; One-hundred sex workers and 100 clients were interviewed at a bar/disco complex in Harare, Zimbabwe in 1989. Sociodemographic characteristics of sex workers and clients were examined. Almost a third of sex workers and nearly 90% of clients had engaged in commercial sex over 5 or
AIDS training and social services.: AIDS Care. 1989;1(3):287-96. Unique Identifier : AIDSLINE MED/91175850; Samuel JC; Boyle M; Department of Psychology, Community Tower Hamlets Health; Authority, London, United Kingdom.; To be effective, AIDS training must be based on an understanding of the specific requirements of participants. Knowledge, attitudes and behaviour concerning AIDS have been investigated among the general public and a variety of health care professionals, but the needs of Social Services Department personnel have not be
Providing high quality, low cost legal services to people with AIDS: an antidiscrimination law project.: AIDS Care. 1989;1(3):297-306. Unique Identifier : AIDSLINE MED/91175851; Barnes M; Greenberg DM; Pinsky L; AIDS Law Clinic, Columbia University School of Law, New York; City.
An appraisal of HIV antibody test counselling of injecting drug users.: AIDS Care. 1989;1(3):307-11. Unique Identifier : AIDSLINE MED/91175852; Sonnex C; Petherick A; Hart GJ; Adler MW; Academic Department of Genitourinary Medicine, University College; and Middlesex School of Medicine, London, United Kingdom.; One-hundred and nine injecting drug users entering a methadone detoxification programme underwent HIV antibody test counselling. Approximately 80% of men and women were concerned because of sharing injection equipment ( works ) in the previous year, although other reasons for considering an HIV antibody test, such as
Knowledge and attitudes of health care staff about HIV infection in a health district with low HIV prevalence.: AIDS Care. 1989;1(3):313-7. Unique Identifier : AIDSLINE MED/91175853; Klimes I; Catalan J; Bond A; Day A; Department of Clinical Psychology, Warneford Hospital, Oxford,; United Kingdom.; The level of awareness of HIV related problems and their implications for health workers were investigated in Oxford, where the problem of HIV infection has not reached the levels of other metropolitan areas. Four hundred nurses and doctors in Oxford were surveyed to ascertain their knowledge about HIV infection, thei
Clinical care as part of integrated AIDS management in a Zambian rural community.: AIDS Care. 1989;1(3):319-25. Unique Identifier : AIDSLINE MED/91175854; Chela CM; Campbell ID; Siankanga Z; Salvation Army, Chikankata Hospital, Mazabuka, Zambia.; Inpatient and community-based care can be complementary in relation to the management of HIV disease. Some special features and advantages of community-based care are described, drawing on experience from Zambia .
World Health Organization Global AIDS Statistics.: AIDS Care. 1989;1(3):333-6. Unique Identifier : AIDSLINE MED/91175855
[Subjects infected with human immunodeficiency virus: serological markers of prognostic value]: Rev Med Chil. 1989 Mar;117(3):251-7. Unique Identifier : AIDSLINE MED/91180598; Hurtado C; Velasco M; Sepulveda C; Three stages in the course of acquired immunodeficiency syndrome (AIDS) have been recognized: asymptomatic, AIDS related complex (AIDS-RC) and clinical AIDS. In contrast to asymptomatic patients, subjects with clinical AIDS show HIV antigens in serum and a disappearance of antibodies against the main viral core (anti-
First year medical students' attitudes and knowledge about AIDS.: AIDS Care. 1989;1(1):105-10. Unique Identifier : AIDSLINE MED/91182837; Strunin L; Culbert A; Crane S; Social & Behavioral Science Section, School of Public Health,; Boston University School of Medicine, MA 02118.; Medical students attitudes and resulting behaviors about treating HIV-infected patients are critical and will become increasingly so in the years ahead. An anonymous self-administered questionnaire of 135 first year medical students at Boston University School of Medicine conducted in May 1988 queried students knowle
HIV counselling in prisons.: AIDS Care. 1989;1(1):11-25. Unique Identifier : AIDSLINE MED/91182838; Curran L; McHugh M; Nooney K; Psychological Service, Prison Department, London, United Kingdom.; HIV presents particular problem in penal establishments: the nature of the population; conditions in prison; media attention and misinformation; the possibility of transmission within and beyond the prison population; the extra issues that apply to female prisoners. These are discussed in the context of prison policy
Condom use among homosexual men.: AIDS Care. 1989;1(1):27-33. Unique Identifier : AIDSLINE MED/91182839; Golombok S; Sketchley J; Rust J; Department of Psychology, City University, Northampton Square,; London, U.K.; A postal questionnaire survey of 262 homosexual men was carried out to investigate patterns of sexual behaviour and the use of condoms. Two hundred and twenty-nine of these subjects had been sexually active during the past year, with the mean number of male sexual partners being 8.09. One hundred and eighty men engage
The fear of AIDS: psychiatric symptom or syndrome?: AIDS Care. 1989;1(1):35-8. Unique Identifier : AIDSLINE MED/91182840; Jacob KS; John JK; Verghese A; John TJ; Department of Psychiatry, Christian Medical College, Vellore,; India.; The clinical characteristics of 13 patients who presented with the fear of AIDS are documented. The common features included anxiety traits in premorbid personality, a past history of promiscuous heterosexual behaviour, signs and symptoms of an anxiety state. The current controversies regarding the diagnostic status o
Paradoxical interventions in counselling for people with an intractable AIDS-worry.: AIDS Care. 1989;1(1):39-44. Unique Identifier : AIDSLINE MED/91182841; Salt H; Miller R; Perry L; Bor R; District AIDS Counselling Unit, Royal Free Hospital, London,; United Kingdom.; This article has two main objectives. Firstly, consideration is given to the context in which certain individuals become convinced that they have been infected with the Human Immunodeficiency Virus (HIV), despite repeated negative HIV antibody tests and reassurance. Secondly, it is to describe an intervention which is
Lifestyle factors for drug users in relation to risks for HIV.: AIDS Care. 1989;1(1):45-50. Unique Identifier : AIDSLINE MED/91182842; Mulleady G; Sherr L; Department of Clinical Psychology, St Mary's Hospital, London,; United Kingdom.; Lifestyle factors in drug users may render them particularly vulnerable to HIV infection. This study examined a group of 74 registered drug users at a Drug Dependency Clinic and compared lifestyle factors in those who were HIV-positive and those HIV-negative. Despite HIV status, sharing was extensive (over 90%). Shari
Counselling for HIV infection and AIDS: the past and the future.: AIDS Care. 1989;1(1):5-10. Unique Identifier : AIDSLINE MED/91182843; Green J; St Mary's Hospital, London, United Kingdom.; The history of counselling in HIV infection and AIDS is reviewed and the stages in the development of the area are set out. The way in which the area has developed in the West is related to local circumstances and the need for the development of models suited to local circumstances elsewhere in the world is stressed.
Sexual behaviour of injecting drug users and associated risks of HIV infection for non-injecting sexual partners.: AIDS Care. 1989;1(1):51-8. Unique Identifier : AIDSLINE MED/91182844; Donoghoe MC; Stimson GV; Dolan KA; University of London, Goldsmiths' College, United Kingdom.; The sexual behaviour of 142 clients of syringe-exchange schemes was measured using a questionnaire interview based survey method. Two to four months later the questionnaire was repeated to provide measures of behavioural change. The majority of these clients were sexually active, 77% having one or more sexual partners
AIDS and children: some of the issues in haemophilia care and how to address them.: AIDS Care. 1989;1(1):59-65. Unique Identifier : AIDSLINE MED/91182845; Miller R; Goldman E; Bor R; Kernoff P; Haemophilia Centre, Katherine Dormandy Haemophilia Centre and; Haemostasis Unit, Royal Free Hospital, London, United Kingdom.; Haemophilia is a life-long, life-threatening inherited condition for which there is treatment but no cure. It affects not only the patient but all members of the family. This paper focuses on how AIDS/HIV, which shares these characteristics with haemophilia, has affected children with HIV, their siblings, those who ha
An innovative program of counseling family members and friends of seropositive haemophiliacs.: AIDS Care. 1989;1(1):67-75. Unique Identifier : AIDSLINE MED/91182846; Greenblat CS; Katz S; Gagnon JH; Shannon D; Rutgers University, New Brunswick, New Jersey, State University; of New York Rutgers, Department of Sociology, NJ 08903.; This paper describes current efforts to construct a set of innovative educational and skill building materials targetted at groups of persons with HIV infection, those at risk for HIV, their families and friends, and health professionals. The ENCOUNTERS family of interactive simulations is designed to provide particip
AIDS and the press: an analysis of the coverage of AIDS by Zimbabwe newspapers.: AIDS Care. 1989;1(1):77-83. Unique Identifier : AIDSLINE MED/91182847; Pitts M; Jackson H; Department of Psychology, North East London Polytechnic, London,; United Kingdom.; An analysis of articles about HIV and AIDS in Zimbabwe newspapers for the period January 1987 to September 1988 reveals several areas of concern. An analysis of coverage before and after a Government campaign designed to increase awareness of issues related to AIDS indicated only
HIV spectrum disorders and the family: selected interventions based on stylistic dimensions.: AIDS Care. 1989;1(1):85-92. Unique Identifier : AIDSLINE MED/91182848; Britton PJ; Zarski JJ; Counselling Psychology Program, University of Akron, Ohio 44325.; Curvilinear stylistic dimensions of the family, illness stages, individual developmental stages, and the life cycle stage of the family are discussed in relation to HIV spectrum disorders. Centripetal and centrifugal family styles are then used as a framework for presenting intervention strategies that allow the famil
Condoms and sexual behaviour of young tourists in Copenhagen.: AIDS Care. 1989;1(1):93-6. Unique Identifier : AIDSLINE MED/91182849; Worm AM; Lillelund H; Department of Dermato-Venereology, Bispebjerg Hospital,; Copenhagen, Denmark.; Sleep-in is a summer youth hostel in the center of Copenhagen with 459 beds, which was used for 19,296 overnight stays in July and August 1987. In the summer of 1987, each of the guests, 95% of whom were young tourists, received an envelope with a condom and a written reminder about the use of condoms during sexual re
AIDS/HIV counselling in occupational health.: AIDS Care. 1989;1(1):97-103. Unique Identifier : AIDSLINE MED/91182850; Cockcroft A; Occupational Health Unit, Hampstead Health Authority, London,; United Kingdom.; AIDS/HIV counselling will increasingly become part of the role of occupational health professionals. Issues that arise in the occupational setting include: occupational transmission, knowledge and attitudes, problems with family and friends, AIDS dementia , and uncertainty. Dilemmas
Rapid high-performance liquid chromatographic determination of suramin in plasma of patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC).: J Pharm Biomed Anal. 1989;7(1):123-6. Unique Identifier : AIDSLINE MED/91182908; Teirlynck O; Bogaert MG; Demedts P; Taelman H; Heymans Institute of Pharmacology, University of Ghent Medical; School, Belgium.
The prevalence of HIV infection in the United States: a reappraisal of the Public Health Service estimate.: AIDS Clin Rev. 1989;:1-17. Unique Identifier : AIDSLINE MED/91190655; Osmond DH; Moss AR; University of California-San Francisco.
Controversies in HIV-related central nervous system disease: neuropsychological aspects of HIV-1 infection.: AIDS Clin Rev. 1989;:151-91. Unique Identifier : AIDSLINE MED/91190662; Levy RM; Bredesen DE; Northwestern University Medical School, Chicago, Illinois.
Occupational HIV infection: risk assessment.: AIDS Clin Rev. 1989;:19-27. Unique Identifier : AIDSLINE MED/91190664; Gerberding JL; University of California-San Francisco.
AIDS-associated lymphomas.: AIDS Clin Rev. 1989;:193-204. Unique Identifier : AIDSLINE MED/91190665; Kaplan LD; University of California-San Francisco.
Zidovudine: clinical experience in symptomatic HIV disease.: AIDS Clin Rev. 1989;:221-42. Unique Identifier : AIDSLINE MED/91190669; Fischl MA; University of Miami School of Medicine, Florida.
Priorities for AIDS risk reduction: research and programmatic direction.: AIDS Clin Rev. 1989;:29-52. Unique Identifier : AIDSLINE MED/91190672; Coates TJ; Stall R; Catania JA; Dolcini MM; Hoff CC; University of California-San Francisco.
Laboratory tests for HIV infection.: AIDS Clin Rev. 1989;:53-67. Unique Identifier : AIDSLINE MED/91190673; Wilber JC; San Francisco Department of Public Health, California.
Natural history of human immunodeficiency virus infection and key predictors of HIV disease progression.: AIDS Clin Rev. 1989;:69-93. Unique Identifier : AIDSLINE MED/91190675; Hessol NA; Lifson AR; Rutherford GW; AIDS Office, San Francisco Department of Public Health,; California.
[AIDS: acquired immunodeficiency syndrome]: Mikrobiyol Bul. 1989 Oct;23(4):379-87. Unique Identifier : AIDSLINE MED/91203659; Sener B; Ustacelebi S; Hacettepe Universitesi, Tip Fakultesi, Mirkobiyoloji Anabilim; Dali Arastirma, Gorevlisi.; In this article the molecular biology of HIV (Human Immunodeficiency Virus) which is the causative agent of acquired immune deficiency syndrome and the pathogenesis, epidemiology and clinical picture of the syndrome, the current therapeutic approaches and the developments in the vaccination studies were reviewed.
Activation of the interleukin-2 receptor alpha gene: regulatory role for DNA-protein interactions flanking the kappa B enhancer.: New Biol. 1989 Oct;1(1):83-92. Unique Identifier : AIDSLINE MED/91175682; Ballard DW; Bohnlein E; Hoffman JA; Bogerd HP; Dixon EP; Franza BR; Greene WC; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, North Carolina 27710.; The human interleukin-2 receptor alpha (IL2R alpha) gene is transcriptionally activated by both phorbol esters and the HTLV-I trans-activator (Tax) protein through a mechanism that involves the interaction of inducible DNA binding proteins with a kappa B-like enhancer element (-267 to -256). Using mutated IL2R alpha p
Recent developments in the therapy and management of Pneumocystis carinii pneumonia in patients with AIDS.: AIDS Clin Rev. 1989;:109-24. Unique Identifier : AIDSLINE MED/91190656; Montgomery AB; University of California, San Francisco.
Evaluation and treatment of pruritus in the HIV-infected patient.: AIDS Clin Rev. 1989;:205-20. Unique Identifier : AIDSLINE MED/91190667; Berger TG; University of California-San Francisco.
The acidic amino-terminal region of the HIV-1 Tat protein constitutes an essential activating domain.: New Biol. 1989 Oct;1(1):101-10. Unique Identifier : AIDSLINE MED/91175671; Rappaport J; Lee SJ; Khalili K; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; The Tat protein encoded by the human immunodeficiency virus (HIV) is an efficient activator of HIV gene expression. Many eukaryotic transcriptional activators contain a nucleic acid binding domain and a separate activating domain. These activating regions are acidic and often amphipathic. The amino terminus of the HIV
Prophylaxis of AIDS-related opportunistic infections (OIs).: AIDS Clin Rev. 1989;:125-50. Unique Identifier : AIDSLINE MED/91190659; Hardy WD; School of Medicine, University of California-Los Angeles.
HIV trans-activation and transcription control mechanisms.: New Biol. 1989 Nov;1(2):127-35. Unique Identifier : AIDSLINE MED/91190808; Jones KA; Salk Institute for Biological Studies, La Jolla, CA 92037.; Promoter-specific transcription factors, whose function was once thought to be limited to initiation, are now known to have more diverse roles in RNA metabolism, including the cellular localization of transcripts and the integration of RNA initiation with attenuation and RNA 3 end formation. The human immunodeficienc
E. coli ribosomes re-phase on retroviral frameshift signals at rates ranging from 2 to 50 percent.: New Biol. 1989 Nov;1(2):159-69. Unique Identifier : AIDSLINE MED/91190814; Weiss RB; Dunn DM; Shuh M; Atkins JF; Gesteland RF; Howard Hughes Medical Institute, University of Utah School of; Medicine, Salt Lake City 84132.; Many retroviruses express gag-pol or gag-pro-pol polypeptides by coupling their translation from overlapping reading frames with 1 ribosomal frameshifts. Here, we show that the well-known ribosomal frameshift signals found in retroviral mRNA will provoke Escherichia coli ribosomes to shift frame in the same manner as
Feline immunodeficiency virus infection in a population of pet cats from southeastern Florida.: J Vet Diagn Invest. 1989 Oct;1(4):339-42. Unique Identifier : AIDSLINE MED/91191020; Fisch H; Altman NH; Department of Pathology, University of Miami School of Medicine; (R-46), FL 33101.; Blood samples from 95 randomly selected pet cats that were brought to veterinarians in southeastern Florida were tested for antibodies to feline immunodeficiency virus (FIV). Virus-specific antibodies (indicative of virus infection) were found in 8 of the 95 (8.4%) cats tested. All of the virus-infected cats were male
[Clinical and therapeutic profile of 3 cases of cryptococcal meningitis in patients with AIDS]: G Ital Chemioter. 1989 Jan-Dec;36(1-3):95-9. Unique Identifier : AIDSLINE MED/91200559; Michelone G; Tacconi F; Maccabruni A; Lanzarini P; Tinelli M; Dei Cas A; We report three cases of cryptococcal meningitis in patients with AIDS observed in our Institution. In addition, we discuss antifungal treatment during and after the acute phase of the disease and the use of fluconazole as a prophylactic treatment of disease relapse.
The natural history of HIV infection.: AIDS Care. 1989;1(2):177-9. Unique Identifier : AIDSLINE MED/91175832; Lee CA; Royal Free Hospital, London, United Kingdom.
Recent advances in clinical management.: AIDS Care. 1989;1(2):180-3. Unique Identifier : AIDSLINE MED/91175833; Squire B; Royal Free Hospital, London, United Kingdom.
AIDS counselling.: AIDS Care. 1989;1(2):184-7. Unique Identifier : AIDSLINE MED/91175834; Bor R; Royal Free Hospital & School of Medicine, London, United Kingdom.
Health education.: AIDS Care. 1989;1(2):188-92. Unique Identifier : AIDSLINE MED/91175835; Sherr L; St. Mary's Hospital, London, United Kingdom.
Worried well and psychological issues.: AIDS Care. 1989;1(2):193-4. Unique Identifier : AIDSLINE MED/91175836; Hedge B; St. Mary's Hospital, London, United Kingdom.
African contributions on AIDS/HIV.: AIDS Care. 1989;1(2):195-8. Unique Identifier : AIDSLINE MED/91175837; Wilson D; Department of Psychology, University of Zimbabwe, Mount Pleasant,; Harare.
Progress for developing countries.: AIDS Care. 1989;1(2):199-202. Unique Identifier : AIDSLINE MED/91175838; Liskin L; Johns Hopkins University, Population Information Programme,; Baltimore, Maryland 21202.
Neuropsychiatry of AIDS.: AIDS Care. 1989;1(2):203-5. Unique Identifier : AIDSLINE MED/91175839; King MB; Academic Department of Psychiatry, Royal Free Hospital, London,; United Kingdom.
AIDS and drugs.: AIDS Care. 1989;1(2):206-11. Unique Identifier : AIDSLINE MED/91175840; Hartgers C; Department of Public Health, Amsterdam, The Netherlands.
HIV and haemophilia.: AIDS Care. 1989;1(2):212-5. Unique Identifier : AIDSLINE MED/91175841; Miller R; Harrington C; Royal Free Hospital, London, United Kingdom.
The economic impact of AIDS.: AIDS Care. 1989;1(2):216-8. Unique Identifier : AIDSLINE MED/91175842; Drummond MF; Health Services Management Centre, University of Birmingham,; United Kingdom.
AIDS and women.: AIDS Care. 1989;1(2):219-22. Unique Identifier : AIDSLINE MED/91175843; Elmslie KD; Federal Centre for AIDS, Health Protection Branch, Health and; Welfare, Canada.
Clinical significance of HIV-2 infection in West Africa.: AIDS Clin Rev. 1989;:95-108. Unique Identifier : AIDSLINE MED/91190677; Kanki PJ; Harvard School of Public Health, Boston, Massachusetts.
The Developmental and Family Services Unit--a model AIDS project serving developmentally disabled children and their families.: AIDS Care. 1989;1(3):281-5. Unique Identifier : AIDSLINE MED/91175849; Hopkins KM; Grosz J; Cohen H; Diamond G; Nozyce M; Albert Einstein College of Medicine, Bronx, New York.; This paper describes a model program that uses a multidisciplinary team to assess the developmental and psychosocial needs of HIV-infected children and their families. The objective of the program is to assess the needs of the children, in order to provide rehabilitative and psychosocial services; and to improve the q
AIDS risk behavior patterns among intravenous drug users in Puerto Rico and the United States.: Bol Asoc Med P R. 1990 Dec;82(12):523-7. Unique Identifier : AIDSLINE MED/91174842; Robles RR; Colon HM; Matos TD; Marrero CA; Lopez CM; Research Institute, Puerto Rico Department of Anti-Addiction; Services, Rio Piedras 00928-1414.; We interviewed 385 IV drug users recruited in the streets of the San Juan metropolitan area and compared our findings with comparable results from projects in the United States . As expected, intravenous (IV) drug users, irrespectively of the race or ethnic group they belong to or the g
AIDS pathogenesis: HIV envelope and its interaction with cell proteins [see comments]: Immunol Today. 1990 Nov;11(11):418-25. Unique Identifier : AIDSLINE MED/91174894; Habeshaw JA; Dalgleish AG; Bountiff L; Newell AL; Wilks D; Walker LC; Manca F; Retrovirus Research Group, MRC Clinical Research Centre, Harrow,; UK.; The immune deficiency induced by HIV has its origin in the interaction of the outer envelope glycoprotein gp120/gp41 with receptors present on human immunocytes. Virus binding to cells, virus entry and subsequent compartmentalization resulting in productive infection depends on the interaction of gp120/gp41 with CD4 a
Absence of HTLV-I DNA in blood from patients with multiple sclerosis [letter]: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1219. Unique Identifier : AIDSLINE MED/91175185; Lisby G; Frederiksen J; Olesen J; Reitz MS Jr
The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1221-31. Unique Identifier : AIDSLINE MED/91175186; Regier DA; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is
Vaccine protection of rhesus macaques against simian immunodeficiency virus infection.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1239-46. Unique Identifier : AIDSLINE MED/91175188; Carlson JR; McGraw TP; Keddie E; Yee JL; Rosenthal A; Langlois AJ; Dickover R; Donovan R; Luciw PA; Jennings MB; et al; Department of Pathology, School of Medicine, University of; California, Davis 95616.; Rhesus macaques (Macaca mulatta) immunized with an inactivated whole SIVmac vaccine and muramyl dipeptide (MDP), incomplete Freund s adjuvant (IFA), or aqueous suspension were challenged intravenously with 0.1 TCID50 of cell-free SIVmac. Whereas virus was readily recovered from the peripheral blood lymphocytes of 10 o
Conservative mutations in the putative metal-binding region of human immunodeficiency virus tat disrupt virus replication.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1257-63. Unique Identifier : AIDSLINE MED/91175191; Sadaie MR; Mukhopadhyaya R; Benaissa ZN; Pavlakis GN; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; The tat trans-activator proteins of the primate immunodeficiency viruses contain a highly conserved cysteine-rich domain. In human immunodeficiency virus type 1 tat there are seven cysteines located between residues 22 and 37 that are thought to form a metal-nucleic acid-binding structure. Most of the previous mutagen
Enhancement of soluble CD4-mediated HIV neutralization and gp 120 binding by CD4 autoantibodies and monoclonal antibodies.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1273-9. Unique Identifier : AIDSLINE MED/91175193; Moore JP; Sattentau QJ; Clapham PR; Chester Beatty Laboratories, Institute of Cancer Research,; London, England.; We have identified 6 sera containing autoantibodies to CD4 in 174 human immunodeficiency virus-type (HIV-1) positive sera tested in an antigen-capture enzyme-linked immunosorbent assay (ELISA) using sCD4, and none in 34 HIV type 2 sera. These autoantibodies do not bind to cellular CD4, but react with sCD4 to increase
A bioassay for HIV-1 based on Env-CD4 interaction.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1281-7. Unique Identifier : AIDSLINE MED/91175194; Ciminale V; Felber BK; Campbell M; Pavlakis GN; National Cancer Institute-Frederick Cancer Research and; Development Center, ABL-Basic Research Program, Frederick, MD; 21702-1201.; The binding of human immunodeficiency virus type 1 (HIV-1) gp120env to CD4 is the first event leading to infection and represents an important target for possible therapeutic intervention. To provide a tool for screening and quantitation of the effects of drugs inhibiting the Env-CD4 interaction, we developed a simple
Oligopeptide inhibitors of HIV-induced syncytium formation.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1289-96. Unique Identifier : AIDSLINE MED/91175195; Owens RJ; Tanner CC; Mulligan MJ; Srinivas RV; Compans RW; Department of Microbiology, University of Alabama, Birmingham; 35294.; The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is essential for virus entry and the formation of multinucleated giant cells by cell fusion, one of the major virus-induced cytopathic effects. To study the effects of potential fusion inhibitors, a vaccinia virus recombinant expressing the envelope
Expression of the HTLV-I tax transactivator in yeast: correlation between phenotypic alterations and tax function in higher eukaryotes.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1305-9. Unique Identifier : AIDSLINE MED/91175197; Kramer RA; Tomchak L; Ruben SM; Rosen CA; Department of Molecular Genetics, Hoffmann-La Roche Inc., Nutley,; NJ 07110.; The transcriptional activator protein (Tax) from human T-cell leukemia virus type 1 was expressed in yeast using several different promoters in several strains: In all instances, expression of Tax resulted in very strong aggregation of the yeast cells. This phenotype appears to be identical by all criteria tested to t
Expression of HTLV-I envelope protein fused to hydrophobic amino-terminal peptide of baculovirus polyhedrin in insect cells and its application for serological assays.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1311-21. Unique Identifier : AIDSLINE MED/91175198; Nyunoya H; Ogura T; Kikuchi M; Iwamoto H; Yamashita K; Maekawa M; Takebe Y; Miyamura K; Yamazaki S; Shimotohno K; Virology Division National Cancer Center Research Institute,; Tsukiji, Japan.; The envelope of human T-cell leukemia virus type I (HTLV-I) consists of two glycoproteins gp46 and p20E. Recombinant envelope proteins were produced by using an expression vector derived from insect baculovirus, Bombyx mori nuclear polyhedrosis virus. Polyhedrin fusion proteins C182, N147, and N287 contained whole reg
Rapid and quantitative detection of enzymatically amplified HIV-1 DNA using chemiluminescent oligonucleotide probes.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1323-9. Unique Identifier : AIDSLINE MED/91175199; Ou CY; McDonough SH; Cabanas D; Ryder TB; Harper M; Moore J; Schochetman G; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA.; A hybridization protection assay (HPA) that uses acridinium ester (AE) labeled oligonucleotide probes which are specific for a conserved gag gene region of human immunodeficiency virus type 1 (HIV-1) was developed to measure the amount of HIV-1 nucleic acid. Hybridization of the single-stranded probes with their targe
Extensive antigenic mimicry by retrovirus capsid proteins [letter]: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1361-2. Unique Identifier : AIDSLINE MED/91175202; Garry RF
Extraction of HIV-1 in aqueous two-phase systems to obtain a high yield of gp120.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1379-88. Unique Identifier : AIDSLINE MED/91175205; Hammar L; Gilljam G; Department of Veterinary Virology, Biomedical Center, Uppsala,; Sweden.; The conventionally applied centrifugation protocols for the concentration and purification of human immunodeficiency virus type 1 (HIV-1) result in a low recovery of the external glycoprotein, gp120. This is consistent with what has been found with other retroviruses. In the search for a method allowing the copurifica
Activation of human immunodeficiency virus type 1 by oxidative stress.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1389-97. Unique Identifier : AIDSLINE MED/91175206; Legrand-Poels S; Vaira D; Pincemail J; van de Vorst A; Piette J; Department of Microbiology, University of Liege, Belgium.; An important aspect of the infection by the human immunodeficiency virus (HIV-1) type 1 is its clinical latency, suggesting that the virus itself or the provirus may remain latent for extended periods of time after primary infection. Certain heterologous viral proteins or chemical and physical agents are able to react
Expression of HIV-1 integrase in E. coli: immunological analysis of the recombinant protein [published erratum appears in AIDS Res Hum Retroviruses 1991 Jul;7(7):636]: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1399-408. Unique Identifier : AIDSLINE MED/91175207; Marcus-Sekura CJ; Woerner AM; Zweig M; Court DL; Levin JG; Klutch M; Division of Virology, Center for Biologics Evaluation and; Research, Bethesda, MD.; Sequences encoding the human immunodeficiency virus type 1 (HIV-1) integrase gene have been cloned and expressed in Escherichia coli. The expressed protein is a lambda cII fusion protein of 37 kD containing the carboxyl-terminal 23 [corrected] amino acids of reverse transcriptase fused to the entire integrase sequence
Infection of human gastrointestinal cells by HIV-1.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1409-15. Unique Identifier : AIDSLINE MED/91175208; Moyer MP; Huot RI; Ramirez A Jr; Joe S; Meltzer MS; Gendelman HE; Department of Surgery, University of Texas Health Science Center,; San Antonio.; Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replicatio
Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1417-23. Unique Identifier : AIDSLINE MED/91175209; Gupta P; Balachandran R; Thampatty P; Rinaldo C; Ho M; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh School of; Medicine, PA.; The development of drugs that can inhibit both acute and persistent anti-human immunodeficiency virus type 1 (HIV-1) infection is a major goal in the treatment of patients with acquired immunodeficiency syndrome (AIDS). Most of the anti-HIV-1 drugs reported thus far, such as azidothymidine (
In vitro inhibition of HIV-1 infectivity by human salivas.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1425-32. Unique Identifier : AIDSLINE MED/91175210; Archibald DW; Cole GA; Department of Oral Pathology, Baltimore College of Dental; Surgery, University of Maryland.; Inhibitory factors to human immunodeficiency virus type 1 (HIV-1) in saliva may be responsible for the infrequent isolation of virus from saliva and also may account for the marked infrequency of salivary and/or oral transmission of HIV-1. Incubation of HIV-1 with human saliva followed by addition of the mixture to su
Acid sensitivity of cell-free and cell-associated HIV-1: clinical implications.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1433-6. Unique Identifier : AIDSLINE MED/91175211; Ongradi J; Ceccherini-Nelli L; Pistello M; Specter S; Bendinelli M; Department of Biomedicine, University of Pisa, Italy.; Infectivity of free and cell-associated human immunodeficiency virus type 1 (HIV-1) treated in vitro at pH 7.4 to 4.9 for 2 hours was assessed on susceptible CEM-ss cells. Viral activity was monitored by cytopathology and production of reverse transcriptase and p24 antigen. The infectivity of cell-free virus was gradu
Platelet antibodies in serum of patients with human immunodeficiency virus (HIV) infection.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1443-9. Unique Identifier : AIDSLINE MED/91175213; Magnac C; de Saint Martin J; Pidard D; Legrand C; Dighiero G; Laboratoire d'Immunohematologie et d'Immunopathologie, Institut; Pasteur, Paris, France.; Between 10 and 15% of human immunodeficiency virus (HIV) seropositive individuals develop an immune thrombocytopenic purpura; however, the mechanism involved in platelet destruction is not yet established. In the present work, we have analyzed 208 sera from HIV seropositive individuals, including 85 thrombocytopenic p
Detection of HIV-2 infection in the Gulf region.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1469-70. Unique Identifier : AIDSLINE MED/91175216; Guman M; al Karmi T; Lukic ML; Behbehani K; WHO Collaborating Centre on AIDS, Department of Microbiology,; Faculty of Medicine, Kuwait University.
Platelet-activating factor activates HIV promoter in transfected SH-SY5Y neuroblastoma cells and MOLT-4 T lymphocytes.: J Mol Neurosci. 1990;2(2):79-84. Unique Identifier : AIDSLINE MED/91175330; Squinto SP; Braquet P; Block AL; Bazan NG; Department of Biochemistry and Molecular Biology, Louisiana State; University Medical Center, New Orleans 70112.; Transfected gene constructs comprising the long terminal repeat (LTR) sequence of the human immunodeficiency virus (HIV) genome spliced to an assayable reporter gene have made possible the evaluation of a lipid mediator, platelet-activating factor (PAF), as a potential HIV transcriptional regulatory molecule. We asses
Regulation of expression of human immunodeficiency virus.: New Biol. 1990 Jan;2(1):20-31. Unique Identifier : AIDSLINE MED/91175688; Pavlakis GN; Felber BK; National Cancer Institute, Frederick Cancer Research Facility,; BRI-Basic Research Program, MD 21701-1013.; Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS), encodes regulatory factors necessary for its expression. The study of these factors clearly indicates the importance and complexity of post-trascriptional processes in regulating gene expression. Two regulatory prote
The sore throat. When to investigate and when to prescribe.: Drugs. 1990 Dec;40(6):854-62. Unique Identifier : AIDSLINE MED/91176897; Lang SD; Singh K; Middlemore Hospital, Auckland.; Sore throats are most commonly due to infections, many of which are viral and do not require specific treatment. Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of
Paranasal sinus Burkitt's lymphoma in a human immunodeficiency virus (HIV) positive male.: Ear Nose Throat J. 1990 Dec;69(12):844-6. Unique Identifier : AIDSLINE MED/91176909; Schoem SR; Morton AL; Department of Otolaryngology-Head and Neck Surgery, National; Naval Medical Center, Bethesda, MD.; Patients infected with the HIV virus have been reported to develop several malignant neoplasms, the most frequent of which is Kaposi s sarcoma. Although an increasing number of lymphomas, primarily non-Hodgkin s lymphomas, have been described who are HIV seropositive, few cases of Burkitt s lymphoma have been reported
Shifts of isoelectric points between cellular and secreted antibodies as revealed by isoelectric focusing and immobilized pH gradients.: Electrophoresis. 1990 Nov;11(11):966-9. Unique Identifier : AIDSLINE MED/91176951; Wenisch E; Reiter S; Hinger S; Steindl F; Tauer C; Jungbauer A; Katinger H; Righetti PG; Institute of Applied Microbiology, University of Agriculture and; Forestry, Vienna.; Charge microheterogeneity of monoclonal antibodies, as revealed by isoelectric focusing in carrier ampholytes, has been known for a long time. Here we demonstrate, in the case of monoclonals against the gp-41 of the HIV-1 virus, that this heterogeneity is already present within the cell sap of hybridoma cells during a
The risk of HIV transmission in dentistry.: Dent Update. 1990 Jul;17(6):241-3. Unique Identifier : AIDSLINE MED/91177202; Samaranayake LP; Glasgow Dental Hospital and School.
[Changes in immunologic phenotype of cells in hairy cell leukemia]: Gematol Transfuziol. 1990 Oct;35(10):23-5. Unique Identifier : AIDSLINE MED/91177289; Muskhelishvili LV; Mandzhgaladze MV; Keniia KTs; Girdaladze DM; Zodelava MM; A case of hairy-cell leukemia (HCL) has been described in which the cells of the pathological clone in the course of time lost their surface immunoglobulins and retained membrane markers associated with the T-lymphoid series. It has been suggested that this change in the immunological phenotype of the cells may lead t
Therapy of chronic delta hepatitis with interferon alfa-2b.: J Hepatol. 1990;11 Suppl 1:S151-4. Unique Identifier : AIDSLINE MED/91178247; Di Bisceglie AM; Martin P; Lisker-Melman M; Kassianides C; Korenman J; Bergasa NV; Baker B; Hoofnagle JH; Liver Diseases Section, National Institute of Diabetes and; Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892.; In this pilot study, 12 patients with chronic delta hepatitis were studied. The diagnosis was based on the presence of antibodies to the hepatitis delta antigen in the serum and hepatitis delta virus RNA and hepatitis delta antigen in the serum and liver. All patients were also positive for hepatitis B surface antigen
Married men and same sex activity: a field study on HIV risk among men who do not identify as gay or bisexual.: J Sex Marital Ther. 1990 Winter;16(4):251-7. Unique Identifier : AIDSLINE MED/91178828; Earl WL; Denver Public Health AIDS Prevention Program, CO 80203-0306.; Interviews that took place at several sites where anonymous sex is practiced suggest that some married men engage in same sex activity without regard for the risk to HIV infection they impose upon themselves and their spouses. Much of the sexual activity is considered to be high risk by Centers for Disease Control sta
[New AIDS-virus receptor and AIDS-virus infection mechanism]: Nippon Hifuka Gakkai Zasshi. 1990 Nov;100(13):1316-22. Unique Identifier : AIDSLINE MED/91178945; Katsunuma N
[Present state of AIDS and its current problems]: Nippon Hifuka Gakkai Zasshi. 1990 Nov;100(13):1323-5. Unique Identifier : AIDSLINE MED/91178946; Abe T
[Malignant lymphoma of the skin--especially cutaneous T-cell lymphoma]: Nippon Hifuka Gakkai Zasshi. 1990 Nov;100(13):1336-8. Unique Identifier : AIDSLINE MED/91178950; Nakajima H
[Two cases of HTLV-I associated myelopathy (HAM) after cardiac operation]: Nippon Geka Gakkai Zasshi. 1990 Dec;91(12):1808-11. Unique Identifier : AIDSLINE MED/91179411; Akita T; Hayase S; Yano Y; Ogawa K; Hiramatsu H; Hattori T; Department of Surgery, Nagoya First Red Cross Hospital, Japan.; Sixty-one and 51-year-old males had progressive walk disturbance after cardiac operations at the intervals of 1 and 2 years. They had received blood transfusion at their operations. Physical examination revealed spastic paraparesis, sensory disturbance of the lower and rectobladder disorder. High titers of anti-Human
[Stereotaxic brain puncture. Indications and results]: Nervenarzt. 1990 Dec;61(12):699-703. Unique Identifier : AIDSLINE MED/91179542; Ebeling U; Degelo W; Markwalder R; Rohner M; Steiger HJ; Seiler RW; Neurochirurgische Universitatsklinik, Universitat Bern.; 228 stereotactic biopsies for the diagnosis of brain lesions were evaluated. In 98.2% a diagnosis could be established. The diagnosis was made of brain tumor in 79.3%, of brain abscess in 7.5% and of encephalitis in 3.5% of cases. In 2.2% of the patients a pathological finding was obtained without a clear histological
HIV-associated periodontal lesions: a study of the literature.: N Y State Dent J. 1990 Dec;56(10):28-30. Unique Identifier : AIDSLINE MED/91179683; Nantista L; Two unusual forms of periodontal disease that do not respond to conventional treatment have been seen in association with HIV infection: HIV-associated gingivitis and HIV-associated periodontitis. With proper diagnosis and prompt aggressive management using adjunctive agents, considerable success has been achieved.
