Induction of monocyte proliferation and HIV expression by IL-3 does not interfere with anti-viral activity of zidovudine. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Induction of monocyte proliferation and HIV expression by IL-3 does not interfere with anti-viral activity of zidovudine.

Blood. 1990 Oct 15;76(8):1490-3. Unique Identifier : AIDSLINE MED/91002905
Schuitemaker H; Kootstra NA; van Oers MH; van Lambalgen R; Tersmette M; Miedema F; Central Laboratory, The Netherlands Red Cross Blood Transfusion; Service, Amsterdam, The Netherlands.

Abstract: Myelosuppression is a major symptom in the acquired immunodeficiency syndrome (AIDS). Moreover zidovudine, an anti-retroviral drug used to treat AIDS patients has myelosuppressive side effects. Therefore treatment with IL-3, a multi-lineage hemopoietic growth factor may be beneficial for zidovudine-treated individuals. In this study we examined the effect of IL-3 on human immunodeficiency virus (HIV) expression. The proliferative response to rIL-3 and the effects on the replication of the monocytotropic HIV variant, HTLV-III Ba-L, in the absence or presence of the anti-retroviral drug zidovudine was studied in purified human peripheral blood monocytes. Zidovudine concentrations sufficient for complete inhibition of HIV replication did not affect rIL-3 induced monocyte proliferation. Although rIL-3, like rGM-CSF, was able to augment HIV expression in monocytes, it did not interfere with the anti-retroviral activity of zidovudine. These data indicate that rIL-3 is a potential candidate for use in myelosupportive therapy in AIDS patients treated with anti-retroviral drugs.
Keywords: Cell Division Cells, Cultured Human HIV/DRUG EFFECTS/*PHYSIOLOGY Interleukin-3/*PHARMACOLOGY Monocytes/*CYTOLOGY/MICROBIOLOGY Support, Non-U.S. Gov't Virus Replication/DRUG EFFECTS Zidovudine/*PHARMACOLOGY JOURNAL ARTICLEKWDcelldivisioncells,culturedhumanhiv/drugeffects/KWDphysiologyinterleukin-3/KWDpharmacologymonocytes/KWDcytology/microbiologysupport,non-uKWDsKWDgov'tvirusreplication/drugeffectszidovudine/KWDpharmacologyjournalarticle
910130
M9110563

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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