Macrophage tropism of HIV-1. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Macrophage tropism of HIV-1.

AIDS Res Hum Retroviruses. 1990 Aug;6(8):1017-21. Unique Identifier : AIDSLINE MED/91026265
Gartner S; Popovic M; Primate Research Institute, Holloman AFB, NM 88330.

Abstract: Both in vivo and in vitro studies clearly demonstrate that cells of the mononuclear phagocyte lineage are major hosts for human immunodeficiency virus type 1 (HIV-1) replication. Presumably these cells play a key role in the pathogenesis of acquired immunodeficiency syndrome (AIDS). To further delineate the interactions between HIV-1 and host cells, the susceptibility and permissivity of normal human peripheral blood-derived monocyte/macrophages (M/M) and T lymphocytes, and neoplastic monocytoid and lymphoid cell lines to various HIV-1 isolates was assessed. The results suggest: (1) fresh isolates recovered from patients and propagated only in normal host cells exhibit a dual tropism for both M/M and T cells, regardless of their tissue of origin or the cell type from which they were isolated; (2) the repeated passage of an HIV-1 isolate through normal M/M does not generally result in the loss of the ability to infect normal T cells nor vice versa; (3) the majority of fresh HIV-1 isolates do not infect neoplastic cells of either origin, and those that do show no preference for monocytoid or lymphoid targets, regardless of their cell origin.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY Human HIV-1/*PATHOGENICITY Macrophages/*MICROBIOLOGY T-Lymphocytes/MICROBIOLOGY Tumor Cells, Cultured/MICROBIOLOGY Virus Replication JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDetiologyhumanhiv-1/KWDpathogenicitymacrophages/KWDmicrobiologyt-lymphocytes/microbiologytumorcells,cultured/microbiologyvirusreplicationjournalarticle
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M9120687

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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