[Myocardiopathy in AIDS]: Pathologica. 1990 Sep-Oct;82(1081):523-5. Unique Identifier : AIDSLINE MED/91179820; Giampalmo A; Badini A; Quaglia AC; Istituto di anatomia patologica dell'Universita di Genova.; We have previously described a few peculiar myocardial abnormalities occurring in AIDS patients. In this report we have extended out observations on twenty-eight additional cases where the presence of perivessel fibrosclerosis and sclerosis mostly of intramural arteries, as well focal myocytolysis were confirmed at th
[Pathology of adrenal glands and hypophysis in AIDS]: Pathologica. 1990 Sep-Oct;82(1081):527-30. Unique Identifier : AIDSLINE MED/91179821; Giampalmo A; Badini A; Carli F; Castellaneta A; Paladino B; Quaglia AC; Istituto di anatomia patologica dell'Universita di Genova.; More than 50% of AIDS patients show adrenal compromise. The major pathological findings include inflammatory changes of both the cortical and medullary portion with necrosis and haemorrhage. The principal determinant of these abnormalities appears to be CMV infe
[Drug dependence and HIV infection: epidemiologic study in a jail population]: Riv Eur Sci Med Farmacol. 1990 Apr;12(2):119-25. Unique Identifier : AIDSLINE MED/91180455; Quarto M; Germinario C; Troiano T; Fontana A; Barbuti S; Istituto di Igiene, Universita degli Studi di Bari.; We carried out an epidemiological study in jail community of Bari, in order to evaluate the incidence of drug abuse on the presence of HIV infection among prison inmates. During the period 1988-89, 1609 adults have been examined 40% of whom were intravenous drug abusers, and 221 adolescents, the 9.5% included in the m
Acute meningoradiculitis concomitant with seroconversion to human immunodeficiency virus type 1.: Res Virol. 1990 Jul-Aug;141(4):427-33. Unique Identifier : AIDSLINE MED/91180462; Paton P; Poly H; Gonnaud PM; Tardy JC; Fontana J; Kindbeiter K; Tete R; Madjar JJ; Hopital de l'Hotel-Dieu, Service de Medecine Interne, Lyon,; France.; We report a case of acute regressive meningoradiculitis concomitant with HIV1 primoinfection. The clinical symptoms were mild and disappeared spontaneously. Electromyographic studies confirmed the regressive demyelinating-type process. The biological diagnosis of HIV1 infection was demonstrated by viral antigen detect
Evaluation of a dip-stick methodology for detection of antibodies to HIV1.: Res Virol. 1990 Jul-Aug;141(4):465-71. Unique Identifier : AIDSLINE MED/91180467; Lyons SF; McGillivray GM; Schoub BD; Smith AN; Medical Research Council AIDS Virus Research Unit, University of; the Witwatersrand, Sandringham, South Africa.; An HIV1 antibody screening assay, the ImmunoComb HIV1 kit which uses a dip-stick methodology, was evaluated using a panel of selected sera. The ImmunoComb detected 144 of 147 (98%) Western-blot-confirmed positive sera. However, when the ImmunoComb was compared with a recombinant EIA capable of detecting early seroconv
[AIDS--an ominous figure]: Sygeplejersken. 1990 Sep 26;90(39):14-5. Unique Identifier : AIDSLINE MED/91180832
[Health policy. WHO will continue to be a champion for the weak]: Sygeplejersken. 1990 Sep 26;90(39):16-7, 22. Unique Identifier : AIDSLINE MED/91180833; Ravn K; Rosdahl N
Effect of heat inactivation of HIV on specific serum proteins and tumour markers.: Ann Clin Biochem. 1990 Nov;27 ( Pt 6):592-4. Unique Identifier : AIDSLINE MED/91181845; Gleeson M; Herd L; Burns C; Hunter Immunology Unit, Royal Newcastle Hospital, NSW, Australia.; The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56 degrees C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for alpha-1-antitrypsin, beta-2-microglobulin, IgE, fibrinogen,
Computer-assisted structure-activity correlations of dideoxynucleoside analogs as potential anti-HIV drugs.: Antiviral Res. 1990 Sep;14(3):125-48. Unique Identifier : AIDSLINE MED/91181864; Nasr M; Litterst C; McGowan J; Division of AIDS, National Institute of Allergy and Infectious; Diseases, NIH, Rockville, Maryland 20892.
Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.: Antiviral Res. 1990 Sep;14(3):149-59. Unique Identifier : AIDSLINE MED/91181865; Hansen JE; Witzke NM; Nielsen C; Mathiesen LR; Teglbjaerg LS; Nielsen CM; Nielsen JO; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N -(2-(4 -methylmorpholinio)ethyl)N-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N -(3-dimethylamin
A tribute to nurses who care for pediatric AIDS patients [editorial]: J Pediatr Oncol Nurs. 1990 Oct;7(4):129-30. Unique Identifier : AIDSLINE MED/91182301; Fochtman D
Similarities between the nursing care needs of children with cancer and children with human immunodeficiency virus infection.: J Pediatr Oncol Nurs. 1990 Oct;7(4):149-53. Unique Identifier : AIDSLINE MED/91182304; Cohen DG; The incidence of human immunodeficiency virus (HIV)-related diseases among children is steadily increasing. The most common clinical manifestations of pediatric HIV infection are similar to those seen in childhood cancer. There are striking similarities between the care needs of these children and children with other
Needlestick!--now what?: Dent Today. 1990 May;9(4):19-21. Unique Identifier : AIDSLINE MED/91182363; Jacobsen PL
[Toxoplasmosis in patients with HIV infections: diagnosis and treatment]: Enferm Infecc Microbiol Clin. 1990 Jun-Jul;8(6):376-83. Unique Identifier : AIDSLINE MED/91182877; Bolao F; Podzamczer D; Gudiol F; Unidad de Enfermedades Infecciosas, Hospital de; Bellvitge-Princeps d'Espanya, Universidad de Barcelona.
[Spontaneous bacterial myositis and human immunodeficiency virus: a casual association? (letter)]: Enferm Infecc Microbiol Clin. 1990 Jun-Jul;8(6):395-6. Unique Identifier : AIDSLINE MED/91182884; Tomas Vecina S; Pedro-Botet Montoya J; Miralles Basseda R; Coll Daroca J
A family of mathematical models to describe the risk of infection by a sexually transmitted agent.: Epidemiology. 1990 Jan;1(1):30-3. Unique Identifier : AIDSLINE MED/91183022; Allard R; Department of Community Health, Maisonneuve-Rosemont Hospital,; Montreal, Quebec, Canada.; Several recent publications have used, without demonstrating its derivation, a mathematical model that describes the risk of being infected by a sexually transmitted agent as a function of four parameters: the number of partners, the number of contacts with each partner, the per-contact probability of transmission, an
White swans, black ravens, and lame ducks: necessary and sufficient causes in epidemiology.: Epidemiology. 1990 Jan;1(1):47-50. Unique Identifier : AIDSLINE MED/91183027; Pearce N; Department of Community Health, Wellington School of Medicine,; Wellington Hospital, New Zealand.; Several authors have used Popper s white swan example to support arguments for a falsificationist approach to epidemiology. The statement all swans are white cannot be verified by finding even a large number of white swans, but can be falsified by finding a single black swan. An analogous epidemiologic example that ha
Kaposi's sarcoma in patients with AIDS: sex, transmission mode, and race.: Biomed Pharmacother. 1990;44(9):461-6. Unique Identifier : AIDSLINE MED/91183152; Haverkos HW; Drotman DP; Morgan WM; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857.; We review epidemiologic studies aimed at identifying the cause(s) or cofactors for AIDS-related Kaposi s sarcoma (KS). The epidemiology of AIDS-related KS in the United States differs from that of other forms of KS. One important feature of the epidemiology of AIDS-related KS is that i
Double-blind trial of bestatin in HIV-positive patients.: Biomed Pharmacother. 1990;44(9):475-8. Unique Identifier : AIDSLINE MED/91183154; Hording M; Gotzsche PC; Dalh Christensen L; Bygbjerg IC; Faber V; Department of Infectious Diseases, Rigshospital, Copenhagen,; Denmark.; Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytoha
WHO revises global estimates of HIV infection. Ups global total to 8 to 10 million.: Bull Int Union Tuberc Lung Dis. 1990 Dec;65(4):74. Unique Identifier : AIDSLINE MED/91183245
Paediatric AIDS cases send estimates soaring.: Bull Int Union Tuberc Lung Dis. 1990 Dec;65(4):75. Unique Identifier : AIDSLINE MED/91183246
AIDS postage stamps issued (15 March 1990) fight AIDS worldwide.: Bull Int Union Tuberc Lung Dis. 1990 Dec;65(4):76. Unique Identifier : AIDSLINE MED/91183247
Further facts about HIV.: Bull Int Union Tuberc Lung Dis. 1990 Dec;65(4):77. Unique Identifier : AIDSLINE MED/91183248
Women and AIDS.: Bull Int Union Tuberc Lung Dis. 1990 Dec;65(4):78-80. Unique Identifier : AIDSLINE MED/91183249
Zidovudine treatment for anti-HIV positive haemophiliacs.: Clin Lab Haematol. 1990;12(4):367-78. Unique Identifier : AIDSLINE MED/91183797; Lim SG; Lee CA; Kernoff PB; Academic Department of Haematology, Royal Free Hospital, London.; Twenty haemophiliacs (17 CDC group IV and 3 CDC group II) were treated with zidovudine for a median of 37 weeks (range 10-66). Eight (40%) tolerated zidovudine without a dose change. Two patients died and five patients (29%) developed opportunist infections. Haematological toxicity occurred in ten CDC IV patients (59%
[AIDS and the skin]: G Ital Dermatol Venereol. 1990 Oct;125(10):413-21. Unique Identifier : AIDSLINE MED/91184835; De Filippi C; IRCCS Policlinico S. Matteo, Pavia.; Numerous skin symptoms are observed during the course of HIV infection, including a wide spectrum of affections which range from infective pathologies to tumours. Some of these, for example villous leukemia, oral hairy leukoplakia are only seen in AIDS subjects: others, even if not specific to AIDS, are often found in
[Staphylococcal scalded-skin syndrome in AIDS]: G Ital Dermatol Venereol. 1990 Oct;125(10):461-4. Unique Identifier : AIDSLINE MED/91184844; Strumia R; Bedetti A; Cavazzini L; Clinica Dermatologica, Universita di Ferrara.; The Authors report a case of SSSS in a patient with AIDS. SSSS in adults is rare. Immunosuppression for several causes could predispose towards SSSS. The principal diagnostic differential to be made is from toxic drug induced epidermal necrolysis. Exfoliative cytology and histology can be useful in the diagnosis.
Narcotic addiction: the expectant mother and her baby.: Ir Med J. 1990 Dec;83(4):139-42. Unique Identifier : AIDSLINE MED/91184990; Thornton L; Clune M; Maguire R; Griffin E; O'Connor J; Coombe Lying-in Hospital, Dublin.; In a retrospective study of the period 1982-1985, the records of 29 narcotic-addicted mothers and their 42 babies were reviewed. All mothers were from socially deprived backgrounds, had a poor record of ante-natal attendance and had frequent admissions to hospital. Thirteen mothers had a past history of hepatitis B an
AIDS/HIV infection and employment.: Ir Med J. 1990 Dec;83(4):148-50. Unique Identifier : AIDSLINE MED/91184994; Malone JM; Surgeons Office, Depot Hospital, Phoenix Park, Dublin.; It is now emerging that most large employment sectors have HIV carriers on their staff. Usually occupation has not contributed to the aetiology of the employee acquiring HIV infection. Pre-employment HIV screening has been rejected, although there have been exceptions to this generally accepted position. Having known
Cryptococcal meningitis occurring in HIV infected individuals.: Ir Med J. 1990 Dec;83(4):157-8. Unique Identifier : AIDSLINE MED/91184999; Horgan M; Boothman S; Keane CT; Temperley IJ; Mulcahy F; Jackson F; Department of Microbiology, St. James's Hospital, Dublin.; Three cases of cryptococcal meningitis in patients with HIV infection are described. A high index of suspicion is required for diagnosis. India ink preparation and culture of the CSF for cryptococcus is mandatory in HIV seropositive patients irrespective of the CSF white cell count
Acquired rod-body myopathy associated with human immunodeficiency virus infection.: Ital J Neurol Sci. 1990 Dec;11(6):609-13. Unique Identifier : AIDSLINE MED/91185014; Scelsi R; Lombardi M; Banfi P; Cosi V; Poggi P; Istituto di Istologia ed Anatomia Patologica, Universita di; Pavia.; A 35 year old homosexual man showed clinical features of myopathy, with progressive muscular weakness of proximal muscles. EMG demonstrated a myopathic pattern; serum CPK was mildly elevated and CSF examination revealed antibodies to HIV and a blood-brain barrier damage. An open biopsy of the quadriceps femoris muscle
High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids.: J Chromatogr. 1990 Nov 30;533:133-40. Unique Identifier : AIDSLINE MED/91185493; Bigelow JC; Chrin LR; Mathews LA; McCormick JJ; Department of Pharmacology, University of Vermont, Burlington; 05405.; Phosphorothioate oligodeoxynucleotides (S-ODNs) have potential as anti-viral agents and are being investigated for the chemotherapy of AIDS. A high-performance liquid chromatographic method is described for the analysis, in urine and plasma, of a 28-unit deoxycytidine homopolymer (S-dC28) and a 28-unit S-ODN antisense
Application of capillary DNA chromatography to detect AIDS virus (HIV-1) DNA in blood.: J Chromatogr. 1990 Nov 30;533:87-96. Unique Identifier : AIDSLINE MED/91185524; Brownlee RG; Sunzeri FJ; Busch MP; Irwin Memorial Blood Bank, San Francisco, CA 94118.; The application of capillary DNA chromatography to the detection of the AIDS human immunodeficiency virus, type 1 (HIV-1) proviral DNA in blood is reported for the first time. Combining polymerase chain reaction with fluorescence-labeled DNA probes provides the basis for the amplification and specific detection of the
Immunotoxins: new therapeutic reagents for autoimmunity, cancer, and AIDS.: J Clin Immunol. 1990 Nov;10(6 Suppl):15S-18S. Unique Identifier : AIDSLINE MED/91185529; Vitetta ES; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235.; Immunotoxins consist of cell-reactive ligands coupled to toxins or their toxic subunits. The ligands are usually antibodies, hormones, or growth factors and the toxins are of bacterial or plant origin. In vitro studies using A chain-containing immunotoxins specifically to kill tumor cells were successful and led to fu
[Evaluation of specificity of EIA kit (ED-007)]: Rinsho Byori. 1990 Dec;38(12):1363-7. Unique Identifier : AIDSLINE MED/91186521; Nishimura Y; Fukuoka N; Fukuyoshi Y; Matsuo Y; Yamaguchi K; Takatsuki K; Blood Transfusion Service, Kumamoto University Hospital.; EIA (Eitest: Eisai) and Gelatin Particle Agglutination: PA (SERODIA: Fujirebio) assays were performed for the detection of HTLV-I antibodies with 10,780 sera from patients since 1986. Eleven point five percent were reactive by both EIA and PA, while 1.1% was PA(+), EIA(-), these PA false positive occurred on low titer
Effects of succinylated concanavalin A on infectivity and syncytial formation of human immunodeficiency virus.: Med Microbiol Immunol (Berl). 1990;179(5):225-35. Unique Identifier : AIDSLINE MED/91186864; Matsui T; Kobayashi S; Yoshida O; Ishii S; Abe Y; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.; The effects of various lectins on the infectivity of human immunodeficiency virus (HIV) type 1 was investigated. Among the 25 lectins investigated, 2 types of concanavalin A (Con A) and 3 types of phytohemagglutinin were found to inhibit HIV infection. Succinylated Con A (S-Con A) efficiently blocked HIV-induced forma
[Verbal interaction between the nursing team and the AIDS patient]: Rev Esc Enferm USP. 1990 Aug;24(2):301-13. Unique Identifier : AIDSLINE MED/91188102; Gir E; Moriya TM; 3,336 verbal behaviors between 3 AIDS patients and a nursing team were analyzed. The pattern and priority areas of verbal behaviors which occur, according to the SAVI system, as well as the amount of information transmitted were determined. The results showed that the verbal behaviors ranged from relative ambiguity in
Mutation of conserved N-glycosylation sites around the CD4-binding site of human immunodeficiency virus type 1 GP120 affects viral infectivity.: Virus Res. 1990 Dec;18(1):9-20. Unique Identifier : AIDSLINE MED/91188700; Dirckx L; Lindemann D; Ette R; Manzoni C; Moritz D; Mous J; Central Research Units, F. Hoffmann-La Roche Ltd, Basle,; Switzerland.; Infection by the human immunodeficiency virus type 1 (HIV-1) is initiated through interaction of its exterior envelope glycoprotein gp120 with the CD4 receptor on target cells. To address the possible role of N-glycosylation of HIV-1 gp120 in binding CD4, we mutated different conserved N-glycosylation site Asn-residue
An autopsy case of human T lymphotropic virus type I-associated myelopathy (HAM) with a duration of 28 years.: Acta Neuropathol (Berl). 1990;81(2):219-22. Unique Identifier : AIDSLINE MED/91188819; Sasaki S; Komori T; Maruyama S; Takeishi M; Iwasaki Y; Department of Neurology, Tokyo Women's Medical College, Japan.; An autopsy case of human T lymphotropic virus I-associated myelopathy (HAM) of a duration of 28 years in a 61-year-old man with serological confirmation of HTLV-I infection was reported. The spinal cord was grossly atrophic. There was severe symmetrical degeneration of the lateral funiculi, particularly of the bilater
Antibodies against retroviral core proteins in relation to disease outcome in patients with mycosis fungoides.: Arch Dermatol Res. 1990;282(8):532-8. Unique Identifier : AIDSLINE MED/91189755; Ranki A; Niemi KM; Nieminen P; Krohn K; Department of Dermatology, Helsinki University Central Hospital,; Finland.; We have studied the relationship of antibodies reacting with human retroviral core proteins to the disease outcome in Finnish mycosis fungoides (MF) patients in a prospective manner. Antibodies recognizing human T-cell leukaemia/lymphoma virus I (HTLV-I) or human immunodeficiency virus type 1 (HIV-1) core proteins wer
[Criteria for the morphologic diagnosis of AIDS in autopsy material]: Arkh Patol. 1990;52(11):46-51. Unique Identifier : AIDSLINE MED/91189919; Tsinzerling AV; Abroian NA; Komarova DV; Bykov LV; Our own lethal case of AIDS and the results of the study of other generalized viral infections, and literature data allow us to conclude that lymphoid system damage is the most characteristic feature of the disease. Hyperplasia of lymph nodes and the spleen occurs in the acute stage of the disease. Hyperplasia with su
Occupational transmission of HIV: the ethics of physician risk and responsibility.: AIDS Clin Rev. 1990;:1-10. Unique Identifier : AIDSLINE MED/91190654; Cooke M; University of California, San Francisco.
Epidemiologic trends of AIDS in the United States in the context of the 1987 revision of the case definition.: AIDS Clin Rev. 1990;:11-24. Unique Identifier : AIDSLINE MED/91190657; Selik RM; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, Georgia.
Disseminated Mycobacterium avium complex infection.: AIDS Clin Rev. 1990;:165-91. Unique Identifier : AIDSLINE MED/91190663; Inderlied CB; Young LS; Childrens Hospital Los Angeles, California.
Cryptococcal disease in AIDS.: AIDS Clin Rev. 1990;:193-213. Unique Identifier : AIDSLINE MED/91190666; Bozzette SA; Waskin HA; University of California, San Diego.
Toxoplasmic encephalitis.: AIDS Clin Rev. 1990;:215-34. Unique Identifier : AIDSLINE MED/91190668; Luft BJ; Fuhrer J; State University of New York, Stony Brook.
Race/gender issues in the sexual transmission of AIDS.: AIDS Clin Rev. 1990;:25-62. Unique Identifier : AIDSLINE MED/91190671; Fullilove MT; Weinstein M; Fullilove RE 3d; Crayton EJ Jr; Goodjoin RB; Bowser B; Gross S; University of California, San Francisco.
Predictors of HIV disease progression.: AIDS Clin Rev. 1990;:63-79. Unique Identifier : AIDSLINE MED/91190674; Hessol NA; Lifson AR; AIDS Office, San Francisco Department of Public Health,; California.
Oral lesions of HIV infections: features and therapy.: AIDS Clin Rev. 1990;:81-93. Unique Identifier : AIDSLINE MED/91190676; Greenspan D; Greenspan JS; University of California, San Francisco.
Pathogenesis and treatment of HIV-related immune thrombocytopenia.: AIDS Clin Rev. 1990;:95-114. Unique Identifier : AIDSLINE MED/91190678; Stricker RB; University of California, San Francisco.
High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals.: Int Immunol. 1990;2(8):707-12. Unique Identifier : AIDSLINE MED/91190784; Gotch FM; Nixon DF; Alp N; McMichael AJ; Borysiewicz LK; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford,; UK.; Human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) have been detected in most patients following infection. It has also been suggested that the specific CTL response, which may play an important role in delaying disease in infected humans, may decline during the course of disease progre
Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.: New Biol. 1990 Jul;2(7):621-36. Unique Identifier : AIDSLINE MED/91190842; Waterman ML; Jones KA; Salk Institute, La Jolla, CA 92037.; The differentiation of T cells into functionally diverse subpopulations is controlled in part, by transcriptional activation and silencing; however, little is known in detail about the proteins that influence this developmental process. We have purified a new T-cell-specific factor, TCF-1 alpha, that is implicated in
An ethnographic study of HIV-related risk practices among Glasgow rent boys and their clients: report of a pilot study.: AIDS Care. 1990;2(1):17-24. Unique Identifier : AIDSLINE MED/91190941; Bloor M; McKeganey N; Barnard M; MRC Medical Sociology Unit, Glasgow University, UK.; This paper provides an early report of a continuing ethnographic study of male prostitution in Glasgow. Pilot work indicates that rent boy activity may be of considerable importance for the spread of HIV infection. Although there is little evidence of an association between rent boy activity and injecting drug use, re
The impact of community-based groups to help persons reduce HIV infection risk behaviours.: AIDS Care. 1990;2(1):25-36. Unique Identifier : AIDSLINE MED/91190942; Kelly JA; St Lawrence JS; Department of Psychiatry and Human Behavior, University of; Mississippi Medical Center, Jackson 39216.; In addition to widescale AIDS education campaigns, interventions are also needed which can directly assist in the development of skills to reduce HIV infection. Cognitive-behavioural and skills training approaches have long been used to help individuals learn to change other behaviour patterns related to health and ca
AIDS care--into the 1990's [editorial]: AIDS Care. 1990;2(1):3-4. Unique Identifier : AIDSLINE MED/91190943; Bor R; Elford J; Hart G; Sherr L
HIV infection and dental care: views and experiences among HIV-seropositive patients.: AIDS Care. 1990;2(1):37-42. Unique Identifier : AIDSLINE MED/91190944; Scheutz F; Department of Child Dental Health and Community Dentistry, Royal; Dental College, Aarhus, Denmark.; This study reports the views and experiences of HIV-seropositive individuals within the Danish Dental Care System. One hundred and thirty-five consecutive HIV-seropositive outpatients visiting the infectious departments at three Danish hospitals completed a structured questionnaire anonymously; participation rate was
Cognitive behavioural couples therapy with gay men referred for counselling in an AIDS setting: a pilot study.: AIDS Care. 1990;2(1):43-51. Unique Identifier : AIDSLINE MED/91190945; Ussher JM; Psychology Division, University of Sussex, Falmer, Brighton, UK.; Counselling and psychological therapy is now an established part of health care in most AIDS settings, yet intervention has thus far tended to focus on the individual. It is argued that there is a need for greater development of therapy for couples in the AIDS field, based on the results of a pilot study of cognitive-
Psycho-social aspects of HIV testing--the Swedish case.: AIDS Care. 1990;2(1):5-16. Unique Identifier : AIDSLINE MED/91190946; Mansson SA; School of Social Work, Research Department, University of Lund,; Sweden.; Almost 10% of the Swedish population--more than 800,000 people--have been tested for HIV antibody to date. More people in Sweden have been tested (per million inhabitants) than in any other European country. The number of people found to be HIV positive has steadily decreased since
Attitudes, knowledge, experience and behaviour related to HIV and AIDS among Zimbabwean social workers.: AIDS Care. 1990;2(1):53-61. Unique Identifier : AIDSLINE MED/91190947; Pitts M; Jackson H; Wilson P; Department of Psychology, University of Zimbabwe, Harare, UK.; A recent study of Samuels & Boyle (1989) examined knowledge, attitudes, and behaviours of social service team members in Newham, East London in relation to HIV and AIDS. This study extends theirs to investigate social workers, both experienced and in training, in Harare, Zimbabwe
Complacency, risk perception and the problem of HIV education.: AIDS Care. 1990;2(1):63-8. Unique Identifier : AIDSLINE MED/91190948; MacDonald G; Smith C; Institute of Health Promotion, University of Wales, UK.; Many public surveys on the issue of HIV and AIDS have concentrated on the relationship between attitudes and knowledge. Often this relationship has been found wanting or at most tenuous. A recent survey of 1,002 people in Wales has supported these earlier findings, but found additionally that discriminatory and compla
HIV prevention: current health promoting behaviour models for understanding psycho-social determinants of condom use.: AIDS Care. 1990;2(1):69-75. Unique Identifier : AIDSLINE MED/91190949; Salt H; Boyle M; Ives J; Royal Free Hospital, London, UK.; The application of current health promoting behaviour models for understanding psycho-social determinants of condom use is discussed. It was concluded that their utility is reduced because they are individualistic models and do not take into account interaction between couples, and contextual factors. Systemic AIDS co
The impact of AIDS mortality on children's education in Kampala (Uganda).: AIDS Care. 1990;2(1):77-80. Unique Identifier : AIDSLINE MED/91190950; Muller O; Abbas N; League Red Cross and Red Crescent Societies, Geneva, Switzerland.; The socioeconomic impact of the AIDS epidemic in Uganda has been evaluated through carrying out a household survey in central Kampala. A chronic disease with fever and weight loss, occurring mainly in young adult, caused about 1% mortality in 1988 in the area studied. There was a n
Approaches to HIV counselling in a Zambian rural community.: AIDS Care. 1990;2(1):81-7. Unique Identifier : AIDSLINE MED/91190951; Chaava T; Salvation Army, Chikankata Hospital, Mazabuka, Zambia.; The counselling experience at Chikankata hospital for the first year of the AIDS care and prevention programme is described. People in the counselling team are selected according to specific criteria. Counselling is conducted in integrated AIDS management context, at the individual family and community levels. Counsel
World Health Organization Global AIDS Statistics.: AIDS Care. 1990;2(1):97-100. Unique Identifier : AIDSLINE MED/91190952
Recent advances in non-gonococcal urethritis: pathogenesis, investigation and treatment [editorial]: Int J STD AIDS. 1990 May;1(3):157-60. Unique Identifier : AIDSLINE MED/91190989; Woolley PD
Sexually transmitted diseases in lesbians.: Int J STD AIDS. 1990 May;1(3):178-81. Unique Identifier : AIDSLINE MED/91190992; Edwards A; Thin RN; Department of Genitourinary Medicine, St Thomas' Hospital,; London, UK.; The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in
The usefulness of the HIV-CHEK assay as a simple, rapid and sensitive screening test for HIV infection [see comments]: Int J STD AIDS. 1990 May;1(3):182-3. Unique Identifier : AIDSLINE MED/91190993; Walzman M; Natin D; Shahmanesh M; Department of Genitourinary Medicine, General Hospital,; Birmingham, UK.; The purpose of this study was to evaluate the usefulness of the HIV-CHEK kit for human immunodeficiency virus (HIV) antibody testing. A comparison with the Serodia-HIV test was made on 42 fresh serum samples. Both tests accurately identified the 11 true positive serum samples, while there was one false positive with t
Comparison of an enzyme immunoassay (Ortho) with cell culture and immunofluorescence for the detection of genital chlamydial infection.: Int J STD AIDS. 1990 May;1(3):187-90. Unique Identifier : AIDSLINE MED/91190995; Mumtaz G; Ridgway GL; Nayagam AT; Robinson AJ; Department of Microbiology, University College Hospital, London,; UK.; An enzyme immunoassay (EIA) test (Ortho Diagnostic Systems Ltd) was evaluated against cell culture for the detection of chlamydial genital infection. Specimens were obtained from 409 patients (204 men and 205 women). Sensitivity, specificity, predictive value of a positive result (PVP) and predictive value of a negati
Evaluation of the significance of Mycoplasma hominis and Ureaplasma urealyticum in female genital tract infection--a retrospective case note study.: Int J STD AIDS. 1990 May;1(3):191-4. Unique Identifier : AIDSLINE MED/91190996; Crawshaw SC; Stocker DI; Sugrue DL; Haran MV; Department of Genitourinary Medicine, Central Outpatients; Department, Stoke-on-Trent, UK.; Routine screening for sexually transmitted diseases in new patients attending the Genitourinary Clinic in Stoke-on-Trent includes a culture for Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU). A retrospective study was carried out on 400 female patients to ascertain whether there were any significant differenc
Comparison of Pharmacia Chlamydia EIA, IDEIA and cell culture in the detection of urogenital chlamydial infection.: Int J STD AIDS. 1990 May;1(3):199-204. Unique Identifier : AIDSLINE MED/91190998; Bygdeman SM; Lidbrink P; Nahkiaisoja M; Parkhede U; Karolinska Institute, Department of Clinical Bacteriology,; Huddinge Hospital, Stockholm, Sweden.; Two commercial test kits, Pharmacia Chlamydia EIA (PhEIA) and IDEIA Chlamydia Test, for the identification of Chlamydia trachomasis and McCoy cell culture were compared in urogenital specimens. The sediments of the transportation buffers of specimens with discordant results were investigated for elementary bodies (EB)
Screening for Chlamydia trachomatis genital infection in young men in Stockholm.: Int J STD AIDS. 1990 May;1(3):205-6. Unique Identifier : AIDSLINE MED/91190999; Larsson S; Ruden AK; Bygdeman SM; Matteus Primary Health Care Center, Stockholm, Sweden.; The purpose of this study was to investigate the prevalence of genital chlamydial infection in male military recruits in Stockholm, Sweden . Two hundred and thirty-eight men who admitted to sexual experience were included in the study. One hundred and five (44%) of these 238 men con
Sexually transmitted diseases among patients seeking HIV antibody test for AIDS.: Int J STD AIDS. 1990 May;1(3):207-8. Unique Identifier : AIDSLINE MED/91191000; Mohanty KC; Department of Genitourinary Medicine, St. Luke's Hospital,; Bradford, UK.; A total of 489 patients who had blood tests for antibodies to the human immunodeficiency virus (HIV) were given medical advice for sexually transmitted disease (STD) screening. Of 378 patients who had STD screening, STDs were found to be present in 47%. Among various STDs, non-specific urethritis (NSU) in men and chla
Nosocomial outbreak of scabies associated with Norwegian scabies in an AIDS patient.: Int J STD AIDS. 1990 May;1(3):209-10. Unique Identifier : AIDSLINE MED/91191001; Rostami G; Sorg TB; Dayton Department of Veterans Affairs Medical Center, Ohio 45428.
Retinal changes associated with severe anaemia in the acquired immunodeficiency syndrome.: Int J STD AIDS. 1990 May;1(3):211-2. Unique Identifier : AIDSLINE MED/91191002; French PD; Murphy SM; Forster SM; Department of Genito-Urinary Medicine, St Mary's Hospital,; London, UK.
Infection with Chlamydia sp and HTLV-I in a patient mimicking infective endocarditis.: Int J STD AIDS. 1990 May;1(3):213-5. Unique Identifier : AIDSLINE MED/91191003; Wilson AP; Wright PA; Kelsey MC; Patterson DL; Department of Microbiology, Whittington Hospital, London, UK.
AIDS Literature Index.: Int J STD AIDS. 1990 May;1(3):217-32. Unique Identifier : AIDSLINE MED/91191004
Are barrier methods protective against cervical cancer? [editorial; comment]: Epidemiology. 1990 Jul;1(4):261-2. Unique Identifier : AIDSLINE MED/91191027; Daling JR; Weiss NS
[DNA probe containing elements of the gene of surface glycoprotein of HIV-1 virus, an effective molecular marker in genotyposcopy of man]: Biull Eksp Biol Med. 1990 Dec;110(12):646-7. Unique Identifier : AIDSLINE MED/91191137; Rogaev EI; Shlenskii AB
[AIDS and the eye]: Fortschr Ophthalmol. 1990;87 Suppl:S94-100. Unique Identifier : AIDSLINE MED/91192771; Lund OE; Klauss V; Scheiffarth OF; Universitats-Augenklinik, Munchen, Bundesrepublik Deutschland.; Seventy percent of patients with AIDS have AIDS-related ocular involvement. This is a special challenge for the ophthalmologist which requires specific knowledge. The nature and frequency of the ocular involvement as well as the time of manifestation during the HIV-disease are discussed. The potential therapy for such
Follicle lysis in HIV-free lymphoid tissues.: Int Arch Allergy Appl Immunol. 1990;92(4):390-5. Unique Identifier : AIDSLINE MED/91192962; Shiota M; Toyama K; Mori S; Department of Pathology, University of Tokyo, Japan.; Follicle lysis (FL), the moth-eaten degeneration of follicular dendritic cells (FDCs), previously regarded as specific for HIV-infected lymph follicles, was later claimed to exist in HIV-free patients. This study was performed to clarify the differences between HIV-free and HIV-induced FL. HIV-free and HIV-infected
Analysis of cellular fatty acids and proteins by capillary gas chromatography and sodium dodecyl sulphate polyacrylamide gel electrophoresis to differentiate Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium scrofulaceum (MAIS) complex species.: J Chromatogr. 1990 Nov 16;532(2):209-16. Unique Identifier : AIDSLINE MED/91193309; Fourche J; Capdepuy M; Maugein J; Le Moigne F; Laboratoire de Biochimie Medicale, Universite de Bordeaux II,; France.; Infections due to atypical mycobacteria have increased during the past 30 years. Species of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium scrofulaceum are among the most common non-tuberculous mycobacteria isolated from patients with AIDS or immunosuppressed. These three organisms are taxonomical
Erythrocyte antibodies in AIDS are associated with mycobacteriosis and hypergammaglobulinemia.: Klin Wochenschr. 1990 Nov 9;68(21):1050-3. Unique Identifier : AIDSLINE MED/91194202; Bogner JR; Gathof B; Heinrich B; Matuschke A; Backer U; Goebel FD; Medizinische Poliklinik, Universitat Munchen.; Positive direct antiglobulin results prior to transfusion in some of our AIDS patients, as well as some reports in the literature on red cell antibodies in AIDS patients, prompted us to investigate the prevalence of erythrocyte antibodies in AIDS patients with transfusion requiring anemia. In addition we studied the q
[Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. An analysis of 67 cases with a study of the prognostic factors]: Med Clin (Barc). 1990 Sep 29;95(10):361-5. Unique Identifier : AIDSLINE MED/91194350; Azon Masoliver A; Mallolas J; Miro JM; Gatell JM; Castel T; Iranzo P; Lecha M; Mascaro JM; Departamentos de Dermatologia y Hospital Clinic i Provincial,; Barcelona.; The features and prognostic factors of 67 cases of Kaposi s sarcoma (KS) associated to the acquired immunodeficiency syndrome (AIDS) diagnosed at the Hospital Clinic, Barcelona, are analyzed. All the patients were male; mean age was 39.7 years, ranging from 22 and 62 years. 64 were homosexuals (95.5%), two were homose
[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases]: Med Clin (Barc). 1990 Oct 13;95(12):441-6. Unique Identifier : AIDSLINE MED/91194365; Gonzalez-Clemente JM; Miro JM; Pedrol E; Alvarez R; Gatell JM; Mallolas J; Graus F; Mercader JM; Guelar A; Jimenez de Anta MT; et al; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Universitat de Barcelona.; During a 40-month period 78 episodes of encephalic toxoplasmosis (ET) were diagnosed in 57 patients among 394 with acquired immunodeficiency syndrome (AIDS) (based on CDC criteria) in the Hospital Clinic from Barcelona. 38 patients were parenteral drug abusers (66.7%), 17 were homosexual males (29.8%) and 2 were heter
[An evaluation of the efficacy of different commercial kits in the serological diagnosis of the early phase of human immunodeficiency virus infection]: Med Clin (Barc). 1990 Oct 13;95(12):451-3. Unique Identifier : AIDSLINE MED/91194367; Aguado I; Rey C; Calderon E; Torres Y; Pineda JA; Leal M; Lissen E; Departamento de Medicina Interna, Hospital Universitario Virgen; del Rocio, Sevilla.; The aim of the present study was to identify the most useful serum markers for the early identification of the infection by the human immunodeficiency virus (HIV). To this end, sequential serum samples of 19 individuals who later had seroconversion to anti-HIV were evaluated. The p24 antigen (Ag-HIV) was the earliest
[The survival of acquired immunodeficiency syndrome patients with neurological forms of presentation (letter)]: Med Clin (Barc). 1990 Oct 13;95(12):476-7. Unique Identifier : AIDSLINE MED/91194375; Casabona J; Sanchez E; Graus F; Abos J
[The evaluation of heterosexual transmission of the human immunodeficiency virus by nucleic acid amplification technics]: Med Clin (Barc). 1990 Oct 27;95(14):535-7. Unique Identifier : AIDSLINE MED/91194389; Soriano V; Hewlett I; Tor J; de Amo C; Lazaro I; Muga R; Clotet R; Ribas-Mundo M; Foz M; Unidad de Enfermedades Infecciosas, Hospital de Badalona Germans; Trias i Pujol, Universidad Autonoma de Barcelona.; Heterosexual couples of individuals infected by HIV represent a group of high risk of virus infection. We have investigated the presence of fragments of the HIV genome with a new nucleic acid amplification technique (PCR or polymerase chain reaction) in lymphocytes from 33 seronegative couples with anti-HIV antibodies
[The General Health Questionnaire (GHQ-28) with health personnel (letter; comment)]: Med Clin (Barc). 1990 Oct 27;95(14):556. Unique Identifier : AIDSLINE MED/91194396; Jimenez Roset P; Llobregat Quiros R; Pineda Cuenca M; Jimenez Roset J
[Spontaneous pyomyositis in the acquired immunodeficiency syndrome (letter)]: Med Clin (Barc). 1990 Oct 27;95(14):556-7. Unique Identifier : AIDSLINE MED/91194397; Carton JA; Carcaba V; Rodriguez Junquera M; Maradona JA
[The evidence for HTLV-1 infection in different risk groups in Barcelona (letter; comment)]: Med Clin (Barc). 1990 Oct 27;95(14):559. Unique Identifier : AIDSLINE MED/91194402; Soriano V; Tor J
[Intensive care of AIDS patients. Clinical experience]: Minerva Anestesiol. 1990 Nov;56(11):1425-8. Unique Identifier : AIDSLINE MED/91194862; Latis G; Foroni C; Malusardi P; Minuto A; Sicignano A; Vesconi S; Divisione di Anestesia e Rianimazione, Ospedale San Paolo,; Milano.; Six patients with AIDS and severe respiratory failure from diffuse interstitial pneumonia, have been treated in one year in ICU. The authors describe diagnostic and therapeutic characteristics and management problems, underlining the good results in the short and medium term.
