Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion.

Cancer. 1990 Oct 1;66(7):1524-8. Unique Identifier : AIDSLINE MED/91003852
Picard F; Dreyfus F; Le Guern M; Tulliez M; d'Auriol L; Neron S; Galibert F; Saragosti S; Varet B; Department of Hematology, Hopital Cochin, France.

Abstract: The authors observed a pleiomorphic lymphoma mimicking Hodgkin's lymphoma in a French Guyana black woman lacking antibodies for human T-cell lymphoma/leukemia virus type I (HTLV I). After two courses of chemotherapy with either mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) or doxorubicin, bleomycin, vincaleukoblastine, and dacarbazine (ABVD), a typical acute T-cell leukemia/lymphoma developed with HTLV I seroconversion. Specific HTLV I DNA sequences were detected using the polymerase chain reaction (PCR) on a lymph node biopsy obtained before chemotherapy. The mechanisms of the seroconversion are discussed.
Keywords: Adult Antigens, CD/ANALYSIS Base Sequence Case Report Diagnosis, Differential DNA, Viral/ANALYSIS Female Hodgkin's Disease/*DIAGNOSIS Human HTLV-I/ISOLATION & PURIF HTLV-I Antibodies/ANALYSIS Immunoenzyme Techniques Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*DIAGNOSIS/ GENETICS/IMMUNOLOGY Molecular Sequence Data Polymerase Chain Reaction JOURNAL ARTICLEKWDadultantigens,cd/analysisbasesequencecasereportdiagnosis,differentialdna,viral/analysisfemalehodgkin'sdisease/KWDdiagnosishumanhtlv-i/isolation&purifhtlv-iantibodies/analysisimmunoenzymetechniquesleukemia-lymphoma,t-cell,acute,htlv-i-associated/KWDdiagnosis/genetics/immunologymolecularsequencedatapolymerasechainreactionjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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