Cytogenetic studies of human T-cell leukemia virus type I carriers. A family study. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Cytogenetic studies of human T-cell leukemia virus type I carriers. A family study.

Cancer Genet Cytogenet. 1990 Oct 15;49(2):157-63. Unique Identifier : AIDSLINE MED/91003919
Itoyama T; Sadamori N; Tokunaga S; Sasagawa I; Nakamura H; Yao E; Jubashi T; Yamada Y; Ikeda S; Ichimaru M; Department of Hematology, Nagasaki University School of Medicine,; Japan.

Abstract: Recently, the chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL), and this anomaly has also been confirmed in the preleukemic state of adult T-cell leukemia (pre-ATL) patients. Because the cytogenetic abnormality at the stage of human T-cell leukemia virus type I (HTLV-I) carrier remains uncertain, we performed cytogenetic studies of lymphocytes stimulated with phytohemagglutinin in three HTLV-I carriers and three non-HTLV-I carriers in an ATL family. As a result, in three HTLV-I carriers, four of 311 cells examined (1.3%) had chromosome 14q11 anomaly. However, in three non-HTLV-I carriers, none of 260 cells examined had chromosome 14q11 anomaly. These results suggest that chromosome 14q11 anomaly is already present at the stage of HTLV-I carrier and seems to be an important cytogenetic clue to the pathogenesis of ATL.
Keywords: Adult Aged Blood Cell Count Case Report Chromosome Aberrations/*GENETICS *Chromosomes, Human, Pair 14 Female Human HTLV-I/*GENETICS Karyotyping Leukemia, T-Cell/*GENETICS/IMMUNOLOGY Male Middle Age Phytohemagglutinins/PHARMACOLOGY JOURNAL ARTICLEKWDadultagedbloodcellcountcasereportchromosomeaberrations/KWDgeneticsKWDchromosomes,human,pair14femalehumanhtlv-i/KWDgeneticskaryotypingleukemia,t-cell/KWDgenetics/immunologymalemiddleagephytohemagglutinins/pharmacologyjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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