What's new in primary central nervous system lymphomas?: Pathol Res Pract. 1990 Dec;186(6):809-16. Unique Identifier : AIDSLINE MED/91195122; Xerri L; Gambarelli D; Horschowski N; Andrac L; Hassoun J; Laboratoire d'Anatomie Pathologique et de Neuropathologie,; Faculte de Medecine de Marseille, France.; Primary central nervous system lymphomas (CNSL) are uncommon neoplasms accounting for about 1% of primary brain tumors. Patients with congenital or acquired immunodeficiencies including AIDS patients and transplant recipients represent the main high-risk population for CNSL occurrence. An important point emerging from
[AIDS--psychiatric problems]: Psychiatr Pol. 1990 Mar-Apr;24(2):160-4. Unique Identifier : AIDSLINE MED/91195411; Lutynska E; II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii w; Warszawie.
AIDS knowledge and homophobia among French and American university students.: Psychol Rep. 1990 Dec;67(3 Pt 2):1147-52. Unique Identifier : AIDSLINE MED/91195434; Conner G; Richman CL; Wallace S; Tilquin C; Department of Psychology, Wake Forest University, Winston-Salem,; NC 27109.; 22 male American and 24 male French college students knowledge of AIDS scores were equivalent on a currently constructed 18-item questionnaire. Both groups answered more than 75% of the questions correctly. The American students homophobic bias and reaction scores were higher than those of the French students on a 4
Attitudes of emergency medical service providers towards AIDS.: Psychol Rep. 1990 Dec;67(3 Pt 2):1314. Unique Identifier : AIDSLINE MED/91195451; Matin SA; Lester D; Richard Stockton State College, Pomona, NJ 08240.; 19 mobile, intensive care paramedics and 21 RNs scored similarly on Rotter s I-E scale and on a 15-item attitude inventory. Aware of dangers associated with treating people with AIDS, they do not want to change careers and, on the average, agree slightly that they treat AIDS patients like other patients.
AIDS--a question of informed consent [editorial]: Quintessence Int. 1990 Nov;21(11):857. Unique Identifier : AIDSLINE MED/91195481; Simonsen RJ
[HIV-1 infection in blood donors and blood recipients]: Przegl Epidemiol. 1990;44(3):149-54. Unique Identifier : AIDSLINE MED/91195553; Moraczewska Z; Seyfriedowa H; Kacperska E; Szata W; Mazurkiewicz W; Babiuch L; Zaklad Serologii Instytutu Hematologii w Warszawie.; The results of the tests on HIV-1 infection in blood donors in the years 1985-1989 were presented. Out of 3.222.345 serum samples, in 66 donors HIV-1 antibodies were detected. In 1989 the significant raise of HIV-1 carriers, among whom there were 17 intravenous drug users, was noticed. The transmission of HIV-1 infect
[Detection of HIV antibodies among prisoners from penitentiary units within the district penal institutions in Cracow]: Przegl Epidemiol. 1990;44(3):155-9. Unique Identifier : AIDSLINE MED/91195554; Caban J; Dolezal M; Blach A; Wisniowski Z; Klinika Chorob Zakaznych IMW AM w Krakowie.; The reports on the high percentage of HIV infected persons in West European prisons brought about similar investigations in Krakow. 2794 prisoners and a control group of 241 people were examined. The authors used a questionnaire and detected HIV antibodies. The number of seropositive prisoners was not essential. The v
[AIDS and drugs in Italy (news)]: Riv Biol. 1990;83(2-3):204. Unique Identifier : AIDSLINE MED/91195672
[Rheumatic manifestations in HIV infection]: Z Rheumatol. 1990 Nov-Dec;49(6):324-8. Unique Identifier : AIDSLINE MED/91196419; Seglias J; Aeschlimann A; Muller W; Stadtspital Triemli, Abteilung Rheumatologie, Zurich, Schweiz.; The two main rheumatic manifestations of infection by human immunodeficiency virus (HIV) are arthropathies and autoimmune diseases. The pathogenesis of the rheumatic manifestations is currently undefined. Among the different mechanisms implicated, the severe immunosuppression and immunodysregulation, as well as recurr
The involvement of the cerebral cortex in human immunodeficiency virus encephalopathy: a morphological and immunohistochemical study.: Acta Neuropathol (Berl). 1990;81(1):51-9. Unique Identifier : AIDSLINE MED/91196475; Ciardi A; Sinclair E; Scaravilli F; Harcourt-Webster NJ; Lucas S; Department of Neuropathology, National Hospital, London, UK.; The encephalopathy resulting from direct infection of the brain by human immunodeficiency virus (HIV), which correlates clinically with the AIDS dementia complex, has been reported as being localized to the white matter where it induces myelin loss, gliosis and perivascular infiltr
Demyelination and remyelination in spinal cord lesions of human lymphotropic virus type I-associated myelopathy.: Acta Neuropathol (Berl). 1990;81(1):78-83. Unique Identifier : AIDSLINE MED/91196480; Ohama E; Horikawa Y; Shimizu T; Morita T; Nemoto K; Tanaka H; Ikuta F; Department of Pathology, School of Medicine, Niigata University,; Japan.; We describe postmortem findings in a patient with human T lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). The patient developed the disease 8 years after blood transfusion and showed good response to corticosteroid treatment but died of cardiac failure. Histologically, chronic, mild meningoencephalomye
Clinical overview of acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV)-related disease.: Am Ind Hyg Assoc J. 1990 Nov;51(11):A738-41. Unique Identifier : AIDSLINE MED/91196679; Barnes KE; Department of Medicine, St. Luke's Hospital, San Francisco, CA; 94134.
Epidemiology of AIDS: an overview of AIDS epidemiology and major modes of transmission.: Am Ind Hyg Assoc J. 1990 Nov;51(11):A742-6. Unique Identifier : AIDSLINE MED/91196680; Lamm SH; Epidemiology and Occupational Health, Inc., Washington, DC 20007.
Response to: 'Alcohol, sex and AIDS' [letter; comment]: Alcohol Alcohol. 1990;25(6):711-3. Unique Identifier : AIDSLINE MED/91197306; Pillai R; Watson RR
Adolescents, sex and injecting drug use: risks for HIV infection.: AIDS Care. 1990;2(2):103-16. Unique Identifier : AIDSLINE MED/91198157; Barnard M; McKeganey N; Social Paediatric & Obstetric Research Unit, University of; Glasgow, UK.; In this paper we present data on the HIV-related risks for adolescents growing up in an area where injecting drug use is prevalent and HIV infection has been identified among local injecting drug users. We report on young peoples knowledge, attitudes and perceptions of drug use and injectors; HIV and AIDS; sex, safer
Attitudes of US primary care physicians about HIV disease and AIDS.: AIDS Care. 1990;2(2):117-25. Unique Identifier : AIDSLINE MED/91198158; Bresolin LB; Rinaldi RC; Henning JJ; Harvey LK; Hendee WR; Schwarz MR; American Medical Association, Chicago, IL 60610.; Telephone interviews were conducted with 500 primary care physicians, drawn from a stratified random sample of internists, family practitioners, pediatricians, general practitioners, and OB/GYN physicians. Respondents were asked to report their experience treating AIDS patients and to estimate the percentage of their
Developing care in the community: GPs and the HIV epidemic.: AIDS Care. 1990;2(2):127-32. Unique Identifier : AIDSLINE MED/91198159; Roderick P; Victor CR; Beardow R; Department of Public Health, St Mary's Hospital, London, UK.; Services for HIV infection and AIDS in Parkside DHA have been largely hospital based with little active involvement of local GPs. In response to the wishes of those with HIV/AIDS and predicted increases in the number of patients the DHA is now developing an AIDS strategy which identifies the development of primary and
Factors associated with risk behaviour among injecting drug users.: AIDS Care. 1990;2(2):133-45. Unique Identifier : AIDSLINE MED/91198160; Klee H; Faugier J; Hayes C; Boulton T; Morris J; Faculty of Community Studies, Manchester Polytechnic, U.K.; A project which investigated the injecting and sexual behaviour of drug users in the North West of England revealed several social and behavioural factors strongly associated with HIV-related risk behaviour. For example, homelessness, crime, ignorance of drug-related health problems and drug use by a regular partner w
Group intervention with HIV seropositive patients and their partners.: AIDS Care. 1990;2(2):147-54. Unique Identifier : AIDSLINE MED/91198161; Hedge B; Glover LF; Department of Psychology, Paterson Wing, St Mary's Hospital,; London, UK.; Persons with HIV infection and AIDS may have complex psychosocial needs. Many find it difficult to share fears and feelings so are unlikely to join traditional support groups, although they lack crucial social support. As they frequently report a need for more information it was proposed to use an information group
Effects of counselling on knowledge about HIV-1 among transfusion recipients and their partners. Transfusion Safety Study Group.: AIDS Care. 1990;2(2):155-62. Unique Identifier : AIDSLINE MED/91198162; Miller K; Donegan E; Curran P; Shelley TJ; Department of Laboratory Medicine, University of California San; Francisco 94143.; The present study determined how much HIV-1-positive persons knew about AIDS, and HIV-1 transmission and prevention, in comparison with HIV-1-negative controls in a predominantly heterosexual cohort. The subjects were blood donors, blood recipients, hemophiliacs, and their sexual partners. A 16-item questionnaire abou
Gay men, social support and HIV disease: a study of social integration in the gay community.: AIDS Care. 1990;2(2):163-70. Unique Identifier : AIDSLINE MED/91198163; Hart G; Fitzpatrick R; McLean J; Dawson J; Boulton M; Academic Department of Genito-Urinary Medicine, University; College and Middlesex School of Medicine, London, U.K.; As part of a large study of the effects of HIV and AIDS on gay male sexual behaviour, we investigated the extent to which gay men in the UK have access to social support and informal care at times of illness. The study sample (n = 502) demonstrated high levels of willingness to disclose sexuality to others, sociabilit
Hospital health care for HIV infection with particular reference to injecting drug users.: AIDS Care. 1990;2(2):171-81. Unique Identifier : AIDSLINE MED/91198164; Brettle RP; Department of Medicine, Edinburgh University, UK.; Models of health care developed for HIV and AIDS tend to reflect the experience of San Francisco or London where the majority of patients affected have been homosexual or bisexual. The services developed in these areas may not be appropriate for other risk groups such as injecting drug users. The author, who has been
Integrated AIDS management.: AIDS Care. 1990;2(2):183-8. Unique Identifier : AIDSLINE MED/91198165; Campbell ID; Rader AD; Salvation Army, London, UK.; AIDS is a multi-disciplinary problem, but also a multi-disciplinary opportunity, given the capacity of individuals, groups and organizations to integrate talents and resources. The impact of AIDS in east, southern and central Africa is discussed in general terms to answer the question. Why integrate? Ways in which int
World Health Organization Global AIDS Statistics.: AIDS Care. 1990;2(2):193-6. Unique Identifier : AIDSLINE MED/91198166
Recovery of HIV antigen in peritoneal dialysis fluid.: Perit Dial Int. 1990;10(1):67-9. Unique Identifier : AIDSLINE MED/91198253; Correa-Rotter R; Saldivar S; Soto LE; Ponce de Leon S; Ojeda F; Ruiz-Palacios G; Pena JC; Department of Nephrology, Instituto Nacional de la Nutricion; Salvador Zubiran, Mexico City, Mexico.; We investigated the presence of HIV antigen in dialysis fluid of patients with end-stage renal disease (ESRD) undergoing continuous ambulatory peritoneal dialysis (CAPD), previously known to be infected with this virus. Sixteen adult patients and 6 adult volunteers were included in the study in 4 groups as follows: Gr
Statistical analysis of HIV infectivity based on partner studies.: Biometrics. 1990 Dec;46(4):1133-50. Unique Identifier : AIDSLINE MED/91198414; Jewell NP; Shiboski SC; Department of Statistics, University of California, Berkeley; 94720.; Partner studies produce data on the infection status of partners of individuals known or assumed to be infected with the human immunodeficiency virus (HIV) after a known or estimated number of contacts. Previous studies have assumed a constant probability of transmission (infectivity) of the virus at each contact. Rec
Statistical modelling of the AIDS epidemic for forecasting health care needs.: Biometrics. 1990 Dec;46(4):1151-63. Unique Identifier : AIDSLINE MED/91198415; Brookmeyer R; Liao JG; Department of Biostatistics, Johns Hopkins University, Baltimore,; Maryland 21205.; The objective of this paper is to develop statistical methods for estimating current and future numbers of individuals in different stages of the natural history of the human immunodeficiency (AIDS) virus infection and to evaluate the impact of therapeutic advances on these numbers. The approach is to extend the metho
Accommodating change due to treatment in the method of back projection for estimating HIV infection incidence.: Biometrics. 1990 Dec;46(4):1165-70. Unique Identifier : AIDSLINE MED/91198416; Solomon PJ; Wilson SR; National Centre for Epidemiology and Population Health,; Australian National University, Canberra ACT.; This note shows how the method of back projection, which is being widely applied to predict the incidence of HIV infection, can be extended to incorporate distributional changes due to a treatment effect, such as zidovudine (commonly known as AZT ). By
An enlarged suprachiasmatic nucleus in homosexual men.: Brain Res. 1990 Dec 24;537(1-2):141-8. Unique Identifier : AIDSLINE MED/91198822; Swaab DF; Hofman MA; Netherlands Institute for Brain Research, Amsterdam.; Morphometric analysis of the human hypothalamus revealed that the volume of the suprachiasmatic nucleus (SCN) in homosexual men is 1.7 times as large as that of a reference group of male subjects and contains 2.1 times as many cells. In another hypothalamic nucleus which is located in the immediate vicinity of the SCN
Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.: Cell Struct Funct. 1990 Oct;15(5):295-9. Unique Identifier : AIDSLINE MED/91199234; Nozaki-Renard J; Iino T; Sato Y; Marumoto Y; Ohta G; Furusawa M; Department of Microbiology, Tokyo Medical College, Japan.; Infection of the human lymphocyte CEM cell line with the HIV-1 (human immunodeficiency virus-1, LAV-1 strain) results in cell death. A fluoroquinolone antibiotic, ofloxacin, protected the infected cells from HIV-1-mediated cytolysis. Other fluoroquinolones, e.g. ciprofloxacin, norfloxacin, and enoxacin, also protected
Enhanced transdermal delivery of zidovudine in rats and human skin.: Chem Pharm Bull (Tokyo). 1990 Nov;38(11):3086-9. Unique Identifier : AIDSLINE MED/91199320; Seki T; Toeda C; Kawaguchi T; Juni K; Sugibayashi K; Morimoto Y; Faculty of Pharmaceutical Sciences, Josai University, Saitama,; Japan.; Zidovudine (azidothymidine, AZT ), a potent antiviral agent acting on acquired immunodeficiency syndrome virus, was examined with regard to permeation through rat and human skin. A steady state plasma concentration of AZT after transdermal application
[Epidemiology of infections caused by HIV-1, HIV-2 and HTLV-1 in the republic of Chad]: Bull Soc Pathol Exot. 1990;83(5):603-10. Unique Identifier : AIDSLINE MED/91199339; Louis JP; Trebucq A; Hengy C; Danyod M; Fatchou G; Tirandibaye N; Granga D; Buriot D; Meslet B; Milleliri JM; et al; Organisation de Coordination pour la lutte contre les Endemies; en Afrique Centrale (OCEAC), Yaounde Cameroun.; From March to July 1989 sero-epidemiological surveys have been carried out in four Chadian towns on representative samples of adults aged 15-44 years in the general population. For the first time, HIV1 virus circulation was shown off with seroprevalence rates varying from 0 to 1.1%. Rates are non-existent for HIV2 and
[Late cutaneous porphyria associated with a human immunodeficiency virus infection in a 29 year old Burundi]: Bull Soc Pathol Exot. 1990;83(5):690-2. Unique Identifier : AIDSLINE MED/91199352; Aubry P; Nikoyagize E; Kabahizi JP; Talec R; Ricodel I; Moalic JL; Floch JJ; Departement de Medecine Interne, CHU de Kamenge, Bujumbura,; Burundi.
Update: heterosexual transmission of acquired immunodeficiency syndrome and human immunodeficiency virus infection: United States [editorial]: Dis Markers. 1990 Sep-Oct;8(5):296. Unique Identifier : AIDSLINE MED/91199545
Use of polymerase chain reaction for early detection of the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers [editorial]: Dis Markers. 1990 Sep-Oct;8(5):296-7. Unique Identifier : AIDSLINE MED/91199546
Ethnobotany and the identification of therapeutic agents from the rainforest.: Ciba Found Symp. 1990;154:22-31; discussion 32-9. Unique Identifier : AIDSLINE MED/91199729; Balick MJ; Institute of Economic Botany, New York Botanical Garden, Bronx; 10458.; Many rainforest plant species, including trees and herbaceous plants, are employed as medicines by indigenous people. In much of the American tropics, locally harvested herbal medicines are used for a significant portion of the primary health care, in both rural and urban areas. An experienced curandero or herbal heal
Nutrition in the management of HIV antibody positive patients: a longitudinal study of dietetic out-patient advice.: Eur J Clin Nutr. 1990 Nov;44(11):823-9. Unique Identifier : AIDSLINE MED/91200013; Dowling S; Mulcahy F; Gibney MJ; Department of Clinical Medicine, TCD Medical School, Dublin,; Ireland.; The efficacy of a dietetic service was evaluated in an AIDS clinic; 17 asymptomatic (CDC II) and 17 symptomatic (CDC IV) patients participated in a 12 week evaluation of out-patient dietetic advice. The symptomatic group, classified as CDC stage IV according to the Centre for Disease Control classification, were signi
HIV infection and AIDS in thalassemia and sickle cell disease.: Haematologica. 1990 Sep-Oct;75 Suppl 5:128-31. Unique Identifier : AIDSLINE MED/91200718; Girot R; Lefrere JJ; Hopital Necker-Enfants Malades, Paris, France.
Eight cases of patients with unfounded fear of AIDS.: Int J Psychiatry Med. 1990;20(4):405-11. Unique Identifier : AIDSLINE MED/91200996; Vuorio KA; Aarela E; Lehtinen V; Turku University Central Hospital, Finland.; This article describes eight cases of patients treated at the Psychiatric Department of the University Central Hospital of Turku (UCHT) Finland who all had as a common feature an unfounded fear of AIDS. Three of the patients committ
Rectal non-Hodgkin's lymphoma: a clinicopathologic study and review.: Henry Ford Hosp Med J. 1990;38(4):255-8. Unique Identifier : AIDSLINE MED/91201116; Gottlieb CA; Meiri E; Maeda KM; Department of Pathology, Henry Ford Hospital, Detroit, MI 48202.; A total of 11 patients with lymphomatous involvement of the rectum were seen at Henry Ford Hospital between 1964 and 1987. Eight of these patients had primary rectal lymphoma and three had secondary rectal lymphoma. These patients clinical presentation and course as well as pathological findings are described and com
Serum levels and catabolism of 3'-azido-3'-deoxythymidine in vivo measured using a specific radioimmunoassay.: J Virol Methods. 1990 Oct;30(1):89-98. Unique Identifier : AIDSLINE MED/91201506; Cox S; Ruden U; Nagy K; Albert J; Holmberg V; Sandstrom E; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.; The thymidine analogue 3 -azido-3 -deoxythymidine is an effective inhibitor of HIV replication in vitro and is used in the treatment of acquired immunodeficiency syndrome. We report here upon a rapid sensitive radioimmunoassay for the detection of azidothymidine in serum or plasma. The assay is simple to perform and l
Confirmatory tests for human T-cell leukemia virus type 1 (HTLV-1): western blot compared with RIPA on African sera.: J Virol Methods. 1990 Dec;30(3):283-9. Unique Identifier : AIDSLINE MED/91201513; Verdier M; Leonard G; Sangare A; Prince-David M; Bonis J; Barin F; Denis F; Laboratoire de Virologie, CHU Dupuytren, Limoges, France.; Confirmation of human T-Cell leukemia virus type 1 (HTLV-1) seropositivity calls for reactivity against at least 2 proteins encoded by 2 different genes, revealed by Western blot (WB) and/or radioimmuno-precipitation assay (RIPA). To evaluate the use of WB as a basis for applying these criteria, we conducted a study o
Intrathecal synthesis of anti-HIV antibodies in AIDS patients.: J Neurol Sci. 1990 Nov;99(2-3):281-9. Unique Identifier : AIDSLINE MED/91202183; Lolli F; Colao MG; De Maio E; Di Pietro M; Galli E; Grippo A; Mazzotta F; Pinto F; Dipartimento di Scienze Neurologiche e Psichiatriche, Universita; degli Studi di Firenze, Italy.; We studied the production within the CNS of anti-HIV antibodies, of non-specific IgG, and the presence of HIV antigens in the serum and CSF of 28 HIV infected patients belonging to group IV in the Center for Disease Control classification. CSF and serum were diluted under optimal conditions to equalize their IgG conte
[Hemiballismus in a patient with the acquired immunodeficiency syndrome: an infrequent complication secondary to opportunistic infection of the central nervous system (letter)]: Med Clin (Barc). 1990 Nov 24;95(18):717. Unique Identifier : AIDSLINE MED/91203255; Llibre Codina JM; Bonet Simo JM; Gutierrez Jordan U; Tor Aguilera J
[Wernicke's encephalopathy in a female patient with the acquired immunodeficiency syndrome (letter)]: Med Clin (Barc). 1990 Dec 1;95(19):754-5. Unique Identifier : AIDSLINE MED/91203268; Gomez Manzano C; Fueyo J; Miralles R; Gutierrez J
[Fatality of purulent meningitis in adults 1950 to 1985. Retrospective study of the case histories of 391 patients of the Cologne Neurologic University Clinic]: Med Klin. 1990 Dec 15;85(12):696-9. Unique Identifier : AIDSLINE MED/91203731; Huber M; Jennes HW; Bamborschke S; Klinik und Poliklinik fur Neurologie, Universitat Koln.; Although intensive care medicine and chemotherapy of bacterial infections have made great progress during the last 30 years, therapeutic efficacy in bacterial meningitis in adult patients could not be improved. Retrospective analysis of 391 cases of adult bacterial meningitis between 1950 and 1985 shows no significant
[Non-tropical pyomyositis in Germany]: Med Klin. 1990 Dec 15;85(12):707-14. Unique Identifier : AIDSLINE MED/91203733; Piper C; Henrich R; Wendt B; von Egidy H; Medizinische Klinik A, Klinikum der Landeshauptstadt Wiesbaden.; Haematogenous primary pyomyositis predominantly caused by staphylococcus aureus is a well-known entity in tropical regions. It is sporadicly observed in non-tropical areas. Lack of clinical familiarity not seldom contributes to delayed recognition of pyomyositis in the suppurative or complicated state. Initially, heal
[Psychosocial problems in HIV infected families--possibilities for coping]: Monatsschr Kinderheilkd. 1990 Dec;138(12):789-90. Unique Identifier : AIDSLINE MED/91203971; Rosendahl C; Neumann-Mager J; Schroll E; Fahrenheim E; Autenrieth R; Wintergerst U; Belohradsky BH; Immunodefekt-Ambulanz, Universitats-Kinderkliniken Munchen.; The psychosocial problems of 49 HIV-exposed children (data given as of September 1989) and 19 HIV-infected hemophiliacs cared for in the pediatric immuno-deficiency clinic of the Munich university hospital are described in detail. Drug addiction, financial needs, housing problems and delinquency play an important role
[Prenatal development and postnatal morbidity of newborn infants of HIV positive mothers]: Monatsschr Kinderheilkd. 1990 Dec;138(12):799-802. Unique Identifier : AIDSLINE MED/91203973; Maas U; Kattner E; Koch S; Schfer A; Obladen M; Abteilung fur Neonatologie, Universitats-Klinikum Rudolf; Virchow, Standort Charlottenburg, Freie Universitat Berlin.; Does the maternal HIV-infection itself influence fetal development and neonatal morbidity or are adverse effects related to maternal opiate and nicotine abuse? 17 neonates of HIV-positive women (7 drug users) and 37 controls (17 healthy and 21 opiate exposed newborns) were examined prospectively. A discriminant analys
Inhibition of lymphokine-activated killer activity during HIV infection: role of HIV-1 gp41 synthetic peptides.: Nat Immun Cell Growth Regul. 1990;9(6):366-75. Unique Identifier : AIDSLINE MED/91203981; Cauda R; Tumbarello M; Ortona L; Kennedy RC; Shuler KR; Chanh TC; Kanda P; Department of Infectious Diseases, Catholic University, Rome,; Italy.; Lymphokine-activated killer (LAK) activity was analyzed in 31 human immune deficiency virus 1 (HIV-1)-infected patients. It was found to be reduced in all groups of patients, being more pronounced in those with acquired immune deficiency syndrome (AIDS) and AIDS-related complex compared to HIV-1-seropositive, asymptom
Activation of human immunodeficiency virus by ultraviolet radiation.: Photochem Photobiol. 1990 Dec;52(6):1153-62. Unique Identifier : AIDSLINE MED/91204777; Zmudzka BZ; Beer JZ; Radiation Biology Branch, Center for Devices and Radiological; Health, Rockville, MD 20857.
Expression vectors for quantitating in vivo translational ambiguity: their potential use to analyse frameshifting at the HIV gag-pol junction.: Res Virol. 1990 Nov-Dec;141(6):597-610. Unique Identifier : AIDSLINE MED/91205116; Cassan M; Berteaux V; Angrand PO; Rousset JP; Groupe Fidelite de la Traduction et Differenciation; Cellulaire, URA CNRS 1354, Universite Paris, Orsay, France.; Translational errors are necessary so as to allow gene expression in various organisms. In retroviruses, synthesis of pol gene products necessitates either readthrough of a stop codon or frameshifting. Here we present an experimental system that permits quantification of translational errors in vivo. It consists of a
[Prevalence of retrovirus (HIV-1 and HTLV-I) infection in blood donors in the state of Yucutan, Mexico (letter)]: Sangre (Barc). 1990 Dec;35(6):489-90. Unique Identifier : AIDSLINE MED/91205406; Gongora-Biachi RA; Gonzalez-Martinez P; Puerto IF; Alvarez-Moguel R
Novel bacteriological assay for detection of potential antiviral agents.: Antimicrob Agents Chemother. 1990 Dec;34(12):2337-41. Unique Identifier : AIDSLINE MED/91207022; Block TM; Grafstrom RH; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107.; A prototype assay for the initial screening of potential antiviral agents that uses bacterial growth on selective media is described. The human immunodeficiency virus (HIV) protease recognition sequence was inserted into the tetracycline resistance (Tet) protein encoded by plasmid pBR322 of Escherichia coli. Expressio
Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives.: Antimicrob Agents Chemother. 1990 Dec;34(12):2358-63. Unique Identifier : AIDSLINE MED/91207026; Baba M; De Clercq E; Iida S; Tanaka H; Nitta I; Ubasawa M; Takashima H; Sekiya K; Umezu K; Nakashima H; et al; Department of Bacteriology, Fukushima Medical College, Japan.; The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t
In vitro susceptibility of Mycobacterium avium complex to the new fluoroquinolone sparfloxacin (CI-978; AT-4140) and comparison with ciprofloxacin.: Antimicrob Agents Chemother. 1990 Dec;34(12):2442-4. Unique Identifier : AIDSLINE MED/91207046; Yajko DM; Sanders CA; Nassos PS; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco General Hospital Medical Center 94110.; We tested the activity of the new fluoroquinolone sparfloxacin (CI-978; AT 4140) against 30 strains of Mycobacterium avium complex (MAC) isolated from patients with acquired immune deficiency syndrome. MICs of sparfloxacin (range, less than or equal to 0.06 to 4 micrograms/ml) were lower than MICs of ciprofloxacin for
Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.: Antiviral Res. 1990 Dec;14(6):345-56. Unique Identifier : AIDSLINE MED/91207060; Curley D; McGuigan C; Devine KG; O'Connor TJ; Jeffries DJ; Kinchington D; Department of Chemistry, University College London, U.K.; A series of phosphoramidate derivatives of the anti-HIV drug AZT has been prepared as membrane soluble pro-drugs of the bio-active nucleotide forms and evaluated in vitro against HIV-1. Terminal substituted alkyl amines have a pronounced anti-HIV effe
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.: Antiviral Res. 1990 Dec;14(6):357-69. Unique Identifier : AIDSLINE MED/91207061; Van Aerschot A; Everaert D; Gosselin G; Peeters O; Blaton N; De Ranter C; Imbach JL; Balzarini J; De Clercq E; Herdewijn P; Laboratory of Pharmaceutical Chemistry, Rega Institute for; Medical Research, Leuven, Belgium.; 1-(2-Azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)thymine (2 -N3ddThd) was synthesized from 1-(5-O-trityl-2,3-anhydro-beta-D-lyxofuranosyl)thymine by two different procedures. Method A prepared the title compound by opening of the oxirane ring with LiEt3BH followed by mesylation of the 2 -hydroxyl function, introdu
Why HIV antibody testing is unpopular [letter; comment]: Br J Hosp Med. 1990 Dec;44(6):385. Unique Identifier : AIDSLINE MED/91183289; Youle M
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1247-50. Unique Identifier : AIDSLINE MED/91175189; Emini EA; Schleif WA; Quintero JC; Conard PG; Eichberg JW; Vlasuk GP; Lehman ED; Polokoff MA; Schaeffer TF; Schultz LD; et al; Merck, Sharp and Dohme Research Laboratories, West Point, PA; 19486.; Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced i
Quantitative analysis of HIV-1 proviral DNA in peripheral blood mononuclear cells from patients with AIDS or ARC: decrease of proviral DNA content following treatment with 2',3'-dideoxyinosine (ddI).: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1331-9. Unique Identifier : AIDSLINE MED/91175200; Aoki S; Yarchoan R; Thomas RV; Pluda JM; Marczyk K; Broder S; Mitsuya H; Division of Cancer Treatment, National Cancer Institute, National; Institute of Health, Bethesda, MD 20892.; A rapid and simple method for determining the proviral DNA content in peripheral blood mononuclear cells (PBM) from patients with human immunodeficiency virus type 1 (HIV-1) infection was established by using the polymerase chain reaction (PCR) technique. We found that the majority of HIV proviral DNA copies detectabl
Identification of regions of HIV-1 p24 reactive with sera which give indeterminate results in electrophoretic immunoblots with the help of long synthetic peptides.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1363-72. Unique Identifier : AIDSLINE MED/91175203; Blomberg J; Vincic E; Jonsson C; Medstrand P; Pipkorn R; Department of Medical Microbiology, University of Lund, Sweden.; We analyzed nine sera from persons unlikely to be HIV infected which had an IgG reactivity directed against HIV-1 p24, and in two cases also to its precursor p55, but to no other HIV proteins, nor to proteins of the H9 host cell, in electrophoretic immunoblots (EIB). These sera are also referred to as having an indete
Malnutrition in patients with AIDS.: Nutr Rev. 1990 Nov;48(11):393-401. Unique Identifier : AIDSLINE MED/91179628; Hecker LM; Kotler DP; St. Luke's-Roosevelt Hospital Center, Columbia University College; of Physicians & Surgeons, New York, NY 10025.; Malnutrition is a frequent problem in persons infected with the human immunodeficiency virus. The origin of malnutrition in patients with AIDS may be multifactorial. The primary mechanisms include disorders of food intake, alterations in intermediary metabolism, and nutrient malabsorption. Attention to the problems of
Quantitation of didanosine in human plasma and urine by high-performance liquid chromatography.: J Chromatogr. 1990 Nov 30;533:282-90. Unique Identifier : AIDSLINE MED/91185516; Knupp CA; Stancato FA; Papp EA; Barbhaiya RH; Department of Metabolism and Pharmacokinetics, Bristol-Myers; Squibb Company, Syracuse, NY 13221.
