Perinatal infection of human T-lymphotropic virus type I, the etiologic virus of adult T-cell leukemia/lymphoma. DNA amplification of specific human T-lymphotropic virus type I sequences.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

Perinatal infection of human T-lymphotropic virus type I, the etiologic virus of adult T-cell leukemia/lymphoma. DNA amplification of specific human T-lymphotropic virus type I sequences.

Cancer. 1990 Nov 1;66(9):1933-7. Unique Identifier : AIDSLINE MED/91029100
Saji F; Ohashi K; Tokugawa Y; Kamiura S; Azuma C; Tanizawa O; Department of Obstetrics and Gynecology, Osaka University Medical; School, Japan.

Abstract: A gene amplification technique, polymerase chain reaction, was used to detect human T-lymphotropic virus type I (HTLV-I), the etiologic agent of adult T-cell leukemia/lymphoma, in mononuclear cells in peripheral blood and breast milk of ten HTLV-I carrier gravida. The DNA in umbilical cord blood mononuclear cells of the neonates born to the HTLV-I carrier gravida were also amplified and examined for the possibility of HTLV-I infection via placenta during pregnancy. The HTLV-I sequences were detected both in the peripheral blood and milk of all ten carrier gravida by Southern blot analysis of amplified DNA. However, HTLV-I proviral DNA could not be detected in the cord blood of the carriers' neonates, indicating that transplacental infection of HTLV-I should be rare and that postpartum infection via breast milk is a likely major perinatal transmission route.

Keywords: Antibodies, Neoplasm/IMMUNOLOGY Antigens, Neoplasm/IMMUNOLOGY Base Sequence Blotting, Southern Breast Feeding Female Fetal Blood/MICROBIOLOGY *Gene Amplification Human HTLV-I/*PHYSIOLOGY HTLV-I Infections/BLOOD/TRANSMISSION Infant, Newborn Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/ETIOLOGY/ *MICROBIOLOGY Leukocytes, Mononuclear/PHYSIOLOGY Milk, Human/MICROBIOLOGY Molecular Sequence Data Pregnancy Pregnancy Complications, Infectious/ETIOLOGY/*MICROBIOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE
910228
M9120643

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1991. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1991. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .