Invasive migration of epidemic Kaposi's sarcoma cells in vitro. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Invasive migration of epidemic Kaposi's sarcoma cells in vitro.

Br J Dermatol. 1990 Sep;123(3):313-8. Unique Identifier : AIDSLINE MED/91002379
Schirren CG; Roth WK; Hein R; Werner S; Krieg T; Braun-Falco O; Dermatologische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat Munchen, F.R.G.

Abstract: Kaposi's sarcoma (KS) is a low grade malignant neoplasm which shows invasive growth and often occurs in immunosuppressed patients with the Acquired Immune Deficiency Syndrome (AIDS; epidemic KS). It is also found in elderly men where it is usually limited to the skin (classic KS). The present study investigated the chemotaxis and invasive migration of epidemic KS cells in vitro and compared them to cells grown from classic KS lesions and to fibroblasts. Epidemic KS cells demonstrated invasive migration through reconstituted basement membrane (Matrigel) as well as through interstitial connective tissue (collagen I) in early passages, whereas fibroblasts did not invade either barrier. Epidemic KS cells in late passages did not show any invasive migration. Following pretreatment with tumour necrosis factor alpha (TNF-alpha) there was no enhanced migration through the Matrigel and collagen I for epidemic KS cells, whereas classic KS cells showed an increased migration through the type I collagen barrier.
Keywords: Basement Membrane Cell Movement/PHYSIOLOGY Chemotaxis/PHYSIOLOGY Connective Tissue Fibroblasts/CYTOLOGY Human Male Neoplasm Invasiveness Sarcoma, Kaposi's/*PATHOLOGY Skin Neoplasms/*PATHOLOGY Support, Non-U.S. Gov't Tumor Cells, Cultured/DRUG EFFECTS/PATHOLOGY Tumor Necrosis Factor/PHARMACOLOGY JOURNAL ARTICLEKWDbasementmembranecellmovement/physiologychemotaxis/physiologyconnectivetissuefibroblasts/cytologyhumanmaleneoplasminvasivenesssarcoma,kaposi's/KWDpathologyskinneoplasms/KWDpathologysupport,non-uKWDsKWDgov'ttumorcells,cultured/drugeffects/pathologytumornecrosisfactor/pharmacologyjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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