An ELISA-inhibition assay for antibody to human immunodeficiency virus core antigen (p24).: J Virol Methods. 1990 Oct;30(1):109-14. Unique Identifier : AIDSLINE MED/91201497; Povolotsky J; Gold JW; Darminin P; Chein N; Baron P; Armstrong D; Infectious Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021.; An ELISA-inhibition assay based on commercially available HIV-1 p24 antigen tests was developed for detecting p24 antibodies. The test is specific and simple. p24 antibody was detectable in all p24 antigen negative Western blot positive sera, but was detectable infrequently in antigen positive sera. Sera from patients
Immune activation and decreased tryptophan in patients with HIV-1 infection.: J Interferon Res. 1990 Dec;10(6):599-603. Unique Identifier : AIDSLINE MED/91201935; Fuchs D; Forsman A; Hagberg L; Larsson M; Norkrans G; Reibnegger G; Werner ER; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; We compared tryptophan, neopterin, and interferon-gamma (IFN-gamma) concentrations in serum and cerebrospinal fluid (CSF) of 22 patients with human immunodeficiency virus type 1 (HIV-1) infection. Tryptophan levels were found to be decreased in CSF and serum of patients whereas neopterin levels in CSF and serum and se
HIV isolation from whole blood: a new approach to HIV detection.: Microbiologica. 1990 Oct;13(4):311-5. Unique Identifier : AIDSLINE MED/91203628; Fiore JR; Angarano G; Fico C; Monno L; Carbonara S; Salamina GF; Fracasso C; Pastore G; Clinic of Infectious Diseases, University of Bari, Policlinico; Hospital, Italy.; The authors present a simple and sensitive culture technique for isolation of Human Immunodeficiency Virus (HIV) from small amounts of heparinized whole blood. This method appeared to be highly sensitive at all stages of disease. Among asymptomatics HIV was isolated from 41.3% of subjects by using peripheral blood mon
[HIV diagnostics in the child--methodology, rational use and value]: Monatsschr Kinderheilkd. 1990 Dec;138(12):784-6. Unique Identifier : AIDSLINE MED/91203970; Grosch-Worner I; Eberle J; Kinderklinik und Poliklinik, Universitatsklinikum Rudolf; Virchow, FU Berlin.; The determination of an HIV infection in children of infected mothers has been a problem for years. Despite the development of new diagnostic methods, this problem has not been simplified. On the contrary, contradictions between the clinical courses and the laboratory results become ever more obvious and complicate th
HIV-related thrombocytopenia.: Immunodefic Rev. 1990;2(3):221-31. Unique Identifier : AIDSLINE MED/91175060; Oksenhendler E; Seligmann M; Laboratoire d'Immunochimie et d'Immunopathologie (INSERM U.108),; Hopital Saint Louis, Paris, France.; About 5-10% of HIV seropositive individuals, in all risk groups, develop a syndrome of immunological thrombocytopenic purpura (ITP). Despite the clear association between HIV infection and thrombocytopenia, the exact immune mechanism leading to the peripheral platelet destruction remains unclear. Whereas some data sup
Human immunodeficiency virus vpr gene encodes a virion-associated protein.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1265-71. Unique Identifier : AIDSLINE MED/91175192; Yuan X; Matsuda Z; Matsuda M; Essex M; Lee TH; Department of Cancer Biology, Harvard University School of Public; Health, Boston, MA 02115.; The vpr gene of human immunodeficiency virus type 1 (HIV-1) is one of the seven accessory genes that are believed to have roles in the virus replication cycle. We report here the detection of a 13 kD vpr protein in sucrose gradient-purified HIV-1. This protein was not detected in cells infected with a virus having a t
CD16+ NK cells decrease in all stages of HIV infection through a selective depletion of the CD16+CD8+CD3- subset.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1451-7. Unique Identifier : AIDSLINE MED/91175214; Mansour I; Doinel C; Rouger P; Institut National de Transfusion Sanguine, Paris, France.; Natural killer (NK) cell-related phenotypes were analyzed in human immunodeficiency virus (HIV) infection. Our study involved 168 HIV-infected patients (72 CDC Stage II, 48 Stage III, and 46 Stage IV) and 60 healthy individuals. Analyses were conducted using flow cytometry and monoclonal antibodies. In comparison to t
Current and future treatment of HIV infection.: Oncology (Huntingt). 1990 Nov;4(11):19-26, 29. Unique Identifier : AIDSLINE MED/91175335; Bartlett JA; Department of Medicine, Duke University Medical Center.; After much frustration in the last decade, HIV therapeutics is an emerging discipline. Over the past few years a number of new agents have been evaluated, including such antiviral drugs as zidovudine, dideoxycytidine and dideoxyinosine, and immunomodulators such as alpha interferon and interleukin-2. The author discus
[Atypical lumbar and nerve-root pain associated with the HTLV-1 virus]: Rev Rhum Mal Osteoartic. 1990 Dec;57(12):869-72. Unique Identifier : AIDSLINE MED/91180684; Jean-Baptiste G; Arfi S; Horreard F; Cheniere A; Vernant JC; Bokor J; Medecine Interne, Hopital Pierre Zobda-Quitman, Fort-de-France.; The human retrovirus HTLV-1 (Human T-cell Lymphotrophic Virus) is responsible for malignant proliferations of mature T lymphocytes. It is also now implicated in neurological disorders dominated by spastic paraplegia. A study of 140 cases of lumbar and root pain enabled us to identify 8 of apparently idiopathic atypica
[AIDS and tuberculosis--the status in Cologne]: Offentl Gesundheitswes. 1990 Jan;53(1):23-5. Unique Identifier : AIDSLINE MED/91187351; Muller H; Gesundheitsamt der Stadt Koln.; The incidence of tuberculosis among people with AIDS in the USA is about four per cent. This is one hundred to two hundred times the incidence of that of the general population. The aim of this study is to get more detailed information about the coincidence between HIV infection/AIDS illness and tuberculosis in Cologn
[Reported AIDS cases in the Federal Republic of Germany]: Offentl Gesundheitswes. 1990 Jan;53(1):41-4. Unique Identifier : AIDSLINE MED/91187354
[Epidemiologic aspects of the spread of HIV in Czechoslovakia]: Cesk Epidemiol Mikrobiol Imunol. 1990 Sep;39(5):257-64. Unique Identifier : AIDSLINE MED/91191629; Cervenka J; The author evaluates the present favourable epidemiological situation as regards AIDS in Czechoslovakia. He submits some suggestions for discussion and practice AIDS--control for epidemiologists as well as doctors of other medical disciplines: routine examination of anti-HIV in the population, denominator data (number
Methotrexate therapy for Reiter's syndrome: importance of HIV antibody testing [letter; comment]: J Assoc Physicians India. 1990 Oct;38(10):814-5. Unique Identifier : AIDSLINE MED/91193182; Chogle AR
[Infection by the human immunodeficiency virus in the Spanish population (II). A meta-analysis of the time and geographic trends]: Med Clin (Barc). 1990 Sep 29;95(10):366-71. Unique Identifier : AIDSLINE MED/91194351; Fernandez Sierra MA; Gomez Olmedo M; Delgado Rodriguez M; Galvez Vargas R; Catedra de Medicina Preventiva, Facultad de Medicina,; Universidad de Granada.; The aim of this research was to study the prevalence of infection by the human immunodeficiency virus (HIV) among the Spanish population. Due to the lack of available data we have applied meta-analysis techniques. We analyzed 67 original publications on this field appeared between 1985 and 1989. The prevalence of the
Recent advances in research on tryptases and endogenous tryptase inhibitors.: Monogr Allergy. 1990;27:51-66. Unique Identifier : AIDSLINE MED/91194713; Katunuma N; Kido H; Institute for Enzyme Research, University of Tokushima, Japan.
AIDS and dentistry in South Africa.: J Dent Assoc S Afr. 1990 Jul;45(7):325-6. Unique Identifier : AIDSLINE MED/91196036; Maresky L; Oral and Dental Teaching Hospital, University of Stellenbosch,; Tygerberg 7505.
The AIDS figures [letter]: J Dent Assoc S Afr. 1990 Jul;45(7):344. Unique Identifier : AIDSLINE MED/91196039
The FC and not CD4 receptor mediates antibody enhancement of HIV infection in human cells [editorial]: Dis Markers. 1990 Sep-Oct;8(5):297-8. Unique Identifier : AIDSLINE MED/91199547
Feline immunodeficiency virus (FIV) infection in the cat as a model for HIV infection in man: FIV-induced impairment of immune function.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1373-8. Unique Identifier : AIDSLINE MED/91175204; Siebelink KH; Chu IH; Rimmelzwaan GF; Weijer K; van Herwijnen R; Knell P; Egberink HF; Bosch ML; Osterhaus AD; Laboratory of Immunobiology, National Institute of Public Health; and Environmental Protection, Bilthoven, The Netherlands.; To assess the value of feline immunodeficiency virus (FIV) infection as a model for human immunodeficiency virus (HIV) infection in man, we studied the impairment of certain immunological functions following natural or experimental FIV infection. Proliferative responses of peripheral blood mononuclear cells (PBMC) fro
Exposure factors for HIV-1 infection among heterosexual drug abusers in New Jersey treatment programs [published erratum appears in AIDS Res Hum Retroviruses 1991 Mar;7(3):360]: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1459-67. Unique Identifier : AIDSLINE MED/91175215; Caussy D; Weiss SH; Blattner WA; French J; Cantor KP; Ginzburg H; Altman R; Goedert JJ; Environmental Epidemiology Branch, National Cancer Institute,; Rockville, MD.; In a cross-sectional study of 926 subjects from 10 drug treatment programs conducted in 1984 in New Jersey, the seroprevalence of human immunodeficiency virus (HIV) was 35% overall; 30% in whites, 33% in hispanics, and 46% in blacks (p = 0.01 for comparison of blacks to non-blacks). Univariate analysis showed the sero
Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein.: New Biol. 1990 Oct;2(10):894-902. Unique Identifier : AIDSLINE MED/91175707; Ruben SM; Rosen CA; Department of Molecular Oncology and Virology, Roche Institute of; Molecular Biology, Roche Research Center, Nutley, NJ 07110.; Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I (HTLV-I) leads to activation of the pleiotropic transcription factor NF-kappa B. Consistent with findings obtained with transient expression assays, we observed marked accumulation of the transcription factor NF-kappa B in the nuc
Epstein-Barr virus infection rapidly progressing to monoclonal lymphoproliferative disease in a child with selective immunodeficiency.: Eur J Pediatr. 1990 Nov;150(1):48-53. Unique Identifier : AIDSLINE MED/91177039; Schuster V; Kreth HW; Muller-Hermelink HK; Huppertz HI; Feller AC; Neumann-Haefelin D; Wiegand H; Muller-Lantzsch N; Department of Paediatrics, University of Wurzburg, Federal; Republic of Germany.; We report on a 30-month-old previously healthy Turkish boy who presented with fever, hepatosplenomegaly and generalized lymphadenopathy. He died 4 months after admission in spite of treatment with steroids, acycloguanosine and cyclophosphamide. Epstein-Barr virus (EBV) DNA was detected in the patient s bone marrow and
[Serological markers of viral infections and various indicators of immunity in patients with hemophilia]: Gematol Transfuziol. 1990 Oct;35(10):21-3. Unique Identifier : AIDSLINE MED/91177288; Golosova TV; Somova AV; Margolina AN; Tupoleva TA; Vavilova LM; Kuz'micheva MIu; Likhacheva EA; Pliushch OP; The authors have studied the incidence rate for markers of viruses of AIDS (HIV), hepatitis B (HBV) and cytomegalia ( CMV ), as well as certain parameters of antiinfectious defense in hemophilia patients. A high incidence rate of HBV and CMV markers was establishe
Neurobiology of human oligodendrocytes in culture.: J Neurosci Res. 1990 Dec;27(4):712-28. Unique Identifier : AIDSLINE MED/91178859; Kim SU; Division of Neurology, University of British Columbia, Vancouver,; Canada.; Enriched populations of oligodendrocytes were isolated from adult human brains of 3-15 hours postmortem using the trypsinin digestion-Percoll density gradient method and were cultured for an extended period of time up to 6 months. Cell type specific antigens that were expressed by oligodendrocytes were galactocerebros
[The acquired immunodeficiency syndrome (AIDS) in childhood]: Medicina (Firenze). 1990 Jul-Sep;10(3):256-62. Unique Identifier : AIDSLINE MED/91179318; Terragna A; Ferrazin A; Gotta C; Wenda-Ciravegna B; I Clinica delle Malattie Infettive, Universita di Genova,; Divisione Pediatrica.; There is an increasing concern about HIV infection in paediatric age, due to its increasing incidence in some countries, especially in Europe, and due to its social aspects. HIV infection has particular features, while occurring during paediatric age: infection of child frequently occurs during pregnancy (perinatal fo
Ganciclovir: approved and investigational uses for the treatment of cytomegalovirus retinitis.: Mt Sinai J Med. 1990 Nov;57(6):378-80. Unique Identifier : AIDSLINE MED/91179446; MacArthur RB; Department of Pharmacy, Mount Sinai Medical Center, New York, NY.
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine.: Antiviral Res. 1990 Jul;14(1):11-23. Unique Identifier : AIDSLINE MED/91181859; Puech F; Gosselin G; Balzarini J; Good SS; Rideout JL; De Clercq E; Imbach JL; Laboratoire de Chimie Bio-organique, Universite des Sciences et; Techniques du Languedoc, Montpellier, France.; The 5 ----5 dinucleoside methylphosphonates of 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -dideoxycytidine (DDC) were prepared and evaluated for their inhibitory properties against different viruses, including human immunodeficiency virus (HIV). The s
Amphotropic murine leukemia retrovirus is not an acute pathogen for primates.: Hum Gene Ther. 1990 Spring;1(1):15-30. Unique Identifier : AIDSLINE MED/91182885; Cornetta K; Moen RC; Culver K; Morgan RA; McLachlin JR; Sturm S; Selegue J; London W; Blaese RM; Anderson WF; Laboratory of Molecular Hematology, National Heart Lung and Blood; Institute, National Institutes of Health, Bethesda, MD 20892.; The in vivo fate of amphotropic murine leukemia retrovirus was studied in five rhesus monkeys. Retrovirus infused intravenously into 3 normal animals and 1 immunosuppressed animal was cleared rapidly from the circulation and subsequent viremia has not been detected (mean follow-up of 27.4 months). A fifth monkey was i
[Herpetic immunodeficiency as a condition for a generalized pathologic process (editorial)]: Vopr Virusol. 1990 Nov-Dec;35(6):524-6. Unique Identifier : AIDSLINE MED/91188612
Axonal atrophy in the painful peripheral neuropathy in AIDS.: Acta Neuropathol (Berl). 1990;81(2):198-203. Unique Identifier : AIDSLINE MED/91188815; Fuller GN; Jacobs JM; Guiloff RJ; Department of Neuropathology, Institute of Neurology, London,; Great Britain.; We compared the sural nerves from patients with AIDS; four with the painful peripheral neuropathy (PPN), three patients with non-painful distal symmetrical peripheral neuropathy (DSPN), one without clinical peripheral nerve involvement and two human immunodeficiency v
Ganciclovir therapy for opportunistic cytomegalovirus disease in AIDS.: AIDS Clin Rev. 1990;:149-63. Unique Identifier : AIDSLINE MED/91190661; Jacobson MA; University of California, San Francisco.
Asymptomatic herpes simplex virus shedding from the genital tract whilst on suppressive doses of oral acyclovir.: Int J STD AIDS. 1990 May;1(3):174-7. Unique Identifier : AIDSLINE MED/91190991; Bowman CA; Woolley PD; Herman S; Clarke J; Kinghorn GR; Department of Genito-urinary Medicine, General Infirmary, Leeds,; UK.; Forty-eight patients were recruited into a study of continuous oral acyclovir therapy for the suppression of recurrent genital herpes simplex virus (HSV) infection. Seven of these patients were shown to shed HSV in the absence of clinical
Incidence of herpes simplex virus type-1 and type-2 from patients with primary (first-attack) genital herpes in Sheffield.: Int J STD AIDS. 1990 May;1(3):184-6. Unique Identifier : AIDSLINE MED/91190994; Woolley PD; Kudesia G; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.; In a study to determine the herpes simplex virus (HSV) type isolated from patients with primary (first-attack) genital herpes and to identify any clinical or epidemiological features that might influence the reported incidence of any particular viral type, there was almost an eq
Clinical and laboratory study of first episode genital herpes in Singapore.: Int J STD AIDS. 1990 May;1(3):195-8. Unique Identifier : AIDSLINE MED/91190997; Cheong WK; Thirumoorthy T; Doraisingham S; Ling AE; Middle Road Hospital, National Skin Centre, Singapore.; A prospective study of the epidemiology, clinical aspects and laboratory features of first episode genital herpes was carried out in Middle Road Hospital, Singapore between June 1986 and December 1987. A total of 68 patients were studied.
High-performance liquid chromatographic method for the analysis of 2',3'-dideoxycytidine in human plasma [letter]: J Chromatogr. 1990 Nov 16;532(2):442-4. Unique Identifier : AIDSLINE MED/91193334; Hawkins ME; Poplack DG; Pizzo PA; Balis FM
A chronic postinfectious fatigue syndrome associated with benign lymphoproliferation, B-cell proliferation, and active replication of human herpesvirus-6.: J Clin Immunol. 1990 Nov;10(6):335-44. Unique Identifier : AIDSLINE MED/91193351; Buchwald D; Freedman AS; Ablashi DV; Sullivan JL; Caligiuri M; Weinberg DS; Hall CG; Ashley RL; Saxinger C; Balachandran N; et al; University of Washington School of Medicine, Seattle 98121.; A 17-year-old, previously healthy woman developed an acute mononucleosis-like illness with an associated atypical pneumonitis, followed by years of debilitating chronic fatigue, fevers, a 10-kg weight loss, night sweats, and neurocognitive symptoms. Thereafter, her sister developed a similar but less severe illness. T
[The clinician and cytomegalovirus infections (editorial)]: Med Clin (Barc). 1990 Sep 29;95(10):380-4. Unique Identifier : AIDSLINE MED/91194354; Almirante Gragera B; Pahissa Berga A
Cytomegalovirus (CMV) encephalomyeloradiculitis and human immunodeficiency virus (HIV) encephalitis: presence of HIV and CMV co-infected multinucleated giant cells.: Acta Neuropathol (Berl). 1990;81(1):99-104. Unique Identifier : AIDSLINE MED/91196484; Belec L; Gray F; Mikol J; Scaravilli F; Mhiri C; Sobel A; Poirier J; Departement de Pathologie (Neuropathologie), Hopital Henri; Mondor, Creteil, France.; A 25-year-old homosexual male with AIDS presented with a cauda equina syndrome clinically suggestive of cytomegalovirus ( CMV ) myeloradiculitis. He was treated with ganciclovir with transient improvement of neurological signs
[Circulatory disturbances in patients with AIDS]: Chung Hua I Hsueh Tsa Chih (Taipei). 1990 Sep;70(9):508. Unique Identifier : AIDSLINE MED/91198952; Xiu R
Oral hairy leukoplakia in AIDS patients: an ultrastructural study.: J Dermatol. 1990 Dec;17(12):729-36. Unique Identifier : AIDSLINE MED/91201625; Manca V; Mongiardo N; Pellegrino F; De Rienzo B; Giannetti A; Clinica Dermatologica, University of Modena, Italy.; Hairy leukoplakia is a specific oral lesion associated with the opportunistic development of Epstein-Barr virus in the oral epithelium. It is now considered to be an early sign of HIV-induced immunosuppression. Four cases of oral hairy leukoplakia (OHL) from the lateral borders of the tongue of male AIDS patients were
Amplification of DNA sequences of Epstein-Barr and human immunodeficiency viruses using DNA-polymerase from Thermus thermophilus.: Mol Cell Probes. 1990 Dec;4(6):435-43. Unique Identifier : AIDSLINE MED/91203954; Glukhov AI; Gordeev SA; Vinogradov SV; Kiselev VI; Kramarov VM; Kiselev OI; Severin ES; Research Center of Molecular Diagnostics, USSR Ministry of; Health, Moscow.; Using thermophilic DNA-polymerase from Thermus thermophilus we have amplified by polymerase chain reaction (PCR) specific DNA sequences of Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). DNA-polymerase from Thermus thermophilus (molecular mass of 80-86 kDa) differs in its physico-chemical properties f
[Prevention and therapeutical trials of a few current viral diseases]: Ann Pharm Fr. 1990;48(5):231-41. Unique Identifier : AIDSLINE MED/91206842; German A; Fattal-German M; Laboratoire de Virologie et Immunologie, Faculte de Pharmacie,; Universite de Paris XI, Chatenay-Malabry.; Vaccines afford now good prevention of many viral diseases including Hepatitis B. In revenge, attempts of immunization against Herpes Virus types I and II did not result in large scale application of vaccination. Research for a vaccine against HIV encounters many difficulties due to virus variability and host reaction
Effects of pentamidine alone and in combination with ketoconazole or itraconazole on the growth of Candida albicans.: Antimicrob Agents Chemother. 1990 Dec;34(12):2304-6. Unique Identifier : AIDSLINE MED/91207016; St-Germain G; Laboratoire de Sante Publique du Quebec,; Sainte-Anne-de-Bellevue, Canada.; The in vitro interaction of pentamidine with ketoconazole and with itraconazole was studied with 10 strains of Candida albicans isolated from acquired immunodeficiency syndrome patients and one azole-resistant strain. Although growth curves indicated that concentrations of 1 microgram or more of pentamidine per ml sig
Vaccine and AIDS. San Marino Conference. Republic of San Marino, October 7-11, 1990. Abstracts.: AIDS Res Hum Retroviruses. 1990 Nov;6(11):1341-60. Unique Identifier : AIDSLINE MED/91175201
Human immunodeficiency virus (HIV) circulating immune complexes in infected children.: AIDS Res Hum Retroviruses. 1990 Dec;6(12):1437-41. Unique Identifier : AIDSLINE MED/91175212; Ellaurie M; Calvelli TA; Rubinstein A; Albert Einstein College of Medicine, Department of Pediatrics,; Bronx, NY.; Circulating immune complexes (CIC) were studied for the presence of human immunodeficiency virus (HIV) antigens (HIV-Ag) in 55 children infected by the human immunodeficiency virus type 1 (HIV-1). CIC were elevated in 85% of patients. In 33 of 55 patients CIC included at least one HIV-Ag (HIV-Ag-CIC). Sixty percent of
Human immunodeficiency virus type-2 gene expression: two enhancers and their activation by T-cell activators.: New Biol. 1990 Jan;2(1):57-65. Unique Identifier : AIDSLINE MED/91175694; Arya SK; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; The human immunodeficiency viruses (HIVs) may include a spectrum of retroviruses with varying potential to infect their host, undergo long periods of latent infection, and induce pathology. Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats (LTRs), this s
Acquired immune deficiency syndrome and the developing nervous system.: MACOLOGY World Health JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC Int Rev Neurobiol. 1990;32:305-53. Unique Identifier : AIDSLINE MED/91177673; Brenneman DE; McCune SK; Gozes I; Unit on Neurochemistry, National Institute of Child Health and; Human Development, National Institutes of Health, Bethesda,; Maryland 20892.; �� -|�|
Global warfare against AIDS, report on the Sixth International Conference on AIDS, San Francisco, California, 20-25 June, 1990.: Midwifery. 1990 Dec;6(4):224-6. Unique Identifier : AIDSLINE MED/91179381; Lachat MF; Reports of AIDS cases continue to increase in all countries. Heterosexual transfer is on the rise with subsequent implications for maternity care. Young men and women at the beginning of their sexual lives are at great risk for HIV exposure since unprotected sexual intercourse is rampant. Behaviour changes are necessa
Use of DNA amplification for rapid detection of dengue viruses in midgut cells of individual mosquitoes.: Res Virol. 1990 Jul-Aug;141(4):455-7. Unique Identifier : AIDSLINE MED/91180465; Tardieux I; Poupel O; Unite d'Ecologie des systemes vectoriels, Institut Pasteur,; Paris.
HIV-1 variability and progression to AIDS: a longitudinal study.: J Med Virol. 1990 Dec;32(4):252-6. Unique Identifier : AIDSLINE MED/91186120; Fiore JR; Calabro ML; Angarano G; De Rossi A; Fico C; Pastore G; Bianchi LC; Clinic of Infectious Diseases, University of Bari, Italy.; HIV-1 replicative activity and its relation to the clinical and immunological evolution of infection was studied in a group of 150 HIV-1 seropositive Italian i.v. drug abusers over a 1 year period. HIV-1 was isolated from 90 (60%) subjects; two groups of isolates were distinguished, according to replicative activity i
[Human immunodeficiency virus type 2 infection: is it really present in our area? (letter)]: Med Clin (Barc). 1990 Oct 6;95(11):436-7. Unique Identifier : AIDSLINE MED/91186743; Corzo JE; Calderon E; Rey C; Leal M
Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1 [editorial]: Dis Markers. 1990 Sep-Oct;8(5):295-6. Unique Identifier : AIDSLINE MED/91199544
Effect of HIV-1 infection on CD4 cells in a hemophilia cohort.: Haematologica. 1990 Sep-Oct;75 Suppl 5:132-41. Unique Identifier : AIDSLINE MED/91200719; Green D; Deutsche J; Tang M; Goldsmith J; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois.
Mild brain atrophy in early HIV infection: the lack of association with cognitive deficits and HIV-specific intrathecal immune response.: J Neurol Sci. 1990 Nov;99(2-3):121-36. Unique Identifier : AIDSLINE MED/91202170; Elovaara I; Poutiainen E; Raininko R; Valanne L; Virta A; Valle SL; Lahdevirta J; Iivanainen M; Department of Neurology, University of Helsinki, Finland.; Brain MRI and/or CT were performed on 72 HIV-infected patients at various stages of the disease, and on 34 controls. The neuroradiological findings were related to duration of the infection, neurological symptoms, and cognitive abnormalities as well as to immunological findings in the CSF and blood. All types of brain
Susceptibility of bacterial isolates from AIDS patients to six fluoroquinolones.: J Pharm Pharmacol. 1990 Nov;42(11):808-9. Unique Identifier : AIDSLINE MED/91202345; Lewin CS; Naden M; Watt B; Amyes SG; Bacteriology Department, University Medical School, Edinburgh,; UK.; The susceptibilities to ciprofloxacin, DR-3355 (S-(-)-ofloxacin), enoxacin, lomefloxacin, ofloxacin and PD127,391 of 69 significant bacterial isolates from HIV-positive patients at the City Hospital, Edinburgh have been determined. With the exception of the enterococci, most of the strains tested (including staphyloco
Recognition of oral lesions of HIV infection [letter; comment]: Br Dent J. 1991 Feb 9;170(3):91. Unique Identifier : AIDSLINE MED/91175260; Hay IS
The level of risk of transmission of human immunodeficiency virus between patients and dental staff [see comments]: Br Dent J. 1991 Feb 9;170(3):97-100. Unique Identifier : AIDSLINE MED/91175261; Scully C; Porter S; University Department of Oral Medicine, Bristol Dental Hospital; and School.; Almost a decade into the epidemic of acquired immunodeficiency syndrome (AIDS) there is adequate evidence to address the concerns of dental staff about possible transmission of human immunodeficiency virus (HIV) between patient and staff. This paper reviews that evidence and demonstrates that the risk of HIV transmiss
Tuberculosis and HIV infection.: Wkly Epidemiol Rec. 1991 Jan 25;66(4):19, 22-3. Unique Identifier : AIDSLINE MED/91175343
Effects of a peer-counseled AIDS education program on knowledge, attitudes, and satisfaction of adolescents.: J Adolesc Health. 1991 Jan;12(1):38-43. Unique Identifier : AIDSLINE MED/91175775; Rickert VI; Jay MS; Gottlieb A; University of Arkansas for Medical Sciences, Arkansas Children's; Hospital, Department of Pediatrics, Little Rock 72202.; Education programs for adolescents regarding acquired immunodeficiency syndrome (AIDS) have been advocated by many professionals to help minimize the risk of infection in this population. This study compares a peer-led vs. an adult-led AIDS education program on the knowledge, attitudes, and satisfaction of the adolesc
HIV-relevant sexual behavior among a healthy inner-city heterosexual adolescent population in an endemic area of HIV.: J Adolesc Health. 1991 Jan;12(1):44-8. Unique Identifier : AIDSLINE MED/91175777; Keller SE; Bartlett JA; Schleifer SJ; Johnson RL; Pinner E; Delaney B; Department of Psychiatry, New Jersey Medical School, Newark.; The AIDS crisis has devastated segments of the population including the gay community and those who use intravenous drugs. HIV has spread to other groups including prostitutes and those with other sexually transmitted diseases. We have been studying adolescents in a major Northeast city where there is a major HIV/AIDS
Transgenic mice carrying HIV proviral DNA.: Biotechnology. 1991;16:213-26. Unique Identifier : AIDSLINE MED/91176322; Pezen DS; Leonard JM; Abramczuk JW; Martin MA
Adrenal crisis.: Crit Care Clin. 1991 Jan;7(1):23-42. Unique Identifier : AIDSLINE MED/91176427; Chin R; Department of Medicine, Bowman Gray School of Medicine of Wake; Forest University, Winston-Salem, North Carolina.; In the case study presented in this article, the patient had many of the historical risk factors for bilateral adrenal hemorrhage that Rao outlined. He had recently undergone surgery and was receiving heparin for anticoagulation for a thromboembolic event. Further clues included his fever, hypotension refractory to pr
CMA Code of Ethics: time for a change!: Can Med Assoc J. 1991 Apr 1;144(7):855-7. Unique Identifier : AIDSLINE MED/91176468; Griener GG; Division of Biomedical Ethics and Humanities, University of; Alberta, Edmonton.
Mycobacterial avium-intracellulare infection of a renal allograft [letter]: Clin Nephrol. 1991 Jan;35(1):45-6. Unique Identifier : AIDSLINE MED/91176661; Sumrani N; Delaney V; Hong JH; Sommer BG
AIDS, the patient and the physician [news]: Colo Med. 1991 Feb;88(2):1 p. prior to 36. Unique Identifier : AIDSLINE MED/91176713; Best KB
Squamous cell carcinoma of the anus and HIV infection.: Dis Colon Rectum. 1991 Apr;34(4):336-8. Unique Identifier : AIDSLINE MED/91176814; Lorenz HP; Wilson W; Leigh B; Crombleholme T; Schecter W; Department of Surgery, University of California, San Francisco; 94110.; We retrospectively reviewed six patients with squamous cell carcinoma of the anus (SCCA) and human immunodeficiency virus (HIV) infection treated between 1985 and 1988. All six patients were homosexual men. Five patients had AIDS and one was HIV-positive. The most common symptoms and signs were pain (n = 5), mass (n =
Pilot study of sandostatin (octreotide) therapy of refractory HIV-associated diarrhea.: Dig Dis Sci. 1991 Apr;36(4):476-80. Unique Identifier : AIDSLINE MED/91176831; Fanning M; Monte M; Sutherland LR; Broadhead M; Murphy GF; Harris AG; Department of Medicine, University of Toronto, Ontario, Canada.; Seventeen AIDS patients were enrolled in a prospective open-label dose-finding study of octreotide (Sandostatin) therapy for refractory diarrhea. Five were nonevaluable due to progression of AIDS symptomatology, and one was excluded because of lack of confirmation of HIV infection. Five of 11 evaluable patients respon
Kaposi's sarcoma of the colon in a young HIV-negative woman with Crohn's disease.: Dig Dis Sci. 1991 Apr;36(4):528-31. Unique Identifier : AIDSLINE MED/91176841; Puy-Montbrun T; Pigot F; Vuong PN; Ganansia R; Denis J; Department of Colo-Proctology, Hospital Leopold, Paris, France.; We report a case of isolated colonic Kaposi s sarcoma in a 36-year-old HIV-negative woman with refractory Crohn s disease of the colon and perineum following 11 months treatment with azathioprine. The clinical features of this case are quite different from those classically described in Kaposi s sarcoma. Among the kn
Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome.: J Biol Chem. 1991 Apr 5;266(10):6280-90. Unique Identifier : AIDSLINE MED/91177878; Higgins EA; Siminovitch KA; Zhuang DL; Brockhausen I; Dennis JW; Samuel Lunenfeld Research Institute, Mount Sinai Hospital,; Toronto, Ontario, Canada.; The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive immunodeficiency affecting B lymphocytes, T lymphocytes, and platelets. Previous studies on lymphocytes from WAS patients have revealed that leu-kosialin (CD43), a cell-surface glycoprotein bearing approximately 90 O-linked oligosaccharide chains, shows an ab
Performance of cryptococcus antigen latex agglutination kits on serum and cerebrospinal fluid specimens of AIDS patients before and after pronase treatment.: J Clin Microbiol. 1991 Feb;29(2):333-9. Unique Identifier : AIDSLINE MED/91178059; Hamilton JR; Noble A; Denning DW; Stevens DA; Department of Pathology, Santa Clara Valley Medical Center, San; Jose, California.; Cryptococcal antigen titers in 97 serum and 42 cerebrospinal fluid (CSF) specimens from 37 AIDS patients with culture-proven cryptococcal infection were determined with the Meridian kit (Meridian Diagnostics Inc., Cincinnati, Ohio) before and after treatment with pronase. The geometric mean titers before and after pro
Isolation of Chlamydia pneumoniae from the lungs of patients infected with the human immunodeficiency virus.: J Clin Microbiol. 1991 Feb;29(2):401-2. Unique Identifier : AIDSLINE MED/91178073; Augenbraun MH; Roblin PM; Chirgwin K; Landman D; Hammerschlag MR; Department of Medicine, State University of New York-Health; Science Center, Brooklyn 11203.; Chlamydia pneumoniae is being recognized as a common cause of respiratory tract infections. Bronchoalveolar lavage specimens from human immunodeficiency virus-infected patients were examined by culture for this pathogen. Of 50 specimens examined, 5 (10%) were positive for C. pneumoniae. Four of these (80%) were also p
Pruritic papular eruption of the acquired immunodeficiency syndrome: a clinicopathologic study [see comments]: J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):231-5. Unique Identifier : AIDSLINE MED/91178115; Hevia O; Jimenez-Acosta F; Ceballos PI; Gould EW; Penneys NS; Department of Dermatology and Cutaneous Surgery, University of; Miami.; The pruritic papular eruption of the acquired immunodeficiency syndrome is characterized by generalized, pruritic, skin-colored papules and nodules. Chronic lesions are excoriated and hyperpigmented. The eruption and pruritus typically wax and wane and are resistant to oral antihistamine and topical steroid therapy. T
Multiple primary malignant melanomas in an HIV-positive man.: J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):284-5. Unique Identifier : AIDSLINE MED/91178126; van Ginkel CJ; Sang RT; Blaauwgeers JL; Schattenkerk JK; Mooi WJ; Hulsebosch HJ; Department of Dermatology, University of Amsterdam, The; Netherlands.
