The continuous decrease in the number of SSPE annual cases ten years after compulsory anti-measles immunization. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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The continuous decrease in the number of SSPE annual cases ten years after compulsory anti-measles immunization.

Rev Roum Virol. 1990 Jan-Mar;41(1):13-8. Unique Identifier : AIDSLINE MED/91027598
Cernescu C; Popescu-Tismana G; Alaicescu M; Popescu L; Cajal N; St. S. Nicolau Institute of Virology, Bucharest, Romania.

Abstract: The record of SSPE cases diagnosed immunochemically and serologically in our laboratory, standing for about 60% of the total new cases reported in our country, shows a significant decrease in the incidence in 1988-89 (from 5.21 new cases per year per million total population in 1987 to 1.82 cases in 1988). In 85% of the patients, SSPE onset occurred at the age of 10 years or more, suggesting the possibility of a primary measles infection before anti-measles immunization became compulsory. High serum and CSF anti-measles antibody titres in recently diagnosed patients show subclinical long-term courses. Further serologic tests for viruses inducing persistent infections (herpes viruses, AgHBs and HIV) do not show any difference when compared to a control group excepting an increased incidence of anti-cytomegalic titres.
Keywords: Age Factors Antibodies, Viral/BLOOD Comparative Study Hepatitis B Antibodies/BLOOD Hepatitis B Surface Antigens/BLOOD Herpesviridae/IMMUNOLOGY Human HIV Antibodies/BLOOD Incidence Measles Vaccine/*IMMUNOLOGY Romania/EPIDEMIOLOGY Seroepidemiologic Methods Subacute Sclerosing Panencephalitis/*EPIDEMIOLOGY/IMMUNOLOGY/ PREVENTION & CONTROL Time Factors JOURNAL ARTICLEKWDagefactorsantibodies,viral/bloodcomparativestudyhepatitisbantibodies/bloodhepatitisbsurfaceantigens/bloodherpesviridae/immunologyhumanhivantibodies/bloodincidencemeaslesvaccine/KWDimmunologyromania/epidemiologyseroepidemiologicmethodssubacutesclerosingpanencephalitis/KWDepidemiology/immunology/prevention&controltimefactorsjournalarticle
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M9120671

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