Role of the monocyte-macrophage in influenza virus infection of lymphocytes: implications for HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Role of the monocyte-macrophage in influenza virus infection of lymphocytes: implications for HIV infection.

AIDS Res Hum Retroviruses. 1990 Aug;6(8):965-6. Unique Identifier : AIDSLINE MED/91026273
Mock DJ; Roberts NJ Jr; Department of Medicine, University of Rochester School of; Medicine, NY 14642.

Abstract: Knowledge of the pathogenesis of viruses which are less virulent than human immunodeficiency virus (HIV) may provide valuable insights into the pathogenesis of HIV infection. Influenza virus, an enveloped RNA virus, infects monocyte-macrophages, although the infection is brief and abortive. Isolated purified lymphocytes are completely resistant to infection. In contrast, mixtures of lymphocytes and macrophages can synthesize all virus proteins. Infection requires physical association of monocyte-macrophages and lymphocytes in clusters. These studies with influenza virus suggest that the pathogenesis of virus infections in mixed cell cultures may be very different from that observed in purified cell populations, and they suggest that similar studies should be performed with HIV.
Keywords: Human HIV Infections/*ETIOLOGY/IMMUNOLOGY Influenza/*IMMUNOLOGY Macrophages/*MICROBIOLOGY Monocytes/*MICROBIOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDhumanhivinfections/KWDetiology/immunologyinfluenza/KWDimmunologymacrophages/KWDmicrobiologymonocytes/KWDmicrobiologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M9120683

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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