Endoscopy in the diagnosis of gastrointestinal Mycobacterium avium-intracellulare infection.: J Clin Gastroenterol. 1991 Feb;13(1):20-4. Unique Identifier : AIDSLINE MED/91178208; Monsour HP Jr; Quigley EM; Markin RS; Dalke DD; Goldsmith JC; Harty RF; Department of Internal Medicine, University of Nebraska Medical; Center, Omaha 68198-2000.; Two cases of mycobacterium avium-intracellulare (MAI) infection in association with acquired immunodeficiency syndrome (AIDS) are presented to highlight the distinctive upper gastrointestinal endoscopic appearances: 2 X 4 mm diameter, white nodules with intervening erythema and hemorrhagic erosions covered the mucosa
Pancreatic involvement in human immunodeficiency virus infection.: J Clin Gastroenterol. 1991 Feb;13(1):58-64. Unique Identifier : AIDSLINE MED/91178217; Bonacini M; Department of Medicine, Truman Medical Center, Kansas City,; Missouri.; Involvement of the pancreas by human immunodeficiency virus (HIV) infection has not been adequately addressed and is the object of this review. I analyzed the English language literature, including single case reports of pancreatic involvement and larger series reporting detailed pathological findings of patients with
Cryptosporidium infection in acquired immunodeficiency syndrome: not always a poor prognosis.: J Clin Gastroenterol. 1991 Feb;13(1):94-7. Unique Identifier : AIDSLINE MED/91178226; Saltzberg DM; Kotloff KL; Newman JL; Fastiggi R; Department of Medicine, University of Maryland School of; Medicine, Baltimore.; Chronic diarrhea and malabsorption accompanied by simultaneous infection with the protozoa Giardia lamblia and Cryptosporidium occurred in a 22-year-old homosexual man with antibody to human immunodeficiency virus (HIV). Small bowel biopsy demonstrated total villous atrophy and marked mononuclear infiltration in the l
Living with HIV infection: adaptive tasks of seropositive gay men.: J Health Soc Behav. 1991 Mar;32(1):17-32. Unique Identifier : AIDSLINE MED/91178229; Siegel K; Krauss BJ; Memorial Sloan-Kettering Cancer Center.; With improved understanding of the natural history of HIV/AIDS and the availability of effective early intervention, HIV infection recently has come to be conceptualized as a chronic illness. As we enter the next phase of the epidemic, insights into the challenges of daily living faced by seropositive persons will aid
Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells.: J Exp Med. 1991 Apr 1;173(4):881-7. Unique Identifier : AIDSLINE MED/91178449; Klinman DM; Higgins KW; Conover J; Division of Virology, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892.; The gp120 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) is a dominant target against which the host s humoral immune response is directed. Unfortunately, gp120 proteins from different isolates of HIV are antigenically distinct, complicating the use of the envelope glycoprotein in vaccines design
Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome.: J Exp Med. 1991 Apr 1;173(4):981-91. Unique Identifier : AIDSLINE MED/91178459; Wahl SM; Allen JB; McCartney-Francis N; Morganti-Kossmann MC; Kossmann T; Ellingsworth L; Mai UE; Mergenhagen SE; Orenstein JM; Laboratory of Immunology, National Institute of Dental Research,; National Institutes of Health, Bethesda, Maryland 20892.; The multifunctional cytokine, transforming growth factor beta (TGF-beta), was identified by immunocytochemistry in the brain tissues of four patients with acquired immune deficiency syndrome (AIDS), but not in control brain tissue. The TGF-beta staining was localized to cells of monocytic lineage as well as astrocytes
Adrenal function in children infected with human immunodeficiency virus [letter; comment]: J Pediatr. 1991 Apr;118(4 ( Pt 1)):655. Unique Identifier : AIDSLINE MED/91178611; Oberfield SE; Levine LS
Therapy for acute infectious diarrhea in children.: J Pediatr. 1991 Apr;118(4 ( Pt 2)):S118-28. Unique Identifier : AIDSLINE MED/91178617; Pickering LK; Department of Pediatrics, University of Texas Medical School,; Houston 77030.; This article reviews current recommendations of therapy with antidiarrheal compounds and antimicrobial agents for acute infectious diarrhea in children. In most infants and children with acute infectious diarrhea, treatment with antidiarrheal compounds is not indicated. Many of these compounds interfere with identific
Reciprocal activation of human T-lymphotropic viruses in HTLV-I-transformed cells superinfected with HIV-1.: J Acquir Immune Defic Syndr. 1991;4(4):380-5. Unique Identifier : AIDSLINE MED/91178671; De Rossi A; Saggioro D; Calabro ML; Cenzato R; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.; The finding of dual HTLV-I and HIV-1 infection in populations at risk for AIDS raises the possibility that interaction between the two viruses might have clinical significance. It was shown that HTLV-I enhances HIV-1 expression, but whether HIV-1 activates HTLV-I remains to be demonstrated. To study HTLV-I behaviour f
Characterization of long-term survivors of acquired immunodeficiency syndrome. The Long-term Survivor Collaborative Study Group.: J Acquir Immune Defic Syndr. 1991;4(4):386-91. Unique Identifier : AIDSLINE MED/91178672; Hardy AM; Of 4,073 reported patients diagnosed with AIDS from 1978 through 1983, 821 (20%) were not reported to be dead by January 1987. Of these apparent long-term survivors, 780 (95%) were reported from 14 states or from local areas where collaborating health departments conducted special follow-up investigations: 119 (15%) w
National AIDS incidence trends and the extent of zidovudine therapy in selected demographic and transmission groups.: J Acquir Immune Defic Syndr. 1991;4(4):392-401. Unique Identifier : AIDSLINE MED/91178673; Rosenberg PS; Gail MH; Schrager LK; Vermund SH; Creagh-Kirk T; Andrews EB; Winkelstein W Jr; Marmor M; Des Jarlais DC; Biggar RJ; et al; Epidemiologic Methods Section, National Cancer Institute,; Rockville, MD 20892.; After mid-1987 fewer than the expected number of cases of AIDS were reported in the United States in some demographic and transmission groups but not in others. Gay men (regardless of intravenous drug use), adults with hemophilia, and transfusion recipients exhibited fewer cases than e
Blind serosurvey of HIV antibodies in newborns in 92 Italian hospitals: a method for monitoring the infection rate in women at time of delivery.: J Acquir Immune Defic Syndr. 1991;4(4):402-7. Unique Identifier : AIDSLINE MED/91178674; Ippolito G; Costa F; Stegagno M; Angeloni P; Angeloni U; Guzzanti E; AIDS Unit L. Spallanzani Hospital for Infectious Diseases, Rome,; Italy.; In Italy , drug abusers are the major risk category for HIV infection, representing 67% of all the reported cases of AIDS. This can in part explain the higher incidence of the infection observed in Italian females (17.7%) in comparison with the data reported in Europe (11.5%) or in t
High incidence of hepatitis B infection and evolution of chronic hepatitis B infection in patients with advanced HIV infection.: J Acquir Immune Defic Syndr. 1991;4(4):416-20. Unique Identifier : AIDSLINE MED/91178676; Homann C; Krogsgaard K; Pedersen C; Andersson P; Nielsen JO; Department of Immunology and Rheumatology, Hvidovre Hospital,; University of Copenhagen, Denmark.; Two hundred eleven HIV-seropositive patients with AIDS, AIDS-related complex, or a CD4+ cell count less than 200 x 10(6) were examined for the presence of hepatitis B virus markers during the course of their HIV infection (median follow-up of 18 months; range of 1 to 107 months). Anti-HBs was detected initially in 138
HIV-2 and HIV-1 AIDS cases in Senegal: clinical patterns and immunological perturbations.: J Acquir Immune Defic Syndr. 1991;4(4):421-7. Unique Identifier : AIDSLINE MED/91178677; Le Guenno BM; Barabe P; Griffet PA; Guiraud M; Morcillo RJ; Peghini ME; Jean PA; M'Baye PS; Diallo A; Sarthou JL; Pasteur Institute, Dakar, Senegal.; The serological and immunological parameters, disease patterns, and social characteristics of 39 human immunodeficiency virus type 2 (HIV-2) seropositive CDCIV cases seen in Dakar, Senegal were studied. These data were compared with those obtained from 48 HIV-1 seropositive CDC st
Cerebrospinal fluid anti-cardiolipin antibodies in patients with HIV-1 infection.: J Acquir Immune Defic Syndr. 1991;4(4):435-41. Unique Identifier : AIDSLINE MED/91178679; Brey RL; Arroyo R; Boswell RN; Department of Medicine (Neurology), University of Texas Health; Science Center, San Antonio 78284.; Both cerebrospinal fluid (CSF) immunologic abnormalities and serum anti-cardiolipin antibodies (aCL) have been reported in patients with HIV-1 infection. The antibody specificity of only a small amount of the total CSF IgG in these patients is known, and is directed against a variety of HIV-1 antigens. The specificity
Binding of recombinant HIV-1 and HIV-2 SU glycoproteins to sCD4 [letter]: J Acquir Immune Defic Syndr. 1991;4(4):442-3. Unique Identifier : AIDSLINE MED/91178680; Moore JP; Morikawa Y; Jones IM
AIDS virus infection in Toulouse prostitutes (France) [letter]: J Acquir Immune Defic Syndr. 1991;4(4):443-4. Unique Identifier : AIDSLINE MED/91178681; Gayet-Mengelle C; Puel J; Averous S; Bazex J
HIV-like structure detection in people with indeterminate immunoblotting results [letter]: J Acquir Immune Defic Syndr. 1991;4(4):444-6. Unique Identifier : AIDSLINE MED/91178682; Khaitov RM; Chuvirov GN; Trubcheninova LP; Pinegin BV; Khabakhpasheva NA; Ishchenko ME; Glushchenko MV; Yakovleva LS; Efremova EV; Makarova SA
Crack use and multiple AIDS risk behaviors [letter]: J Acquir Immune Defic Syndr. 1991;4(4):446-7. Unique Identifier : AIDSLINE MED/91178683; Des Jarlais DC; Abdul-Quader A; Minkoff H; Hoegsberg B; Landesman S; Tross S
Prevalence of HIV-1 antibodies in selected groups of a Brazilian city with African sociodemographic characteristics [letter]: J Acquir Immune Defic Syndr. 1991;4(4):448-9. Unique Identifier : AIDSLINE MED/91178684; Ivo-dos-Santos J; Couto-Fernandez JC; Santana AJ; Luna TM; Cunha GC; Moreira L; Lemos AC; Dutra M; Miranda C; Galvao-Castro B
Clarification of AIDS mortality in women [letter]: JAMA. 1991 Apr 17;265(15):1952. Unique Identifier : AIDSLINE MED/91178871; Berkelman RL; Chu SY; Farizo K; Buehler JW
[Dentist may have transmitted HIV infection to three patients]: Lakartidningen. 1991 Mar 13;88(11):960. Unique Identifier : AIDSLINE MED/91179273; Jannerfeldt E
The HIV epidemic and the primary care physician.: Md Med J. 1991 Mar;40(3):185-90. Unique Identifier : AIDSLINE MED/91179305; Cohn JA; Warren JW; Department of Medicine, University of Maryland School of; Medicine, Baltimore.
HIV-associated nephropathy: report of a case and review of the literature.: Md Med J. 1991 Mar;40(3):191-4. Unique Identifier : AIDSLINE MED/91179306; Josselson J; Division of Nephrology, University of Maryland Hospital,; Baltimore 21201.
A controlled study of inhaled pentamidine for primary prevention of Pneumocystis carinii pneumonia [see comments]: N Engl J Med. 1991 Apr 18;324(16):1079-83. Unique Identifier : AIDSLINE MED/91179458; Hirschel B; Lazzarin A; Chopard P; Opravil M; Furrer HJ; Ruttimann S; Vernazza P; Chave JP; Ancarani F; Gabriel V; et al; Division of Infectious Diseases, Hopital Cantonal Universitaire,; Geneva, Switzerland.; BACKGROUND. Current recommendations for prophylaxis of Pneumocystis carinii pneumonia (PCP) are based on data from patients who have had at least one episode of PCP (secondary prevention). We designed a study to determine the efficacy and side effects of inhaled pentamidine in the primary prevention of PCP. METHODS. T
Human experimentation. AIDS trials questioned [news]: Nature. 1991 Mar 28;350(6316):263. Unique Identifier : AIDSLINE MED/91179500; Culliton BJ
AIDS. Will therapy spread disease? [news]: Nature. 1991 Mar 28;350(6316):276. Unique Identifier : AIDSLINE MED/91179506; Weiss RA
Potential of community-wide chemotherapy or immunotherapy to control the spread of HIV-1.: Nature. 1991 Mar 28;350(6316):356-9. Unique Identifier : AIDSLINE MED/91179517; Anderson RM; Gupta S; May RM; Biology Department, Imperial College, University of London, UK.; Whether zidovudine (3 -azido-3 -deoxythymidine, AZT ) should be offered to symptomless individuals infected with human immunodeficiency virus type-1 (HIV-1), in the hope of delaying or even preventing progression to AIDS, has been much debated. The dis
How much is known about HIV?: Nursing (Lond). 1991 Feb 14-27;4(28):14-7. Unique Identifier : AIDSLINE MED/91179644; Sultan G
HIV testing [letter; comment]: N Z Med J. 1991 Jan 23;104(904):19-20. Unique Identifier : AIDSLINE MED/91179666; Tobias MI
MH staff urged to act on AIDS threat [news]: Nurs Times. 1991 Mar 20-26;87(12):8. Unique Identifier : AIDSLINE MED/91179878
Sexual spread of Kaposi's.: Nurs Times. 1991 Mar 27-Apr 2;87(13):13. Unique Identifier : AIDSLINE MED/91179879; Beral V; Bull D; Jaffe H
Arguments for widespread HIV testing 'spurious', says training officer [letter]: Nurs Times. 1991 Mar 27-Apr 2;87(13):16. Unique Identifier : AIDSLINE MED/91179880; Mowlam V
Health for all--lessons from HIV/AIDS reflections of a jobbing public health doctor.: Public Health. 1991 Jan;105(1):51-4. Unique Identifier : AIDSLINE MED/91180287; Leeson J; Department of Public Health Medicine, North Manchester Health; Authority, Crumpsall.; The World Health Organisation initiative Health for All by the Year 2000 has laudable objectives, but are they relevant for health care? The history of HIV/AIDS services in one district suggests that the multisectoral participative approach can be fruitful and can contribute to quality services. It is noted that thi
[HIV infection, horizontal transmission]: Rev Enferm. 1991 Feb;14(150):60-2. Unique Identifier : AIDSLINE MED/91180642; Bartolome Carrascal MS
[Virologic diagnosis of human immunodeficiency]: Rev Prat. 1991 Feb 1;41(4):324-6. Unique Identifier : AIDSLINE MED/91180667; Rouzioux C; Laboratoire de microbiologie, hopital Necker-Enfants Malades,; Paris.; The reference tests for HIV diagnosis are the ELISA and Western-Blot assays. Their rapid development has made it possible to obtain a reliable, specific and highly sensitive diagnosis. The follow-up of HIV-infected subjects includes HIV-p24 antigenaemia, but viral culture and PCR will perhaps permit a quantification o
[Virologic diagnosis of maternal-fetal infections (HIV excluded)]: Rev Prat. 1991 Feb 1;41(4):332-5. Unique Identifier : AIDSLINE MED/91180670; Dussaix E; Le Coz Y; Laboratoire de virologie, hopital de Bicetre, Le; Kremlin-Bicetre.; Some viral infections, such as rubella, cytomegalovirus and parvovirus B 19 infections or varicella, are particularly feared in pregnant women in view of the risk of foetal infection. Laboratory tests play an important role since there is no other way of diagnosing the infection an
Experience and preparation of community nursing staff for work associated with HIV infection and AIDS.: Soc Sci Med. 1991;32(1):71-6. Unique Identifier : AIDSLINE MED/91180764; Bond S; Rhodes T; Philips P; Setters J; Foy C; Bond J; Health Care Research Unit, University of Newcastle upon Tyne,; England.; Some of the findings from a national survey of 3754 community nursing staff in England regarding their experience of and preparation for working with HIV infection and AIDS are reported. The current absence of confidence to deal with HIV infection is explained and suggestions made regarding the content of educational
A case of Rhodococcus equi brain abscess.: Surg Neurol. 1991 Apr;35(4):321-4. Unique Identifier : AIDSLINE MED/91180802; Obana WG; Scannell KA; Jacobs R; Greco C; Rosenblum ML; Department of Neurological Surgery, School of Medicine,; University of California, San Francisco.; We treated a patient with acquired immunodeficiency syndrome for a brain abscess caused by Rhodococcus equi, an actinomycete that usually infects the lung in immunosuppressed hosts. Rhodococcus equi brain abscess is an extremely rare lesion that has never been reported in a patient with acquired immunodeficiency syndr
Studies on the immunogenicity of Chinese hamster ovary cell-derived recombinant gp120 (HIV-1IIIB).: Vaccine. 1991 Jan;9(1):47-52. Unique Identifier : AIDSLINE MED/91181305; Page M; Mills KH; Schild GC; Ling C; Patel V; McKnight A; Barnard AL; Dilger P; Thorpe R; National Institute for Biological Standards and Control, Potters; Bar, Herts, UK.; Recombinant DNA-derived gp120 (HIV-1IIIB) expressed in chinese hamster ovary cells elicited specific humoral and cell-mediated immune responses in a variety of mammals. Antisera from immunized rabbits, sheep and goats recognized virus-derived gp120 and its precursor (gp160). Neutralizing antibodies were also elicited,
Winning the battle against the HIV epidemic.: Am Fam Physician. 1991 Apr;43(4):1432-4. Unique Identifier : AIDSLINE MED/91181521; Bresolin LB; Hendee WR; Rinaldi RC; Henning JJ; American Medical Association, Chicago, Illinois.
[Respiratory failure in a HIV seropositive heroin addict female]: Ann Fr Anesth Reanim. 1991;10(1):74-6. Unique Identifier : AIDSLINE MED/91181754; Magnan A; Ottomani A; Garbe L; Arnaud A; Manelli JC; Service de Pneumologie, Hopital Nord, Marseille.; A 31-year-old woman, heroin addict since ten years, and infected by the human immunodeficiency virus (HIV) since one year, was admitted to the intensive care unit for respiratory failure (PaO2 = 40 mmHg and PaCO2 = 14.8 mmHg, despite breathing pure oxygen). She had been followed up for 6 months for increasing dyspnoea
Cumulative AIDS incidence and altered mortality from mycobacterial disease: New Jersey.: Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):717-20. Unique Identifier : AIDSLINE MED/91181768; Fife D; Crane GL; Bishburg E; AIDS Activities Coordinating Office, Philadelphia Department of; Health, Pennsylvania 19107.; Changes in mycobacterial disease mortality between 1980 and 1986 were examined among New Jersey residents aged 25 to 44 using single cause of death data. The demographic group with the highest cumulative incidence of acquired immune deficiency syndrome (AIDS) (non-white residents of the four urban counties adjacent to
Factors determining pulmonary deposition of aerosolized pentamidine in patients with human immunodeficiency virus infection.: Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):727-37. Unique Identifier : AIDSLINE MED/91181770; Smaldone GC; Fuhrer J; Steigbigel RT; McPeck M; Department of Medicine, State University of New York, Stony Brook; 11794-8172.; Although aerosolized pentamidine (AP) has recently been approved for prophylaxis and is undergoing clinical trials for treatment of pneumocystis, pneumonia (PCP), factors important in the deposition of AP have not been described. Using radioaerosol techniques, deposition was measured in 22 patients receiving AP for pr
Disability in persons hospitalized with AIDS.: Am J Phys Med Rehabil. 1991 Apr;70(2):91-5. Unique Identifier : AIDSLINE MED/91182345; O'Dell MW; Crawford A; Bohi ES; Bonner FJ Jr; Department of Physical Medicine and Rehabilitation, Graduate; Hospital, Philadelphia, Pennsylvania.; This study documents the types and degree of disability seen in persons with AIDS at discharge from acute hospitalization. Based on 37 discharge evaluations using the Functional Independence Measure (FIM), 60% required human assistance in at least one of 18 FIM areas. Thirty-two percent required human assistance in fi
Positive modification of injecting behavior among intravenous heroin users from Milan and northern Italy 1987-1989. NISDA Study.: Br J Addict. 1991 Jan;86(1):91-102. Unique Identifier : AIDSLINE MED/91183230; Nicolosi A; Molinari S; Musicco M; Saracco A; Ziliani N; Lazzarin A; National Research Council, Department of Epidemiology and Medical; Informatics, Milan, Italy.; The prevalence of risk behaviors in 933 intravenous drug users from Milan and other areas of Northern Italy was studied from 1 January 1987 to 15 April 1989. A preventive intervention, based on counseling with HIV antibody testing, was undertaken with i.v. drug users attending detox
Drug abuse.: Bull N Y Acad Med. 1991 Jan-Feb;67(1):43-8. Unique Identifier : AIDSLINE MED/91183266; Des Jarlais DC; Chemical Dependency Institute, Beth Israel Medical Center, New; York, NY.
Hepatitis B and HIV infections in dental professionals: effectiveness of infection control procedures.: J Can Dent Assoc. 1991 Jan;57(1):55-8. Unique Identifier : AIDSLINE MED/91183359; Noble MA; Mathias RG; Gibson GB; Epstein JB; Faculty of Medicine, University of British Columbia, Vancouver.; In a survey carried out in 1987 and 1988 in Vancouver British Columbia, 704 dental professionals filled out an anonymous questionnaire and submitted a blood sample. Of those not immunized, 11% had infection with Hepatitis B, with dentists having a rate of 18%, significantly higher than other dental workers. Two carrie
The oral manifestations of HIV infection.: J Can Dent Assoc. 1991 Jan;57(1):59-61. Unique Identifier : AIDSLINE MED/91183360; Jordan RC; Main JH; Department of Oral Pathology, Faculty of Dentistry, University of; Toronto, Ont.; The spectrum of oral lesions found in the HIV-infected population forms a diverse group of opportunistic conditions, all of which may be seen in non-HIV infected patients. With the continuing increase in HIV-positive individuals, it is important that practising dentists become familiar with the clinical features of HI
Ottawa AIDS reporting system 'in a state of chaos' says statistics chairman [news]: J Can Dent Assoc. 1991 Jan;57(1):9. Unique Identifier : AIDSLINE MED/91183361
HIV infection among Quebec women giving birth to live infants [letter; comment] [see comments]: Can Med Assoc J. 1991 Apr 15;144(8):954-6. Unique Identifier : AIDSLINE MED/91183377; Parker JE
Update: transmission of HIV infection during an invasive dental procedure: United States.: Can Dis Wkly Rep. 1991 Jan 26;17(4):17-22. Unique Identifier : AIDSLINE MED/91183527
Ancient and modern plagues.: Clin Neurosurg. 1991;37:193-202. Unique Identifier : AIDSLINE MED/91183745; Hinman AR; Rosenberg ML
Intrapleural tetracycline for spontaneous pneumothorax in acquired immunodeficiency syndrome.: Chest. 1991 Apr;99(4):1036-7. Unique Identifier : AIDSLINE MED/91183871; Busch E; Barlam BW; Wallace J; Nealon TF; Department of Surgery, Saint Vincent's Hospital and Medical; Center, New York.; Spontaneous pneumothorax is occurring in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii infection with increasing frequency. These patients are typically poor surgical candidates. Conservative management using tetracycline sclerosis was performed with good results in a patient with acqui
Yaws, an endemic treponematosis reconsidered in the HIV era [editorial]: Eur J Clin Microbiol Infect Dis. 1991 Jan;10(1):4-5. Unique Identifier : AIDSLINE MED/91184176; Noordhoek GT; van Embden JD
Male-to-female transmission of human immunodeficiency virus infection by oro-genital sex [letter]: Eur J Clin Microbiol Infect Dis. 1991 Jan;10(1):47. Unique Identifier : AIDSLINE MED/91184182; Puro V; Narciso P; Girardi E; Antonelli L; Zaccarelli M; Visco G
United Kingdom: report on the research programme on AIDS supported by the Medical Research Council [MRCI] [news]: Experientia. 1991 Mar 15;47(3):214-5. Unique Identifier : AIDSLINE MED/91184322
AIDS update. Aids in the workplace.: Fla Nurse. 1991 Mar;39(3):16. Unique Identifier : AIDSLINE MED/91184523
AIDS Task Force update. Testing of the source patient.: Fla Nurse. 1991 Mar;39(3):17. Unique Identifier : AIDSLINE MED/91184524; Russell B
[Disseminated Mycobacterium avium intracellulare infection revealed by hepatomegaly and cholestasis in acquired immunodeficiency syndrome (letter)]: Gastroenterol Clin Biol. 1991;15(1):97-8. Unique Identifier : AIDSLINE MED/91184607; Paraf F; Brenot F; Poynard T; Petitpretz P; Bedossa P; Chaput J; Duroux P
Will the AIDS crisis hurt hospitals' bottom line?: Hospitals. 1991 Apr 5;65(7):64. Unique Identifier : AIDSLINE MED/91184773; Johnsson J
Characterization, isolation and amino terminal sequencing of a rat colon carcinoma-associated antigen.: Int J Cancer. 1991 Apr 1;47(6):903-8. Unique Identifier : AIDSLINE MED/91184910; Chadeneau C; Denis MG; Blottiere HM; Gregoire M; Douillard JY; Meflah K; Department of Medical Biochemistry, Nantes University Hospital,; France.; Monoclonal antibodies have been raised against a cell line derived from a dimethylhydrazine-induced rat colon carcinoma. One of these antibodies (MAb E4) has previously been shown to react slightly with normal small intestine and colon, and not with other normal tissues as determined by immunohistochemistry. Using Wes
Vitreous fluorophotometric recordings in HIV infection.: Int Ophthalmol. 1991 Jan;15(1):37-40. Unique Identifier : AIDSLINE MED/91184963; Cellini M; Baldi A; Universita' Degli Studi di Bologna, Instituto di Clinica; Oculistica, Italia.; Fluorophotometry was performed in 10 patients. Five of these were affected by AIDS and five ARC (AIDS Related Complex). All patients had normal fundi detectable by standard examination and by fluorescein angiography. In spite of the normal condition of the fundus, vitreous fluorophotometry readings were constantly abo
[HTLV-I infection: ungual T-cell lymphoma as a primary manifestation]: Hautarzt. 1991 Jan;42(1):50-2. Unique Identifier : AIDSLINE MED/91185041; Wolter M; Schleussner-Samuel P; Marsch WC; Abteilung, Zentrum der Dermatologie und Venerologie, Johann; Wolfgang Goethe-Universitat Frankfurt am Main.; A 34-year-old woman presented with leathery thickening and haemorrhagic lesions of several finger- and toe-nails as first symptoms of an HTLV-I infection. Histology resembled that found in mycosis fungoides. Later signs of T cell deficiency (e.g. Pneumocystis carinii pneumonia) developed. An erythemato-papular exanthe
The prospects for AIDS vaccines.: Hosp Pract (Off Ed). 1991 Apr 15;26(4):99-106. Unique Identifier : AIDSLINE MED/91185450; Koff WC; Division of AIDS, National Institute of Allergy and Infectious; Diseases, Rockville, Md.; Several vaccine strategies against HIV are under study in phase 1 clinical trials. Many involve recombinant subunit preparations, and the question is which of these components of the virus may be immunogenic. Immune effectors and mediators that protect against HIV are also undefined. Vaccines may ultimately be used to
AIDS and competing health concerns of blacks, Hispanics, and whites.: J Community Health. 1991 Feb;16(1):11-21. Unique Identifier : AIDSLINE MED/91185651; Elder-Tabrizy KA; Wolitski RJ; Rhodes F; Baker JG; AIDS Research & Education Project, California State University,; Long Beach 90840.; Blacks, Hispanics, and whites were interviewed in a door-to-door survey assessing personal concern about AIDS relative to other health threats and willingness to attend in-home AIDS education programs. The survey consisted of three parts: (1) an open-ended inquiry regarding which health problems individuals wanted to
Comparison of saliva and blood for human immunodeficiency virus prevalence testing.: J Infect Dis. 1991 Apr;163(4):699-702. Unique Identifier : AIDSLINE MED/91185861; Major CJ; Read SE; Coates RA; Francis A; McLaughlin BJ; Millson M; Shepherd F; Fanning M; Calzavara L; MacFadden D; et al; Ontario Ministry of Health, Laboratory Services Branch, Toronto,; Canada.; Testing saliva for the detection of human immunodeficiency virus (HIV) antibodies has many potential advantages for epidemiologic surveillance. A commercial ELISA kit and a standardized in-house immunoblot (IB) system were slightly modified to enhance antibody detection in saliva. Frozen saliva specimens from Toronto
Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages.: J Infect Dis. 1991 Apr;163(4):703-9. Unique Identifier : AIDSLINE MED/91185862; Ashorn P; Englund G; Martin MA; Moss B; Berger EA; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; CD4(178)-PE40 is a recombinant protein consisting of a portion of human CD4 linked to active domains of Pseudomonas aeruginosa exotoxin A. In previous experiments with human T cell lines, the hybrid toxin was found to selectively kill cells infected with human immunodeficiency virus type 1 (HIV-1), and to inhibit HIV-
Comparative protective activity of human monoclonal and hyperimmune polyclonal antibody against group B streptococci.: J Infect Dis. 1991 Apr;163(4):792-8. Unique Identifier : AIDSLINE MED/91185877; Hill HR; Gonzales LA; Knappe WA; Fischer GW; Kelsey DK; Raff HV; Department of Pediatrics, University of Utah School of Medicine,; Salt Lake City 84132.; Group B streptococcal (GBS) infections cause significant morbidity and mortality in neonates and compromised hosts, who usually lack opsonic antibody to their infecting strain. Unfortunately, most conventional immunoglobulin preparations possess little GBS antibody. The protective activity of a human monoclonal antibo
Safety and pharmacokinetics of 566C80, a hydroxynaphthoquinone with anti-Pneumocystis carinii activity: a phase I study in human immunodeficiency virus (HIV)-infected men.: J Infect Dis. 1991 Apr;163(4):843-8. Unique Identifier : AIDSLINE MED/91185885; Hughes WT; Kennedy W; Shenep JL; Flynn PM; Hetherington SV; Fullen G; Lancaster DJ; Stein DS; Palte S; Rosenbaum D; et al; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, TN 38101-0318.; A hydroxynaphthoquinone compound (566C80) has been shown to be effective in the prevention and treatment of murine Pneumocystis carinii pneumonitis. In a phase I study, five cohorts of four human immunodeficiency virus-infected men received 100, 250, 750, 1500, and 3000 mg of the compound orally once daily for 12 days
Detection and quantification of human immunodeficiency virus RNA in patient serum by use of the polymerase chain reaction.: J Infect Dis. 1991 Apr;163(4):862-6. Unique Identifier : AIDSLINE MED/91185889; Holodniy M; Katzenstein DA; Sengupta S; Wang AM; Casipit C; Schwartz DH; Konrad M; Groves E; Merigan TC; Department of Medicine, Stanford University Medical Center, CA; 94305.; Human immunodeficiency virus (HIV) RNA was detected and quantified in the serum of HIV-seropositive individuals using the polymerase chain reaction (PCR) and a nonisotopic enzyme-linked affinity assay. Of 55 HIV-infected patients who were not receiving therapy, serum HIV RNA was detected in 9 of 19 who were asymptomat
Hepatic involvement in patients with human immunodeficiency virus infection: discrepancies between AIDS patients and those with earlier stages of infection.: J Infect Dis. 1991 Apr;163(4):866-9. Unique Identifier : AIDSLINE MED/91185890; Prufer-Kramer L; Kramer A; Weigel R; Rogler G; Fleige B; Krause PH; Hahn EG; Riecken EO; Pohle HD; Department of Medicine II (Klinikum Rudolf-Virchow), Freie; Universitat Berlin, Germany.; The effect of human immunodeficiency virus (HIV) infection on type and severity of liver disease was studied in 61 HIV-positive patients who did not have AIDS and in 45 AIDS patients. Liver biopsies revealed viral hepatitis in 12 of 18 non-AIDS patients but in only 4 of 34 AIDS patients (P less than .0005, Fisher s ex
Pneumococcal soft-tissue infections: possible association with connective tissue diseases [published erratum appears in J Infect Dis 1991 Jul;164(1):232]: J Infect Dis. 1991 Apr;163(4):897-900. Unique Identifier : AIDSLINE MED/91185899; DiNubile MJ; Albornoz MA; Stumacher RJ; Van Uitert BL; Paluzzi SA; Bush LM; Nelson SC; Myers AR; Department of Medicine, Cooper Hospital/University Medical; Center, Camden, NJ.; Streptococcus pneumoniae is not a well-recognized cause of soft-tissue infections. In less than 4 years, 12 cases of pneumococcal soft-tissue infection were identified through discussions with infections disease subspecialists in the Philadelphia area. Principal sites of involvement included skin and fascia, tongue, e
HLA-B35 and thrombocytopenia in drug users with AIDS [letter]: J Infect Dis. 1991 Apr;163(4):926-7. Unique Identifier : AIDSLINE MED/91185911; Eisera N; Fabio G; Marchini M; Zarantonello M; Lazzarin A; Scorza R
Talking to patients about AIDS [editorial]: J Fam Pract. 1991 Apr;32(4):367-8. Unique Identifier : AIDSLINE MED/91186097; Koop CE
AIDS in primary care: a report from the Ambulatory Sentinel Practice Network.: J Fam Pract. 1991 Apr;32(4):369-72. Unique Identifier : AIDSLINE MED/91186098; Calonge BN; Miller RS; Dennis LK; Joffe LS; Department of Family Medicine, University of Colorado Health; Sciences Center, Denver.; BACKGROUND. Despite the importance of the epidemic of acquired immune deficiency syndrome (AIDS), little is known about the incidence and prevalence of AIDS in the patient population of primary care physicians. This study was designed as an initial step in evaluating the impact of this disease on primary care practice
Patient attitudes and knowledge about HIV infection and AIDS.: J Fam Pract. 1991 Apr;32(4):373-7. Unique Identifier : AIDSLINE MED/91186099; Epstein R; Department of Family Medicine, University of Rochester School of; Medicine and Dentistry 14620.; BACKGROUND. Family physicians are caring for an increasing number of those with human immunodeficiency virus (HIV) infection, those at risk, and those concerned about HIV disease. METHODS. A questionnaire survey of attitudes and knowledge about HIV infection was conducted in 430 patients in three family practices in M
Evidence of serum-protein leakage across the blood-brain barrier in the acquired immunodeficiency syndrome.: J Neuropathol Exp Neurol. 1991 Mar;50(2):171-83. Unique Identifier : AIDSLINE MED/91186167; Rhodes RH; Los Angeles County-University of Southern California Medical; Center.; Lesions of the central nervous system (CNS) in 23 patients with the acquired immunodeficiency syndrome (AIDS) were compared with control cases for the presence of serum protein by immunoperoxidase staining. A sensitive immunostaining kit in conjunction with rabbit antisera to human serum, albumin, immunoglobulins and
Seroprevalence of human immunodeficiency virus in women admitted to the hospital with pelvic inflammatory disease.: J Reprod Med. 1991 Feb;36(2):122-4. Unique Identifier : AIDSLINE MED/91186364; Sperling RS; Friedman F Jr; Joyner M; Brodman M; Dottino P; Department of Obstetrics, Gynecology and Reproductive Science,; Mount Sinai Medical Center, New York, NY 10029.; To assess the association of the human immunodeficiency virus (HIV) with other sexually transmitted diseases we undertook an anonymous HIV antibody serosurvey of all women admitted to the hospital with pelvic inflammatory disease. All the patients were given HIV risk reduction information and offered voluntary antibod
[PCR assay in HIV infections]: Nippon Rinsho. 1991 Feb;49(2):461-6. Unique Identifier : AIDSLINE MED/91186511; Kurimura T; Yamada O; Department of Pathology, Osaka University.
A female patient with cocaine toxicity, acquired immune deficiency syndrome, and disseminated intravascular coagulopathy.: J Emerg Nurs. 1991 Apr;17(2):70-2. Unique Identifier : AIDSLINE MED/91186573; Edwards N
The future of infections waste management in South Carolina.: J S C Med Assoc. 1991 Feb;87(2):60-2. Unique Identifier : AIDSLINE MED/91186641; Morris P; Bedenbaugh L
The South Carolina Department of Health and Environmental Control's response to the AIDS epidemic.: J S C Med Assoc. 1991 Feb;87(2):94-5. Unique Identifier : AIDSLINE MED/91186652; Jones J; Ball R; Kettinger L
Prolonged fever in a young woman.: J Tenn Med Assoc. 1991 Feb;84(2):76. Unique Identifier : AIDSLINE MED/91186670; Sabbatini P; Neuzil KM; Morgan HJ; Vanderbilt University Hospital, Nashville.
Swedish adolescents' knowledge of sexually transmitted diseases and their attitudes to the condom.: Midwifery. 1991 Mar;7(1):25-30. Unique Identifier : AIDSLINE MED/91186858; Tyden T; Norden L; Ruusuvaara L; In an attempt to assess the risk of AIDS infection in teenagers in Sweden a survey of adolescent sexual behaviour was conducted in Uppsala. Two hundred and nine students in the first form of an upper secondary school completed a questionnaire at the beginning of a lesson on family
AIDS scan.: Nurs RSA. 1991 Jan;6(1):39-40. Unique Identifier : AIDSLINE MED/91187096
Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity.: Nature. 1991 Apr 4;350(6317):439-41. Unique Identifier : AIDSLINE MED/91187118; Braddock M; Thorburn AM; Kingsman AJ; Kingsman SM; Virus Molecular Biology Group, Department of Biochemistry,; Oxford, UK.; Human immunodeficiency virus gene expression is regulated transcriptionally and post-transcriptionally by the virally encoded tat protein (Tat). Tat functions through an RNA target sequence located in the untranslated region at the 5 end of viral transcripts. In Xenopus oocytes, translation of RNA containing the targ
Interleukin-6 in cerebrospinal fluid of HTLV-I-associated myelopathy.: Neurology. 1991 Apr;41(4):594-5. Unique Identifier : AIDSLINE MED/91187228; Ohbo K; Sugamura K; Sekizawa T; Kogure K; Department of Microbiology, Tohoku University School of Medicine,; Sendai, Japan.; We demonstrated significant titers of interleukin-6 (IL-6) in the CSF from 6 of 11 patients with HTLV-I-associated myelopathy (HAM). The patients positive for IL-6 generally had more severe clinical symptoms and signs than those negative for IL-6. There was no correlation between the value of IL-6 and inflammatory fin
MS and HTLV-I [letter; comment]: Neurology. 1991 Apr;41(4):610-1. Unique Identifier : AIDSLINE MED/91187240; Gout O; Tournier-Lasserve E; Lyon-Caen O; Gessain A; De-The G
Should nurses be required to administer care to patients with AIDS? Students respond.: Nurse Educ. 1991 Mar-Apr;16(2):36-8. Unique Identifier : AIDSLINE MED/91187264; Eakes GG; Lewis JB; A total of 40 baccalaureate nursing students were assigned to write a paper that expressed their opinions about providing care to patients with acquired immunodeficiency syndrome (AIDS) and to give the rationale used to support their views. Although 75% of the students believed that nurses should provide care to patie
AIDS 1990 [news]: N Z Med J. 1991 Mar 27;104(908):127. Unique Identifier : AIDSLINE MED/91187301
Occurrence of AIDS in New Zealand: the first seven years. MRC AIDS Epidemiology Group [see comments]: N Z Med J. 1991 Apr 10;104(909):131-4. Unique Identifier : AIDSLINE MED/91187303; Carlson RV; Skegg DC; Paul C; Spears GF; Department of Preventive and Social Medicine, University of Otago; Medical School, Dunedin.; The 179 people in New Zealand with AIDS diagnosed up to the end of 1989 and notified by 30 June 1990 are reviewed. Retrospective data collection provided the first available information on date of diagnosis, ethnic affiliation, district of usual residence, and survival. Of the
Projections of AIDS incidence in New Zealand [letter; comment]: N Z Med J. 1991 Apr 10;104(909):149. Unique Identifier : AIDSLINE MED/91187319; Sharples K; Carlson R; Skegg D; Paul C
Public knowledge about AIDS: a survey of dental school patients. Part I.: Oral Surg Oral Med Oral Pathol. 1991 Mar;71(3):377-85. Unique Identifier : AIDSLINE MED/91187406; Lancaster DM; Barsley RE; Boozer CH; Lundgren GA; Department of Oral Diagnosis, Medicine and Radiology, Louisiana; State University, School of Dentistry, New Orleans.; Surveys have demonstrated that the general public has many misconceptions about acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. Education has been the mainstay of the public health effort to combat the spread of HIV and AIDS. Some studies have shown an increase in the public
Public knowledge about AIDS: a survey of dental school patients. Part II.: Oral Surg Oral Med Oral Pathol. 1991 Mar;71(3):386-91. Unique Identifier : AIDSLINE MED/91187407; Barsley RE; Lancaster DM; Boozer CH; Lundgren GA; Department of Oral Diagnosis, Medicine and Radiology, Louisiana; State University School of Dentistry, New Orleans 70119-2799.; Responses to a questionnaire on acquired immunodeficiency syndrome (AIDS) returned by patients of the Louisiana State University School of Dentistry were compared with responses to an AIDS questionnaire administered by the National Center for Health Statistics (NCHS). Although the questionnaire in this study was not p
[67Ga citrate imaging in AIDS-related Pneumocystis carinii pneumonia in Japan]: Nippon Igaku Hoshasen Gakkai Zasshi. 1991 Jan 25;51(1):59-65. Unique Identifier : AIDSLINE MED/91187596; Kosuda S; Shioyama Y; Kutsukake Y; Tanaka J; Asumi M; Ito K; Kamata N; Suzuki K; Department of Radiology, Tokyo Metropolitan Komagome Hospital.; Six AIDS patients with Pneumocystis carinii pneumonia (PCP) underwent 67Ga scan as part of their evaluation. Only one patient of them showed the characteristic 67Ga distribution pattern for PCP, that is, diffuse, increased, bilateral lung activity greater than liver activity. Two patients who were receiving therapy fo
Post-PCR sterilization: development and application to an HIV-1 diagnostic assay.: Nucleic Acids Res. 1991 Jan 11;19(1):109-16. Unique Identifier : AIDSLINE MED/91187605; Isaacs ST; Tessman JW; Metchette KC; Hearst JE; Cimino GD; HRI Research, Inc., Berkeley, CA 94710.; We have developed an effective post-PCR sterilization process and have applied the procedure to a diagnostic assay for HIV-1. The method, which is based on isopsoralen photochemistry, satisfies both the inactivation and hybridization requirements of a practical sterilization process. The key feature of the technique i
HIV testing urged for pregnancy.: Nurs Times. 1991 Apr 3-9;87(14):11. Unique Identifier : AIDSLINE MED/91187742; Barbacci M; Repke JT; Chaisson RE
Parasitic diseases. Diseases associated with acquired immunodeficiency syndrome.: Prim Care. 1991 Mar;18(1):129-52. Unique Identifier : AIDSLINE MED/91187995; Levine GI; Department of Family Practice, University of Kentucky College of; Medicine, Lexington.; There are several protozoan infections that cause relatively benign illness in normal individuals but result in severe disease manifestations in patients with AIDS. These diseases include Pneumocystis carinii pneumonia, CNS toxoplasmosis, cryptosporidiosis, and isosporiasis
AIDS and human immunodeficiency virus infections: update 1990.: Semin Urol. 1991 Feb;9(1):32-9. Unique Identifier : AIDSLINE MED/91188155; Krieger JN; Department of Urology, University of Washington School of; Medicine, Seattle 98195.
