Susceptibility to HIV infection and AIDS in Italian haemophiliacs is HLA associated. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Susceptibility to HIV infection and AIDS in Italian haemophiliacs is HLA associated.

Br J Haematol. 1990 Aug;75(4):531-6. Unique Identifier : AIDSLINE MED/91002424
Fabio G; Smeraldi RS; Gringeri A; Marchini M; Bonara P; Mannucci PM; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.

Abstract: We compared the frequencies of HLA antigens in two matched groups of 31 HIV-seronegative and 31 HIV-seropositive haemophiliacs, exposed during the years 1981-85 to comparable amounts and batches of presumably infectious clotting factor concentrates. The frequency of A2 was significantly higher in HIV-seropositive than in seronegative haemophiliacs, with a relative risk (RR) of seroconversion of 3.92, whereas both Bw52 and DR4 were negatively associated with it. We also studied the distribution of HLA antigens in a larger group of 76 HIV-seropositive haemophiliacs, who were at different clinical stages of HIV infection (CDC classes II-IV) but were comparable for age and time elapsed since seroconversion. DR3 and DQw2 antigens were, particularly when concomitantly present, associated with a high risk of developing symptomatic HIV infection (RR = 11.79 and 25.33). Our data suggest that the HLA region controls susceptibility to infection with HIV and its progression to symptomatic disease in Italian haemophiliacs.
Keywords: Adolescence Adult Child Christmas Disease/COMPLICATIONS/IMMUNOLOGY Disease Susceptibility Hemophilia/*COMPLICATIONS/GENETICS/IMMUNOLOGY Human HIV Seropositivity/*COMPLICATIONS/GENETICS/IMMUNOLOGY HLA Antigens/*ANALYSIS/GENETICS Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadolescenceadultchildchristmasdisease/complications/immunologydiseasesusceptibilityhemophilia/KWDcomplications/genetics/immunologyhumanhivseropositivity/KWDcomplications/genetics/immunologyhlaantigens/KWDanalysis/geneticsmiddleagesupport,non-uKWDsKWDgov'tjournalarticle
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M9110566

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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