PLASMAPHERESIS FOLLOWED BY IMMUNOGLOBULIN INFUSION FOR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTED PATIENTS WITH HYPERGAMMAGLOBULINAEMIA NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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PLASMAPHERESIS FOLLOWED BY IMMUNOGLOBULIN INFUSION FOR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTED PATIENTS WITH HYPERGAMMAGLOBULINAEMIA

Int J Immunotherapy; 4(4):229-34 1988. Unique Identifier : AIDSLINE ICDB/90657982
Rogna S; Puppo F; Torresin A; Stagnaro R; Setti M; Pierri I; Orlando G; Indiveri F; Inst. of Internal Medicine, Univ. of Genoa, Genoa, Italy

Abstract: AIDS patients (pts) often develop a conspicuous, although functionally ineffective, hypergammaglobulinemia. The authors have treated 9 pts affected by AIDS or AIDS-related diseases with repeated courses of plasma exchange coupled with immunoglobulin infusions. The schedule of each course was as follows: one apheretic treatment once a week for 5 consecutive weeks; each treatment amounted to an av exchange of 3000 ml of plasma, replaced by plasma/protein and 5% albumin/physiological saline solutions, and was followed by infusion of 15 g of human immunoglobulins. Each apheretic course was completed with further weekly administrations of the same amount of human immunoglobulins. Following treatment, a fast cessation of fever, weight gain and an overall clinical amelioration with decrease of infections, asthenia, and anorexia were noted. Hematological, serological, and immunological parameters (particularly IgG serum levels) significantly improved after treatment, too. (14 Refs)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY/ *THERAPY Adult Blotting, Western Combined Modality Therapy Female Human Hypergammaglobulinemia/COMPLICATIONS/IMMUNOLOGY/*THERAPY HIV Antibodies/ANALYSIS Immunoglobulins/*ADMINISTRATION & DOSAGE Male Monitoring, Physiologic Opsonins/ANALYSIS *Plasmapheresis JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/complications/immunology/KWDtherapyadultblotting,westerncombinedmodalitytherapyfemalehumanhypergammaglobulinemia/complications/immunology/KWDtherapyhivantibodies/analysisimmunoglobulins/KWDadministration&dosagemalemonitoring,physiologicopsonins/analysisKWDplasmapheresisjournalarticle
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Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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