Sexually transmitted diseases: treatment guidelines. US Department of Health and Human Services.: Semin Urol. 1991 Feb;9(1):40-70. Unique Identifier : AIDSLINE MED/91188156
Who found AZT works for AIDS? [news]: Science. 1991 Mar 29;251(5001):1554. Unique Identifier : AIDSLINE MED/91188251; Palca J
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.: Science. 1991 Mar 29;251(5001):1597-600. Unique Identifier : AIDSLINE GENBANK/X53021; Gatignol A; Buckler-White A; Berkhout B; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892.; Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation--responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellu
Calmer waters at primate institute? [news]: Science. 1991 Apr 5;252(5002):24. Unique Identifier : AIDSLINE MED/91188277; Wright K
French AIDS researcher cleared [news]: Science. 1991 Apr 12;252(5003):203. Unique Identifier : AIDSLINE MED/91188287; Dorozynski A
Prevalence of HIV antibodies in the antenatal clinic attenders in Ciskei [letter]: S Afr Med J. 1991 Mar 2;79(5):282. Unique Identifier : AIDSLINE MED/91188368; Stevens H; Boon GP
Prevention of HIV transmission in the workplace: category II (emergency service) workers.: Am Ind Hyg Assoc J. 1991 Feb;52(2):A104-7. Unique Identifier : AIDSLINE MED/91189030; Mueller K; California Firefighter Foundation, Sacramento 95833.
AIDS education for labor and management: category III workers.: Am Ind Hyg Assoc J. 1991 Feb;52(2):A108-11. Unique Identifier : AIDSLINE MED/91189031; Alexander D; Askari E; Institute of Occupational Relations, University of California,; Berkeley 94720.
Acquired immunodeficiency syndrome and adolescents. Knowledge, attitudes, and behaviors of runaway and homeless youths.: Am J Dis Child. 1991 Apr;145(4):431-6. Unique Identifier : AIDSLINE MED/91189102; Sugerman ST; Hergenroeder AC; Chacko MR; Parcel GS; University of Texas School of Public Health, Houston.; OBJECTIVE: To describe the knowledge, attitudes, and behaviors of runaway and homeless youths regarding infection with the human immunodeficiency virus (HIV). DESIGN: Cross-sectional, descriptive. SETTING: A crisis shelter for runaway and homeless youths. PARTICIPANTS: One hundred one residents, aged 13 to 20 years, o
Atypical lymphocytes with a multilobated nucleus from a patient with tsutsugamushi disease (scrub typhus) in Japan.: Am J Hematol. 1991 Feb;36(2):150-1. Unique Identifier : AIDSLINE MED/91189155; Iwasaki H; Ueda T; Uchida M; Nakamura T; Takada N; Mahara F; First Department of Internal Medicine, Fukui Medical School,; Japan.; A case of tsutsugamushi disease (scrub typhus) with atypical lymphocytes with a multilobated nucleus is reported. Although this type of atypical lymphocyte has been reported in patients with viral infections such as adult T-cell leukemia, infectious mononucleosis, human immunodeficiency virus (HIV) infection, this is
HIV-associated Hodgkin disease: a clinical study of 18 cases and review of the literature.: Am J Hematol. 1991 Feb;36(2):93-9. Unique Identifier : AIDSLINE MED/91189162; Gold JE; Altarac D; Ree HJ; Khan A; Sordillo PP; Zalusky R; Division of Hematology-Oncology, Beth Israel Medical Center,; Mount Sinai School of Medicine, New York, NY 10003.; Intermediate- and high-grade B-cell non-Hodgkin lymphoma (NHL) occurring in a human immunodeficiency virus (HIV)-infected patient is considered diagnostic of the acquired immunodeficiency syndrome (AIDS). Other neoplasms (both hematopoietic and nonhematopoietic) have also been reported in patients with HIV infection,
Aerosol pentamidine prophylaxis following Pneumocystis carinii pneumonia in AIDS patients: results of a blinded dose-comparison study using an ultrasonic nebulizer [see comments]: Am J Med. 1991 Apr;90(4):418-26. Unique Identifier : AIDSLINE MED/91189182; Murphy RL; Lavelle JP; Allan JD; Gordin FM; Dupliss R; Boswell SL; Waskin HA; Davies SF; Graziano FM; Saag MS; et al; Northwestern University Medical School, Chicago, Illinois 60611.; PURPOSE: To compare the efficacy and safety of three different doses of prophylactic aerosol pentamidine in patients with one prior episode of Pneumocystis carinii pneumonia (PCP) and the acquired immunodeficiency syndrome. PATIENTS AND METHODS: The design of the study was a double-blind, randomized, dose-comparison c
Diphenylhydantoin-induced hypogammaglobulinemia in a patient infected with human immunodeficiency virus.: Am J Med. 1991 Apr;90(4):524-7. Unique Identifier : AIDSLINE MED/91189198; Britigan BE; Department of Internal Medicine, Veterans Administration Medical; Center, Iowa City, Iowa.; A case is reported of reversible panhypogammaglobulinemia in a human immunodeficiency virus (HIV)-infected patient. Onset and resolution were temporally correlated with initiation and termination, respectively, of diphenylhydantoin therapy for a possible seizure. A rapid alteration in peripheral T-cell subpopulations
HIV testing in women with vaginal candidiasis [letter; comment]: Am J Med. 1991 Apr;90(4):536. Unique Identifier : AIDSLINE MED/91189204; DeHart DJ
Aggressive Kaposi's sarcoma and campylobacter bacteremia in a female with transfusion associated AIDS.: Am J Med Sci. 1991 Apr;301(4):256-8. Unique Identifier : AIDSLINE MED/91189219; Aboulafia D; Mathisen G; Mitsuyasu R; Division of Hematology-Oncology, Virginia Mason Clinic, Seattle,; WA 98111.; The vast majority of patients with Kaposi s sarcoma (KS) of the epidemic, endemic or sporadic variety are men. Although 35 percent of men with AIDS will develop KS, only three percent of women will develop this malignancy. To date, a single case report of transfusion associated KS in an HIV-infected female has been de
Simian immunodeficiency virus infection of macaque bone marrow macrophages correlates with disease progression in vivo.: Am J Pathol. 1991 Apr;138(4):921-30. Unique Identifier : AIDSLINE MED/91189308; Kitagawa M; Lackner AA; Martfeld DJ; Gardner MB; Dandekar S; Department of Medical Pathology, University of California, Davis; 95616.; The pathogenesis of hematopoietic abnormalities associated with infection of susceptible hosts with either simian immunodeficiency virus (SIV) or human immunodeficiency virus (HIV) is not fully understood. To determine if bone marrow cells are infected with SIV and if the pattern of viral infection is correlated with
Aspergillus otomastoiditis in acquired immunodeficiency syndrome.: Am J Otol. 1991 Jan;12(1):49-53. Unique Identifier : AIDSLINE MED/91189325; Strauss M; Fine E; Department of Otolaryngology--Head and Neck Surgery, Case Western; Reserve University School of Medicine, Cleveland, Ohio 44106.; The diagnosis and therapy of fungal infection in the paranasal sinuses of the immunocompromised host, including those with acquired immunodeficiency syndrome (AIDS), has been discussed in recent literature. However, only limited reports have been presented on otologic infection in AIDS patients. A review of 26 such pa
Human T-lymphotropic virus type I infection in the Solomon Islands.: Am J Trop Med Hyg. 1991 Feb;44(2):122-30. Unique Identifier : AIDSLINE MED/91189430; Yanagihara R; Ajdukiewicz AB; Garruto RM; Sharlow ER; Wu XY; Alemaena O; Sale H; Alexander SS; Gajudusek DC; National Institutes of Health, Bethesda, Maryland.; To ascertain the prevalence of human T-lymphotropic virus type I (HTLV-I) infection and the occurrence of diseases caused by HTLV-I in the Solomon Islands , we tested 1141 sera from 851 patients (317 females and 534 males), who were
Increased HTLV-I proviral DNA in HTLV-I-associated myelopathy: a quantitative polymerase chain reaction study [published erratum appears in Ann Neurol 1991 Apr;29(4):363]: Ann Neurol. 1991 Feb;29(2):194-201. Unique Identifier : AIDSLINE MED/91189661; Kira J; Koyanagi Y; Yamada T; Itoyama Y; Goto I; Yamamoto N; Sasaki H; Sakaki Y; Department of Neurology, Neurological Institute, Kyushu; University, Fukuoka, Japan.; Using the polymerase chain reaction, we quantitated the amount of human T-lymphotropic virus type I (HTLV-I) proviral DNA in peripheral blood mononuclear cells from 18 patients with HTLV-I--associated myelopathy/tropical spastic paraparesis; 17 HTLV-I carriers without HTLV-I--associated myelopathy/tropical spastic par
The HIV-positive health professional: policy options for individuals, institutions, and states. Public policy and the public--observations from the front line.: Arch Intern Med. 1991 Apr;151(4):655-7. Unique Identifier : AIDSLINE MED/91189802; Landesman SH; Division of Infectious Diseases, State University of New York,; Health Science Center, Brooklyn 11203.
Is individual responsibility a sufficient basis for public confidence?: Arch Intern Med. 1991 Apr;151(4):660-2. Unique Identifier : AIDSLINE MED/91189804; Jonsen AR; Department of Medical History/Ethics, University of Washington,; Seattle 98195.
Zidovudine (AZT) for treatment of patients infected with human immunodeficiency virus type 1. An evaluation of effectiveness in clinical practice.: Arch Intern Med. 1991 Apr;151(4):709-13. Unique Identifier : AIDSLINE MED/91189814; Colson ER; Horwitz RI; Bia FJ; Viscoli CM; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Conn. 06510.; To learn about the patterns of use and the effectiveness of zidovudine therapy in clinical practice, we conducted an observational cohort study of 86 patients with human immunodeficiency virus type 1 infection. All patients were followed up for at least 6 months after starting zidovudine (
Fulminant pseudomonal keratitis and scleritis in human immunodeficiency virus-infected patients.: Arch Ophthalmol. 1991 Apr;109(4):503-5. Unique Identifier : AIDSLINE MED/91189980; Nanda M; Pflugfelder SC; Holland S; Bascom Palmer Eye Institute, University of Miami School of; Medicine, FL 33101.; Patients with human immunodeficiency virus infection are predisposed to fungal, parasitic, and viral infections. Bacterial infection can also be seen, although ocular bacterial infections have not been reported in patients with acquired immunodeficiency syndrome until recently. We present two cases of Pseudomonas corn
Neutrophil-bound immunoglobulin in HIV infection is of autoantibody nature.: Br J Haematol. 1991 Mar;77(3):403-9. Unique Identifier : AIDSLINE MED/91190643; Klaassen RJ; Vlekke AB; von dem Borne AE; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.; Here we report the serological and immunochemical characterization of neutrophil-bound Ig (NBIg) and neutrophil-binding Ig in the serum of 15 individuals infected by the human immunodeficiency virus (HIV). We found no correlation between the presence or amount of NBIg or neutrophil-binding Ig in serum and either the s
HTLV-I infection in human disease.: Br J Ophthalmol. 1991 Mar;75(3):174-5. Unique Identifier : AIDSLINE MED/91190858; Spalton DJ; Nicholson F; Eye Department, St Thomas's Hospital, London.
Is risk of Kaposi's sarcoma in AIDS patients in Britain increased if sexual partners came from United States or Africa? [published erratum appears in BMJ 1991 Mar 30;302(6779):752]: BMJ. 1991 Mar 16;302(6777):624-5. Unique Identifier : AIDSLINE MED/91191204; Beral V; Bull D; Jaffe H; Evans B; Gill N; Tillett H; Swerdlow AJ; Imperial Cancer Research Fund, Cancer Epidemiology Unit,; Radcliffe Infirmary, Oxford.; OBJECTIVE--To determine whether the risk of Kaposi s sarcoma in patients with AIDS is increased by sexual contact with groups from abroad with a high incidence of Kaposi s sarcoma. DESIGN--Analysis of risk of Kaposi s sarcoma in patients with AIDS, according to country of origin of their sexual partners. SETTING--
Testing for HIV antibodies [letter; comment]: BMJ. 1991 Mar 16;302(6777):660-1. Unique Identifier : AIDSLINE MED/91191229; Kell PD; Cracknell MA; Barton SE; Lawrence AG
Autoimmune disease and HTLV-1 infection.: Br J Rheumatol. 1991 Apr;30(2):141-3. Unique Identifier : AIDSLINE MED/91191291; Bowness P; Davies KA; Tosswill J; Bunn CC; MacAlpine L; Weber JN; Walport MJ; Department of Medicine, Hammersmith Hospital and Royal; Postgraduate Medical School, London.; We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection in 20 other patients known to have antibodies to U1
Pneumocystis carinii pneumonia associated with profound lymphopenia and abnormal T-lymphocyte subset ratios during treatment for early-stage breast carcinoma.: Cancer. 1991 May 1;67(9):2407-9. Unique Identifier : AIDSLINE MED/91191470; Brunvand MW; Collins C; Livingston RB; Raghu G; Division of Oncology, University of Washington, Seattle.; Two women with Stage II breast carcinoma treated with lumpectomy followed by breast irradiation and adjuvant chemotherapy developed Pneumocystis carinii pneumonia while receiving cytotoxic chemotherapy. Neither woman had evidence of immunosuppression before therapy. They both had profound lymphopenia, reversed CD4/CD8
Evidence for the mutagenic potential of the vinyl chloride induced adduct, N2, 3-etheno-deoxyguanosine, using a site-directed kinetic assay.: Carcinogenesis. 1991 Apr;12(4):745-7. Unique Identifier : AIDSLINE MED/91191737; Singer B; Kusmierek JT; Folkman W; Chavez F; Dosanjh MK; Donner Laboratory, Lawrence Berkeley Laboratory, University of; California, Berkeley 94720.; N2,3-Ethenoguanine (epsilon G) is a product of vinyl chloride reaction with DNA in vivo and of its ultimate metabolite, chloroacetaldehyde, in vitro. The synthesis of the very labile 5 -triphosphate of N2,3-etheno-deoxyguanosine (epsilon dGuo) has made it possible to study the base pairing properties of this derivativ
[Sex behavior and knowledge about AIDS among students]: Dtsch Med Wochenschr. 1991 Apr 5;116(14):528-34. Unique Identifier : AIDSLINE MED/91191942; Elsing C; Musial F; Enck P; Arendt G; Erckenbrecht JF; Strohmeyer G; Abteilung fur Gastroenterologie, Universitat Dusseldorf.; 604 out of 700 students (330 females, 274 males; mean age 23.3 [19-64] years) completed a questionnaire, which was handed out by their teachers and consisted of 26 questions concerning sexual practices and knowledge about AIDS. 285 subjects were studying natural sciences, 134 arts and 185 medicine. There were signific
The effect of salt on the Michaelis Menten constant of the HIV-1 protease correlates with the Hofmeister series.: FEBS Lett. 1991 Mar 25;280(2):344-6. Unique Identifier : AIDSLINE MED/91192165; Wondrak EM; Louis JM; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis,; NCI-Frederick Cancer Research and Development Center, MD 21702.; The effect of different types of salt on the proteolytic activity of HIV-1 protease was studied. At a similar ionic strength, the enzyme activity changed according to the salting out effect of the ions used (Hofmeister series). Kinetic studies showed that a stronger salting out effect of the ions rather than the highe
Purification of HIV-1 wild-type protease and characterization of proteolytically inactive HIV-1 protease mutants by pepstatin A affinity chromatography.: FEBS Lett. 1991 Mar 25;280(2):347-50. Unique Identifier : AIDSLINE MED/91192166; Wondrak EM; Louis JM; Mora PT; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis,; NCI-Frederick Cancer Research and Development Center, MD 21702.; Recombinant wild-type protease of human immunodeficiency virus, type 1 (HIV-1) expressed in E. coli was purified by pepstatin A affinity chromatography. An 88-fold purification was achieved giving a protease preparation with a specific enzymatic activity of approximately 3700 pmol/min/micrograms. Two proteolytically i
Kaposi's sarcoma + HIV infection = AIDS? [letter]: Dermatologica. 1991;182(1):66. Unique Identifier : AIDSLINE MED/91192263; Harms M; Kinloch S; Saurat JH
Malnutrition and carbohydrate malabsorption in children with vertically transmitted human immunodeficiency virus 1 infection.: Gastroenterology. 1991 May;100(5 Pt 1):1296-302. Unique Identifier : AIDSLINE MED/91192522; Miller TL; Orav EJ; Martin SR; Cooper ER; McIntosh K; Winter HS; Combined Program in Pediatric Gastroenterology and Nutrition; Children's Hospital, Boston, Massachusetts.; The nutritional needs of children with human immunodeficiency virus infection are poorly understood. Twenty-eight children with vertically transmitted human immunodeficiency virus infection were evaluated for carbohydrate malabsorption using lactose hydrogen breath tests and d-xylose absorption studies. Lactose malabs
Oesophagography and AIDS [letter; comment]: Gut. 1991 Mar;32(3):340. Unique Identifier : AIDSLINE MED/91192683; Levine MS; Herlinger H
Outpatient AIDS care squeezed by high costs, low payments.: Hospitals. 1991 May 5;65(9):40, 42. Unique Identifier : AIDSLINE MED/91192838; Anderson HJ; Thanks to the rapid growth in outpatient AIDS care, many people with AIDS are living longer and improving their quality of life, experts agree. But these successes come with a high price tag. And growing demand, inadequate reimbursement, and tougher competition for federal and foundation funds have put the squeeze on
Adenosine deaminase in cerebrospinal fluid of cerebral toxoplasmosis in AIDS.: Infection. 1991 Jan-Feb;19(1):13. Unique Identifier : AIDSLINE MED/91192930; Pedro-Botet J; Soriano JC; Tomas S; Miralles R; Rubies-Prat J; Department of Medicine, Hospital del Mar, Universidad Autonoma; de Barcelona, Spain.
HIV infection and needle-stick injuries with syringes discarded by drug abusers [letter]: Infection. 1991 Jan-Feb;19(1):57. Unique Identifier : AIDSLINE MED/91192943; Rinaldi R; Francavilla E; Cadrobbi P; Bortolotti F
Spontaneous release of interferon as a predictor of clinical evolution in HIV-positive subjects.: Infection. 1991 Jan-Feb;19(1):7-12. Unique Identifier : AIDSLINE MED/91192945; Biglino A; Surbone A; Lipani F; Cappello N; Forno B; Pollono AM; Busso M; Pugliese A; Istituto di Malattie Infettive, Universita di Torino, Italy.; In order to establish a correlation with disease progression we prospectively evaluated ten clinical and immunologic parameters in 102 consecutive HIV-positive subjects. The eight immunologic variables were: in vitro spontaneous interferon release by peripheral blood monocytic cells, alpha- and gamma-interferon produc
Active production of anti-human T-lymphotropic virus type I (HTLV-I) IgM antibody in HTLV-I-associated myelopathy.: J Neuroimmunol. 1991 May;32(2):105-9. Unique Identifier : AIDSLINE MED/91193360; Nagasato K; Nakamura T; Ohishi K; Shibayama K; Motomura M; Ichinose K; Tsujihata M; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.; We investigated the presence of anti-human T-lymphotropic virus type I (HTLV-I) IgM in sera and cerebrospinal fluid from patients with HTLV-I-associated myelopathy (HAM) by Western blot analysis. Analyses of 36 serum samples revealed that most patients (31/36; 86.1%) had anti-HTLV-I IgM, whereas only four of 23 (17.4%
Opportunistic protozoan infections in human immunodeficiency virus disease: review highlighting diagnostic and therapeutic aspects [see comments]: J Clin Pathol. 1991 Mar;44(3):182-93. Unique Identifier : AIDSLINE MED/91193397; Curry A; Turner AJ; Lucas S; Public Health Laboratory, Withington Hospital, Manchester.
Pathologists urge using some horse sense to avoid doghouse when making diagnoses [news]: JAMA. 1991 Apr 24;265(16):2044-5. Unique Identifier : AIDSLINE MED/91194077; Goldsmith MF
From the Centers for Disease Control. Characteristics of, and HIV infection among, women served by publicly funded HIV counseling and testing services--United States, 1989-1990.: JAMA. 1991 Apr 24;265(16):2051-2. Unique Identifier : AIDSLINE MED/91194081
Non-Hodgkin's lymphoma in patients with advanced HIV infection treated with zidovudine.: JAMA. 1991 May 1;265(17):2208-11. Unique Identifier : AIDSLINE MED/91194120; Moore RD; Kessler H; Richman DD; Flexner C; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Md.; We wished to determine the incidence of human immunodeficiency virus-related high-grade non-Hodgkin s lymphoma (NHL) and identify factors associated with the development of NHL in patients receiving zidovudine. Data are from a 2-year prospective, observational, multisite study of 1
Chylothorax as fatal complication in fulminating Kaposi's sarcoma in a patient with AIDS.: Klin Wochenschr. 1991 Feb 6;69(3):134. Unique Identifier : AIDSLINE MED/91194217; Bogner JR; Gross M; Zietz C; Mandel I; Zollner N; Medizinische Poliklinik, Universitat Munchen.
Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.: Nature. 1991 Apr 11;350(6318):508-11. Unique Identifier : AIDSLINE MED/91194765; Garcia JV; Miller AD; Program in molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, Washington 98104.; A decline in the T-cell population usually marks the onset of progressive immunological disease in individuals infected with the human immunodeficiency virus (HIV). Because CD4+ cells help to coordinate efficient immune responses, some of the defects in the immune function in advanced cases of AIDS may be explained by
Cutaneous diseases associated with HIV infection.: Pathol Annu. 1991;26 Pt 1:265-309. Unique Identifier : AIDSLINE MED/91194997; Harawi SJ; Ghossein RA; Kurban RS; Kurban AK
Burkitt's lymphoma in a child with AIDS.: Pediatr Pathol. 1991 Jan-Feb;11(1):115-22. Unique Identifier : AIDSLINE MED/91195127; Young SA; Crocker DW; Department of Pathology, Cook County Hospital, Chicago, Illinois; 60612.; Few systemic lymphomas have been reported in children with AIDS. We report a case of disseminated Burkitt s lymphoma with lung involvement occurring in a 33-month-old child with acquired immunodeficiency syndrome. Lymphoid interstitial pneumonia was diagnosed by lung biopsy at 23 months of age, but lymphoma was not di
Pathology of the kidney in childhood immunodeficiency: AIDS-related nephropathy is not unique.: Pediatr Pathol. 1991 Jan-Feb;11(1):63-74. Unique Identifier : AIDSLINE MED/91195139; Foster S; Hawkins E; Hanson CG; Shearer W; Department of Pathology, Baylor College of Medicine 77030.; Clinical and nephropathologic findings in autopsy material from 7 children with acquired immune deficiency syndrome (AIDS), 13 with severe combined immune deficiency (SCID), and 6 with a variety of other congenital immune deficiencies were reviewed in an effort to understand better the pathophysiology of the AIDS-rela
Quantitative structure-activity relationships (QSARs) of pyrimidine nucleosides as HIV-1 antiviral agents.: Pharm Res. 1991 Jan;8(1):43-6. Unique Identifier : AIDSLINE MED/91195223; Mahmoudian M; Department of Pharmacology, University of Medical Sciences of; Iran Firoozgar Institute, Tehran.; The structural requirements for the antiviral activity of pyrimidine nucleosides against HIV-1 virus was evaluated with the Hansch SAR analysis. Antiviral activity is best related to the hydrophobicity and steric (L and B3) properties of the substituent at the C5 of pyrimidine ring. Further, the antiviral activity is
Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3097-101. Unique Identifier : AIDSLINE GENBANK/M60165; Westervelt P; Gendelman HE; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, MO 63110.; Profound differences exist in the replicative capacities of various human immunodeficiency virus 1 isolates in primary human monocytes. To investigate the molecular basis for these differences, recombinant full-length clones were constructed by reciprocal DNA fragment exchange between a molecular clone derived from a
Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3195-9. Unique Identifier : AIDSLINE MED/91195319; Gottlinger HG; Dorfman T; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115.; Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the cell surface. The experiments reported here define an important step in the life cycle of the virus, the release of the bud
Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3213-7. Unique Identifier : AIDSLINE MED/91195323; Krausslich HG; Institut fur Virusforschung, Deutsches Krebsforschungszentrum,; Heidelberg, Federal Republic of Germany.; Enzymatically active retroviral proteinases are dimers of identical polypeptide chains with a fold similar to that of other aspartic proteinases. Each polypeptide chain, encoded on one of the viral polyproteins, is less than half the size of cellular aspartic proteinases and contains only one of the two active-site as
Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoprotein.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3238-42. Unique Identifier : AIDSLINE MED/91195328; Gorny MK; Xu JY; Gianakakos V; Karwowska S; Williams C; Sheppard HW; Hanson CV; Zolla-Pazner S; Department of Pathology, New York University Medical Center, NY; 10016.; Cell lines secreting IgG1 human monoclonal antibodies (mAb) to the envelope glycoprotein, gp120, of human immunodeficiency virus (HIV) have been produced by transformation of peripheral blood cells from HIV-infected individuals and by fusion of transformed cells to a human-mouse heteromyeloma cell line (SHM-D33). Two
Observations after human immunodeficiency virus immunization and challenge of human immunodeficiency virus seropositive and seronegative chimpanzees.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3348-52. Unique Identifier : AIDSLINE MED/91195348; Gibbs CJ Jr; Peters R; Gravell M; Johnson BK; Jensen FC; Carlo DJ; Salk J; Laboratory of Central Nervous System Studies, National Institute; of Neurological Disorders and Stroke, National Institutes of; Health, Bethesda, MD 20892.; Two human immunodeficiency virus (HIV)-seropositive chimpanzees (A-3 and A-86c) infected 4 yr earlier with HIV, along with one uninfected animal (A-36), were inoculated intramuscularly three times in a year with a gamma-irradiated gp120-depleted HIV immunogen in incomplete Freund s adjuvant. Both previously infected a
Adolescents' perceptions of risk for HIV infection: implications for future research.: Soc Sci Med. 1991;32(2):221-8. Unique Identifier : AIDSLINE MED/91195754; Strunin L; Boston University, School of Public Health, MA 02118.; Few studies have investigated adolescents perceptions of their risk for HIV infection. Findings from two studies of adolescents in Massachusetts indicate that there are differences in the knowledge, beliefs, behaviors, and perceptions of risk among adolescents and suggest the need for understanding the differences am
A response to C. Owen Lovejoy [letter; comment]: Soc Sci Med. 1991;32(2):237. Unique Identifier : AIDSLINE MED/91195756; Rushton JP
Effects of prednisone on human immunodeficiency virus infection.: South Med J. 1991 Apr;84(4):431-5. Unique Identifier : AIDSLINE MED/91195761; Saulsbury FT; Bringelsen KA; Normansell DE; Department of Pediatrics, University of Virginia Health Sciences; Center, Charlottesville 22908.; Prednisone is used to treat a number of complications of the human immunodeficiency virus (HIV) infection, but there is little information about the immunologic consequences of such therapy. We gave prednisone to six boys with hemophilia who were infected with HIV in order to study its effects on their clinical status
Human immunodeficiency virus associated with thrombotic thrombocytopenic purpura: successful treatment with zidovudine.: South Med J. 1991 Apr;84(4):493-5. Unique Identifier : AIDSLINE MED/91195776; Salem G; Terebelo H; Raman S; Department of Medicine, Henry Ford Hospital, Detroit, Mich.; Thrombocytopenia associated with human immunodeficiency virus (HIV) is well described, and two recent reports show a beneficial effect with the antiretroviral agent zidovudine (ZDV). HIV-associated thrombotic thrombocytopenic purpura (TTP) has recently been observed, but the use of ZDV for it has not been previously d
Effect of terbutaline on bronchoconstriction induced by nebulised pentamidine.: Thorax. 1991 Feb;46(2):122-3. Unique Identifier : AIDSLINE MED/91195953; Leigh TR; Wiggins J; Gazzard BG; Collins JV; Westminster Hospital, London.; The severity, duration, and reversibility of pentamidine induced bronchial narrowing was studied with and without pretreatment with nebulised terbutaline 10 mg in an open study of 40 patients seropositive for the human immunodeficiency virus (HIV). All subjects received pentamidine 300 mg in 5 ml water via an Acorn Sy
Tests giving an aetiological diagnosis in pulmonary disease in patients infected with the human immunodeficiency virus [letter; comment]: Thorax. 1991 Feb;46(2):150. Unique Identifier : AIDSLINE MED/91195965; Parry CM; Evans HM; Beeching NJ
Regulation of HTLV-II gene expression by Rex involves positive and negative cis-acting elements in the 5'long terminal repeat.: Virology. 1991 Apr;181(2):433-44. Unique Identifier : AIDSLINE MED/91196233; Black AC; Chen IS; Arrigo S; Ruland CT; Allogiamento T; Chin E; Rosenblatt JD; Department of Medicine, UCLA School of Medicine.; Regulation of human T-cell leukemia virus type II (HTLV-II) gene expression by the trans-acting viral protein, Rex, is mediated through specific cis-acting sequences in the HTLV-II long terminal repeat (LTR). Augmentation of 5 LTR-linked gene expression by Rex requires two distinct cis-acting elements: one termed the
Immunodominance and antigenic variation of the principal neutralization domain of HIV-1.: Virology. 1991 Apr;181(2):481-9. Unique Identifier : AIDSLINE MED/91196238; Zwart G; Langedijk H; van der Hoek L; de Jong JJ; Wolfs TF; Ramautarsing C; Bakker M; de Ronde A; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam,; The Netherlands.; The principal neutralization domain (PND) of HIV-1 is located in the third variable region (V3) of the envelope glycoprotein gp 120. Cross-reactivity of experimental and natural sera with recombinant proteins containing the V3 region of four HIV-1 variants showed that a group of viruses (among which HIV-1 MN) had anti
Structural properties of HIV-1 Env fused with the 14-kDa vaccinia virus envelope protein.: Virology. 1991 Apr;181(2):742-8. Unique Identifier : AIDSLINE MED/91196268; Rodriguez JR; Rodriguez D; Esteban M; Department of Biochemistry, State University of New York,; Brooklyn 11203.; To gain insights into the structure-function relationship of the envelope (env) glycoprotein of the human immunodeficiency virus type 1 (HIV-1) we have generated a vaccinia virus (VV) recombinant (VV-14kENV) that expresses a fusion protein (14k-env) consisting of the VV 14-kDa envelope protein (110 amino acids) fused
Pneumocystis carinii infection presenting as necrotizing thyroiditis and hypothyroidism.: Am J Clin Pathol. 1991 Apr;95(4):489-93. Unique Identifier : AIDSLINE MED/91196694; Ragni MV; Dekker A; DeRubertis FR; Watson CG; Skolnick ML; Goold SD; Finikiotis MW; Doshi S; Myers DJ; Department of Medicine, University of Pittsburgh School of; Medicine, Pennsylvania.; Extrapulmonary Pneumocystis infection has been increasingly reported in patients with acquired immune deficiency syndrome (AIDS), in particular, recently in association with the increasing use of aerosolized pentamidine. This report describes the unusual presentation of extrapulmonary Pneumocystis infection as a thyro
Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients.: Am J Clin Pathol. 1991 Apr;95(4):536-9. Unique Identifier : AIDSLINE MED/91196703; Shibata D; Tokunaga M; Sasaki N; Nanba K; Department of Pathology, University of Southern California School; of Medicine, Los Angeles.; Fixed lymphoma tissues from 11 patients seropositive for human T-cell leukemia virus type I (HTLV-I) antibodies were analyzed for proviral sequences by the polymerase chain reaction. Typical adult T-cell leukemia/lymphomas (ATLLs) from nine patients were positive for HTLV-I sequences. In contrast, one of two lymphomas
Kaposi's sarcoma in the bone marrow of a patient with AIDS.: Am J Clin Pathol. 1991 Apr;95(4):561-4. Unique Identifier : AIDSLINE MED/91196707; Ahluwalia C; Bernstein-Singer M; Beckstead J; Brynes RK; Department of Pathology, Los Angeles County/University of; Southern California Medical Center.; The authors report a case of Kaposi s sarcoma (KS) involving the bone marrow of a patient with acquired immune deficiency syndrome (AIDS). The morphologic features, differential diagnosis, immunostaining pattern, and unusually low frequency of marrow involvement by AIDS-related KS are discussed.
Healthcare community unites against mandatory AIDS tests [news]: Am J Nurs. 1991 Apr;91(4):105, 114. Unique Identifier : AIDSLINE MED/91196744
New York jobfocus. AIDS update: the New York picture.: Am J Nurs. 1991 Apr;91(4):77-9, 80-2, 84. Unique Identifier : AIDSLINE MED/91196757; Fondiller S; Teachers College, Columbia University, New York, NY.
Washington, DC jobfocus. AIDS update: the Washington picture.: Am J Nurs. 1991 Apr;91(4):87, 89-90, 92. Unique Identifier : AIDSLINE MED/91196758; Fondiller S; Teachers College, Columbia University, New York, NY.
Serosurveillance of human immunodeficiency virus infection [editorial]: Am J Public Health. 1991 May;81(5):561-2. Unique Identifier : AIDSLINE MED/91196797; Dondero TJ Jr; Curran JW
Cuba's response to the HIV epidemic [see comments]: Am J Public Health. 1991 May;81(5):563-7. Unique Identifier : AIDSLINE MED/91196798; Perez-Stable EJ; Department of Medicine, University of California, San Francisco; 94143-0320.; BACKGROUND: Cuba s response to the human immunodeficiency virus (HIV) epidemic has been to conduct mass testing of the population to ascertain seroprevalence, to enforce mandatory relative quarantine of persons testing positive, and to implement educational interventions using media and school-based programs. METHODS:
Effects of an intervention program on AIDS-related drug and needle behavior among intravenous drug users.: Am J Public Health. 1991 May;81(5):568-71. Unique Identifier : AIDSLINE MED/91196799; Stephens RC; Feucht TE; Roman SW; Department of Sociology, Cleveland State University, OH 44115.; BACKGROUND: Behaviors which entail high risk for human immunodeficiency virus (HIV) infection among intravenous drug users can be significantly reduced through educational intervention. METHODS: The educational intervention was conducted by a health educator in a one-on-one format and provided information about acquir
Adult survivors of childhood sexual abuse and subsequent risk of HIV infection.: Am J Public Health. 1991 May;81(5):572-5. Unique Identifier : AIDSLINE MED/91196800; Zierler S; Feingold L; Laufer D; Velentgas P; Kantrowitz-Gordon I; Mayer K; Department of Community Health, Brown University, Providence, RI; 02912.; BACKGROUND: Epidemiologic description of long-term adverse health effects of childhood sexual abuse is lacking, despite estimates that perhaps 30 percent of adults have experienced sexual assault in childhood. METHODS: In an adult cohort enrolled to investigate causes of transmission of human immunodeficiency virus, w
Evaluating needle exchange: do distributed needles come back?: Am J Public Health. 1991 May;81(5):617-9. Unique Identifier : AIDSLINE MED/91196808; Guydish J; Clark G; Garcia D; Downing M; Case P; Sorensen JL; Center for AIDS Prevention Studies, University of California, San; Francisco 94105.; We employed capture-recapture methods as a strategy for evaluating needle exchange. Needles distributed by the exchange at two time periods were marked with color coded bands indicating the date and site of distribution. Half of the marked needles (2,068/4,239) returned within two weeks of distribution, and 61 percent
Targeted HIV screening at a Los Angeles prenatal/family planning health center.: Am J Public Health. 1991 May;81(5):619-22. Unique Identifier : AIDSLINE MED/91196809; Fehrs LJ; Hill D; Kerndt PR; Rose TP; Henneman C; Division of Immunization, Centers for Disease Control, Atlanta,; GA 30333.; In 1988, the Los Angeles County Health Department conducted a blinded human immunodeficiency virus (HIV) seroprevalence study at a public prenatal (PN) and family planning (FP) center serving mostly Hispanic women in order to determine seroprevalence and to evaluate the center s targeted HIV screening program. Four wo
HIV-1 prevalence in selected Tijuana sub-populations.: Am J Public Health. 1991 May;81(5):623-5. Unique Identifier : AIDSLINE MED/91196810; Guerena-Burgueno F; Benenson AS; Sepulveda-Amor J; Graduate School of Public Health, San Diego State University,; California.; To assess the prevalence of HIV-1 (human immunodeficiency virus) infection among high-risk populations in Tijuana, Mexico , HIV-1 antibody status was determined and information on risk behavior was obtained from 1,069 individuals in three high-risk groups. The prevalence of HIV-1 am
HIV infection in an Ethiopian prison.: Am J Public Health. 1991 May;81(5):625-7. Unique Identifier : AIDSLINE MED/91196811; Kebede Y; Pickering J; McDonald JC; Wotton K; Zewde D; Division of Infectious Diseases, Montreal Children's Hospital,; Quebec, Canada.; HIV-1 antibody was detected in 6.0 percent of prisoners in an Ethiopian prison. HIV-1 seropositivity was strongly associated with positive VDRL status (RR = 3.7) and recent admission to prison (RR = 3.5). Seropositive prisoners were more likely to have prostitute contacts. No correlation was found between seropositivi
Comparison of AIDS knowledge, attitudes, and behaviors among incarcerated adolescents and a public school sample in San Francisco.: Am J Public Health. 1991 May;81(5):628-30. Unique Identifier : AIDSLINE MED/91196812; DiClemente RJ; Lanier MM; Horan PF; Lodico M; Center for AIDS Prevention Studies, University of California, San; Francisco 94105.; Data collected from incarcerated youth (n = 113) and a public school sample (n = 802) demonstrate that both adolescent groups have a high level of AIDS knowledge. Incarcerated youth are less aware of HIV risk-reduction behaviors and report markedly higher rates of HIV risk behaviors. Incarcerated youth are at substant
The effect of mandatory premarital HIV testing on marriage: the case of Illinois.: Am J Public Health. 1991 May;81(5):650-3. Unique Identifier : AIDSLINE MED/91196819; McKillip J; Department of Psychology, Southern Illinois University at; Carbondale 62901.
Community leaders help increase response rates in AIDS survey [news]: Am J Public Health. 1991 May;81(5):654-5. Unique Identifier : AIDSLINE MED/91196820; Longoria JM; Turner NH; Philips BU Jr
HIV seroconversion and oral intercourse [letter]: Am J Public Health. 1991 May;81(5):658. Unique Identifier : AIDSLINE MED/91196822; Lane HC; Holmberg SD; Jaffe HW
Erratum in Heymann article [letter]: Am J Public Health. 1991 May;81(5):658-9. Unique Identifier : AIDSLINE MED/91196823; Heymann SJ
New York State HIV seroprevalence project: goals, windows, and policy consideration.: Am J Public Health. 1991 May;81 Suppl:11-4. Unique Identifier : AIDSLINE MED/91196824; Novick LF; In the summer of 1987, the New York State Department of Health embarked on an extensive effort to determine the prevalence of trends of HIV infection in the state. Sero-surveillance for antibody to HIV was undertaken by blind testing of available blood samples. Six populations were selected as windows on the epidemic:
Newborn seroprevalence study: methods and results.: Am J Public Health. 1991 May;81 Suppl:15-21. Unique Identifier : AIDSLINE MED/91196825; Novick LF; Glebatis DM; Stricof RL; MacCubbin PA; Lessner L; Berns DS; For the 28-month period, November 30, 1987 through March 31, 1990, 653,117 blood specimens obtained on all newborn infants in New York State for detection of metabolic disorders were also analyzed for HIV serologic status. The overall seroprevalence rate was 0.66 percent: 1.24 percent in New York City and 0.17 percent
Comparison of newborn screening records and birth certificates to estimate bias in newborn HIV serosurveys [published erratum appears in Am J Public Health 1991 Sep;81(9):1112]: Am J Public Health. 1991 May;81 Suppl:22-4. Unique Identifier : AIDSLINE MED/91196826; Pass KA; Schedlbauer LM; MacCubbin PA; Glebatis DM; Implicit in the New York State Newborn HIV Seroprevalence Study is the assumption that newborns of all New York State residents are tested for human immunodeficiency virus (HIV) antibodies. We examined this assumption by describing that part of the 1988 New York newborn population not tested in the HIV seroprevalence
Geographic distribution of newborn HIV seroprevalence in relation to four sociodemographic variables.: Am J Public Health. 1991 May;81 Suppl:25-9. Unique Identifier : AIDSLINE MED/91196827; Morse DL; Lessner L; Medvesky MG; Glebatis DM; Novick LF; The geographic distribution of newborn human immunodeficiency virus seroprevalence at zip code level was compared with the distribution of four sociodemographic variables. For New York City significant univariate correlations were found between HIV and low birthweight, drug use (as measured by hospital discharges), ma
Projection of AIDS incidence in women in New York State.: Am J Public Health. 1991 May;81 Suppl:30-4. Unique Identifier : AIDSLINE MED/91196828; Lessner L; The results of the Newborn HIV Seroprevalence Study in New York State for 1988 were used to estimate the number of human immunodeficiency virus (HIV)-infected women of childbearing age in 1988. The estimate was accomplished for each of 80 age, racial/ethnic, and geographic strata by dividing the number of seropositive
HIV infection among women entering the New York State correctional system.: Am J Public Health. 1991 May;81 Suppl:35-40. Unique Identifier : AIDSLINE MED/91196829; Smith PF; Mikl J; Truman BI; Lessner L; Lehman JS; Stevens RW; Lord EA; Broaddus RK; Morse DL; Human immunodeficiency virus infection is the leading medical problem among prison inmates in several states. In 1988 a blinded seroprevalence study was conducted on 480 New York female prison entrants to determine the prevalence of and risk factors for HIV infection in this population. Ninety (18.8 percent) women wer
HIV seroprevalence in clients of sentinel family planning clinics.: Am J Public Health. 1991 May;81 Suppl:41-5. Unique Identifier : AIDSLINE MED/91196830; Stricof RL; Nattell TC; Novick LF; In February 1988 the New York State Department of Health initiated a study to determine the prevalence of HIV antibody in women attending selected, publicly subsidized family planning clinics. During a 26-month study period, 27,549 blood specimens were obtained from women having an initial medical examination in 41 cl
Hospitalization of HIV-seropositive newborns with AIDS-related disease within the first year of life [published erratum appears in Am J Public Health 1991 Sep;81(9):1112]: Am J Public Health. 1991 May;81 Suppl:46-9. Unique Identifier : AIDSLINE MED/91196831; Glebatis DM; Novick LF; Stacy A; The purpose of this study was to estimate the proportion of HIV-seropositive newborns hospitalized for an AIDS-related diagnosis within 12 months of birth and to characterize these hospitalizations. The number of HIV-seropositive infants born December 1987 through June 1988 was derived from the blinded New York State
HIV seroprevalence in a facility for runaway and homeless adolescents.: Am J Public Health. 1991 May;81 Suppl:50-3. Unique Identifier : AIDSLINE MED/91196832; Stricof RL; Kennedy JT; Nattell TC; Weisfuse IB; Novick LF; In October 1987, the New York State Department of Health initiated a study to determine the prevalence of antibody to HIV in clients of a facility for runaway and homeless adolescents in New York City. A risk-assessment component was added in May 1988. As of December 1989, a total of 2,667 adolescents had been tested,
The AIDS epidemic in New York State.: Am J Public Health. 1991 May;81 Suppl:54-60. Unique Identifier : AIDSLINE MED/91196833; Smith PF; Mikl J; Hyde S; Morse DL; New York State has reported more AIDS cases (26,576) through November 1989 than any other state, accounting for 23 percent of all reported cases in the nation at the time. New York City has reported 22,231 (84 percent) of the statewide cases. The epidemiology of AIDS in New York State has been easily influenced by the
HIV seroprevalence surveys: impetus for preventive activities.: Am J Public Health. 1991 May;81 Suppl:61-3. Unique Identifier : AIDSLINE MED/91196834; Novick LF; Seroprevalence determinations of human immunodeficiency virus are essential for design and implementation of preventive strategies. By demonstrating the severity of HIV infections within communities, New York State surveys have spurred preventive interventions, including information to the public and health care provi
Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.: Antimicrob Agents Chemother. 1991 Jan;35(1):198-200. Unique Identifier : AIDSLINE MED/91197080; Szebeni J; Patel SS; Hung K; Wahl LM; Weinstein JN; National Cancer Institute, Bethesda, Maryland 20892.; The effects of thymidine and uridine on the phosphorylation of 3 -azido-3 -deoxythymidine ( AZT ) were studied in various human mononuclear cell preparations. Thymidine suppressed [3H]AZT phosphorylation in the same concentration range (20 to 100 microM
[Epidemiologic study of anti-HTLV-I/II antibodies in blood donors in metropolitan France. The Retrovirus Working Group of the National Blood Transfusion Society]: Rev Fr Transfus Hemobiol. 1991 Jan;34(1):21-34. Unique Identifier : AIDSLINE MED/91197325; Lemaire JM; Coste J; Barin F; Courouce AM; Centre Regional de Transfusion Sanguine, Montpellier.; Between march and april 1989, the prevalence of HTLV-I/II antibodies was studied in a non selected population of 45,033 blood donors of Continental France . Serum samples were collected and screened by 12 Blood Banks located in different parts of the country. Screening was performed
The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?: AIDS Res Hum Retroviruses. 1991 Jan;7(1):3-16. Unique Identifier : AIDSLINE MED/91197563; Clements GJ; Price-Jones MJ; Stephens PE; Sutton C; Schulz TF; Clapham PR; McKeating JA; McClure MO; Thomson S; Marsh M; et al; Celltech Ltd., Slough, Berkshire, England.; Located close to the crown of the V3 type-specific neutralization loop of the human immunodeficiency virus type 1 (HIV-1) (IIIB) SU glycoprotein gp120, are several potential sites that should be susceptible to proteolytic cleavage by enzymes of trypsinlike or chymotrypsinlike specificity, or by aspartic proteinases. T
Anti-Leu3a induces combining site-related anti-idiotypic antibody without inducing anti-HIV activity.: AIDS Res Hum Retroviruses. 1991 Jan;7(1):55-63. Unique Identifier : AIDSLINE MED/91197566; Reeves JP; Buck D; Berkower I; Murphy D; Epstein SL; Molecular Immunology Laboratory, FDA, CBER, OBR, DBB, Bethesda,; MD 20892.; Development of a vaccine for acquired immunodeficiency syndrome (AIDS) has proven difficult, and so alternative approaches such as idiotypic manipulation have been suggested. As applied to AIDS, this approach could involve immunizing with an anti-CD4 antibody resembling gp120, to induce anti-idiotypic antibodies which
Fetal human immunodeficiency virus type 1 infection of different organs in the second trimester.: AIDS Res Hum Retroviruses. 1991 Jan;7(1):83-8. Unique Identifier : AIDSLINE MED/91197569; Mano H; Chermann JC; Unite de Recherches Inserm U 322 sur les Retrovirus et Maladies; Associees, Campus Universitaire de Luminy, Marseille, France.; Human immunodeficiency virus type 1 (HIV-1) infection in utero was examined by isolating the virus and detecting the HIV-1 DNA sequence from different fetal tissues. The brain, thymus, lung, liver, spleen, and placenta tissues from fetuses (10-23 weeks of gestation) born to HIV-1-infected asymptomatic mothers were exa
Human immunodeficiency virus in bone marrow: still more questions than answers [editorial; comment]: Blood. 1991 Apr 15;77(8):1625-6. Unique Identifier : AIDSLINE MED/91198490; Folks TM
Disseminated leiomyosarcoma in a child with acquired immune deficiency syndrome.: Cancer. 1991 May 15;67(10):2618-21. Unique Identifier : AIDSLINE MED/91199033; McLoughlin LC; Nord KS; Joshi VV; DiCarlo FJ; Kane MJ; Department of Pediatrics, Children's Hospital of New Jersey,; UMDNJ-New Jersey Medical School, Newark 07107.; A child with disseminated leiomyosarcoma and acquired immune deficiency syndrome (AIDS) is reported. She was originally believed to have peptic ulcer disease by radiographic and endoscopic evaluation but was found subsequently to have hypergastrinemia, hypochlorhydria, and a smooth muscle tumor. Leiomyosarcoma in chil
Cytokine biology. Implications for transfusion medicine.: Cancer. 1991 May 15;67(10 Suppl):2708-11. Unique Identifier : AIDSLINE MED/91199047; Adamson JW; New York Blood Center, NY.; The development and widespread availability of recombinant products will effect blood centers through reduced product use, replacement of current products, and novel applications of new products. The greatest amount of clinical experience to date has dealt with the use of recombinant human erythropoietin (r-HuEPO) in
Precautions [letter; comment]: Can Nurse. 1991 Apr;87(4):6, 8. Unique Identifier : AIDSLINE MED/91199062; Rafael A; Campbell B; Pequegnat D
Act now.: Can Nurse. 1991 Apr;87(4):60. Unique Identifier : AIDSLINE MED/91199063
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.: Cell. 1991 Apr 19;65(2):241-8. Unique Identifier : AIDSLINE MED/91199194; Malim MH; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.; Expression of the structural proteins of HIV-1 requires the direct interaction of the viral Rev trans-activator with its cis-acting RNA target sequence, the Rev response element or RRE. Here, we demonstrate that this specific RNA-binding event is, as expected, mediated by the conserved arginine-rich motif of Rev. Howe
Predicting AIDS onset for individual patients [editorial]: Clin Chem. 1991 Apr;37(4):486-7. Unique Identifier : AIDSLINE MED/91199384; Goedert JJ; Gail MH
Soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin at delivery.: Clin Exp Immunol. 1991 Apr;84(1):167-9. Unique Identifier : AIDSLINE MED/91199447; Ferreira A; Garcia Rodriguez MC; Omenaca F; Jimenez A; Villar LM; Gonzalez-Porque P; Fontan G; Immunology Unit, Hospital La Paz, Madrid Spain.; In this work we have quantified soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin (beta 2 m) in sera of HIV+ or HIV- mothers at delivery and in cord blood sera of their newborn children. The results obtained for beta 2 m show that cord blood sera of newborn children have higher concentration
Blood pigment found to slow AIDS virus in test [news]: Crit Care Nurse. 1991 Apr;11(4):58. Unique Identifier : AIDSLINE MED/91199611
[Contamination of the operating team with the patient's blood]: Dtsch Med Wochenschr. 1991 Apr 19;116(16):639. Unique Identifier : AIDSLINE MED/91199940
Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins.: FEBS Lett. 1991 Apr 9;281(1-2):77-80. Unique Identifier : AIDSLINE MED/91200319; Tozser J; Blaha I; Copeland TD; Wondrak EM; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis, ABL-Basic; Research Program, NCI-Frederick Cancer Research and Development; Center, MD 21702.; The substrate specificity of the human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) proteinases was compared using oligopeptides corresponding to cleavage sites in the Gag and Gag-Pol polyproteins of both viruses. All peptides mimicking cleavage sites at the junction of major functional protein domains wer
Resolved: free syringes and needles should be made available at high schools for anyone who asks in order to prevent AIDS.: J Am Acad Child Adolesc Psychiatry. 1991 Mar;30(2):325-30. Unique Identifier : AIDSLINE MED/91201237; Fullilove MT; Simmons JQ 3d; Clinical Psychiatry and Public Health, Columbia University.
Relationship of coping style to affective state and perceived social support in asymptomatic and symptomatic HIV-infected persons: implications for clinical management.: J Clin Psychiatry. 1991 Apr;52(4):171-3. Unique Identifier : AIDSLINE MED/91201250; Wolf TM; Balson PM; Morse EV; Simon PM; Gaumer RH; Dralle PW; Williams MH; Department of Psychiatry, Louisiana State University School of; Medicine, New Orleans 70112.; The authors describe the relationship of three coping styles to affective state (mood) and perceived social support in 29 human immunodeficiency virus (HIV)-infected homosexual/bisexual men between the ages of 18 and 45 years. Active-behavioral coping was significantly related to enhanced mood and greater perceived so
HIV antigen detection in circulating immune complexes.: J Virol Methods. 1991 Jan;31(1):67-76. Unique Identifier : AIDSLINE MED/91201529; Kestens L; Hoofd G; Gigase PL; Deleys R; van der Groen G; Institute of Tropical Medicine, Antwerpen, Belgium.; Various methods were evaluated for their effectiveness in releasing HIV antigen (Ag) from artificial immune complexes (IC) and from IC present in serum from HIV antibody (Ab) positive subjects. The most effective methods for recovering HIV Ag from IC were those which included a denaturation step to prevent reassociati
Sensitive detection of anti-human T-cell leukemia virus type I IgG in human serum by a novel enzyme immunoassay (immune complex transfer enzyme immunoassay) using recombinant gag-env hybrid protein as antigen.: J Virol Methods. 1991 Jan;31(1):77-91. Unique Identifier : AIDSLINE MED/91201530; Kohno H; Kohno T; Sakoda I; Ishikawa E; Fuji Research Laboratories, Kyowa Medex Co. Ltd., Shizuoka,; Japan.; Anti-human T-cell leukemia virus type I IgG (anti-HTLV-I IgG) in human serum was detected with high sensitivity by a novel enzyme immunoassay (immune complex transfer enzyme immunoassay) using recombinant gag(14-139)-env(197-295) hybrid protein. Anti-HTLV-I IgG in test serum was reacted simultaneously with dinitrophen
Use of selected vitamin and mineral supplements among individuals infected with human immunodeficiency virus [see comments]: J Am Diet Assoc. 1991 Apr;91(4):476-8. Unique Identifier : AIDSLINE MED/91201717; Martin JB; Easley-Shaw T; Collins C; School of Allied Health Sciences, University of Texas Health; Science Center, Houston 77225.
Culture and properties of cells derived from Kaposi sarcoma.: J Immunol. 1991 May 1;146(9):2972-6. Unique Identifier : AIDSLINE MED/91201858; Corbeil J; Evans LA; Vasak E; Cooper DA; Penny R; Centre for Immunology, St. Vincent's Hospital, Sydney NSW,; Australia.; We describe the establishment of four continuous cell cultures isolated from pleural or peritoneal fluid of patients with Kaposi sarcoma (KS) and show evidence that these cells are derived from vascular endothelium. Although provision of an extracellular matrix (fibronectin, laminin, or matrigel) was essential, the ce
HIV replication and persistence in human gastrointestinal cells cultured in vitro.: J Leukoc Biol. 1991 May;49(5):499-504. Unique Identifier : AIDSLINE MED/91202028; Moyer MP; Gendelman HE; Department of Surgery, University of Texas Health Science Center,; San Antonio 78284-7842.; Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months imp
Maintenance of human immunodeficiency virus type-1 proviral DNA in human fetal dorsal root ganglia neural cells following a nonproductive infection.: J Leukoc Biol. 1991 May;49(5):505-10. Unique Identifier : AIDSLINE MED/91202029; Kunsch C; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033.; Infection of the nervous system by human immunodeficiency virus type-1 (HIV-1) has been implicated in the generation of acquired immunodeficiency syndrome (AIDS)-associated neurologic dysfunction and direct infection of glia has been suggested as one of the potential mechanisms leading to deterioration of nervous syst
Clinical performance of a polymerase chain reaction testing algorithm for diagnosis of HIV-1 infection in peripheral blood mononuclear cells.: J Med Virol. 1991 Jan;33(1):58-63. Unique Identifier : AIDSLINE MED/91202150; Wages JM Jr; Hamdallah M; Calabro MA; Fowler AK; Oster CN; Redfield RR; Burke DS; SRA Technologies, Inc., Rockville, Maryland.; The clinical performance of a modified polymerase chain reaction (PCR) testing algorithm was evaluated for confirming the presence of HIV-1 proviral DNA in peripheral blood mononuclear cells. A whole cell lysate, rather than phenol-purified DNA, was used for PCR amplification, under systematically optimized conditions
Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma [published erratum appears in J Clin Oncol 1992 Feb;10(2):346] [see comments]: J Clin Oncol. 1991 May;9(5):802-8. Unique Identifier : AIDSLINE MED/91202206; Scadden DT; Bering HA; Levine JD; Bresnahan J; Evans L; Epstein C; Groopman JE; New England Deaconess Hospital, Boston, MA 02215.; The combined use of zidovudine (ZDV) and interferon (IFN) alfa-2a has been shown to have antiretroviral and antitumor potential benefit in the treatment of acquired immune deficiency syndrome (AIDS)-associated Kaposi s sarcoma (KS). However, the clinical use of this combination is frequently complicated by the overlap
Employees' sources of AIDS information: the workplace as a promising educational setting.: J Occup Med. 1991 Feb;33(2):143-7. Unique Identifier : AIDSLINE MED/91202257; Barr JK; Waring JM; Warshaw LJ; New York Business Group on Health, Inc., New York, NY 10017-6763.; Employees evaluations of AIDS education in the workplace are related to the nature of the program sponsored by employers. A survey of 3460 employees in eight corporate work sites and four public agencies indicated that workplace programs are more highly valued by employees than are other sources of AIDS information w
Cat scratch disease [editorial]: J Pathol. 1991 Feb;163(2):91-2. Unique Identifier : AIDSLINE MED/91202282; Lucas SB
Approaches and issues in the development of vaccines against HIV.: J Acquir Immune Defic Syndr. 1991;4(5):451-9. Unique Identifier : AIDSLINE MED/91202362; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, National Institutes of Health, Bethesda,; Maryland 20892.
HTLV-I/II seroprevalence and HIV/HTLV coinfection among U.S. intravenous drug users [see comments]: J Acquir Immune Defic Syndr. 1991;4(5):460-7. Unique Identifier : AIDSLINE MED/91202363; Cantor KP; Weiss SH; Goedert JJ; Battjes RJ; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20892.; Data from a continuing multiyear seroprevalence survey of human T-lymphotropic virus types I or II (HTLV-I/II) among intravenous drug users in seven U.S. locations were analyzed to detect demographic patterns of seropositivity and coinfection with human immunodeficiency virus type 1 (HIV-1). Seropositivity for HTLV-I/
Seroprevalence of retroviral infection in women with different fertility statuses in Gabon, western equatorial Africa.: J Acquir Immune Defic Syndr. 1991;4(5):468-70. Unique Identifier : AIDSLINE MED/91202364; Schrijvers D; Delaporte E; Peeters M; Dupont A; Meheus A; Centre International de Recherches Medicales, Franceville, Gabon.; Seroprevalence of retroviral infection (HIV-1, HTLV-1) in women with different fertility statuses was studied in Gabon (Western Equatorial Africa). The overall prevalence rate of HIV-1 was 1.4% and of HTLV-1, 6.8%. In the primary infertile women the age-adjusted prevalence rate of H
Hospital use by HIV patients in Italy: a retrospective longitudinal study. National Study Group on HIV-Related Hospital Use.: J Acquir Immune Defic Syndr. 1991;4(5):471-9. Unique Identifier : AIDSLINE MED/91202365; Greco D; Declich S; Pezzotti P; Bellomi G; Visco G; AIDS Operational Center, Istituto Superiore di Sanita, Rome,; Italy.; Hospital-based treatment for HIV patients consumes considerable health care resources, and for planning purposes it is important to know the hospital needs for each stage of infection. In this paper, we report the results of a national study in Italy on hospital stay for cohorts of
Antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virus.: J Acquir Immune Defic Syndr. 1991;4(5):489-98. Unique Identifier : AIDSLINE MED/91202367; Lundgren B; Bottiger D; Ljungdahl-Stahle E; Norrby E; Stahle L; Wahren B; Oberg B; Department of Virology, Karolinska Institute, Stockholm, Sweden.; An acute infection with simian immunodeficiency virus (SIVSM) in cynomolgus monkeys was used to evaluate the antiviral effects of 3 -fluorothymidine (FLT) and 3 -azidothymidine [zidovudine (ZDV)]. Neither compound prevented the infection despite dosing prior to virus inoculation. FLT was about ten times more potent th
Early-initiated zidovudine therapy prevents disease but not low levels of persistent retrovirus in mice.: J Acquir Immune Defic Syndr. 1991;4(5):506-12. Unique Identifier : AIDSLINE MED/91202369; Morrey JD; Okleberry KM; Sidwell RW; AIDS Research Program, Utah State University, Logan 84322-5600.; An F1 hybrid mouse strain containing the Rfv-3r/s genotype was inoculated with Friend virus complex (FV) and treated with zidovudine (ZDV) intraperitoneally three times daily for 20 days beginning as early as 10 min after initial viral exposure. This strain of mice develops FV-specific neutralizing antibodies that aid
Postexposure chemoprophylaxis: approval criteria for clinical trials.: J Acquir Immune Defic Syndr. 1991;4(5):513-5. Unique Identifier : AIDSLINE MED/91202370; Beninger PR; Cooper EC; Division of Antiviral Drug Products, U.S. Food and Drug; Administration, Rockville, Maryland 20857.; Five scenarios are proposed that investigators and clinicians might consider in the evaluation of an investigational drug for postexposure chemoprophylaxis. They are (a) safety as the only standard required for an indication for postexposure chemoprophylaxis; (b) efficacy of the drug for treatment of HIV-infected pati
The spectrum of Mycobacterium kansasii disease associated with HIV-1 infected patients.: J Acquir Immune Defic Syndr. 1991;4(5):516-20. Unique Identifier : AIDSLINE MED/91202371; Valainis GT; Cardona LM; Greer DL; Infectious Disease Section, Tulane University Medical Center, New; Orleans, Louisiana.; Louisiana is known to be an area endemic for Mycobacterium kansasii (MK). Since MK tends to disseminate in immunocompromised patients, one might, therefore, expect to observe an increasing number of MK infections associated with human immunodeficiency virus (HIV-1). A systematic 60-month review of clinical, microbiolo
Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole.: J Acquir Immune Defic Syndr. 1991;4(5):532-7. Unique Identifier : AIDSLINE MED/91202373; Hughes WT; Killmar JT; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee.; Pneumocystis carinii pneumonitis was effectively prevented in 90% of immunosuppressed rats by the administration of 100 mg of erythromycin and 300 mg/kg/day of sulfisoxazole. All of the untreated control and erythromycin-treated animals developed the infection and 80% of rats given sulfisoxazole alone had the pneumoni
Correlation between HIV infection and central nervous system (CNS) changes in fetal brain [letter]: J Acquir Immune Defic Syndr. 1991;4(5):540. Unique Identifier : AIDSLINE MED/91202375; Encha-Razavi F; Larroche JC; Vazeux R; Roume J; Mulliez N
Measles antibody status of HIV-infected prison inmates [letter]: J Acquir Immune Defic Syndr. 1991;4(5):540-1. Unique Identifier : AIDSLINE MED/91202376; Glaser JB; DeCorato DR; Greifinger R
Detection of HTLV-I and not HTLV-II infection in Guinea Bissau (west Africa) [letter]: J Acquir Immune Defic Syndr. 1991;4(5):541-2. Unique Identifier : AIDSLINE MED/91202377; Lillo F; Varnier OE; Sabbatani S; Ferro A; Mendez P
Use of central venous catheterization for AIDS patients [letter]: J Acquir Immune Defic Syndr. 1991;4(5):543. Unique Identifier : AIDSLINE MED/91202378; Negri C; Saracco A; Lazzarin A
Podophyllin resin 25% for treatment of oral hairy leukoplakia: an old treatment for a new lesion [letter]: J Acquir Immune Defic Syndr. 1991;4(5):543-6. Unique Identifier : AIDSLINE MED/91202379; Lozada-Nur F
In vitro evaluation of phosphocholine and quaternary ammonium containing lipids as novel anti-HIV agents.: J Med Chem. 1991 Apr;34(4):1377-83. Unique Identifier : AIDSLINE MED/91202492; Meyer KL; Marasco CJ Jr; Morris-Natschke SL; Ishaq KS; Piantadosi C; University of North Carolina, School of Pharmacy, Division of; Medicinal Chemistry and Natural Products, Chapel Hill 27599.; A series of synthetic lipids containing a two- or three-carbon backbone substituted with a thio, oxy, or amidoalkyl functionality and either a phosphocholine or quaternary ammonium moiety was evaluated as potential anti-HIV-1 agents. Several analogues were identified as possessing activity with the most promising comp
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).: J Med Chem. 1991 Apr;34(4):1394-9. Unique Identifier : AIDSLINE MED/91202494; Tanaka H; Baba M; Ubasawa M; Takashima H; Sekiya K; Nitta I; Shigeta S; Walker RT; De Clercq E; Miyasaka T; School of Pharmaceutical Sciences, Showa University, Tokyo,; Japan.; Several analogues of a new lead for anti-HIV-1 agents, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT), in which the C-2, N-3, or C-4 position was modified were synthesized. These involve 2-thiothymine (11), 2-thiouracil (12), 4-thiothymine (17), 4-thiouracil (18), 5-methylcytosine (27), and cytosine (28) der
Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.: J Med Chem. 1991 Apr;34(4):1426-30. Unique Identifier : AIDSLINE MED/91202499; Hiebl J; Zbiral E; Balzarini J; De Clercq E; Institut fur Organische Chemie, Universitat Wien, Austria.; The 5 -azidonucleosides 3 and 4 were obtained by treating thymidine and 2 -deoxyuridine with TPP/DEAD/HN3. The 3 -O-silylated 5 -azido-5 -deoxythymidine 5 and the corresponding 2 -deoxyuridine derivative 6 were transformed to the formamides (7 and 8, respectively) and dehydrated to the protected 5 -isocyano derivative
Specific anti-HIV-1 acyclonucleosides which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.: J Med Chem. 1991 Apr;34(4):1508-11. Unique Identifier : AIDSLINE MED/91202512; Tanaka H; Baba M; Saito S; Miyasaka T; Takashima H; Sekiya K; Ubasawa M; Nitta I; Walker RT; Nakashima H; et al; School of Pharmaceutical Sciences, Showa University, Tokyo,; Japan.
Human immunodeficiency virus type 1 infection of human placenta: potential route for fetal infection.: J Virol. 1991 May;65(5):2231-6. Unique Identifier : AIDSLINE MED/91202559; Amirhessami-Aghili N; Spector SA; Department of Pediatrics, University of California, San Diego; 92103.; To determine the potential role of the placenta in transmission of human immunodeficiency virus (HIV) from mother to fetus, the ability of human placental tissue to support HIV type 1 (HIV-1) infection was examined. HIV-1-seronegative first-trimester placentas were maintained in culture and infected with HIV-1. Virus
Human T-cell leukemia virus (HTLV) type II Rex protein binds specifically to RNA sequences of the HTLV long terminal repeat but poorly to the human immunodeficiency virus type 1 Rev-responsive element.: J Virol. 1991 May;65(5):2261-72. Unique Identifier : AIDSLINE MED/91202563; Yip MT; Dynan WS; Green PL; Black AC; Arrigo SJ; Torbati A; Heaphy S; Ruland C; Rosenblatt JD; Chen IS; Department of Microbiology and Immunology, University of; California, School of Medicine, Los Angeles 90024-1678.; The human T-cell leukemia viruses (HTLVs) encode a trans-regulatory protein, Rex, which differentially regulates viral gene expression by controlling the cytoplasmic accumulation of viral mRNAs. Because of insufficient amounts of purified protein, biochemical characterization of Rex activity has not previously been pe
Antigenic and genetic variation in influenza A (H1N1) virus isolates recovered from a persistently infected immunodeficient child.: J Virol. 1991 May;65(5):2340-50. Unique Identifier : AIDSLINE GENBANK/M59334; Rocha E; Cox NJ; Black RA; Harmon MW; Harrison CJ; Kendal AP; Influenza Branch, Centers for Disease Control, Atlanta, Georgia; 30333.; Antigenic and genetic variations have been analyzed in eight consecutive isolates recovered from a child with severe combined immunodeficiency syndrome persistently infected with naturally acquired type A (H1N1) influenza virus over a 10-month period. Hemagglutination inhibition reactions and T1 oligonucleotide finger
A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.: J Virol. 1991 May;65(5):2415-21. Unique Identifier : AIDSLINE MED/91202582; Charneau P; Clavel F; Unite d'Oncologie Virale, Departement SIDA et Retrovirus,; Institut Pasteur, Paris, France.; The structure of unintegrated human immunodeficiency virus type 1 (HIV-1) DNA from acutely infected human lymphoid cells was analyzed by nuclease S1 cleavage. We observed a unique, discrete single-stranded gap in unintegrated linear DNA molecules, located near the center of the genome. Oligonucleotide primer extension
Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.: J Virol. 1991 May;65(5):2436-44. Unique Identifier : AIDSLINE MED/91202585; Zeichner SL; Kim JY; Alwine JC; Department of Pediatrics, Children's Hospital of Philadelphia,; Pennsylvania.; We have compared the relative importance of transcription regulatory regions in the U3 and R regions of the human immunodeficiency virus type 1 long terminal repeat (LTR) by using linker-scanning mutational analysis. Twenty-six mutant LTR-chloramphenicol acetyltransferase (CAT) transient expression plasmids were prepa
Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.: J Virol. 1991 May;65(5):2452-6. Unique Identifier : AIDSLINE MED/91202587; Kubota S; Nosaka T; Cullen BR; Maki M; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; Two chimeric mutant genes derived from rev of human immunodeficiency virus type 1 and rex of human T-cell leukemia virus type I were constructed to investigate the functions of the nucleolar-targeting signals (NOS) in Rev and Rex proteins. A chimeric Rex protein whose NOS region was substituted with the NOS of Rev was
Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus.: J Virol. 1991 May;65(5):2612-21. Unique Identifier : AIDSLINE MED/91202607; Gitlin SD; Lindholm PF; Marriott SJ; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.; Human T-cell lymphotropic virus type I (HTLV-I) encodes a 40-kDa nuclear transactivating phosphoprotein, TAX1. The results presented in this study demonstrate that deletion of amino acids 2 through 59 of TAX1 (delta 58 TAX1) decreased transactivation of the HTLV-I long terminal repeat 10- to 20-fold. S1 nuclease analy
The N-terminal 31 amino acids of human immunodeficiency virus type 1 envelope protein gp120 contain a potential gp41 contact site.: J Virol. 1991 May;65(5):2682-5. Unique Identifier : AIDSLINE MED/91202615; Ivey-Hoyle M; Clark RK; Rosenberg M; Department of Gene Expression Sciences, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.; We have compared the expression of full-length gp160 envelope protein from human immunodeficiency virus type 1 with that of a deletion mutant lacking the N-terminal 31 amino acids of the mature protein (gp160 delta 32). The gp160 and gp160 delta 32 proteins are processed to yield gp41 and gp120 or gp120 delta 32, resp
Unintegrated human immunodeficiency virus type 1 DNA in chronically infected cell lines is not correlated with surface CD4 expression.: J Virol. 1991 May;65(5):2695-8. Unique Identifier : AIDSLINE MED/91202618; Besansky NJ; Butera ST; Sinha S; Folks TM; Retrovirus Diseases Branch, Centers for Disease Control, Atlanta,; Georgia 30333.; Using a polymerase chain reaction-based assay on total cell lysates, we have detected unintegrated human immunodeficiency virus type 1 (HIV-1) DNA in chronically infected T-lymphocytic (ACH-2, J1) and promyelocytic (OM-10.1) cell lines. Treatment with 3 -azido-3 -deoxythymidine (
Office-based testing for antibody to human immunodeficiency virus in urology patients.: J Urol. 1991 May;145(5):1012-4. Unique Identifier : AIDSLINE MED/91202636; Krieger JN; Ferrera CA; Berger RE; Montana JP; Krieger MS; Department of Urology, University of Washington School of; Medicine, Seattle.; Knowledge of the status of a patient regarding antibody to human immunodeficiency virus type 1 (HIV-1) may be important in many clinical situations. Consequently, we evaluated a rapid test for antibody to HIV-1 peptides that might be suitable for a physician office practice. We evaluated the time necessary to learn to
Physicians infected with HIV [letter]: JAMA. 1991 May 8;265(18):2337-8. Unique Identifier : AIDSLINE MED/91202693; Lederman MM; Mehlman MJ
Pharmacokinetic interaction of antimicrobial agents with levomethadon in drug-addicted AIDS patients.: Klin Wochenschr. 1991 Jan 4;69(1):16-8. Unique Identifier : AIDSLINE MED/91203056; Brockmeyer NH; Mertins L; Goos M; Universitatshautklinik Essen.; Morphine and its derivatives are metabolized by the liver microsomal enzyme system with a high first-pass effect after oral application. In four of 44 HIV-infected i.v. drug abusers who participated in a levomethadon maintenance program, we observed sustained symptoms of under-dosage and loss of effect of there to for
Schools need to provide infection control training and supplies.: J Sch Health. 1991 Feb;61(2):106-7. Unique Identifier : AIDSLINE MED/91203086; Kerr DL; American School Health Association, Kent, OH 44240-0708.
Infection of inbred rabbits with cell-free HTLV-I.: Leuk Res. 1991;15(2-3):105-10. Unique Identifier : AIDSLINE MED/91203212; Seto A; Isono T; Ogawa K; Department of Microbiology, Shiga University of Medical Science,; Otsu, Japan.; Inbred rabbits were infected by cell-free HTLV-I to become virus carriers with provirus-carrying cells in the peripheral blood. Repeated injections of cell-free virus into newborn animals led to an increase in the provirus-carrying cells in the peripheral blood and to a lymphocytic infiltration in the portal spaces of
Major prognostic factors of patients with adult T-cell leukemia-lymphoma: a cooperative study. Lymphoma Study Group (1984-1987).: Leuk Res. 1991;15(2-3):81-90. Unique Identifier : AIDSLINE MED/91203223; A total of 854 patients with anti-HTLV-I antibody positive ATL, newly diagnosed from 1983 to 1987, were analyzed for prognostic factors. There were 466 males and 388 females with a mean age of 57.1. Of these 269 (31.5%) were alive with a median follow-up time of 14 months from diagnosis, while 585 (65.5%) were dead wi
Serum deoxythymidine kinase in adult T-cell leukemia-lymphoma and its related disorders.: Leuk Res. 1991;15(2-3):99-103. Unique Identifier : AIDSLINE MED/91203225; Sadamori N; Ikeda S; Yamaguchi K; Mine M; Hakariya S; Kinoshita H; Hayashi K; Nakamura T; Nagataki S; Ichimaru M; Department of Hematology, Atomic Disease Institute, Nagasaki; University School of Medicine, Japan.; Serum deoxythymidine kinase (TK) was measured in 15 patients with the acute type of adult T-cell leukemia (ATL), in 4 with chronic ATL, in 10 with lymphoma type ATL, in 9 with pre-ATL, in 11 with human T-cell leukemia virus type I (HTLV-I) associated with myelopathy (HAM) and in 19 HTLV-I carriers. All these patients
[Communicable disease control regulations have no place in the prevention of HIV]: Lakartidningen. 1991 Mar 20;88(12):1048-9. Unique Identifier : AIDSLINE MED/91203305; Berglund O; Roslagstulls sjukhus.
[HIV-infected drug addicts in a clinic for infectious diseases are dissatisfied and desire more treatment]: Lakartidningen. 1991 Mar 20;88(12):1069, 1071-2. Unique Identifier : AIDSLINE MED/91203315; Tokaker PO; Spangberg L; Pehrson P; Psykiatriska kliniken, Helsingborgs lasarett.; In structured interviews with 171 HIV-positive iv drug abusers at the HIV clinic of Roslagstull Hospital in Stockholm, were investigated their current drug abuse and any wishes they might have as to their treatment. Over 75 per cent reported drugs abuse in the past 12-month period-chiefly iv heroin. Half of them repor
Routine antenatal screening for HIV--not justified at present [letter]: Med J Aust. 1991 Apr 15;154(8):566. Unique Identifier : AIDSLINE MED/91203717; Garland SM; Kliman LJ
Public health and community-based problem solving [interview]: Minn Med. 1991 Feb;74(2):7-9. Unique Identifier : AIDSLINE MED/91203777; Kurowski JL
Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element.: Mol Cell Biol. 1991 May;11(5):2567-75. Unique Identifier : AIDSLINE MED/91203877; Fankhauser C; Izaurralde E; Adachi Y; Wingfield P; Laemmli UK; Department of Biochemistry, University of Geneva, Switzerland.; The human immunodeficiency virus type 1 (HIV) Rev protein is thought to be involved in the export of unspliced or singly spliced viral mRNAs from the nucleus to the cytoplasm. This function is mediated by a sequence-specific interaction with a cis-acting RNA element, the Rev response element (RRE), present in these in
Strategy for developing a genetically-engineered whole-virus vaccine against HIV.: Mol Immunol. 1991 Mar;28(3):231-4. Unique Identifier : AIDSLINE MED/91203941; Haynes JR; Yao FL; Ma J; Cao SX; Klein MH; Connaught Centre for Biotechnology Research, Willowdale, Ontario,; Canada.; The production of genetically-engineered, noninfectious virions of human immunodeficiency virus (HIV) represents a novel approach to the development of a safe and effective vaccine for the acquired immune deficiency syndromes (AIDS). Insofar as preparations of inactivated simian immunodeficiency virus (SIV) are now de
Mycobacterium avium complex infection in the acquired immunodeficiency syndrome.: N Engl J Med. 1991 May 9;324(19):1332-8. Unique Identifier : AIDSLINE MED/91204018; Horsburgh CR Jr; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA; 30333.
AIDS research. French minister clears Zagury [news]: Nature. 1991 Apr 18;350(6319):546. Unique Identifier : AIDSLINE MED/91204037; Culliton BJ
Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection.: Nature. 1991 Apr 18;350(6319):625-6. Unique Identifier : AIDSLINE MED/91204058; Riviere Y; Blank V; Kourilsky P; Israel A; Unite de Virologie et Immunologie Cellulaire URA CNRS 1157,; Institut Pasteur, Paris, France.; Transcription of the human immunodeficiency virus type-1 (HIV-1) genome is regulated in part by cellular factors and is stimulated by activation of latently infected T cells. T-cell activation also correlates with the induction of the factor NF-kappa B which binds to two adjacent sites in the HIV-1 long terminal repea
Listeriosis in patients infected with human immunodeficiency virus.: Rev Infect Dis. 1991 Jan-Feb;13(1):115-9. Unique Identifier : AIDSLINE MED/91205164; Berenguer J; Solera J; Diaz MD; Moreno S; Lopez-Herce JA; Bouza E; Department of Clinical Microbiology Hospital, General Gregorio; Maranon, Madrid, Spain.; Although resistance to Listeria monocytogenes infection requires intact T cell-mediated immunity, only 20 patients with human immunodeficiency virus (HIV) infection and listeriosis (including one patient described herein) have been reported to date. Listeriosis developed before AIDS in five cases. Syndromes included m
Rhodococcus equi infection in patients with and without human immunodeficiency virus infection.: Rev Infect Dis. 1991 Jan-Feb;13(1):139-45. Unique Identifier : AIDSLINE MED/91205168; Harvey RL; Sunstrum JC; Department of Medicine, Wayne State University, Detroit,; Michigan.; Rhodococcus equi is an uncommon pathogen in humans that has occasionally been reported to cause infection in individuals with impaired cellular immunity. We summarize 30 previously published reports of human infection with R. equi and describe one additional case in a patient with AIDS. Eleven (35%) of the patients di
Treatment of Listeria bacteremia with vancomycin [letter]: Rev Infect Dis. 1991 Jan-Feb;13(1):181-2. Unique Identifier : AIDSLINE MED/91205177; Blatt SP; Zajac RA
Administration of zidovudine for treatment of infection due to human immunodeficiency virus [letter; comment]: Rev Infect Dis. 1991 Jan-Feb;13(1):186-7. Unique Identifier : AIDSLINE MED/91205181; Blott KW
Manifestations of pulmonary cryptococcosis in patients with acquired immunodeficiency syndrome.: Rev Infect Dis. 1991 Jan-Feb;13(1):64-7. Unique Identifier : AIDSLINE MED/91205190; Cameron ML; Bartlett JA; Gallis HA; Waskin HA; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710.; Cryptococcosis is a common opportunistic infection in patients with AIDS. Meningitis is the most frequent manifestation of infection with Cryptococcus neoformans; pneumonia due to this organism, though less frequently recognized, is also a significant entity. A retrospective review was performed of all patients seen a
Rhodococcus equi infection in the patient with AIDS: literature review and report of an unusual case.: Rev Infect Dis. 1991 Jan-Feb;13(1):91-6. Unique Identifier : AIDSLINE MED/91205196; Emmons W; Reichwein B; Winslow DL; Department of Medicine, Medical Center of Delaware, Wilmington; 19899.; Rhodococcus equi is an aerobic, intracellular, gram-positive rod-coccus that is partially acid fast. The organism is primarily a pathogen in animals and has only rarely been seen in immunocompromised humans. Its most common manifestation is a slowly progressive pneumonia that may cavitate. Infections are thought to be
AIDS research at NIH [letter; comment]: Science. 1991 Apr 19;252(5004):360. Unique Identifier : AIDSLINE MED/91205295; Brown S; Ende J
The sobering geography of AIDS [news]: Science. 1991 Apr 19;252(5004):372-3. Unique Identifier : AIDSLINE MED/91205298; Palca J
The male street prostitute: a vector for transmission of HIV infection into the heterosexual world.: Soc Sci Med. 1991;32(5):535-9. Unique Identifier : AIDSLINE MED/91205359; Morse EV; Simon PM; Osofsky HJ; Balson PM; Gaumer HR; Department of Psychiatry, Louisiana State University Medical; Center, New Orleans 70112.; Two hundred and eleven New Orleans male street prostitutes were interviewed and tested for antibodies to the human immunodeficiency virus (HIV). The subjects lifestyle characteristics and their sex and drug use practices were evaluated to determine the prostitutes potential to function as a vector for transmission o
Primary lymphoma of the central nervous system.: Tumori. 1991 Feb 28;77(1):32-5. Unique Identifier : AIDSLINE MED/91205624; Amadori M; Maltoni M; Ravaioli A; Rosti G; Pasquini E; Leoni M; Amadori D; Oncology Department, Pierantoni Hospital, Forli, Italy.; Primary lymphoma of the central nervous system (CNS) represents a pathology that is no longer considered rare, also in the light of its high correlation with the human immunodeficiency virus (HIV) syndrome reported recently. Often the correct diagnosis of the disease is difficult to reach, owing to the wide spectrum o
In vitro cleavage of HIV-1 vif RNA by a synthetic ribozyme.: Virus Genes. 1991 Jan;5(1):17-23. Unique Identifier : AIDSLINE MED/91205759; Lorentzen EU; Wieland U; Kuhn JE; Braun RW; Institute of Medical Virology, University of Heidelberg, FRG.; Using the method of Haseloff and Gerlach, we constructed a ribozyme specifically targeted against the virion infectivity factor (vif) of HIV-1. Both, the vif gene and an oligonucleotide representing the catalytic RNA sequence were cloned into pSPT19 downstream of the T7 promoter and transcribed with T7 RNA polymerase.
A defective proviral DNA with a 2.6-kb deletion of human immunodeficiency virus type 1 (HIV-1) in a persistently HIV-1 infected cell clone.: Virus Genes. 1991 Jan;5(1):81-8. Unique Identifier : AIDSLINE MED/91205767; Imai H; Maotani-Imai K; Shin YS; Ikuta K; Suehiro S; Kurimura T; Kato S; Hirai K; Section of Serology, Hokkaido University, Sapporo, Japan.; A cell line (H2-5) producing defective doughnut-shaped particles of human immunodeficiency virus type I (HIV-1) was found to contain proviral DNA with a large deletion of 2558 bases, corresponding to the 3 half of pol gene, the vif and vpr genes, and the 5 terminal of the tat gene.
Alterations of nocturnal sleep in patients with HIV infection.: Acta Neurol Scand. 1991 Feb;83(2):141-2. Unique Identifier : AIDSLINE MED/91206000; Wiegand M; Moller AA; Schreiber W; Krieg JC; Holsboer F; Max Planck Institute of Psychiatry, Munich, Germany.; Nocturnal sleep of 14 patients with HIV infection was characterized by longer sleep onset latency, shorter total sleep time, reduced sleep efficiency, more time spent awake and in Stage 1. There was significantly less sleep Stage 2 than in healthy controls. REM latency was slightly reduced and correlated negatively wi
Primary lymphoma of the CNS in an infant with AIDS: imaging findings.: AJR Am J Roentgenol. 1991 May;156(5):1037-8. Unique Identifier : AIDSLINE MED/91206221; Douek P; Bertrand Y; Tran-Minh VA; Patet JD; Souillet G; Philippe N; Department of Pediatric Radiology, UFR Lyon-Nord, France.
CT of AIDS-related lymphoma.: AJR Am J Roentgenol. 1991 May;156(5):969-74. Unique Identifier : AIDSLINE MED/91206258; Townsend RR; Department of Radiology, San Francisco General Hospital, CA; 94110.; A spectrum of CT findings in patients with AIDS-related lymphoma (ARL) is illustrated herein. When a solid mass anywhere in the body is encountered in a patient with AIDS, lymphoma must be considered in the differential diagnosis. Although the CT findings alone generally are not enough for a specific diagnosis of lymp
The challenge of combination antiretroviral therapy for AIDS. An introduction.: Am J Med. 1991 Apr 10;90(4A):1S. Unique Identifier : AIDSLINE MED/91206415; Groopman JE; Department of Medicine, New England Deaconess Hospital, Boston,; Massachusetts 02215.
The challenge of combination antiretroviral therapy. Proceedings of a symposium. June 20, 1990, San Francisco, California.: Am J Med. 1991 Apr 10;90(4A):1S-30S. Unique Identifier : AIDSLINE MED/91206416
Antiretroviral therapy and immunomodulators in patients with AIDS.: Am J Med. 1991 Apr 10;90(4A):18S-21S. Unique Identifier : AIDSLINE MED/91206417; Groopman JE; Department of Medicine, New England Deaconess Hospital, Boston,; Massachusetts 02215.; A number of studies have illustrated the effectiveness of hematopoietic growth factors in managing treatment-related cytopenias in patients with human immunodeficiency virus (HIV) infection. One of these factors, granulocyte-macrophage colony-stimulating factor, has been shown to restore absolute neutrophil counts in
Antiretroviral therapy in combination with interferon for AIDS-related Kaposi's sarcoma.: Am J Med. 1991 Apr 10;90(4A):2S-7S. Unique Identifier : AIDSLINE MED/91206418; Fischl MA; Department of Medicine, University of Miami School of Medicine,; Florida 33101.; In vitro studies have shown that 3 -azido-3 -deoxythymidine (zidovudine, AZT ) and interferon synergistically inhibit the replication of the human immunodeficiency virus type 1 (HIV) in peripheral blood mononuclear cells at concentrations achievable in
Relative resistance of primary HIV-1 isolates to neutralization by soluble CD4.: Am J Med. 1991 Apr 10;90(4A):22S-26S. Unique Identifier : AIDSLINE MED/91206419; Daar ES; Ho DD; Department of Medicine, Cedars-Sinai Medical Center, University; of California, Los Angeles School of Medicine.; Replication of the human immunodeficiency virus type 1 (HIV-1) underlies the pathogenesis and progression of the acquired immunodeficiency syndrome (AIDS). A soluble form of the virus receptor, CD4, has been developed as a potential therapeutic agent with good activity against laboratory strains of HIV-1 in vitro. How
Treatment of AIDS with combinations of antiretroviral agents: a summary.: Am J Med. 1991 Apr 10;90(4A):27S-30S. Unique Identifier : AIDSLINE MED/91206420; Groopman JE; Department of Medicine, New England Deaconess Hospital, Boston,; Massachusetts 02215.
Risk factors for needle sharing among methadone-treated patients.: Am J Psychiatry. 1991 May;148(5):636-40. Unique Identifier : AIDSLINE MED/91206613; Metzger D; Woody G; De Philippis D; McLellan AT; O'Brien CP; Platt JJ; Center for Studies on Addiction, University of Pennsylvania,; Philadelphia 19104.; OBJECTIVE: This paper examines the sociodemographic and psychiatric characteristics of patients taking methadone who continue to share needles. METHOD: Three hundred twenty-three patients were recruited from four methadone programs. Data were collected by using questionnaires and interviews. Psychiatric symptoms were
Implications of self-reported cognitive and motor dysfunction in HIV-positive patients.: Am J Psychiatry. 1991 May;148(5):641-3. Unique Identifier : AIDSLINE MED/91206614; Wilkins JW; Robertson KR; Snyder CR; Robertson WK; van der Horst C; Hall CD; AIDS Neurologic Center, School of Medicine, University of North; Carolina, Chapel Hill.; OBJECTIVE: The authors examined HIV-positive subjects to determine the relationship of patient complaints of cognitive and motor dysfunction to psychiatric status and performance on established cognitive and motor function tests. METHOD: HIV-positive volunteers (N = 77) were evaluated at entry into a longitudinal neur
Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use.: Am J Psychiatry. 1991 May;148(5):667-9. Unique Identifier : AIDSLINE MED/91206620; Nunes EV; Quitkin FM; Brady R; Stewart JW; Depression Evaluation Service, New York State Psychiatric; Institute, NY 10032.; Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further contr
[Mollusca contagiosa-like cutaneous cryptococcosis in AIDS: a case]: Ann Dermatol Venereol. 1991;118(1):29-32. Unique Identifier : AIDSLINE MED/91206832; Poizot-Martin I; Grob JJ; Fournerie JR; Dhiver C; Andrac L; Gastaut JA; Bonerandi JJ; Service de Dermatologie Venereologie, Hopital Sainte; Marguerite, Marseille.
The human immunodeficiency virus long terminal repeat contains sequences showing partial homology to glucocorticoid responsive elements.: Anticancer Res. 1991 Jan-Feb;11(1):381-3. Unique Identifier : AIDSLINE MED/91206937; Katsanakis CD; Sekeris CE; Spandidos DA; Institute of Biological Research and Biotechnology, National; Hellenic Research Foundation, Athens, Greece.; Steroid hormone receptor genes represent a multigene family encoding ligand activated transcription factors which act by binding to defined nucleotide sequences termed Hormone Responsive Elements (HREs). Many retroviruses contain Glucocorticoid Responsive Elements in their Long Terminal Repeats (LTRs). In view of the
Inhibition of HIV-1 proteinase by non-peptide carboxylates.: Biochem Biophys Res Commun. 1991 Apr 15;176(1):241-6. Unique Identifier : AIDSLINE MED/91207399; Brinkworth RI; Woon TC; Fairlie DP; Graduate School of Science and Technology, Bond University, Qld,; Australia.; Some simple dicarboxylates are among the first reported non-peptide inhibitors of HIV-1 proteinase. Only weak inhibition (IC50 greater than or equal to 10 microM) was observed but this may be significant since only two potential enzyme-binding groups are present. Dixon plots and preliminary kinetic data are reported a
Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects.: Biochem Biophys Res Commun. 1991 Apr 15;176(1):65-9. Unique Identifier : AIDSLINE MED/91207450; Rebholz KL; Northrop DB; Division of Pharmaceutical Biochemistry, School of Pharmacy,; University of Wisconsin, Madison 53706.; The relatively fast artificial substrate Leu-Ser-rho-nitro-Phe-Nle-Ala-Leu-OMe generates a solvent isotope effect of 1.51 +/- 0.02 only on the maximal velocity of peptide hydrolysis catalyzed by porcine pepsin (EC 3.4.23.1). The absence of an isotope effect on V/K places the isotopically-sensitive step after peptide b
Changing disease patterns in AIDS [news]: Nurs Stand. 1991 Feb 20-26;5(22):16. Unique Identifier : AIDSLINE MED/91175344; Peters BS
Policy results in 'false prison figures' for HIV [news]: Nurs Stand. 1991 Feb 20-26;5(22):7. Unique Identifier : AIDSLINE MED/91175358
International Council of Nurses. Playing a vital role [interview by Derek Hand]: Nurs Stand. 1991 Feb 27-Mar 5;5(23):17-8. Unique Identifier : AIDSLINE MED/91175360; Kim MI
Risks and benefits of home parenteral nutrition in the acquired immunodeficiency syndrome.: JPEN J Parenter Enteral Nutr. 1991 Jan-Feb;15(1):75-9. Unique Identifier : AIDSLINE MED/91178904; Singer P; Rothkopf MM; Kvetan V; Kirvela O; Gaare J; Askanazi J; Department of Anesthesiology, Montefiore Medical Center, Bronx,; New York 10467.; The gastrointestinal tract is a major target of the human immunodeficiency virus. Many AIDS patients have weight loss and/or diarrhea. Parenteral nutrition can be used to treat malnutrition associated with malabsorption. We reviewed retrospectively the clinical course of 22 patients with AIDS and weight loss greater t
Otolaryngology problems in the immune compromised patient--an evolving natural history.: Otolaryngol Head Neck Surg. 1991 Feb;104(2):196-203. Unique Identifier : AIDSLINE MED/91179738; Corey JP; Seligman I; Department of Otolaryngology-Head and Neck Surgery, University of; Chicago, IL.; As the human immunodeficiency virus is being detected in increasing numbers of asymptomatic individuals at risk, newer earlier patterns of disease have become apparent--including cranial and cervical herpes zoster, oral hairy leukoplakia, and oral candidiasis--thus linking viral and other disease to the development of
Sudden hearing loss due to AIDS-related cryptococcal meningitis--a temporal bone study.: Otolaryngol Head Neck Surg. 1991 Feb;104(2):265-9. Unique Identifier : AIDSLINE MED/91179750; Kwartler JA; Linthicum FH; Jahn AF; Hawke M; Division of Otolaryngology, University of Medicine and Dentistry; of New Jersey, Newark.; We have presented the clinical history and temporal bone findings in a patient who manifested sudden hearing loss, and who subsequently was found to have cryptococcal meningitis associated with AIDS. The histopathologic findings are similar to earlier reports in patients without AIDS. Because cryptococcal infection is
Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells.: Blood. 1991 Apr 1;77(7):1436-41. Unique Identifier : AIDSLINE GENBANK/S55817; Kelleher K; Bean K; Clark SC; Leung WY; Yang-Feng TL; Chen JW; Lin PF; Luo W; Yang YC; Genetics Institute, Cambridge, MA.; We have isolated the genomic sequence of human interleukin-9 (IL-9) based on its sequence homology with a human IL-9 cDNA isolated from human T-cell leukemia virus (HTLV)-I-transformed T cells by expression cloning. The entire genomic sequence has been determined and the gene consists of five exons and four introns. T
British AIDS funding: unfair distribution [news]: Br J Addict. 1991 Jan;86(1):113. Unique Identifier : AIDSLINE MED/91183218; Farrell M
Antiviral AIDS drug nears approval [news]: Science. 1991 Apr 12;252(5003):206-7. Unique Identifier : AIDSLINE MED/91188288
Low-dose intermittent trimethoprim-sulfamethoxazole for prevention of Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection.: Arch Intern Med. 1991 Apr;151(4):688-92. Unique Identifier : AIDSLINE MED/91189810; Wormser GP; Horowitz HW; Duncanson FP; Forseter G; Javaly K; Alampur SK; Gilroy SA; Lenox T; Rappaport A; Nadelman RB; Department of Medicine, Westchester County Medical Center.; The important role of chemoprophylaxis for the prevention of Pneumocystis carinii pneumonia (PCP) in human immunodeficiency virus type 1 (HIV)-infected patients is undisputed. The most cost-effective regimen, however, is unknown. We reviewed our experience at two hospitals in the New York City area in which low-dose,
An idiotypic network model of AIDS immunopathogenesis.: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3060-4. Unique Identifier : AIDSLINE MED/91195291; Hoffmann GW; Kion TA; Grant MD; Department of Microbiology, University of British Columbia,; Vancouver, Canada.; Considerations from a network theory of the immune system suggest that human immunodeficiency virus and allogeneic stimuli may act synergistically to cause AIDS. The immune responses to these stimuli include two components that are directed against each other. In some AIDS risk groups other antigens that mimic major h
Perturbation of host-cell membrane is a primary mechanism of HIV cytopathology.: Virology. 1991 Apr;181(2):500-11. Unique Identifier : AIDSLINE MED/91196240; Cloyd MW; Lynn WS; Department of Microbiology, University of Texas Medical Branch,; Galveston, Texas 77550.; Cytopathic viruses injure cells by a number of different mechanisms. The mechanism by which HIV-1 injures T cells was studied by temporally examining host-cell macromolecular syntheses, stages of the cell cycle, and membrane permeability following acute infection. T cells cytopathically infected at an m.o.i. of 1-5 gr
Highly immunogenic human immunodeficiency viruslike particles are produced by recombinant vaccinia virus-infected cells.: AIDS Res Hum Retroviruses. 1991 Jan;7(1):29-36. Unique Identifier : AIDSLINE MED/91197562; Vzorov AN; Bukrinsky MI; Grigoriev VB; Tentsov YYu; Bukrinskaya AG; Central Institute of Training of Physicians, USSR Minstry of; Health, Moscow.; CV-1 cells were infected with two recombinant vaccinia viruses carrying the gag gene with deletion of 231 bp from 3 terminus (strain vC5) and env gene (strain vE234L) of human immunodeficiency virus type 1 (HIV-1). Both recombinant proteins synthesized in the cells (p50gag and gp160/120env) were localized predominant
B-ly-7, a monoclonal antibody labeling of activated lung lymphocytes [letter]: Blood. 1991 Apr 15;77(8):1855-6. Unique Identifier : AIDSLINE MED/91198522; Zambello R; Feruglio C; Cipriani A; Cadrobbi P; Semenzato G
Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals.: Clin Exp Immunol. 1991 Apr;84(1):109-15. Unique Identifier : AIDSLINE MED/91199436; Vyakarnam A; Matear P; Meager A; Kelly G; Stanley B; Weller I; Beverley P; Academic Department of Genito Urinary Medicine, University; College, London, UK.; In vitro studies shows that recombinant tumour necrosis factor (TNF) alpha and beta, and interferon-gamma (IFN-gamma) can enhance HIV replication, and peripheral blood mononuclear cells (PBMC) infected with HIV in vitro secrete high levels of the same cytokines. As T cells secrete all three mediators, the capacity of
Serological markers as prognostic criteria for the course of HIV infection.: Infection. 1991;19 Suppl 2:S89-92. Unique Identifier : AIDSLINE MED/91200937; Kleinschmidt A; Matuschke A; Goebel FD; Erfle V; Hehlmann R; Med. Poliklinik der Universitat Munchen, Germany.; 576 serum samples from 139 HIV infected patients were analyzed for the presence of HIV antigens, as well as anti-core, anti-env and neutralizing antibodies. The results were correlated with the clinical and immunological stages of the patients. While almost all sera were positive for anti-env antibodies, only two thir
Tumor necrosis factor and interferon as prognostic markers in human immunodeficiency virus (HIV) infection.: Infection. 1991;19 Suppl 2:S93-7. Unique Identifier : AIDSLINE MED/91200938; Hess G; Rossol S; Rossol R; Meyer zum Buschenfelde KH; I. Medizinische Klinik und Poliklinik, Johannes Gutenberg; Universitat Mainz, Germany.; Peripheral blood cells were obtained from patients at different stages of their human immunodeficiency virus (HIV) infection. It was found that the capacity to generate interferon alpha was reduced already at Walter Reed stage 2 (WR) while the interferon gamma capacity remained largely unaffected until WR stage 4. End
Bidirectional effects of cytokines on the growth of Mycobacterium avium within human monocytes.: J Immunol. 1991 May 1;146(9):3165-70. Unique Identifier : AIDSLINE MED/91201888; Shiratsuchi H; Johnson JL; Ellner JJ; Department of Medicine, Case Western Reserve University,; Cleveland, OH 44106.; Certain cytokines including IFN-gamma possess macrophage-activating factor activity that enhances the ability of these effector cells to destroy intracellular pathogens. A panel of recombinant and highly purified human cytokines was screened to detect this effect on the activation of human monocytes to kill Mycobacter
Human immunodeficiency virus-1 (HIV-1) in the vapors of surgical power instruments.: J Med Virol. 1991 Jan;33(1):47-50. Unique Identifier : AIDSLINE MED/91202148; Johnson GK; Robinson WS; Division of Orthopedic Surgery, Stanford University School of; Medicine, California 94305-5107.; Cool vapors and aerosols produced by several common surgical power instruments and hot smoke plumes generated with electrocautery on known HIV-1 innoculated blood were gently bubbled through sterile viral culture media. Tissue culture cells were then added and cell infection was detected by the appearance of HIV-1 P-2
Synthesis and evaluation of novel ether lipid nucleoside conjugates for anti-HIV-1 activity.: J Med Chem. 1991 Apr;34(4):1408-14. Unique Identifier : AIDSLINE MED/91202496; Piantadosi C; Marasco CJ Jr; Morris-Natschke SL; Meyer KL; Gumus F; Surles JR; Ishaq KS; Kucera LS; Iyer N; Wallen CA; et al; University of North Carolina, School of Pharmacy, Division of; Medicinal Chemistry and Natural Products, Chapel Hill 27599.; Combinations of an amidoalkylphosphocholine, 8, and AZT have been found to cause an apparent synergistic action in suppressing infectious HIV-1 replication. In addition, amidoalkyl, oxyalkyl, and thioalkyl ether lipids have been chemically linked to a
Human immunodeficiency virus (HIV)-infected tumor xenografts as an in vivo model for antiviral therapy: role of alpha/beta interferon in restriction of tumor growth in nude mice injected with HIV-infected U937 tumor cells.: J Virol. 1991 May;65(5):2245-53. Unique Identifier : AIDSLINE MED/91202561; Puddu P; Locardi C; Sestili P; Varano F; Petrini C; Modesti A; Masuelli L; Gresser I; Belardelli F; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The host factors involved in the restriction of tumor growth were studied in nude mice transplanted with a cloned line of chronically human immunodeficiency virus (HIV)-infected U937 cells. HIV-infected and uninfected U937 cells exhibited the same growth patterns in culture. However, HIV-infected cells were not tumori
Mandatory HIV testing and the duty to screen [letter]: Mil Med. 1991 Mar;156(3):A6-7. Unique Identifier : AIDSLINE MED/91204167; Longfield JN; Takafuji E
HIV infection: military occupational sequelae.: Mil Med. 1991 Mar;156(3):108-13. Unique Identifier : AIDSLINE MED/91204170; Prier RE; McNeil JG; Burge JR; Department of Psychiatry, Walter Reed Army Medical Center,; Washington, DC.; The military experience of 573 soldiers found to be HIV seropositive and their 2,262 matched seronegative controls were compared to determine if differences exist. Examination of personnel records for study members showed an expected difference in assignment changes, with seropositives being moved significantly more o
Psychiatric care of the homeless mentally ill: an opportunity for military psychiatry training.: Mil Med. 1991 Mar;156(3):121-6. Unique Identifier : AIDSLINE MED/91204173; Koshes RJ; Department of Psychiatry, St. Elizabeths Hospital.; This paper reviews the phenomenon of homelessness in the United States and locally in Washington, D.C. Prevalence data of psychiatric illness in the homeless is presented, as is the formation of a psychiatric service network to treat the homeless mentally ill. Additionally, the author
[Seroprevalence of hepatitis C in human immunodeficiency virus infected patients]: Pathol Biol (Paris). 1991 Feb;39(2):126-30. Unique Identifier : AIDSLINE MED/91204339; Ranger S; Aussel L; Weinbreck P; Loustaud V; Rogues AM; Mounier M; Delpeyroux C; Denis F; Service de Bacteriologie-Virologie, CHU Dupuytren, Limoges,; France.; Prevalence of antibodies against hepatitis C virus (HCV) was evaluated using Ortho and Abbott HCV Elisa assays and the Abbott EIA Neutralization assay in 150 human immunodeficiency virus (HIV)-seropositive patients and compared with the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) markers. Overall
Benign lymphoepithelial parotid tumors in AIDS patients: CT and MR findings in nine cases.: AJNR Am J Neuroradiol. 1991 Mar-Apr;12(2):271-4. Unique Identifier : AIDSLINE MED/91206275; Kirshenbaum KJ; Nadimpalli SR; Friedman M; Kirshenbaum GL; Cavallino RP; Department of Radiology, Illinois Masonic Medical Center, Chicago; 60657.; Benign lymphoepithelial parotid neoplasm with associated cervical adenopathy is a newly described head and neck manifestation of HIV infection, characterized previously as purely cystic masses on both CT and MR evaluations. The CT and MR findings in nine cases of surgically proved benign lymphoepithelial parotid lesio
Intracranial cryptococcosis in immunocompromised patients: CT and MR findings in 29 cases.: AJNR Am J Neuroradiol. 1991 Mar-Apr;12(2):283-9. Unique Identifier : AIDSLINE MED/91206278; Tien RD; Chu PK; Hesselink JR; Duberg A; Wiley C; Department of Radiology, UCSD Medical Center 92103.; CT and MR scans of 29 immunocompromised patients (28 with AIDS or ARC, one with diabetes mellitus) who had documented intracranial cryptococcal infection were reviewed retrospectively. All patients had CT studies; 26 received iodinated contrast agent. CT findings included normal results in nine of 29, atrophy only in
An ABC of oral health care in patients with HIV infection [see comments]: Br Dent J. 1991 Feb 23;170(4):149-50. Unique Identifier : AIDSLINE MED/91175271; Scully C; Porter SR; Luker J; University Department of Oral Medicine, Surgery and Pathology,; Bristol Dental Hospital and School.
Free brochure on disseminated MAI in persons with AIDS [news]: Oncology (Huntingt). 1991 Feb;5(2):36. Unique Identifier : AIDSLINE MED/91182580
An AIDS compendium [news]: Oncology (Huntingt). 1991 Feb;5(2):62. Unique Identifier : AIDSLINE MED/91182583
Protein S deficiency and HIV infection [letter]: N Engl J Med. 1991 Apr 25;324(17):1220. Unique Identifier : AIDSLINE MED/91187087; Lafeuillade A; Alessi MC; Poizot-Martin I; Dhiver C; Quilichini R; Aubert L; Gastaut JA; Juhan-Vague I
[Thermal processing of homologous bone transplants for the bone bank as additional safety measure in AIDS prophylaxis]: Z Orthop Ihre Grenzgeb. 1991 Jan-Feb;129(1):108-10. Unique Identifier : AIDSLINE MED/91188673; Staudte HW; Breickmann B; Orthopadische Abteilung, Kreiskrankenhauses Wurselen.; Under the supposition that retrovirus is inactivated by heating at 56 degrees C, we explored what time was necessary to reach 65 degrees C as a central temperature in a femoral head by heating (14 femoral heads). We found that at a stove temperature of 85 degrees C and a femoral head volume of 81 ml the average centra
Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status.: Ann Neurol. 1991 Feb;29(2):202-9. Unique Identifier : AIDSLINE MED/91189662; Heyes MP; Brew BJ; Martin A; Price RW; Salazar AM; Sidtis JJ; Yergey JA; Mouradian MM; Sadler AE; Keilp J; et al; Laboratory of Clinical Science, National Institute of Mental; Health, Bethesda, MD 20892.; Quinolinic acid is an excitotoxic metabolite and an agonist of N-methyl-D-aspartate receptors. Of patients infected with human immunodeficiency virus type 1 (HIV-1) who were neurologically normal or exhibited only equivocal and subclinical signs of the acquired immunodeficiency syndrome (AIDS)
Interferon-alpha 2a in the treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma.: J Immunother. 1991 Feb;10(1):39-50. Unique Identifier : AIDSLINE MED/91190879; Evans LM; Itri LM; Campion M; Wyler-Plaut R; Krown SE; Groopman JE; Goldsweig H; Volberding PA; West SB; Mitsuyasu RT; et al; Hoffmann-La Roche, Nutley, New Jersey.; In a series of studies, recombinant interferon-alpha 2a (rIFN alpha 2a, Roferon-A) was administered alone (273 men) or combined with vinblastine (91 men) to patients with acquired immunodeficiency syndrome (AIDS)-related Kaposi s sarcoma (KS). Patients were treated with daily doses of rIFN alpha 2a ranging from 3 to 5
Molecular mimicry among human autoantigens [letter]: Immunol Today. 1991 Jan;12(1):46-7. Unique Identifier : AIDSLINE MED/91197357; Manfredi AA; Bellone M; Protti MP; Conti-Tronconi BM
Lymphocyte subsets as surrogate markers in antiretroviral therapy.: Infection. 1991;19 Suppl 2:S103-8. Unique Identifier : AIDSLINE MED/91200933; Bogner JR; Goebel FD; Medizinische Poliklinik, Universitat Munchen, Germany.; Efficacy of antiretroviral treatment is evaluated usually according to reduction of serious events (e.g. opportunistic infections while on therapy) and improvement of survival time. In stages of asymptomatic disease treatment trials have to cover very long time periods to fulfil these requirements. In asymptomatic sta
Early activation events render T cells susceptible to HIV-1-induced syncytia formation. Role of protein kinase C.: J Biol Chem. 1991 Apr 15;266(11):7233-8. Unique Identifier : AIDSLINE MED/91201386; Mohagheghpour N; Chakrabarti R; Stein BS; Gowda SD; Engleman EG; Stanford Blood Center, Palo Alto, California 94304.; In human immunodeficiency virus-1 (HIV-1)-infected cell culture